Unraveling TGF-β1’s Role in Mediating Fibrosis and Cell Death in Feline Kidney Cells by Chanyanuch Intachat, Phongsakorn Chuammitri, Benjaporn Sornpet, Prapas Patchanee, Nawin Manachai, Kakanang Piyarungsri

“…TGF-β1 signaling through the non-canonical/smad-independent pathway activates mitogen-activated protein kinase (MAPK) signaling, which is linked to fibrosis and apoptosis. …”
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Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation by Mohammad Alhashmi, Abdulrahman M. E. Gremida, Santosh K. Maharana, Marco Antonaci, Amy Kerr, Shijian Fu, Sharna Lunn, David A. Turner, Noor A. Al-Maslamani, Ke Liu, Maria M. Meschis, Hazel Sutherland, Peter Wilson, Peter Clegg, Grant N. Wheeler, Robert J. van ‘t Hof, George Bou-Gharios, Kazuhiro Yamamoto

“…Mechanistically, we show that LRP1 regulates core non-canonical Wnt/planar cell polarity (PCP) components that may explain the malformation of long bones. …”
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« L’or vert » - « Le don divin » - « La définition de la famille » : Perceptions et attitudes des visiteurs nationaux du tourisme oléicole à l’égard du patrimoine oléicole en Grèce... by Maria Kouri, Marios Kondakis

“…Par conséquent, les sites oléicoles devraient proposer des contenus de médiation culturelles complets abordant ces dimensions, en mettant l’accent sur les aspects environnementaux et économiques, ainsi que sur les qualités moins connues des olives et de l’huile d’olive. Cette approche répond aux attentes et aux besoins d’un marché intérieur bien informé, favorise le tourisme d’intérêt particulier et contribue en fin de compte à la sauvegarde du patrimoine oléicole.…”
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The Lion’s Share of Laughter: A French Angle on the Dramaturgy of Pyramus and Thisbe by Richard Hillman

“…Donc de deux points de vue très différents, les intertextes français convergent pour suggérer le potentiel parodique qui semble avoir attiré Shakespeare à cette histoire très connue afin d’insinuer, de façon novatrice et subtile, la fragilité des frontières génériques.…”
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Targeted genome modifcation in protoplasts of a highly regenerable Siberian barley cultivar using RNA-guided Cas9 endonuclease by S. V. Gerasimova, A. M. Korotkova, C. Hertig, S. Hiekel, R. Hofe, N. Budhagatapalli, I. Otto, G. Hensel, V. K. Shumny, A. V. Kochetov, J. Kumlehn, E. K. Khlestkina

“…The detected modifcations comprised deletions in all three target sites and of various sizes, whereas insertions were observed in only one of the target genes (Vrs1) and were confned to the size of 1 nucleotide. This study demonstrates the possibility of site-directed genome modifcation in Siberian barley. …”
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Ethanol extract of Polygonatum cyrtonema Hua mitigates non-alcoholic steatohepatitis in mice by Dongliang Chen, Yue Shen, Yue Shen, Fang Huang, Bo Huang, Shangfu Xu, Shangfu Xu, Lisheng Li, Lisheng Li, Jie Liu, Zheng Li, Xia Li

“…Ingenuity pathway analysis of RNA-seq data revealed key canonical pathways and upstream molecules regulated by PCE.ConclusionOur findings confirm the ability of PCE in alleviating NASH and underscores AMPK/SIRT1 pathway as a potential theraputic target for NASH treatment.…”
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The Town and the City in Charles Williams's Fiction by Maurice Levy

“…Charles Williams n'est pas très connu en France. Il a pourtant eu son heure de gloire entre les deux guerres, comme ami de C.S. …”
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Développement d’un marqueur moléculaire pour l’identification des lamproies au stade juvénile by Ahmed SOUISSI, Anne-Laure BESNARD, Guillaume EVANNO

“…La répartition des trois espèces reste mal connue en France, et ce projet visait initialement à développer une approche de détection des trois espèces à partir d’ADN environnemental (ADNe). …”
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The correlation between coagulation biomarkers, bone turnover markers, and bone mineral density in Chinese adults aged ≥ 50 years by Zhengming Wang, Rui Wang, Haiya Ge, Yong Gu, Sicheng Xian, Laijun Yan, Guoqing Du, Zhibi Shen, Shuaijie Lv, Hongsheng Zhan, Zhengyan Li

“…The relationships between coagulation biomarkers, BTMs, and BMD were investigated by Spearman correlation analysis and canonical correlation analysis (CCA). Consequently, age, bone mass stage, 25-hydroxyvitamin D (25-(OH)D), and BMD were included as independent variables in the logistic regression model. …”
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Mémoire et Denkraum. Réflexions épistémologiques sur la Kulturwissenschaftliche Bibliothek Warburg by Maud Hagelstein

“…La bibliothèque imaginée par Aby Warburg est à plusieurs égards le reflet d’une pensée parmi les plus originales que l’histoire de l’art ait connu. On connaît généralement cette bibliothèque grâce au témoignage d’Ernst Cassirer qui voyait s’y déployer un « ensemble de problèmes ». …”
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Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion by Mehul Vora, Jonathan Dietz, Zachary Wing, Karen George, Jun Kelly Liu, Christopher Rongo, Cathy Savage-Dunn

