Shared genetics between breast cancer and predisposing diseases identifies novel breast cancer treatment candidates by Panagiotis N. Lalagkas, Rachel D. Melamed

“…Then, we use a network approach to link these shared genes to canonical pathways. Similarly, for all drugs treating the predisposing disease, we link their targets to pathways. …”
Get full text

Trellis Decoding for Qudit Stabilizer Codes and Its Application to Qubit Topological Codes by Eric Sabo, Arun B. Aloshious, Kenneth R. Brown

“…Here, we improve the scalability and practicality of their theory, show that it has strong structure, extend the results using classical coding theory as a guide, and demonstrate a canonical form from which the structural properties of the decoding graph may be computed. …”
Get full text

Farmers’ desire to make changes in their agricultural branches in the first wave of COVID-19 pandemic restrictions: The example of Türkiye by Yener Ataseven, Şule Coşkun Cevher, Celal Cevher

“…A survey study was conducted with broad participation and telephone interviews involving 2125 farmers in different production branches in 22 provinces. Nonlinear Canonical Correlation Analysis was used to analyze variables. …”
Get full text

Effect of a single rectal fecal microbiota transplantation on clinical severity and fecal microbial communities in dogs with chronic inflammatory enteropathy by Jorge Pérez‐Accino, Mazdak Salavati, Laura Glendinning, Silke Salavati Schmitz

“…Materials and Methods Six dogs received a single FMT, 1 dog received 3 consecutive FMTs. Canine chronic enteropathy clinical activity index (CCECAI) and fecal samples were obtained before (Day 0), and 7, 30 and 90 days after FMT. …”
Get full text

Investigation of the influence of the heterogeneous structure of concrete on its strength by V.M. Volchuk, M.A. Kotov, Ye G. Plakhtii, O.A. Tymoshenko, O.H. Zinkevych

“…Analysis results of the canonical spectrum f(α), statistical characteristics of structural components: uniformity, orderliness Δ=f(α)q = 1−f(α)q = 100, and regularity K=f(α)q = -100−f(α)q = 100 were calculated. …”
Get full text

Extensive composable entropy for the analysis of cosmological data by Constantino Tsallis, Henrik Jeldtoft Jensen

“…Being extensive means that in the micro-canonical, or uniform, ensemble where all micro-state occur with the same probability, the entropy becomes proportional to N asymptotically: S(N)∝N for N→∞. …”
Get full text

The root canal morphology of mandibular anterior teeth and its correlation with the occurrence of three-rooted mandibular first molars by ZHU Peng, GU Yongchun, WU Yihan, XU Xiaoming

“…Results The incidence of double-canaled system was 10.4%, 18.6% and 6.5% in mandibular central incisors, lateral incisors and canines, respectively; the bilateral concurrence rates were 5.7%, 11.1% and 3.0%, respectively, and Spearman correlation coefficients (rho) were 0.487, 0.505 and 0.440 (P<0.01), respectively; gender difference and side difference were not detected (P>0.05). …”
Get full text

Antitumor Effect of Demethylzeylasteral (T-96) on Triple-Negative Breast Cancer via LSD1-Mediate Epigenetic Mechanisms by Zhengjie Shen, Yongjuan Gu, Ruiyang Jiang, Heya Qian, Siyuan Li, Lixian Xu, Wenzhe Gu, Yun Zuo

“…Our previous study found that T96 could inhibit TNBC invasion via suppressing the canonical and noncanonical TGF-β signaling pathways. …”
Get full text

Association of a non-synonymous substitution in the condensin NCAPG gene with traits of eggs in laying hens by O. Yu. Barkova, M. G. Smaragdov

“…The results obtained are discussed in connection with the role of the canonical condensin complex in the compaction of chromatin and segregation of chromosomes.…”
Get full text

Research note: Increased lipid accumulation within broiler preadipocytes during differentiation in vitro at atmospheric oxygen tension by Jéssica Moraes Cruvinel, Elizabeth S. Greene, Rachel W. Read, Kichoon Lee, Sami Dridi, Paula R. Chen

“…Culture at 1% O2 resulted in increased abundance of HIF1α, a canonical protein stabilized during hypoxia, thus confirming effectiveness of the treatment. …”
Get full text

From physical activity patterns to cognitive status: development and validation of novel digital biomarkers for cognitive assessment in older adults by Ling-Jie Fan, Feng-Yi Wang, Jun-Han Zhao, Jun-Jie Zhang, Yang-An Li, Jia Tang, Tao Lin, Quan Wei

