LRRK2 Mutations and Asian Disease-Associated Variants in the First Parkinson’s Disease Cohort from Kazakhstan by Rauan Kaiyrzhanov, Akbota Aitkulova, Chingiz Shashkin, Nazira Zharkinbekova, Mie Rizig, Elena Zholdybayeva, Zharkyn Jarmukhanov, Vadim Akhmetzhanov, Gulnaz Kaishibayeva, Talgat Khaibullin, Altynay Karimova, Serik Akshulakov, Askhat Bralov, Nurlan Kissamedenov, Zhanar Seidinova, Anjela Taskinbayeva, Aliya Muratbaikyzy, Henry Houlden

“…None of the study subjects carried LRRK2 mutations, whereas the following Asian variants were found with insignificant odds ratios (OR): p.Gly2385Arg (1.2%, minor allele frequency (MAF) 0.007, OR 1.25, p=0.8), p.Ala419Val (3.7%, MAF 0.02, OR 1.5, p=0.4), and p.Arg1628Pro was found only in 1% of controls. p.Gly2385Arg was positive in a big family with PD and tremor, although with incomplete segregation. …”
Get full text

Frailty Assessment Tools in Chronic Kidney Disease: A Systematic Review and Meta-analysis by Alisha Puri, Anita M. Lloyd, Aminu K. Bello, Marcello Tonelli, Sandra M. Campbell, Karthik Tennankore, Sara N. Davison, Stephanie Thompson

“…The pooled aHR for the Clinical Frailty Scale for mortality in pre-frail versus non-frail was 1.75 (95% CI, 1.17-2.60; I2 = 26%) and 2.20 (95% CI, 1.00-4.80; I2 = 66%) in frail versus non-frail. …”
Get full text

Statewide Forest Canopy Cover Mapping of Florida Using Synergistic Integration of Spaceborne LiDAR, SAR, and Optical Imagery by Monique Bohora Schlickmann, Inacio Thomaz Bueno, Denis Valle, William M. Hammond, Susan J. Prichard, Andrew T. Hudak, Carine Klauberg, Mauro Alessandro Karasinski, Kody Melissa Brock, Kleydson Diego Rocha, Jinyi Xia, Rodrigo Vieira Leite, Pedro Higuchi, Ana Carolina da Silva, Gabriel Maximo da Silva, Gina R. Cova, Carlos Alberto Silva

“…Using a random forest algorithm, our model achieved an R² of 0.69, RMSD of 0.17, and MD of 0.001, based on out-of-bag samples for internal validation. …”
Get full text

Epidemiology, Controversies, and Dilemmas of Perioperative Nutritional Risk/Malnutrition: A Narrative Literature Review by He M, Long Y, Peng R, He P, Luo Y, Zhang Y, Wang W, Yu X, Deng L, Zhu Z

“…Miao He,1– 3 Yuanzhu Long,2 Rong Peng,4 Pinglin He,5 Yue Luo,6 Yan Zhang,6 Weiwei Wang,7 Xiaoqian Yu,8 Lei Deng,1,9 Zhaoqiong Zhu2,3 1Department of Anesthesiology, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, People’s Republic of China; 2Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People’s Republic of China; 3Suzhou Medical College of Soochow University, Suzhou, Jiangsu, People’s Republic of China; 4Department of Clinical Nutrition, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, People’s Republic of China; 5Department of Urological Surgery, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, People’s Republic of China; 6Nursing School of Zunyi Medical University, Zunyi, Guizhou, People’s Republic of China; 7Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium; 8Department of Painology, West China Hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of China; 9School of Public Administration, Southwest Minzu University, Chengdu, Sichuan, People’s Republic of ChinaCorrespondence: Lei Deng, Department of Anesthesiology, Affiliated Hospital of Chengdu University, No. 82, North Second Section 2nd Ring Road, Jinniu District, Chengdu, Sichuan, 610081, People’s Republic of China, Tel +86-13666278563, Email denglei@cdu.edu.cn Zhaoqiong Zhu, Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, 149, Da Lian Road, Zunyi, Hui Chuan District, 563003, People’s Republic of China, Tel +86-13035529980, Email zhuzhaoqiong@zmu.edu.cnAbstract: Current perioperative nutrition management is discouraging due to the under-recognition of clinical nutrition and the lagging development of clinical nutriology. …”
Get full text

Exploring the impact of APOE ɛ4 on functional connectivity in Alzheimer’s disease across cognitive impairment levels by Kangli Dong, Wei Liang, Ting Hou, Zhijie Lu, Yixuan Hao, Chenrui Li, Yue Qiu, Nan Kong, Yan Cheng, Yaqi Wen, Wanyin Ma, Wenbin Zheng, Jitian Guan, Yan Lin, Kai Huang, Lu Zhang, Siya Chen, Xiangyuan Ma, Renhua Wu, Naili Wei