“…In C. elegans, the BMP2/4 ortholog DBL-1 regulates multiple biological functions, including body size, via a canonical receptor-Smad signaling cascade. Here, we identify functional binding sites for SMA-3/Smad and its transcriptional partner SMA-9/Schnurri based on ChIP-seq peaks (identified by modEncode) and expression differences of nearby genes identified from RNA-seq analysis of corresponding mutants. …”
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Etudes menées sur les sculptures d'Auvergne en bois polychromé by Marie-Blanche Potte, Dominique Faunières, Agnès Blossier, Lucretia Kargère

“…Tandis que les sculptures conservées dans les musées ont acquis un certain prestige, celles qui sont conservées dans leurs églises restent moins connues et ont rarement fait l’objet d’études techniques. …”
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Genomic characterization and molecular predictive biomarkers for chemotherapy in patients with metastatic triple-negative breast cancer treated in a real-world setting by Erik Olsson, Henrik Lindman, Evangelos Digkas, Viktoria Thurfjell, Haidar Mir Ali, Ute Krüger, Anna-Karin Wennstig, Marie Sundqvist, Antonios Valachis

“…Genomic alterations were subdivided into canonical oncogenic pathways and noted for their involvement in homologous recombination deficiency (HRD). …”
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Microglia TRPC1 SUMOylation drives neuroinflammation after stroke by modulating NLRP3 activity via increasing TRPC1 interaction with ARRB2 by Huinan Zhang, Xinzhe Du, Tian Gao, Xing Wang, Huifeng Zhang, Manyang Yu, Jing Huang

“…Microglial canonical transient receptor potential channel 1 (TRPC1) has been proposed to influence neuroinflammation after cerebral ischemia and reperfusion injury (CIRI), however, the underlying mechanism remains poorly understood. …”
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A hybrid model for prediction of software effort based on team size by Prerana Rai, Dinesh Kumar Verma, Shishir Kumar

“…These techniques are mostly based on statistical methods (viz. simple linear regression (SLR), multi linear regression, support vector machine, cascade correlation neural network (CCNN) etc.) and some probability‐based models. They use historical data of similar projects. …”
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Semidissonanzen. Ein Beitrag zur Didaktik der Harmonielehre by Hans Aerts

“…Der Ansatz verfolgt somit das Ziel, Schüler*innen und Studierende erkennen zu lassen, dass das Umkehrungsdenken ältere Vorstellungen überlagert, aber nicht ausgelöscht hat, und dass sie beide Sichtweisen je nach satztechnischer und analytischer Fragestellung gleichermaßen einnehmen können. …”
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Potential and mechanisms of indigenous Indonesian medicinal plants in treating sexual dysfunction: A systematic review and pharmacological network overview by Sukardiman, Roihatul Mutiah, Rosita Handayani

“…The pharmacology network analysis demonstrated that the compounds present in Eurycoma longifolia, specifically stigmasterol, eurycomanone, and eurycomalactone, target 13 genes associated with erectile dysfunction (ED), which include BCL2, AKT1, SOAT1, PCSK9, ACHE, BDNF-AS, TMX2-CTNND1, GSK3B, LINCO1672, TP53, H19, HIF1A, and IL1B. …”
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The impact of integrated genomic analysis on molecular classifications and prognostic risk stratification in endometrial cancer: a Chinese experience by Qian Zheng, Qian Zheng, Qian Zheng, Di Shao, Jin Shu, Jin Shu, Jin Shu, Qin Zhang, Qin Zhang, Qin Zhang, Min Huang, Dong Wang, Dong Wang, Dong Wang, Dongling Zou, Dongling Zou, Dongling Zou

“…This study aimed to investigate the molecular characteristics of EC patients at a single center by large-scale next generation sequencing(NGS), including clinicopathological features and gene mutations in patients with distinct molecular types, and to assess the relevance of molecular subtyping for postoperative adjuvant therapy.ResultsNSMP group was the most prevalent, comprising 46.0% (92/200) of cases, followed by the TP53mut group at 17.5% (35/200), the MSI-H group at 23.5% (47/200), and the POLEmut group at 13.0% (26/200). CTNNB1 mutations were common in the POLEmut group but rare in the TP53mut group. …”
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Dysfunction in mitochondrial electron transport chain drives the pathogenesis of pulmonary arterial hypertension: insights from a multi-omics investigation by Xin Zhang, Jieling Li, Minyi Fu, Xijie Geng, Junjie Hu, Ke-Jing Tang, Pan Chen, Jianyong Zou, Xiaoman Liu, Bo Zeng

“…Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis investigated shared pathways, and canonical correlation analysis assessed gene-metabolite relationships. …”
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Interpretation of Cyclic Form in Bach’s “Goldberg Variations” through Performance History by Majid Motavasseli

“…Dieser Aufsatz untersucht anhand quantitativer und qualitativer Analysen von 76 ausgewählten Aufnahmen aus dem Zeitraum von 1928 bis 2020, inwieweit Interpret*innen die ›Goldberg-Variationen‹ als Zyklus interpretieren. …”
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