Integration of metabolomic and transcriptomic analyses reveals regulatory functions of the ChREBP transcription factor in energy metabolism by Jie An, Inna Astapova, Guofang Zhang, Andrew L. Cangelosi, Olga Ilkayeva, Hannah Marchuk, Michael J. Muehlbauer, Tabitha George, Joseph Brozinick, Mark A. Herman, Christopher B. Newgard

“…In sum, our study reveals functions of ChREBP beyond its canonical roles in carbohydrate and lipid metabolism to include regulation of substrate transport, mitochondrial function, and energy balance.…”
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A Homemade Snare: An Alternative Method for Mechanical Removal of Dirofilaria immitis in Dogs by Ana Margarida Alho, António Fiarresga, Miguel Landum, Clara Lima, Óscar Gamboa, José Meireles, José Sales Luís, Luís Madeira de Carvalho

“…Canine dirofilariosis is a life-threatening parasitic disease that is increasingly reported worldwide. …”
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Unusual Transalveolar and Transmuco-Gingival Root Avulsion of a Fractured Primary Central Incisor: A Case with an 8-Year Follow-Up by E. Ferrés-Amat, C. Díaz-Martínez, S. Herrera-Martínez, I. Maura-Solivellas, E. Ferrés-Padró

“…A 3-year-old male patient came for consultation after a dentoalveolar trauma with a “fragment that looks like canine” found in his mouth by his mother. This boy suffered root fracture of the upper primary central right incisor, accompanied by transalveolar and transmuco-gingival avulsion of the tooth root fragment, leaving the crown in its position in the dental arch. …”
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PDPN+ cancer‐associated fibroblasts enhance gastric cancer angiogenesis via AKT/NF‐κB activation and the CCL2‐ACKR1 axis by Zhenxiong Zhao, Hui Sun, Yingxue Liu, Yanqiu Zhang, Xin Wang, Xu Wang, Cong Tan, Shujuan Ni, Weiwei Weng, Meng Zhang, Lei Wang, Dan Huang, Wenchao Gu, Jinjia Chang, Weiqi Sheng, Mi‐die Xu

“…Mechanistically, PDPN(+) CAFs enhance angiogenesis by activating the AKT/NF‐κB signaling pathway. The canonical NF‐κB signaling protein P65 binds to the promoter region of CCL2, inducing its expression. …”
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Executioner caspases degrade essential mediators of pathogen-host interactions to inhibit growth of intracellular Listeria monocytogenes by Marilyne Lavergne, Raffael Schaerer, Sara De Grandis, Safaa Bouheraoua, Oluwadamilola Adenuga, Tanja Muralt, Tiffany Schaerer, Léa Chèvre, Alessandro Failla, Patricia Matthey, Michael Stumpe, Dieter Kressler, Pierre-Yves Mantel, Michael Walch

“…With that, we uncovered an underappreciated defense barrier and a non-canonical role of executioner caspases to degrade virulence mediators, thus impairing intracellular Listeria growth.…”
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Daily Activity Monitoring and Fall Detection Based on Surface Electromyography and Plantar Pressure by Xugang Xi, Wenjun Jiang, Zhong Lü, Seyed M. Miran, Zhi-Zeng Luo

“…A feature-level fusion method, named as the global canonical correlation analysis of weighting genetic algorithm, was proposed to reduce dimensions. …”
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Classical eikonal from Magnus expansion by Joon-Hwi Kim, Jung-Wook Kim, Sungsoo Kim, Sangmin Lee

“…Abstract In a classical scattering problem, the classical eikonal is defined as the generator of the canonical transformation that maps in-states to out-states. …”
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Rabies in a Vaccinated 9-Month-Old German Shepherd Dog, Akure, 2010: A Case Report by A. M. Qasim, A. A. Obadua, P. A. Okewole, I. S. Tekki, O. S. Omoleye

“…Rabies has traditionally been associated with dogs more than any other animal, and in parts of the world where domestic animal control and vaccination programs are limited, dogs remain the most important reservoir of the disease. We report a case of canine rabies in a vaccinated 9-month-old German shepherd female dog. …”
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Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3 by Ling Ye, Shengqi Shen, Qiankun Mao, Hui Lu, Haiying Liu, Pinggen Zhang, Zetan Jiang, Wenhao Ma, Yuchen Sun, Yiyang Chu, Zilong Zhou, Rui Liu, Jian Li, Shi-ting Li, Ping Gao, Huafeng Zhang

“…Summary: Metabolic enzymes play significant roles in the pathogenesis of various cancers through both canonical and noncanonical functions. Hexokinase domain-containing protein 1 (HKDC1) functions beyond glucose metabolism, but its underlying mechanisms in tumorigenesis are not fully understood. …”
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The Fate of the Tumor in the Hands of Microenvironment: Role of TAMs and mTOR Pathway by Danilo Figueiredo Soave, Marina Pacheco Miguel, Fernanda Dias Tomé, Liliana Borges de Menezes, Patrícia Resende Alo Nagib, Mara Rúbia Nunes Celes

