Comprehensive Assessment of the Effect of Urban Built-Up Land Expansion and Climate Change on Net Primary Productivity by Pengyan Zhang, Yanyan Li, Wenlong Jing, Dan Yang, Yu Zhang, Ying Liu, Wenliang Geng, Tianqi Rong, Jingwen Shao, Jiaxin Yang, Mingzhou Qin

“…The average correlation coefficients between temperature and NPP and precipitation and NPP were 0.267 and 0.020, respectively, indicating that an increase in temperature and precipitation can promote NPP despite significant spatial differences. …”
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Enhanced motivated behavior mediated by pharmacological targeting of the FGF14/Nav1.6 complex in nucleus accumbens neurons by Nolan M. Dvorak, Paul A. Wadsworth, Guillermo Aquino-Miranda, Pingyuan Wang, Douglas S. Engelke, Jingheng Zhou, Nghi Nguyen, Aditya K. Singh, Giuseppe Aceto, Zahra Haghighijoo, Isabella I. Smith, Nana Goode, Mingxiang Zhou, Yosef Avchalumov, Evan P. Troendle, Cynthia M. Tapia, Haiying Chen, Reid T. Powell, Timothy J. Baumgartner, Jully Singh, Leandra Koff, Jessica Di Re, Ann E. Wadsworth, Mate Marosi, Marc R. Azar, Kristina Elias, Paul Lehmann, Yorkiris M. Mármol Contreras, Poonam Shah, Hector Gutierrez, Thomas A. Green, Martin B. Ulmschneider, Marcello D’Ascenzo, Clifford Stephan, Guohong Cui, Fabricio H. Do Monte, Jia Zhou, Fernanda Laezza

“…Here, we identified compound 1028 (IUPAC: ethyl 3-(2-(3-(hydroxymethyl)-1H-indol-1-yl)acetamido)benzoate), a brain-permeable small molecule that targets FGF14R117, a critical residue located within a druggable pocket at the FGF14/Nav1.6 PPI interface. …”
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Neural markers of error processing relate to task performance, but not to substance-related risks and problems and externalizing problems in adolescence and emerging adulthood by Olga D. Boer, Thea Wiker, Shervin H. Bukhari, Rikka Kjelkenes, Clara M.F. Timpe, Irene Voldsbekk, Knut Skaug, Rune Boen, Valerie Karl, Torgeir Moberget, Lars T. Westlye, Ingmar H.A. Franken, Hanan El Marroun, Rene J. Huster, Christian K. Tamnes

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Eskişehir İl Halk Kütüphanesi Dermesinde Bulunan Resimli Çocuk Kitaplarının Fiziksel ve İçerik Özelliklerinin Ödünç Alınma Üzerinde Etkisi by Gözde Yılmaz, Bülent Yılmaz

“…Bulgular: Çalışmada elde edilen bulgulara göre, Eskişehir İl Halk Kütüphanesindeki resimli çocuk kitaplarının %60,8’inin yılda ortalama 1-3 kez ödünç alındığı; kalın karton kapaklı kitapların %56,2’si yılda ortalama 7 kez ve daha fazla ödünç alınırken, bu oranın ince kartonlu kapağa sahip kitaplar için %5,3 olduğu; özgün çocuk kitaplarının %81,9’unun, çeviri çocuk kitaplarının ise %96,6’sının ödünç alındığı; kapağı görsel çekiciliği sahip resimli çocuk kitaplarının %96,6’sı ödünç alınırken, bu oranın kapağı görsel açıdan çekici olmayan kitaplar için %81,7’ye düştüğü; çocuğun ilgi ve gereksinimlerine uygun olan kitapların %94,7’si ödünç alınırken, çocuğun gelişimine uygun olmadığı belirlenen kitaplarda ödünç alınma oranının %66,7’ye, kısmen uygun olanlarda ise %81,2’ye düştüğü; çocukta okuma isteği uyandıracak nitelikte olan resimli çocuk kitaplarının %98,2’si, kısmen bu nitelikte olanların %89,5 ve niteliksiz çocuk kitaplarının da %72,3’ü yılda en az 1 kez ödünç alındığı anlaşılmıştır. …”
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Effect of Zhuanggu Jianxi Decoction on Synovitis in Knee Osteoarthritis Rabbits via LXRs/NF-κB Pathway by CHEN Peng, GUO Jiemei, XIAO Yan, WANG Jianhui, SU Youxin