“…Demographic characteristics were also incorporated, and multimodal data fusion was achieved through canonical correlation analysis. We then developed explainable machine learning models, primarily random forest, optimized with hyperparameters, to predict individual cognitive function status. …”
Get full text

Conformational diversity in class C GPCR positive allosteric modulation by Giuseppe Cannone, Ludovic Berto, Fanny Malhaire, Gavin Ferguson, Aurelien Fouillen, Stéphanie Balor, Joan Font-Ingles, Amadeu Llebaria, Cyril Goudet, Abhay Kotecha, Vinothkumar K.R., Guillaume Lebon

Get full text

Addressing genome scale design tradeoffs in Pseudomonas putida for bioconversion of an aromatic carbon source by Deepanwita Banerjee, Javier Menasalvas, Yan Chen, Jennifer W. Gin, Edward E. K. Baidoo, Christopher J. Petzold, Thomas Eng, Aindrila Mukhopadhyay

“…However, sustainable feedstocks pose a challenge due to incomplete high-resolution metabolic data for non-canonical carbon sources required to curate GSMM and identify implementable designs. …”
Get full text

Mapping the Discourse. Architecture Periodicals in/for the Teaching of Architecture History by Gaia Caramellino, Valeria Casali, Nicole De Togni

“…On the one hand, the cross-reading of “journal biographies” and the study of the “anatomy” of diverse genres of magazines contribute to question canonical interpretations and timeframes of a 20th century architectural history still centered on the European and North American editorial scene, offering a more nuanced understanding of the times and forms of production of architectural culture. …”
Get full text

X-ray emission from hot gas and XRBs in the NGC 5846 galaxy by Kyadampure Anil, Vagshette Nilkanth, Patil Madhav

“…Among 90, only one source exhibits an X-ray luminosity greater than 1039ergs−11{0}^{39}\hspace{0.33em}{\rm{erg}}\hspace{0.33em}{{\rm{s}}}^{-1}, exceeding the Eddington limit for a canonical mass of a neutron star and occupies a position in the hard region of the X-ray color–color plot. …”
Get full text

Non-thermal plasma as promising anti-cancer therapy against bladder cancer by inducing DNA damage and cell cycle arrest by Jojanneke Stoof, Zakaria Kalmoua, Ana Sobota, Ruud H. Brakenhoff, Marijke Stigter, Thang V. Pham, Sander R. Piersma, Alex Henneman, Tonny Lagerweij, Richard de Goeij-de Haas, R. Jeroen A. van Moorselaar, Connie R. Jimenez, Irene V. Bijnsdorp

Get full text

Echinococcosis of dogs in the North Caucasian Subjects (infrastructural, epizootological and sanitary-hygienic analysis) by S. Sh. Kabardiev, A. M. Bittirov, S. A. Aigubova, N. Kh. Gyulakhmedova

“…The issues of soil contamination with Echinococcus granulosus eggs are understudied that’s why the objective of the research was to study canine echinococcosis which poses a threat to animal and human disease freedom in the North Caucasian countries. …”
Get full text

Can Orthodontic Treatment Be Stable 20 Years after the End of the Treatment Scheme? Treatment of a Class 2, Division 1 Malocclusion with Severe Skeletal Discrepancy and Its 20-Year... by Domenico Aiello, Riccardo Nucera, Stefania Costa, Michele Mario Figliuzzi, Sergio Paduano

“…The photos at the end of treatment show an important improvement in the profile; a full class I ratio of molar and canine teeth was achieved with an excellent interarch relationship and a correction of the V-shaped upper arch. …”
Get full text

TNBC response to paclitaxel phenocopies interferon response which reveals cell cycle-associated resistance mechanisms by Nicholas L. Calistri, Tiera A. Liby, Zhi Hu, Hongmei Zhang, Mark A. Dane, Sean M. Gross, Laura M. Heiser

“…Single-cell RNA sequencing (scRNA-seq) of TNBC cells after paclitaxel treatment revealed upregulation of innate immune programs canonically associated with interferon response and downregulation of cell cycle progression programs. …”
Get full text

NLRP3 Inflammasome Simultaneously Involved in Autophagy and Phagocytosis of THP-1 Cells to Clear Aged Erythrocytes by Qin Li, Fengyong Zhao, Jiamin Zhang, Ying Yang, Zhonghui Guo, Chen Wang, Qixiu Yang, Ying Sun, Ziyan Zhu

“…The occurrence of autophagy was dominated by microtubule-associated protein 1A/1B-light chain 3- (LC3-) associated phagocytosis accompanied by canonical autophagy. A negative correlation exists between the clearance of RBCs by THP-1 cells and the degree of autophagy. …”
Get full text