Bionic nanovesicles sequentially treat flaps with different durations of ischemia by thrombolysis and prevention of ischemia-reperfusion injury by Linzhong Yang, Yuanchen Liu, Cheng Tao, Zichen Cao, Shilin Guo, Zheng Wei, Yanyi Wang, Tao Liu, Lin Chen, Ke Xiong, Xingyu Luo, Jianchuan Ran, Wei Han

“…The experimental results demonstrated that an ischemia-timed strategy can not only efficiently promote thrombolysis, but also effectively remove harmful elements in the microenvironment of ischemia-reperfusion injury. …”
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Epidermal stem cell derived exosomes-induced dedifferentiation of myofibroblasts inhibits scarring via the miR-203a-3p/PIK3CA axis by Shixin Zhao, Haoran Kong, Dahu Qi, Yushuang Qiao, Yu Li, Zhiming Cao, Hanwen Wang, Xuefeng He, Hengdeng Liu, Hao Yang, Suyue Gao, Tao Liu, Julin Xie

“…Our results indicate that PIK3CA is overexpressed in HS tissues and positively correlates with fibrosis. …”
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Visualizing stepwise evolution of carbon hybridization from sp 3 to sp 2 and to sp by Wei Xiong, Guang Zhang, De-Liang Bao, Jianchen Lu, Lei Gao, Yusen Li, Hui Zhang, Zilin Ruan, Zhenliang Hao, Hong-Jun Gao, Long Chen, Jinming Cai

“…Density-functional-theory calculations unveil the pivotal role of the electron-withdrawing cyano group in activating neighboring methylene to form C(sp 3 )–C(sp 3 ) bonds, and in facilitating subsequent stepwise HCN eliminations to realize the transformation across three carbon-carbon bond types. …”
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Iguratimod Inhibits the Aggressiveness of Rheumatoid Fibroblast-Like Synoviocytes by Jin Lin, Ye Yu, Xuanwei Wang, Yini Ke, Chuanyin Sun, Lihuan Yue, Guanhua Xu, Bei Xu, Liqin Xu, Heng Cao, Danyi Xu, Nancy Olsen, Weiqian Chen

“…Here, we aimed to find whether iguratimod can inhibit the aggressive behavior and promote apoptosis of rheumatoid fibroblast-like synoviocytes (RA-FLSs). …”
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GREENHOUSE SYSTEM WITH FORCED AIR FLOW FOR PRE-DISTILLED KAFFIR (CITRUS HYSTRIX) LEAF TREATMENT by Chandrawati Cahyani, Vivi Nurhadianty, Aji Hendra Sarosa, Moch Fitron Muttaqin, Fahrul Huzain Hidayat, Dicky Gabriel Partogi Sarumpaet, Mellyantika Alga Safitri, Thiara Jatayuning Miranti, Naufaliyah Rifdah Rifdah

“…The greenhouse effect, which is a global issue, can provide benefits in the agricultural sector, especially in the processing of essential oils, which require drying raw materials before being purified. …”
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Individualized diagnosis of Parkinson’s disease based on multivariate magnetic resonance imaging radiomics and clinical indexes by Qianqian Ye, Chenhui Lin, Fangyi Xiao, Tao Jiang, Jialong Hou, Yi Zheng, Jiaxue Xu, Jiani Huang, Keke Chen, Jinlai Cai, Jingjing Qian, Weiwei Quan, Yanyan Chen

“…The integrated clinical-radiomics model showed enhanced diagnostic accuracy, with AUC = 0.983 (95% CI, 0.897–0.996) in the training set and AUC = 0.837 (95% CI, 0.786–0.902) in the test set. …”
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Akkermansia muciniphila and its metabolite propionic acid maintains neuronal mitochondrial division and autophagy homeostasis during Alzheimer’s disease pathologic process via GPR4... by Zifan Wang, Cai Wang, Boyu Yuan, Li Liu, Haoming Zhang, Mingqiang Zhu, Hongxia Chai, Jie Peng, Yanhua Huang, Shuo Zhou, Juxiong Liu, Liyong Wu, Wei Wang