“…After the model was identified successfully, the synovial tissue of the right hind limb knee was cut into small pieces with a size about 1-2 mm³ under aseptic operation, 60 pieces were collected and randomly divided into model group, Zhuanggu Jianxi decoction group, LXRα inhibitor group and N-CoR inhibitor group with 15 pieces each, the synovial tissue pieces in each group were cultured in 6 well plates with every 3 pieces in each well, the four groups were intervened with 10% blank serum, 10% drug-containing serum, 10% drug-containing serum+5CPPSS-50 and 10% drug-containing serum+ML-792 respectively; the synovium of the blank group was prepared by the same method and cultured with 10% blank serum for 5 wells. …”
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BPZ inhibits early mouse embryonic development by disrupting maternal-to-zygotic transition and mitochondrial function by Zhiming Ding, Huilei Chen, Huiru Cheng, Caiyun Wu, Hongzhen Ruan, Bingjing Zhu, Ping Zhou, Zuying Xu, Huifen Xiang

“…Additionally, BPZ exposure alters the expression levels of histone modifications, including H3K27me2, H3K27me3, H3K9me3, and H3K27ac, in early embryos. …”
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J-TAIL-2: A Prospective, Observational Study of Atezolizumab Combined With Carboplatin and Etoposide in Patients With Extensive-Stage SCLC in Japan by Eisaku Miyauchi, MD, PhD, Makoto Nishio, MD, PhD, Kadoaki Ohashi, MD, PhD, Atsushi Osoegawa, MD, PhD, Eiki Kikuchi, MD, PhD, Hideharu Kimura, MD, PhD, Yasushi Goto, MD, PhD, Junichi Shimizu, MD, PhD, Hiroshige Yoshioka, MD, PhD, Ichiro Yoshino, MD, PhD, Toshihiro Misumi, PhD, Nobuyuki Katakami, MD, PhD, Masahide Oki, MD, PhD, Takashi Kijima, MD, PhD, Kenichi Chikamori, MD, PhD, Kazumi Nishino, MD, PhD, Yuki Kobayashi, MS, Asako Miwa, BA, Misa Tanaka, MS, Akihiko Gemma, PhD

“…Results: Overall, 403 patients were included; the median age was 71 years, 16.6% (n = 67) had an Eastern Cooperative Oncology Group performance status 2 or more, 26.8% (n = 108) had brain metastasis, 6.9% (n = 28) had interstitial lung disease, 4.0% (n = 16) had autoimmune disease, and 72.7% (n = 293) were IMpower133-unlike. …”
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Several factors that predict the outcome of large B‐cell lymphoma patients who relapse/progress after chimeric antigen receptor (CAR) T‐cell therapy can be identified before cell administration by Alice Sýkorová, František Folber, Kamila Polgárová, Heidi Móciková, Juraj Ďuraš, Kateřina Steinerová, Aleš Obr, Adriana Heindorfer, Miriam Ladická, Ľubica Lukáčová, Erika Čellárová, Ivana Plameňová, David Belada, Andrea Janíková, Marek Trněný, Tereza Jančárková, Vít Procházka, Andrej Vranovský, Margaréta Králiková, Jan Vydra, Lukáš Smolej, Ľuboš Drgoňa, Martin Sedmina, Eva Čermáková, Robert Pytlík

Subjects: “…CAR T‐cell failure…”
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بررسی تاثیر آبیاری با نسبت های مختلف اختلاط زه آب با آب شیرین و محلول پاشی کود کامل بر عملکرد و اجزای عملکرد چای ترش (.Hibiscus sabdariffa L)... by محمد فروزنده, سمیه میرشکاری, فاظمه بیدرنامنی

