Early treatment discontinuation in patients with deficient mismatch repair or microsatellite instability high metastatic colorectal cancer receiving immune checkpoint inhibitors by Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Julien Taieb, David Tougeron, Margherita Ambrosini, Michael J Overman, Alice Boilève, Lisa Salvatore, Rosine Guimbaud, Priya Jayachandran, Frank A Sinicrope, Thibault Mazard, Javier Ros, Vincenzo Nasca, Simon Pernot, Emily Alouani, Marie Decraecker, Emilie Hafliger, Pauline Parent

“…After a median follow-up of 44 months (IQR: 30–67), similar PFS (HR: 0.92, 95% CI: 0.60 to 1.40, p=0.69) and OS (HR: 1.15, 95% CI: 0.66 to 1.99, p=0.62) from the start of ICIs were observed in ETD and LTD patients. …”
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بررسی تنوع ژنوتیپ‌های گندم نان بر اساس عملکرد و صفات مرتبط با عملکرد تحت شرایط تنش بیماری زنگ زرد (Puccinia striiformis)... by امین افضلی فر, فرزاد افشاری, لیلا فهمیده, صالحه گنجعلی, محمدرضا بی‌همتا, هادی علی پور

“…همچنین بدلیل ایجاد نوترکیبی بالا در عامل بیماری این بیماری هرساله نژادهای جدیدی در آن به وجود می‌آید که همین موضوع به‌نژادگران را وادار به مطالعه دائم این بیماری و یافتن ژنوتیپ های مقاوم گردانده است.مواد و روش‌ها: به‌منظور ارزیابی اثر بیماری زنگ زرد بر برخی از ویژگی‌های زراعی ژنوتیپ های گندم نان شامل 297 رقم تجاری و ژنوتیپ بومی ایران، آزمایشی مزرعه‌ای در سال زراعی 1398-1399 در قالب طرح آلفا لاتیس با دو تکرار اجرا شد. …”
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La desnutrición infantil en la comunidad wichí y sus representaciones sociales: un abordaje desde la teoría de los campos de Bourdieu by María Paula Costas Czarnescki, Carolina Antonela Curti, Mónica Patricia Millán, Maria Emilce Romero Talló, Andrea Paula Cravero Bruneri

“…La información se analizó desde la teoría de los CPB, de acuerdo con las categorías propuestas por el autor. …”
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‘Dynamic zero-COVID’ policy and viral clearance during an omicron wave in Tianjin, China: a city-wide retrospective observational study by Qi Wu, Yan Xie, Tao Cheng, Junping Wu, Wentao Jiang, Lixia Shi, Xiaolong Liu, Yu Hu, Yahui Feng, Hongxia Shao, Xiaowen Gong, Zhen Song, Saibing Qi, Xueou Liu, Qiujin Shen, Junren Chen

“…An exploratory analysis identified a feature cluster associated with earlier viral clearance, with HRs of 3.56 (95% CI 1.66 to 7.63) and 3.15 (95% CI 1.68 to 5.91) in the training and validation sets, respectively.Conclusions The ‘dynamic zero-COVID’ policy can suppress an omicron wave within a month. …”
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Tadalafil treatment for fetuses with early-onset growth restriction: a protocol for a multicentre, randomised, placebo-controlled, double-blind phase II trial (TADAFER IIb) by Hiroaki Tanaka, Yasuhiro Tanaka, Yoichi Aoki, Masayuki Endo, Tomoaki Ikeda, Shintaro Maki, Masafumi Nii, Kayo Tanaka, Satoshi Tamaru, Toru Ogura, Yuki Nishimura, Tomomi Kotani, Akihiko Sekizawa, Masahiko Nakata, Koji Nakamura, Kenji Nagao, Ichiro Yasuhi, Hiroshi Kawamura, Sho Takakura, Mayumi Kotera, Takafumi Ushida, Norihiko Kikuchi, Tadatsugu Kinjo, Mayumi Takano, Sachie Suga, Michi Kasai, Osamu Yasui, Yuka Maegawa, Shigeru Aoki, Yoshio Yoshida