“…In addition, short-chain fatty acids (SCFA) produced by intestinal microbiota metabolism have been considered to be important factors affecting central nervous system (CNS) homeostasis. Among the main mediators of host-microbe interactions, volatile fatty acids play a crucial role. …”
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Melatonin Alleviates LPS-Induced Pyroptotic Cell Death in Human Stem Cell-Derived Cardiomyocytes by Activating Autophagy by Ya Qiu, Yan Ma, Min Jiang, Sulei Li, Jibin Zhang, Haixu Chen, Mengqi Xu, Shan Gao, Lei Tian, Bo Tao, Yabin Wang, Dong Han, Feng Cao

“…This study explored, for the first time, the protective effect of Mel on the pyroptosis of human stem cell-derived cardiomyocytes (hiPSC-CMs) exposed to lipopolysaccharide (LPS). Our results showed that treatment with 1 μM or 10 μM Mel for 12 h significantly improved 1 μg/ml LPS-induced hiPSC-CM injuries, as reflected by drastically decreased LDH release and increased cell viability, which was accompanied by the overt induction of autophagy. …”
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CircRNAs in colorectal cancer: potential roles, clinical applications, and natural product-based regulation by Jingjing Yang, Jingjing Yang, Qiqi Fan, Yiyun Wang, Yuanyue Liu, Xiaoning Xu, Yeqi Liang, Jiakang Xie, Jiajie Li, Fengting Ai, Yong Cao, Shangzhen Yu, Jinman Liu

Subjects: “…colorectal cancer (CRC)…”
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Development of chimeric Nanobody-Granzyme B functionalized ferritin nanoparticles for precise tumor therapy by Baijin Xia, Huolun Feng, Xinmiao Jiang, Jialing Guo, Keming Lin, Wenxing Zhang, Fan Xing, Lixue Cao, Yong Li, Hui Zhang, Xu Zhang, Wenyu Li, Fei Yu

“…We fused nanobody (Nb) targeting CD30 and CD5 with GrB and coupled them to human ferritin (h-HFn) using the Gv/Sd system, creating a novel therapeutic nanoparticle named BiCD30/5-GF, which specifically targets CD30 and CD5 receptors on TCL tumor cells. …”
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Estimation of the Corneal Young’s Modulus In Vivo Based on a Fluid-Filled Spherical-Shell Model with Scheimpflug Imaging by Po-Jen Shih, Chun-Ju Huang, Tzu-Han Huang, Hung-Chou Lin, Jia-Yush Yen, I-Jong Wang, Hui-Jyun Cao, Wen-Pin Shih, Chi-An Dai

“…By embedding a new model-based correction to the Corvis® ST, we can extract the corneal Young’s modulus from the patient data. …”
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An improved lightweight ConvNeXt for rice classification by Pengtao Lv, Heliang Xu, Qinghui Zhang, Lei Shi, Heng Li, Youyang Chen, Yana Zhang, Dengke Cao, Zhongyang Liu, Yixin Liu, Jingwen Han, Zhan Zhang, Yiran Qi

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Coupled effects of chlorides and sulfates on steel reinforcement corrosion in concrete structures: A comprehensive review by Ye Tian, Yu Liu, Yu-Meng Xie, Guo-Yi Zhang, Hai-Long Ye, Dong-Ming Yan, Yun-Jian Li, Bei Li, Hong-Jing Xue, Qing Cai

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CAR-T therapy for endocrine neoplasms: novel targets and combination of therapies by Fang Wang, Ruiqi Zhang, Zhaokai Zhou, Run Shi, Fu Peng, Yudi Xu, Shuai Yang, Zhan Wang, Pengpeng Zhang, Rui Tu, Chun Zhang, Xingchen Liu, Jun Cai