“…اثر متقابل آبیاری و محلول‌پاشی به غیر از ارتفاع بوته، قطر ساقه و وزن هزاردانه بر سایر صفات مورد بررسی معنی‌دار بود. بیشترین (6/227 کیلوگرم در هکتار) و کمترین (4/69 کیلوگرم در هکتار) عملکرد کاسبرگ به ترتیب از آبیاری با آب شیرین در تمام طول فصل رشد (شاهد) و آبیاری با زه آب حاصل شد. …”
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Parasitic infection prevalence in tuberculosis patients and their household contacts in the Littoral Region of Cameroon by Lucy Cho Nchang, Chefor Magha, Patience Agwa Fonong, Narcisse Victor Tchamatchoua Gandjui, Nancielle Mbiatong Tchatat, Desmond Akumtoh Nkimbeng, Frank Noel Nietcho, Juluis Visnel Foyet, Fanny Fri Fombad, Tatiana Djikeussi Katcho, Jerome Fru Cho, Achim Hoerauf, Manuel Ritter, Samuel Wanji

“…TB patients and household contacts living in urban areas had lower odds of being associated with helminth infections (AOR 0.2, 95 % CI: 0.10–0.40; p ˂ 0.0001 and AOR 0.11, 95 % CI: 0.04–0.27; p ˂ 0.0001 respectively) as compared to those residing in rural areas. …”
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Association study of the JAK/STAT signaling pathway with susceptibility to COVID-19 in moroccan patient and in-silico analysis of rare variants by Meriem El Houdi, Hanaa Skhoun, Meriem El Fessikh, Reda Benmansour, Fatima-Zahra El Yousfi, Chaimae Nebhani, Mohamed Rida Tagajdid, Idriss Lahlou Amine, Hicham El Annaz, Rabii Ameziane El Hassani, Zohra Ouzzif, Redouane Abouqal, Khalid Ennibi, Ahmed Bouhouche, Jamila El Baghdadi

“…Additionally, STAT2 p.Met594Ile showed an association to COVID-19 risk (p=0.042), with heterozygous GC being linked to infection (p=0.037, OR=2.7135 [0.5684 -12.9532]). Notably, IFNAR1 p.Val168Leu mutated C allele was significantly associated with reduced susceptibility to COVID-19 severity (p=0.028, OR=0.5936 [0.3725 – 0.9461]), under the additive model (p=0.045, OR=0.626 [0.3958 – 0.9899]).Rare variants IFNAR1 p.Trp318Cys, p.Ser476Phe, and IFNAR2 p.Cys271Tyr were predicted deleterious, impacting protein structure via hydrogen bond and hydrophobic interaction alterations. …”
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CHARACTERISTICS OF CIRCADIAN BLOOD PRESSURE PROFILE IN PATIENTS WITH ACUTE CORONARY SYNDROME AND THEIR ASSOCIATION WITH THYROID FUNCTION by Nataliia Kuz, Tetiana Solomenchuk

“…In particular, in Group I, the proportion of individuals with UA was 23.53%, and with MI - 76.47%; in Group II, the proportion of individuals with UA was 32.43%, and with MI - 67.57%, p>0,05 between Groups I and II. …”
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Spotted fever group rickettsiae in black rats, pets, and humans in Zungarococha community, A rural area in the surroundings of Iquitos, Peru by Cusi Ferradas, Guillermo Salvatierra, David Payahuanca, Winnie Contreras, Andrés M. López-Pérez, Therangika A. Hangawatte, Diana León, Bruno M. Ghersi, Ricardo Gamboa, Katia Manzanares Villanueva, Viviana Pinedo-Cancino, Risa Pesapane, Gabriela Salmón-Mulanovich, Andrés G. Lescano, Janet Foley

“…IgG seroprevalences were 38.3 %, 58.5 %, 16.7 % and 48.1 % among humans, dogs, cats, and rats, respectively. …”
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Anti-SARS-CoV-2 serology based on ancestral RBD antigens does not correlate with the presence of neutralizing antibodies against Omicron variants by Léa Dépéry, Isabelle Bally, Axelle Amen, Benjamin Némoz, Marlyse Buisson, Laurence Grossi, Aurélie Truffot, Raphaële Germi, Delphine Guilligay, Mélanie Veloso, Antoine Vilotitch, Olivier Epaulard, Patrice Morand, Winfried Weissenhorn, Pascal Poignard, Julien Lupo