“…In this study, we systematically analyzed functional magnetic resonance imaging (fMRI) data from two distinct cohorts: an In-house dataset includes 59 AD patients (73.37 ± 6.42 years), and the ADNI dataset includes 117 AD patients (74.91 ± 7.91 years). …”
Get full text

Relevance of superoxide dismutase type 1 to lipoid pneumonia: the first retrospective case-control study by Yinan Hu, Yanhong Ren, Yinzhen Han, Zhen Li, Weiqing Meng, Yuhui Qiang, Mengyuan Liu, Huaping Dai

“…Results In multivariate regression analysis, the sole independent risk factor of LP was the level of SOD1 (OR 0.922, 95% CI: 0.878 ~ 0.967, P < 0.001), while smoking status (β= -0.177, 95% CI -18.645~-2.836, P = 0.008), diabetes mellitus (β= -0.191, 95% CI: -20.442~-3.592, P = 0.005), and total sialic acid (TSA) (β= -0.426, 95% CI: -0.915~ -0.433, P < 0.001) independently influenced the level of SOD1. …”
Get full text

Transcriptomic profiles of monocyte-derived macrophages exposed to SARS-CoV-2 VOCs reveal immune-evasion escape driven by delta by Alessia Gallo, Josè Camilla Sammartino, Roberta Vazzana, Roberto Giambruno, Claudia Carcione, Nicola Cuscino, Salvatore Castelbuono, Vitale Miceli, Matteo Bulati, Daniele Lilleri, Irene Cassaniti, Pier Giulio Conaldi, Fausto Baldanti

“…Methods We analysed the gene expression profiles of monocyte-derived macrophages (MDM) isolated from whole blood of healthy participants exposed to the 5 different SARS-CoV-2 VOC: D614G, Alpha (B.1.1.7), Gamma (P1), Delta (B.1.617.2), and Omicron BA.1 (B.1.1.529), and to the HCoV-OC43 strain, a coronavirus already present in the population before the SARS-CoV-2 pandemic. …”
Get full text

Role and prognostic value of growth differentiation factor 15 in patient of heart failure with preserved ejection fraction: insights from the PURSUIT-HFpEF registry by Tetsuhisa Kitamura, Shungo Hikoso, Takahisa Yamada, Yoshio Yasumura, Akito Nakagawa, Toshihiro Takeda, Hirota Kida, Akihiro Sunaga, Tomoharu Dohi, Katsuki Okada, Daisaku Nakatani, Yasushi Matsumura, Yasushi Sakata, Shunsuke Tamaki, Takaharu Hayashi, Yoshiharu Higuchi, Masaharu Masuda, Mitsutoshi Asai, Toshiaki Mano, Hisakazu Fuji, Daisaku Masuda, Shizuya Yamashita, Masami Sairyo, Yusuke Nakagawa, Haruhiko Abe, Yasunori Ueda, Kunihiko Nagai, Masamichi Yano, Masami Nishino, Jun Tanouchi, Yoh Arita, Shinji Hasegawa, Takamaru Ishizu, Minoru Ichikawa, Yuzuru Takano, Eisai Rin, Tetsuya Watanabe, Shiro Hoshida, Masahiro Izumi, Hiroyoshi Yamamoto, Hiroyasu Kato, Kazuhiro Nakatani, Mayu Nishio, Keiji Hirooka, Takahiro Yoshimura, Akihiro Tani, Yasushi Okumoto, Yasunaka Makino, Katsuomi Iwakura, Yoshiyuki Kijima, Takashi Kitao, Masashi Fujita, Koichiro Harada, Masahiro Kumada, Osamu Nakagawa, Ryo Araki, Takayuki Yamada, Fusako Sera, Kei Nakamoto, Hidetaka Kioka, Tomohito Ohtani, Nobuyuki Ogasawara, Yukinori Shinoda, Koichi Tachibana, Yohei Sotomi, Taiki Sato, Yuji Yasuga, Toshinari Onishi, Kazunori Kashiwase, Ryu Shutta, Masahiro Seo, Yuki Matsuoka, Yasuhiro Akazawa, Daisuke Sakamoto

“…GDF15 was linked to poor prognosis in this elderly multimorbid cohort with HFpEF (adjusted HR for log-transformed GDF15: 13.67, 95% CI: 2.78 to 67.22, p=0.001). Furthermore, GDF15 added significant incremental value to the MAGGIC risk score (net reclassification improvement=0.4955 (95% CI: 0.1367 to 0.8543), p=0.007; integrated discrimination improvement=0.0278 (95% CI: 0.0013 to 0.0543), p=0.040).Conclusions GDF15 was associated with anaemia, inflammation, renal dysfunction, cardiac burden and malnutrition. …”
Get full text

