Effects of removing reimbursement restrictions on targeted therapy accessibility for non-small cell lung cancer treatment in Taiwan: an interrupted time series study by Jason C Hsu, Chen-Fang Wei, Szu-Chun Yang

“…Interventions Targeted therapies have been proven to provide clinical benefits to patients with metastatic non-small cell lung cancer (NSCLC). Gefitinib was initially approved and reimbursed as a third-line therapy for patients with advanced NSCLC by the Taiwan National Health Insurance (NHI) in 2004; subsequently it became a second-line therapy (in 2007) and further a first-line therapy (in 2011) for patients with epidermal growth factor receptor mutation-positive advanced NSCLC. …”
Get full text

Clinical validation and optimization of machine learning models for early prediction of sepsis by Xi Liu, Meiyi Li, Xu Liu, Yuting Luo, Dong Yang, Hui Ouyang, Jiaoling He, Jinyu Xia, Fei Xiao, Fei Xiao, Fei Xiao

“…We evaluated the performance of the five ML models and the evaluation metrics were: area under the ROC curve (AUC), accuracy, F1-score, sensitivity and specificity. The data of another cohort of 2,286 patients between October 1, 2020 and April 1, 2022 were used to validate the performance of the model performing best in the in the internal validation set. …”
Get full text

Urban vs Suburban: Is the Door-to-Balloon Time Affected by Geographic, Socioeconomic, or Racial Differences? A Tale of Two Campuses by Marc Zughaib, Patrick Ters, Robby Singh, Marcel Zughaib

“…This time window is defined as the door-to-balloon time (DTB) and is recommended to be under 90 minutes to improve patient mortality. To add another layer of complexity, patients with varying socioeconomic status and racial differences experience large disparities in health. …”
Get full text

A comparison of development methods used to define portion sizes in food-based dietary guidelines around the world by Fanny Salesse, Fanny Salesse, Alison L. Eldridge, Tsz Ning Mak, Eileen R. Gibney, Eileen R. Gibney

“…Thirty-nine FBDGs were derived from a combination of consensus/review and another method. Of the countries providing portion size information, only one did not report its methodological approach. …”
Get full text

Solving Nonlinear Energy Supply and Demand System Using Physics-Informed Neural Networks by Van Truong Vo, Samad Noeiaghdam, Denis Sidorov, Aliona Dreglea, Liguo Wang

“…However, the method utilizing neural networks is considered a modern and promising approach, as it effectively exploits the superior computational power of advanced computer systems, especially in solving complex problems. Another advantage is that the neural network model, after being trained, can solve the nonlinear system of differential equations across a continuous domain. …”
Get full text

Using Peer-Learning and Game-Based Instruction for Achieving Long-Lasting Knowledge of Cybersecurity in Primary Schools by Maja Videnovik, Vladimir Trajkovik, Tone Vold, Linda Vibeke Kionig, Ana Madevska Bogdanova, Sonja Filiposka

“…Upper-grade students deliver lectures and create educational games for their lower-grade peers, fostering learning communities where students share their knowledge and experiences, and learn from one another’s diverse perspectives. The game-based approach is used to create interactive and engaging learning environments where students design or play games to develop their critical thinking skills and empower their cybersecurity knowledge. …”
Get full text

A Comparison of Penguin Swarm Optimization Algorithms for Enhancing Network Throughput by Talha Akhtar, Najmi Ghani Haider, Nadeem Kafi Khan, Rashid Uddin

“…Inspired by the penguin behavior, the Penguin Colony Optimization algorithm (PeCO) is a new meta-heuristic technique used in this study to solve the network load balancing issues. …”
Get full text

Role of Astrocytic Dysfunction in the Pathogenesis of Parkinson’s Disease Animal Models from a Molecular Signaling Perspective by Lucas Udovin, Cecilia Quarracino, María I. Herrera, Francisco Capani, Matilde Otero-Losada, Santiago Perez-Lloret

“…Another major pathway involves IκB kinase (IKK) downregulation by ARL6ip5 (ADP-ribosylation-like factor 6 interacting protein 5, encoded by the cell differentiation-associated, JWA, gene). …”
Get full text