“…Our findings will be widely disseminated through peer-reviewed publications.Trial registration jRCTs041190065.…”
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Differences in the response to TNF inhibitors at distinct joint locations in patients with psoriatic arthritis: results from nine European registries by Adrian Ciurea, Seraphina Kissling, Andrea Götschi, Lykke Midtbøll Ørnbjerg, Simon Horskjær Rasmussen, Bálint Tamási, Burkhard Möller, Michael J. Nissen, Bente Glintborg, Anne Gitte Loft, Almut Scherer, René Bräm, Karel Pavelka, Jakub Závada, Joao Madruga Dias, Paula Valente, Bjorn Gudbjornsson, Olafur Palsson, Vappu Rantalaiho, Ritva Peltomaa, Catalin Codreanu, Corina Mogosan, Florenzo Iannone, Marco Sebastiani, Gareth T. Jones, Gary J. Macfarlane, Isabel Castrejon, Ziga Rotar, Brigitte Michelsen, Johan K. Wallman, Irene van der Horst-Bruinsma, Oliver Distler, Mikkel Østergaard, Merete Lund Hetland, Raphael Micheroli, Caroline Ospelt

“…Within fingers, and using the same reference, joint swelling resolved fastest in digit 4 (1.77, 1.49–2.11) and digit 5 (1.88, 1.53–2.31). A lower rate of resolution of joint swelling was found for the knee in comparison to the elbow, the corresponding joint on the upper limb (0.56, 0.40–0.78). …”
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بررسی تنوع ژنتیکی برخی ژنوتیپ‌های لیمو اسیدی (Citrus aurantifolia Swingle) ایران بر پایه نشانگر AFLP by شاهین جهانگیرزاده خیاوی, یوسف حمیداوغلی, بهروز گلعین, عاطفه صبوری

“…دامنه تعداد نوارهای تکثیر شده برای هر ترکیب پرایمری در محدوده 26 الی 37 بود (متوسط 22 نواربه ازای هر ترکیب). حداکثر تعداد نوارمشاهده شده‌ی چند شکل در ترکیب ECCA/MAGT به تعداد 27 نواربود. …”
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Efficacy and safety of home-based transcranial direct current stimulation as adjunct treatment for cognitive improvement in major depressive disorder: A double-blind, randomized, m... by CW Lee, K Park, JE Ahn, Y Jang, YS Park, H Yu, D Lee, HK Ihm, J Lee, J Kim, YI Lee, S-E Lim, SS Kwon, HY Park, TH Ha, I-Y Yoon, Woojae Myung, Ji Hyun Baek

“…Results In the tDCS study, of 141 participants (102 [72.3%] women; mean age 35.7 years, standard deviation 12.7), 95 completed the trial. …”
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Physical impairments in individuals with Long COVID by Imane Salmam, Imane Salmam, Kadija Perreault, Kadija Perreault, Krista L. Best, Krista L. Best, Imane Zahouani, Gilles Drouin, Jean Tittley, François Desmeules, François Desmeules, Alexandre Campeau-Lecours, Alexandre Campeau-Lecours, Simon Beaulieu-Bonneau, Simon Beaulieu-Bonneau, Jean-Sébastien Paquette, Jean-Sébastien Paquette, Jean-Sébastien Paquette, Simon Deslauriers, Sarah-Maude Brouillard, Katherine Lepage, Jean-Sébastien Roy, Jean-Sébastien Roy

“…Physical assessments included handgrip strength (HGS), Short Physical Performance Battery (SPPB), 6-minute-walk-test (6MWT), perceived exertion during the 6MWT (Modified-Borg Scale), and daily step count during a 7-day period.ResultsMean age (mean [SD]) for LCG, SCG, and CG was 44.2 [11.2], 42.1 [16.4], and 46[15.9], respectively. …”
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Some Claims of Liman von Sanders On The Gallipoli Campaign by Sezen Kılıç

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Temporal trends in guideline-recommended medical therapy after an acute heart failure decompensation event: an observational analysis from Generator Heart Failure DataMart by Antonio Gasbarrini, Giuseppe Patti, Filippo Crea, Giovanni Scambia, Domenico D'Amario, Vincenzo Valentini, Gianluigi Savarese, Alfredo Cesario, Jacopo Lenkowicz, Stefano Patarnello, Renzo Laborante, Agni Delvinioti, Andrada Mihaela Tudor, Chiara Iacomini, Antonio Iaconelli, Donato Antonio Paglianiti, Mattia Galli, Daniele Rodolico, Attilio Restivo, Giuseppe Ciliberti, Gaetano Rizzo, Emiliano Bianchini, Matteo Busti, Luca Sensini