Prevalence of peptic ulcer disease and its associated factors in Jeddah Saudi Arabia by Muazzam Sheriff Maqbul, Reem Saleh Alzaki, Reema Sami Meeralam, Norah Abdulmajeed Alqutami, Bayan Mohammed Alturki, Lina Sultan Alhazmi, Reem Mamdouh Alaseeri, Lama Saad Alghamdi, Reem Khalid bin Brik, Shaima Tariq Mansoor Beig, Muath Saeed Alamri, Wjood Abdullah A. Alshehri, Turki Ayed Almutairi, Maha Abdullah Alqurashi, Ahmed Jamal Nasef

“…The study revealed a high PUD prevalence, with 463 respondents (82.53 ​%) reporting a history of the disease, primarily gastric ulcers (256 cases, 45.63 ​%) and duodenal ulcers (207 cases, 36.89 ​%). Treatment mainly involved outpatient antibiotic use (419 respondents, 74.68 ​%), while 44 respondents (7.84 ​%) required hospitalization. …”
Get full text

Effects of different rapeseed varieties on egg production performance, egg quality, hormone levels, follicle development, and thyroid function in hens by Liping Zhu, Jianping Wang, Xuemei Ding, Shiping Bai, Qiufeng Zeng, Yue Xuan, Keying Zhang

“…The 11.5% rapeseed diets varied in Gls and EA levels: 1) Deyou no. 6 (DY6) with Gls at 22.67 μmol/g and EA at 0.7%, 2) Mianbangyou no. 1 (MB1) with Gls at 43.23 μmol/g and EA at 3.5%, 3) Deyou no. 5 (DY5) with Gls at 74.66 μmol/g and EA at 16.20%, 4) Xiheyou no. 3 (XH3) with Gls at 132.83 μmol/g and EA at 44.60%. …”
Get full text

早产儿脑白质损伤核磁共振成像定量评估与血细胞参数和围产期因素的相关性分析 by 钟俊炎, 陈雪雨, 杨默

“…④MCH诊断WMD的AUC为0.708， 95%CI为（0.595，0.820），截断值为37.10 pg。PLT诊断WMD的AUC为0.669，95%CI为（0.551，0.787），截断值为227.50×10⁹/L。…”
Get full text

Evaluation of Southern African wild edible plants for potential herb-drug interactions through ex vivo p-glycoprotein and in vitro cytochrome P450 3A4 inhibitory effects by P.S. Kheoane, K.C. Mokhetho, S. Mokhele, K.C. Mbara, C.M. Leonard, T.H. Gadaga, C. Tarirai

“…Coville had significant (p < 0.05) p-glycoprotein inhibitory effects with Papp eff of (6.60±0.52) × 10–6 cm/s and Jeff of 1.11±0.08 µg/cm2/min, and Papp eff of 6.58±0.67 × 10–6 cm/s and Jeff of 1.19±0.12 µg/cm2/min, respectively. …”
Get full text

Osteopenia Metabolomic Biomarkers for Early Warning of Osteoporosis by Jie Wang, Dandan Yan, Suna Wang, Aihua Zhao, Xuhong Hou, Xiaojiao Zheng, Jingyi Guo, Li Shen, Yuqian Bao, Wei Jia, Xiangtian Yu, Cheng Hu, Zhenlin Zhang

“…Metabolites were further selected to identify osteopenia (nine metabolites in females; eight metabolites in males), and their ability to discriminate osteopenia was improved significantly compared to traditional bone turnover markers (BTMs) (female AUC = 0.717, 95% CI 0.547–0.882, versus BTMs: <i>p</i> = 0.036; male AUC = 0.801, 95% CI 0.636–0.966, versus BTMs: <i>p</i> = 0.007). …”
Get full text

Associations between milk infrared-predicted plasma biomarkers of stress resilience and fertility in dairy cattle: Insights for enhancing breeding programs and herd management by Alessio Cecchinato, Hugo Toledo-Alvarado, Lucio Flavio Macedo Mota, Vittoria Bisutti, Erminio Trevisi, Riccardo Negrini, Sara Pegolo, Stefano Schiavon, Luigi Gallo, Giovanni Bittante, Diana Giannuzzi

“…Among factors influencing fertility in dairy cattle, metabolic stress and systemic inflammation of animals are of main relevance, especially in the postpartum stage when ovarian activity begins and cows are inseminated. Our study aimed to infer the associations between milk infrared-predicted blood biomarkers of stress resilience and fertility traits, namely the interval from calving to first service (iCF), days open (DO), and the pregnancy rate at first service (PRF) in a multibreed population of 89,097 dairy cows. …”
Get full text