PERSPECTIVES ON THE CHALLENGES TO THE WATCHDOG FUNCTION OF THE MEDIA IN NIGERIA by EMMANUEL OMULA, ROSELINE OGBOLE

“…Findings revealed that, both public and private media owners have a lot of influence on the media they operate and  these owners, have used their media organizations to: influence public opinion, which is also another form of impediment to the watchdog role of the media It was concluded that, the watchdog function of the media  cannot bring about the desired accountability, good governance and dividends of democracy  in  a country where the institutions are weak and power does not reside in the electorates .It was recommended that heads of the various institutions of the state should not be appointed by the President and our institutions must be allowed to function without fear or favour. …”
Get full text

Content of Investigative Situations of the Initial Stage of Investigating Coercion to Fulfill or Non-Fulfillment of Civil Obligations Committed by Organized Criminal Groups by E. V. Zozulya

Subjects: Get full text

Comparison of the Efficiency of Two Novel Guided Bone Regeneration Devices in the Rabbit Calvarial Model by Osama Zakaria

“…The smart GBR (SGBR) device, composed of silicone sheets and Nitinol strips, were inserted beneath the periosteum in the calvarial area of another 10 rabbits. Half of each group was sacrificed 2 months after surgery, and the other half was sacrificed after 4 months. …”
Get full text

Queers non blanc·hes en France by Najwa Ouguerram-Magot

“…Can we bring out specific experiences of non-heterosexual backgrounds for non-white people ? …”
Get full text

Forms of interaction of units of the National Police units with the public under martial law by O. M. Muzychuk, A. T. Komziuk, V. O. Naida

“…An attempt has also been made to outline the features of police activity under martial law, which in one way or another are related to interaction with the public. …”
Get full text

Effect of Instituting Upper Limits for Chest Compression Depth for Laypersons at Six-months After Chest Compression-Only Training: A Randomized Controlled Simulation Study

“…Considering the situation of out-of-hospital cardiac arrest in Japan, studies focusing on compression depths in another aged people should be considered.…”
Get full text

A Cloud-Based Optimized Ensemble Model for Risk Prediction of Diabetic Progression—An Azure Machine Learning Perspective by V. K. Daliya, T. K. Ramesh

“…The method’s effectiveness is validated against another risk prediction dataset, proving its reliability. …”
Get full text

Patterns of pregabalin prescribing in four German federal states: analysis of routine data to investigate potential misuse of pregabalin by Ronja Flemming

“…Of the patients misusing pregabalin, 365 (42%) had a diagnosed history of substance use disorders and 359 (41%) had been prescribed another drug with addictive potential (opioids) before. …”
Get full text

Venezuela: Political Confrontation and the World Community by Z. W. Iwanowski, D. M. Rozental

“…In the worst-case scenario, a constantly worsening situation may result in a social explosion which threatens to make the Bolivarian Republic another hot spot of the planet.…”
Get full text

Akram’s lifestyle: An effective remedy for the management of gastroesophageal reflux disease by Sadia A. Khan, Javeria Z. Khan, Tayyab S. Akhter, Hamama-Tul-Bushra Khaar, Talay Yar, Mohammad A. Randhawa

“…The intake of food on top of another meal may cause gastroesophageal reflux either by generating transient lower-esophageal sphincter relaxations (TLESRs) subsequent to distention of the upper part of the stomach or/and delayed gastric emptying due to inhibition of migrating motor complexes (MMCs) in the distal part of the stomach. …”
Get full text

Body Mass Index Trajectories during 6–18 Years Old and the Risk of Hypertension in Young Adult: A Longitudinal Study in Chinese Population by Haoyue Teng, Jia Hu, Wenxin Ge, Qiling Dai, Ji Liu, Chengqi Xiao, Jieyun Yin, Xiaoyan Zhu

“…Compared with the low slow-increasing group, another three increasing groups had gradually elevated risk of hypertension, yielding maximally adjusted odds ratio (95% confidence interval) (OR (95% CI)) of 2.48 (1.39–4.42), 3.24 (1.66–6.31), and 3.28 (1.19–9.08), respectively, whereas the elevated-decreasing group reversed overweight/obesity to normal weight in childhood, rendering its association with hypertension as not statistically significant (OR (95% CI) = 2.74 (0.98–7.65)). …”
Get full text

The Potential Diagnostic Value of Immune-Related Genes in Interstitial Fibrosis and Tubular Atrophy after Kidney Transplantation by Bin Yang, Dike Shi, Yahong Chen, Yi Zhu

“…LASSO regression analysis selected 6 (including ANGPTL3, APOH, LTF, FCGR2B, HLA-DQA2, and EGF) out of 14 DE-IRGs as diagnostic genes to construct a diagnostic model. …”
Get full text