“…In multivariate analysis, the use of ACEi/ARB/ARNi was associated with a lower risk of 30-day all-cause death and urgent rehospitalisation (adjusted OR 0.38; 95% CI 0.24 to 0.59; p<0.01). Conversely, the prescription of furosemide at discharge (adjusted OR 2.25; 95% CI 95% 1.29 to 3.94; p<0.01) and a previous genitourinary infection (adjusted OR 4.02; 95% CI 1.67 to 9.68; p<0.01) were associated with higher risk of 30-day all-cause death and urgent rehospitalisation.Conclusions In our study, early adoption of guideline-recommended medical therapy is still limited, with a significant rise in SGLT2i prescriptions after January 2022 and a lower risk of the composite of all-cause death and urgent readmissions at 30 days restricted to the use of ACEi/ARB/ARNi.…”
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Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut by Xina Xiao, Meng Hu, Li Gao, Huan Yuan, Baochen Chong, Yu Liu, Rou Zhang, Yanqiu Gong, Dan Du, Yong Zhang, Hao Yang, Xiaohui Liu, Yan Zhang, Huiyuan Zhang, Heng Xu, Yi Zhao, Wenbo Meng, Dan Xie, Peng Lei, Shiqian Qi, Yong Peng, Tao Tan, Yang Yu, Hongbo Hu, Biao Dong, Lunzhi Dai

“…Interestingly, we observed that the Sto levels ranged from 0.97% to 99.88%, exhibiting two distinct peaks and increasing with age. …”
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Tumor cell-based liquid biopsy using high-throughput microfluidic enrichment of entire leukapheresis product by Avanish Mishra, Shih-Bo Huang, Taronish Dubash, Risa Burr, Jon F. Edd, Ben S. Wittner, Quinn E. Cunneely, Victor R. Putaturo, Akansha Deshpande, Ezgi Antmen, Kaustav A. Gopinathan, Keisuke Otani, Yoshiyuki Miyazawa, Ji Eun Kwak, Sara Y. Guay, Justin Kelly, John Walsh, Linda T. Nieman, Isabella Galler, PuiYee Chan, Michael S. Lawrence, Ryan J. Sullivan, Aditya Bardia, Douglas S. Micalizzi, Lecia V. Sequist, Richard J. Lee, Joseph W. Franses, David T. Ting, Patricia A. R. Brunker, Shyamala Maheswaran, David T. Miyamoto, Daniel A. Haber, Mehmet Toner

“…CTC size varies within patients, with 67% overlapping in diameter with WBCs. …”
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Three-dimensional aortic arch geometry and blood flow in neonates after surgical repair for aortic coarctation by Katrin Fricke, Katrin Fricke, Lea Christierson, Lea Christierson, Lea Christierson, Einar Heiberg, Einar Heiberg, Pia Sjöberg, Pia Sjöberg, Erik Hedström, Erik Hedström, Erik Hedström, Erik Hedström, Kristoffer Steiner, Constance G. Weismann, Constance G. Weismann, Constance G. Weismann, Johannes Töger, Johannes Töger, Petru Liuba, Petru Liuba

“…Re-CoA was associated with repair technique (lateral thoracotomy 100% vs. 33%, p = 0.02), higher postoperative isthmic flow velocity by echocardiography (1.9 [0. 9] m/s vs. 1.25 [0.5] m/s, p = 0.04) and postoperative crenel aortic arch (100% vs. 21%, p = 0.007) with a larger distance between the first and last branching points (12.6 [3.1] mm vs. 7.3 [7.0] mm; p = 0.01). …”
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Effects of external ankle support on balance control outcomes following muscle fatigue in individuals with ankle instability: A systematic review and meta-analysis by Hanieh KHALILIYAN, Mahmood BAHRAMIZADEH, Amirhossein ZARE, Kavita BATRA, Gabriella NUCERA, Aldo SITIBONDO, Aanuoluwapo AFOLABI, Majid ANSARI, Olayinka ILESANMI, Lukasz SZARPAK, Alireza KHAGHANI, Shahla MOHAJERI, Farhad GHAFFARI, Arash SHARAFATVAZIRI