POTENCIA Y ACTIVIDAD ELECTROMIOGRÁFICA EN VOLEIBOLISTAS UNIVERSITARIOS by Esteban Aedo-Muñoz, Valentin Tamayo Contreras, Cristian Rojas Reyes, Cristian Hernández Wimmer, Ciro Brito, Bianca Miarka, Rodrigo Arghoty Bucheli, Fabio Dal Bello, Tomás Herrera Valenzuela

“…Se presentaron diferencias significativas en %PeakRMS del VL (G1=65.210.2; G2=54.0±11.7 %PeakRMS; p<0.05) en CMJ, mientras que en ABK presentaron diferencias significativas VL (G1=69.6±17.3; G2=55.1±12.3 %PeakRMS; p<0.05) y GASLAT (G1=61.4±13.4;G2=50.6±7.2 %PeakRMS; p<0.05), para la potencia relativa no se presentaron diferencias significativas entre CMJ (p>0.05) y ABK (p>0.05).…”
Get full text

Evaluation of an Alternative Screening Method for Gestational Diabetes Diagnosis During the COVID-19 Pandemic (DIABECOVID STUDY): An Observational Cohort Study by Alba Casellas, Cristina Martínez, Judit Amigó, Roser Ferrer, Laia Martí, Carme Merced, Maria Carmen Medina, Istria Molinero, Marta Calveiro, Anna Maroto, Ester del Barco, Elena Carreras, Maria Goya

“…An adjusted analysis showed no differences in the composite adverse outcomes for pregnancy complications (OR: 1.57; 95% CI: 0.84–2.98), delivery complications (OR: 1.21; 95% CI: 0.63–2.35), and neonatal complications (OR: 1.35; 95% CI: 0.61–3.04). …”
Get full text

The Accuracy of the Passive Leg Raising Test Using the Perfusion Index to Identify Preload Responsiveness—A Single Center Study in a Resource-Limited Setting by Marialessia Casazzo, Luigi Pisani, Rabiul Alam Md Erfan Uddin, Abdus Sattar, Rashed Mirzada, Abu Shahed Mohammad Zahed, Shoman Sarkar, Anupam Barua, Sujat Paul, Mohammad Abul Faiz, Abdullah Abu Sayeed, Stije J. Leopold, Sue J. Lee, Mavuto Mukaka, Mohammed Abul Hassan Chowdhury, Ketsanee Srinamon, Marja Schilstra, Asok Kumar Dutta, Salvatore Grasso, Marcus J. Schultz, Aniruddha Ghose, Arjen Dondorp, Katherine Plewes

“…The best identified PI change cutoff to discriminate responders from non–responders was 9.7%. The accuracy of PLR using PI in discriminating a preload responsive patient at baseline was good (area under the ROC 0.87 95% CI 0.75–0.99). …”
Get full text

Comparison of long-term ankle joint function after one-stage and staged microsurgical repair of open achilles tendon defects by Jianjie Mao, Yang Xiang, Hui Chu, GenYang Jin, Guangyan Su, Chang zeng Liu, Feng Zhu

“…The surgical method (OR = 49.725, 95% CI: 16.996 ~ 145.478) and the preoperative heel region defect area (OR = 0.947, 95% CI: 0.903 ~ 0.992) were found to be independent risk factors affecting the postoperative follow-up of ankle joint function in patients with open Achilles tendon defects. …”
Get full text

Relaciones entre el recuento de células somáticas, test de mastitis California, conductividad eléctrica y el diagnóstico de mastitis subclínicas en cabras lecheras by V.H. SUAREZ, G.M. MARTINEZ, V. GIANRE, L. CALVINHO, A. RACHOSKI, M. CHAVEZ, A. SALATIN, S. OROZCO, V. SANCHEZ, E. BERTONI

“…El CCS tuvo una correlación de r=0,86 (p<0,0001) con el VMYP, de r=0,64 (p<0,0001) con el CMT, de r=0,24 (p<0,0001) con la CE y de 0,47 (p<0,009) con el PortaSCC. …”
Get full text

The Role of Open and Distance Learning (ODL) in Promoting Access to Women's Education in Northwestern Nigeria: A Case Study of the National Open University of Nigeria (NOUN) by Shehu Usman Adamu, Bala Kwata Waziri, Adewale Adesina, Babangida Iro

“…L’étude a également examiné les facultés où ces femmes se sont inscrites au cours des 4 dernières années afin de déterminer le rôle de l’enseignement ouvert et à distance dans l’accès des femmes à l’enseignement supérieur. …”
Get full text