“…Biologically, two forms of activated macrophages can be observed: classically activated macrophages (M1) and alternative activated macrophages (M2). Despite the canonical pathways that control this puzzle of macrophages polarization, recently, mTOR signaling pathway has been implicated as an important piece in determining the metabolic and functional differentiation of M1 and M2 profiles. …”
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Prognostic Factors for Cancer-Specific Survival and Disease-Free Interval of Dogs with Mammary Carcinomas by Elaine da Silva Soares, Fabrício Luciani Valente, Carolina Camargos Rocha, Carlos Eduardo Real Pereira, Thaís Barroso Sarandy, Fabiano Luiz Dulce de Oliveira, Sabrina Loise de Morais Calado, Andréa Pacheco Batista Borges

“…Canine mammary tumors (CMTs) are the most diagnosed neoplasms in dogs; however, there are few studies analyzing the influence of epidemiological, clinicopathological, and histopathological data on cancer-specific survival (CSS), disease-free interval (DFI), and overall survival (OS) in a large cohort. …”
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The Sublingua of <i>Lemur catta</i> and <i>Varecia variegata</i>: Only a Cleaning Function? by Juan Francisco Pastor, Magdalena Natalia Muchlinski, Josep María Potau, Aroa Casado, Yolanda García-Mesa, José Antonio Vega, Roberto Cabo

“…In addition to the sublingua, prosimians have modified lower incisors and canines called “dental comb”. The anatomy of sublingua has been studied macro and microanatomically since the early 19th century. …”
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Global Gene Expression Profiling in PPAR-γ Agonist-Treated Kidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease by Daisuke Yoshihara, Masanori Kugita, Tamio Yamaguchi, Harold M. Aukema, Hiroki Kurahashi, Miwa Morita, Yoshiyuki Hiki, James P. Calvet, Darren P. Wallace, Takafumi Toyohara, Takaaki Abe, Shizuko Nagao

“…By Gene Set Enrichment Analysis of 30655 genes, 13 of the top 20 downregulated gene ontology biological process gene sets and six of the top 20 curated gene set canonical pathways identified to be downregulated by PIOtreatment were related to cell cycle and proliferation, including EGF, PDGF and JNK pathways. …”
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Guided Bilateral Transcanine Implant Placement and Implant-Supported Oral Rehabilitation in a Patient with Progressive Systemic Scleroderma by Igor Smojver, Ivan Katalinić, Marko Vuletić, Luka Stojić, Dražena Gerbl, Dragana Gabrić

“…Placement of the dental implants through impacted canines and the creation of interfaces other than implant-bone interfaces did not lead to postoperative pain or implant failure. …”
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Beyond destruction: emerging roles of the E3 ubiquitin ligase Hakai by Juan-José Escuder-Rodríguez, Andrea Rodríguez-Alonso, Lía Jove, Macarena Quiroga, Gloria Alfonsín, Angélica Figueroa

“…Most of the knowledge about the protein was associated to its E3 ubiquitin ligase canonical role. However, important recent published research has highlighted the noncanonical role of Hakai, independent of its E3 ubiquitin ligase activity, underscoring its involvement in the N 6-methyladenosine (m6A) writer complex and its impact on the methylation of RNA. …”
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Socio‐economic evaluation of human–dog coexistence: A 40,000 years history by Mohammad Fallahi, Ali Akbar Masoudi, Rasoul Vaez Torshizi, Ali Maghsoudi

“…Subsequently, questions arise regarding the important and symbolic roles that canines played in ancient cultures, religions and mythological traditions. …”
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FOX DOMESTICATION: MOLECULAR MECHANISMS INVOLVED IN SELECTION FOR BEHAVIOR by L. N. Trut, Yu. E. Herbeck, A. V. Kharlamova, R. G. Gulevich, A. V. Kukekova

“…The result is the more so significant that the region is similar to the region on canine chromosome 5 presumed to be responsible for early domestication of wolves and their evolutionary transformation to primitive dogs.…”
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A Cone-Beam Computed Tomography Scanning of the Root Canal System of Permanent Teeth among the Moscow Population by Svetlana Razumova, Anzhela Brago, Lamara Khaskhanova, Ammar Howijieh, Haydar Barakat, Ashot Manvelyan

“…The maxillary incisors and canines had one root with one canal in 100%. Maxillary premolars had one root with one or two canals and two roots with two canals, while mandibular premolars were single-rooted with one or two canals. …”
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Role of Eukaryotic Initiation Factors during Cellular Stress and Cancer Progression by Divya Khandige Sharma, Kamiko Bressler, Harshil Patel, Nirujah Balasingam, Nehal Thakor

“…In this review, we will focus on this context by describing both canonical and noncanonical roles of eIFs, which alter mRNA translation.…”
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Three-dimensional assessment of the ideal insertion angle and position of temporary anchorage devices in the anterior palate: (in a sample of erbil city). by Melav Musa Ibrahim, Omar Fawzi Chawshli

“…The thickest point in the anterior palate was 6mm away from the midline at the contact point between canine and first premolar on both the left and right sides. …”
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