“…Identification of specific and safe targets for endocrine cancer is the initial stage towards establishing a successful CAR-T treatment. Various therapies under investigation offer potential enhancements to CAR T cell efficacy through diverse mechanisms. …”
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Th1/Th2 Cells and Associated Cytokines in Acute Hepatitis E and Related Acute Liver Failure by Jian Wu, Yurong Guo, Xuan Lu, Fen Huang, Feifei Lv, Daqiao Wei, Anquan Shang, Jinfeng Yang, Qiaoling Pan, Bin Jiang, Jiong Yu, Hongcui Cao, Lanjuan Li

“…The Th lymphocyte levels (CD3+, CD4+) in the AHE and HEV-ALF groups were significantly higher than those in the HC group (both P<0.05), but there was no significant difference between the AHE and HEV-ALF groups (P>0.05). …”
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Observation of ultraviolet photothermoelectric bipolar impulse in gallium-based heterostructure nanowires by Jinjie Zhu, Qing Cai, Pengfei Shao, Shengjie Zhang, Haifan You, Hui Guo, Jin Wang, Junjun Xue, Bin Liu, Hai Lu, Youdou Zheng, Rong Zhang, Dunjun Chen

“…The device achieves exceptional responsivity (17.1 mA/W) and remarkably fast speed (8.8 ms) at 0 V, surpassing existing semiconductor electrochemical cells. …”
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Nomogram for predicting early cancer-related death due to recurrence after liver resection in hepatocellular carcinoma patients with Barcelona Clinic Liver Cancer (BCLC) stage B/C: a multicenter study by Zhan-Cheng Qiu, Hao-Zheng Cai, You-Wei Wu, Jun-Long Dai, Wei-Li Qi, Chu-Wen Chen, Yue-Qing Xu, Chuan Li, Tian-Fu Wen

“…Compared with the ATS score, BCLC stage and AAR, the nomogram both had better predictive ability in both the training cohort (ATS score, AUC: 0.699, 95%CI: 0.646–0.752, p = 0.010; BCLC stage, AUC: AUC: 0.684, 95%CI: 0.637–0.732, p < 0.001; AAR, AUC: 0.593, 95%CI: 0.522–0.663, p < 0.001) and the validation cohort (ATS score, AUC: 0.659, 95%CI: 0.577–0.740, p = 0.002; BCLC stage, AUC: 0.688, 95%CI: 0.622–0.753, p = 0.009; AAR, AUC: 0.540, 95%CI: 0.436–0.645, p < 0.001). …”
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Size-segregated Characteristics and Formation Mechanisms of Water-soluble Inorganic Ions during Different Seasons in Heshan of Guangdong, China by Bo Huang, Ting Gan, Chenglei Pei, Mei Li, Peng Cheng, Duohong Chen, Ridong Cai, Yujun Wang, Lei Li, Zhengxu Huang, Wei Gao, Zhong Fu, Zhen Zhou

“…., Na+, NH4+, K+, Mg2+, Ca2+, Cl−, NO2−, NO3−, and SO42−, were investigated. …”
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Neuromorphic Vision Based Multivehicle Detection and Tracking for Intelligent Transportation System by Guang Chen, Hu Cao, Muhammad Aafaque, Jieneng Chen, Canbo Ye, Florian Röhrbein, Jörg Conradt, Kai Chen, Zhenshan Bing, Xingbo Liu, Gereon Hinz, Walter Stechele, Alois Knoll

“…If the accuracy is prioritized, the tracking task can also be performed robustly at a relatively high rate with different combinations of algorithms. …”
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The geometry evolution of Early Paleozoic carbonate platform in the southwestern Tarim Basin, China: evidence from sequence stratigraphic analysis and seismic forward modeling by Jie Li, Jie Li, Zicheng Cao, Feng Geng, Suju Yang, Xuguang Sha, Mingjie Lan, Shenghou Wang, Yongchao Lu, Yangbo Lu, Daqing Tang, Zhao Zhang, Fang Hao

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