“…The meta-analysis results indicate that compared to the control group, external ankle supports after muscle fatigue significantly change Y balance clinical test-posterolateral [MD=1.22, 95% CI (0.16, 2.28), p=0.03], Y balance clinical test-posteromedial [Mean difference=2.60, 95% CI (0.42, 4.79), p=0.03], center of pressure time to stabilization-mediolateral [Mean difference=-0.68, 95% CI (-1.29, -0.07), p=0.04], center of pressure time to stabilization-vertical [Mean difference=-0.62, 95% CI (-0.94, -0.30), p=0.01], and vertical ground reaction force [Mean difference=0.58, 95% CI (0.21, 0.96), p=0.02]. …”
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Efficacy and safety of jaktinib hydrochloride tablets in active axial spondyloarthritis: a multicentre, randomised, double-blind, placebo-controlled phase II clinical trial by Xiaomei Li, Xiaoxia Wang, Jian Wu, Xiao Zhang, Chunde Bao, Shengqian Xu, Lingyun Sun, Juan Wang, Guixiu Shi, Xiaofei Wang, Qing Dai, Antao Xu, Huaxiang Wu, YongQing Wang, Yan Ye, Yongfu Wang, Huaxiang Liu, Chenyin Lv, Jun Miao, Weiqi Min, Kuanting Wang, Luan Xue, Shanhui Ye

“…The ASAS40 response rates were significantly higher with jaktinib (100 mg two times per day group: 47.2%, 75 mg two times per day group: 37.1%) compared with placebo (13.9%). …”
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Carbon stock dynamics of forest to oil palm plantation conversion for ecosystem rehabilitation planning by D. Frianto, E. Sutrisno, A. Wahyudi, E. Novriyanti, W.C. Adinugroho, A.S. Yunianto, H. Kurniawan, H. Khotimah, A. Windyoningrum, I.W.S. Dharmawan, H.L. Tata, S. Suharti, H.H. Rachmat, E.M. Lim

“…According to measurements taken at breast height, the aboveground biomass of these species was measured, leading to projected estimates of carbon stocks in Kepau Jaya specific purpose forest area reaching 19,455 tonnes of carbon by the year 2030, with Coffea liberica contributing 4,148 tonnes carbon and Shorea balangeran contributing 15,307 tonnes carbon. CONCLUSION: The study area experienced a substantial reduction in forest cover, whereas the extent of oil palm areas expanded significantly. …”
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بررسی همزیستی اندوفایت روی صفات مورفولوژیکی و بِیوشیمیایی در گونه چمانواش بلند تحت تنش خشکی by سیده آزاده علینقی مداح, عبداله حاتم زاده, احد یامچی, رضا محمدی

“…در مورد وزن تر و خشک گیاه، اثرات تنش آبی، قارچ اندوفایت، ژنوتیپ گیاهی و برهمکنش این سه اثر بر هم بسیار معنی دار شد (P <0/01) و بیشترین مقدار وزن تر (1/167گرم) و وزن خشک (0/184گرم) به ترتیب مربوط به ژنوتیپ نتاج و ژنوتیپ والد بدون اندوفایت و در شرایط کنترل بود. …”
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OrchidBase 6.0: increasing the number of Cymbidium (Orchidaceae) genomes and new bioinformatic tools for orchid genome analysis by You-Yi Chen, Ye Sun, Chung-I Li, Shao-Ting Lin, Hao-Chen Zheng, Zhe-Bin Zhang, Bing-Ru Lee, Chun-Lin Hsieh, Yu-Yun Hsiao, Chi-Nga Chow, Chien-Wen Yang, Wen-Chi Chang, Heming Chen, Feng-Xi Yang, Gen-Fa Zhu, Qinyao Zheng, Cheng-Yuan Zhou, Zhuang Zhao, Ye Ai, Lin-Ying Wang, Deqiang Chen, Xin He, Ming-Zhong Huang, Dong-Hui Peng, Hao Yu, Siren Lan, Zhong-Jian Liu, Wei-Sheng Wu, Wen-Chieh Tsai

“…Description Recently, three whole-genome sequences of the Epidendroideae species, Cymbidium sinense, C. ensifolium and C. goeringii, were sequenced de novo, assembled, and analyzed. …”
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Cambios epidemiológicos de pacientes hospitalizados en un servicio de medicina interna del Hospital Edgardo Rebagliati Martins 2008 vs. 2018 by Jorge Luis Solari Yokota, Jesús Alberto Fernández Apolaya, Martín Alonso Gamboa Orozco, John Bryan Chinchayán Méndez, José Luis Qwistgaard Espinal, Fabián André Vargas Giuria, Claudia Consuelo Gamero Montoya, Cristopher César Ortiz Patiño, Lilianna Ofelia Lavado De La Vega, Martín Diego Alonso Uribe Chamochumbi

“…Se usó la información de los registros de enfermería de 1640 pacientes mayores de 18 años hospitalizados en el Servicio de Medicina Interna N.º 5 (piso 7C) del Hospital Edgardo Rebagliati Martins (Jesús María-Lima, Perú) durante los años 2008 y 2018. …”
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