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4921
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4922
Injectable supramolecular hydrogel co-loading abemaciclib/NLG919 for neoadjuvant immunotherapy of triple-negative breast cancer
Published 2025-01-01“…Herein, we create an abemaciclib-loaded supramolecular peptide hydrogel formed by peptide-drug amphiphiles for neoadjuvant immunotherapy of triple-negative breast cancer, where the amphiphile is a conjugate of a β-sheet-forming peptide with 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol (NLG919), an inhibitor of indoleamine 2,3-dioxygenase 1. The hydrogel can be injected into the tumor site and retained for at least one week for the sustained release of both abemaciclib and NLG919. …”
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4923
Improved Left Ventricular Aneurysm Repair with Cell- and Cytokine-Seeded Collagen Patches
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4924
USE OF ISOTOPE DILUTION METHOD FOR DETERMINATION OF Ce, Sm, AND Yb ABUNDANCES IN GEOLOGICAL SAMPLES BY ICP-MS
Published 2019-08-01Subjects: “…các nguyên tố đất hiếm (rees)…”
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4925
Electroacupuncture Treatment Alleviates Central Poststroke Pain by Inhibiting Brain Neuronal Apoptosis and Aberrant Astrocyte Activation
Published 2016-01-01“…The pain-related behavioral responses, neuronal apoptosis, glial activation, and the expression of pain signal transmission-related factors (β-catenin, COX-2, and NK-1R) were assessed using behavioral tests, Nissl staining, TUNEL staining, and immunohistochemical staining, respectively. …”
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4926
《卒中患者吞咽障碍护理规范》团体标准解读 Interpretation of the Association Standard of Nursing Practice for Dysphagia in Stroke Patients
Published 2025-01-01“…摘要: 2023年12月,中国研究型医院学会发布了《卒中患者吞咽障碍护理规范》(T/CRHA 027—2023)团体标准,提出了卒中患者吞咽障碍护理的基本要求,并对患者的进食护理、口腔护理、气道护理、服药护理、康复护理、心理护理、健康教育、延续性护理和并发症预防及处理等操作进行了规范说明。…”
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4927
Effects of dietary compound acidifier (Biomin) on the growth, anti-oxidation, immunity, and intestinal health of juvenile channel catfish (Ictalurus punctatus)
Published 2025-03-01“…The GOT (glutamic oxalacetic transaminase) and GPT (glutamic pyruvic transaminase) activities in the serum notably decreased by 0.10–0.20 % and 0.05 % of dietary CA, respectively (P < 0.05). The T-CHO (total cholesterol) and HDL-C (high density lipoprotein cholesterol) contents in the serum increased by 0.80 % and 0.05 %-0.80 % of dietary CA (P < 0.05). …”
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4928
Association between NFKB1 −94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis
Published 2014-01-01“…We used pooled odds ratios (ORs) with their 95% confidence intervals (95% CIs) to assess the association. We found that the NFKB1 promoter −94ins/del ATTG polymorphism was significantly associated with cancer risk in four genetic models (ins/ins versus del/del, OR = 1.47, 95% CI = 1.11–1.93; dominant model, OR = 1.26, 95% CI = 1.03–1.53; recessive model, OR = 1.26, 95% CI = 1.05–1.51; ins allele versus del allele, OR = 1.19, 95% CI = 1.05–1.35). …”
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4929
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4930
Intranasal Delivery of miR-146a Mimics Delayed Seizure Onset in the Lithium-Pilocarpine Mouse Model
Published 2017-01-01“…In the current study, a C57BL/6 TLE mouse model was established using the lithium-pilocarpine protocol. …”
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4931
Watershed: a more efficient sampling unit for mountain camera traps
Published 2025-02-01“…Using watersheds as sampling units for CTs can match the mountains’ elevation differences and complex topography well, aids in capturing wildlife diversity and understanding mountain species distribution. …”
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4932
Abnormal Expression of DICER1 Leads to Dysregulation of Inflammatory Effectors in Human Synoviocytes
Published 2019-01-01“…Firstly, RNAi of DICER1 led to increased COX2, MMP3, and MMP13 protein production, while DICER1 overexpression could reduce MMP13 expression. …”
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4933
Ammonifying and phosphorus-solubilizing function of Aliikangiella maris sp. nov. isolated from Phaeocystis globosa bloom and algal–bacterial interactions
Published 2025-02-01“…Specifically, cell densities were observed to increase by 19.6–86.0%, accompanied by substantial enhancements in photosynthetic performance with increases of 8.0–30.6% in Fv/Fm and 10.9–27.9% in rETRmax. Overall, these results shed light on intricate relationships between P. globosa and its associated bacterial partners, which may influence the growth characteristics of algae.…”
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4934
Noninvasive rejuvenation strategy of nickel-rich layered positive electrode for Li-ion battery through magneto-electrochemical synergistic activation
Published 2024-11-01“…The strategy demonstrates that low-quality positive electrodes can be converted to high-quality ones. Notably, the method can revitalize an aged Li-ion pouch cell (SiC||NCM811, 8 Ah nominal capacity) via optimizing cation occupancy and increase its capacity by 10% from 6.49 to 7.14 Ah at 1 C, illustrating the benefits of the upcycling process.…”
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4935
The sulfur-related metabolic status of Aspergillus fumigatus during infection reveals cytosolic serine hydroxymethyltransferase as a promising antifungal target
Published 2025-12-01“…We further showed that the structure of the ligand-binding pocket of the fungal enzyme differs significantly from its human counterpart, suggesting that specific inhibitors can be designed. Therefore, in vivo transcriptomics is a powerful tool for identifying genes crucial for fungal pathogenicity that may encode promising antifungal target candidates.…”
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4936
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4937
Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy
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4938
A Neural Circuit From Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens Mediates Inflammatory Pain in Mice
Published 2025-01-01“…Then in a well‐established mouse model of CFA‐induced inflammatory pain, immunofluorescence staining was utilized to evaluate changes in c‐Fos protein expression within PVT neurons. …”
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4939
Targeting estrogen-regulated system xc − promotes ferroptosis and endocrine sensitivity of ER+ breast cancer
Published 2025-01-01“…Moreover, SLC7A11 and SLC3A2 levels were elevated in endocrine-resistant breast cancer cells and tumors. …”
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4940