Subjects: “…SARS-CoV-2…”
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بررسی پایداری عملکرد لاین‌های زمستانه کلزا در اقلیم سرد ایران با استفاده از مدل AMMI by بهرام علیزاده, بهمن پاسبان اسلام, عباس رضایی زاد, محمد یزدان دوست همدانی, معرفت مصطفوی راد

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Dynamics of coagulation proteins upon ICU admission and after one year of recovery from COVID-19: a preliminary study by Raquel Behar-Lagares, Ana Virseda-Berdices, Ana Virseda-Berdices, Óscar Martínez-González, Óscar Martínez-González, Óscar Martínez-González, Rafael Blancas, Rafael Blancas, Rafael Blancas, Marcela Homez-Guzmán, Eva Manteiga, Juan Churruca-Sarasqueta, Madian Manso-Álvarez, Madian Manso-Álvarez, Madian Manso-Álvarez, Ángela Algaba, Ángela Algaba, Ángela Algaba, Salvador Resino, Salvador Resino, Amanda Fernández-Rodríguez, Amanda Fernández-Rodríguez, María A. Jiménez-Sousa, María A. Jiménez-Sousa

Subjects: “…SARS-CoV2…”
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The added value of coupling anti-dsDNA and anti-chromatin antibodies in follow-up monitoring of systemic lupus erythematosus patients by Caroline Carlé, Françoise Fortenfant, Chloé Bost, Julie Belliere, Stanislas Faguer, Dominique Chauveau, Antoine Huart, David Ribes, Laurent Alric, Gregory Pugnet, Laurent Sailler, Yves Renaudineau

“…The DP + group, which presented important anti-dsDNA/Ab variations during follow-up, was at risk to develop lupus nephritis (56.8 % versus 2.4 % in SP-C+ and 29.7 % in SP-D+ groups, p < 0.04) and serositis (30 % versus 9.5 % in SP-C+ group, p = 0.006). …”
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Association of the blood urea nitrogen to serum albumin ratio and all-cause mortality in critical ill acute ischemic stroke patients: a retrospective cohort study of MIMIC-IV datab... by Yongwei Huang, Zongping Li, Jianjun Wang, Jianjun Wang, Decai Wang, Decai Wang, Xiaoshuang Yin

“…After fully adjustment, MCR models indicated a heightened mortality risk for the ICU (hazard ratio [HR] = 1.55, 95% confidence interval [CI]: 1.08–2.22; p = 0.02), 30-day (HR = 1.87, 95% CI: 1.46–2.38; p &lt; 0.001), 90-day (HR = 1.75, 95% CI: 1.42–2.15; p &lt; 0.001), and 365-day (HR = 1.81, 95% CI: 1.50–2.19; p &lt; 0.001) in the high BAR group as opposed to the low BAR group. …”
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مدل‌سازی مکانی زمین‌‌لغزش‌‌های استان خراسان رضوی با استفاده از روش‌‌های یادگیری ماشین by ملیحه محمدنیا, ابوالقاسم امیراحمدی, لیلی گلی مختاری

“…همچنین، نتایج ارزیابی مدل‌‌های یادگیری ماشین با استفاده از منحنی تشخیص عملکرد نسبی (ROC) نشان داد نقشه تهیه شده با روش جنگل تصادفی بیشترین دقت (0.97) را در تهیه نقشه پتانسیل زمین‌‌لغزش در منطقه موردمطالعه داشته است و بر این اساس، بیش از 25 درصد منطقه در کلاس خطر زیاد و خیلی ‌‌زیاد قرار دارد.   …”
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Whole blood ratio of CDK1/CX3CR1 mRNA expression combined to lactate refines the prediction of ICU mortality in septic patients in the Sepsis-3 era: a proof-of-concept study by Marie-Angélique Cazalis, Marie-Angélique Cazalis, Louis Kreitmann, Louis Kreitmann, Guillaume Monneret, Guillaume Monneret, Alexandre Pachot, Alexandre Pachot, Karen Brengel-Pesce, Karen Brengel-Pesce, Jean-François Llitjos, Jean-François Llitjos, Jean-François Llitjos

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