Effect of Tiaoxin Recipe on Memory Learning and Synaptic Plasticity in APP/PS1 Double Transgenic Alzheimer's Disease Mice based on αCaMKⅡ-CREB-BDNF Signal Pathway by Xiaowen WANG, Hong QIAN, Chunjuan SHEN, Yanjun LI, Haixin YUAN, Jian WANG

“…Real-time fluorescence quantitative PCR (RT-qPCR) was used to detect the expression of αCaMKⅡ, CREB, BDNF and PSD-95mRNA in hippocampal hippocampus of mice in four groups, and Western blotting (WB) was used to detect the expression of paired p-αCaMKⅡ, p-CREB, BDNF and PSD-95 in hippocampus of four groups of mice.Results:①Electrophysiological results: under the intensity of 0.1-0.7 mA stimulation, there was no significant difference in the slope of hippocampal I/O curve among the four groups (<italic>P</italic>&gt;0.05). …”
Get full text

Analyzing practice pattern in treating partial-thickness rotator cuff tears: a dual perspective from national database and American Shoulder and Elbow Surgeons PARCIAL research gro... by H. Mike Kim, MD, Emily Leary, PhD, Champ L. Baker, 3rd, MD, Leslie A. Barnes, MD, R. Alexander Creighton, MD, Frances Cuomo, MD, Matthew J. DiPaola, MD, Abdullah Foad, MD, James M. Gregory, MD, Brian F. Grogan, MD, Scott G. Kaar, MD, MBA, Eitan M. Kohan, MD, Sumant G. Krishnan, MD, Eddie Y. Lo, MD, John T. Moor, MD, Michael Nguyen, BS, Monica DiFiori, MD, Gabriel Masters, BA, Te Feng Arthur Chou, MD, Riccardo Raganato, MD, Lucas P. Bowen, BS, Jordan J. Harmon, BS, Tessa C. Griffin, BS, Alec E. Winzenried, MD, Evan M. Polce, BS, Cory J. Call, BS, Benjamin Nwadike, MD, Alvin Ouseph, MS, Monia Nazemi, MS, Kyle McCall, BA

“…The retrospective chart review of the ASES research group revealed that PTRCT repairs constituted 27.8% of all rotator cuff repairs with substantial variability among institutions (8.6%-67.1%), that nonoperative measures were commonly employed, with a mean 12-month duration before surgical repair, and that the most common type of nonoperative treatment was supervised physical therapy combined with corticosteroid injection (37.7%). …”
Get full text

Inflamed immune phenotype predicts favorable clinical outcomes of immune checkpoint inhibitor therapy across multiple cancer types by Jeanne Shen, Sergio Pereira, Chan-Young Ock, Yung-Jue Bang, Seulki Kim, Sehhoon Park, Se-Hoon Lee, George A Fisher, Young Kwang Chae, Yoon-La Choi, Jin-Haeng Chung, Tony S K Mok, Leeseul Kim, Jun-Eul Hwang, Gahee Park, Sanghoon Song, Seunghwan Shin, Yoojoo Lim, Wonkyung Jung, Heon Song, Hyojin Kim, Taebum Lee, Sukjun Kim, Chang Ho Ahn, Seokhwi Kim, Ben W Dulken, Stephanie Bogdan, Maggie Huang, Chiyoon Oum, Siraj M. Ali

“…We evaluated the correlation between the IIP and ICI treatment outcomes in terms of objective response rates (ORR), progression-free survival (PFS), and overall survival (OS) in a cohort of 1,806 ICI-treated patients representing over 27 solid tumor types retrospectively collected from multiple institutions.Results We observed an overall IIP prevalence of 35.2% and significantly more favorable ORRs (26.3% vs 15.8%), PFS (median 5.3 vs 3.1 months, HR 0.68, 95% CI 0.61 to 0.76), and OS (median 25.3 vs 13.6 months, HR 0.66, 95% CI 0.57 to 0.75) after ICI therapy in IIP compared with non-IIP patients, respectively (p&lt;0.001 for all comparisons). …”
Get full text

Arbovirus vectors of epidemiological concern in the Americas: A scoping review of entomological studies on Zika, dengue and chikungunya virus vectors. by Reilly Jones, Manisha A Kulkarni, Thomas M V Davidson, RADAM-LAC Research Team, Benoit Talbot

“…Few studies examined natural infection rates of Zika virus, vertical transmission, or co-infection with other viruses. This is in contrast to the wealth of research available on natural infection and co-infection for dengue and chikungunya viruses, although vertical transmission research was sparse for all three viruses.…”
Get full text

Analysis of stomatal characteristics of maize hybrids and their parental inbred lines during critical reproductive periods by Changyu Zhang, Changyu Zhang, Yu Jin, Yu Jin, Jinglu Wang, Jinglu Wang, Ying Zhang, Ying Zhang, Yanxin Zhao, Xianju Lu, Xianju Lu, Wei Song, Xinyu Guo, Xinyu Guo

“…Manual validation revealed high detection accuracies for stomatal density, width, and length, with R2 values of 0.92, 0.97, and 0.95, respectively. Phenotypic analyses indicated a significant positive correlation between stomatal density and the percentage of guard cells and pore area (r=0.36), and a negative correlation with stomatal area and subsidiary cell area (r=-0.34 and -0.46). …”
Get full text

Awareness, knowledge, and attitudes of the Belgian general population towards paternal perinatal depression: a descriptive cross-sectional study by Ayse Akalin, Ayse Akalin, Florence D’haenens, Sandra Tricas-Sauras, Sandra Tricas-Sauras, Joeri Vermeulen, Joeri Vermeulen, Joeri Vermeulen, Dennis Demedts, Dennis Demedts, Ronald Buyl, Maaike Fobelets, Maaike Fobelets

“…Data were analysed using descriptive statistics, Chi² analysis, and independent sample t-test.ResultsA total of 314 participants, including women (n=165) and men (n=149) completed the questionnaire. …”
Get full text

اثر سالیسلیک‌اسید و ملاتونین بر کلروفیل ‌فلورسانس و رشد اولیه گوجه‌فرنگی گلخانه‌ای در تنش شوری by مصطفی نیازی خوجه, مهدی رضائی, زیبا قسیمی حق

Get full text

Development, implementation, and evaluation of an innovative clinical trial operations training program for Africa (ClinOps) by Dawit Asmamaw Ejigu, Abebaw Fekadu, Jeremy Whitty, Tsegahun Manyazewal, Pamela Nebeta, Almari Conradie, Brenda Okech, Alice Neequaye, Sinéad Whitty, Jennifer Lehrman, Renee Holt, Rahel Birhane, Mahnaz Vahedi, Helen Demarest, Eyasu Makonnen

“…Post-training scores demonstrated substantial improvement compared to pre-training scores in each competency area, including in designing (pre-post training median score = 3.6 vs. 4.6, median difference = 1.0, 95% CI 0.8–1.1, p < 0.001), managing (pre-posttest median score = 3.4 vs. 4.2, median difference = 0.6, 95% CI 0.4–0.8, p < 0.001), conducting (pre-post training median score = 3.9 vs. 4.7, median difference = 0.9, 95% CI 0.6-1.0, p < 0.001), and reporting (pre-posttest median score = 3.0 vs. 4.5, median difference = 1.0, 95% CI 0.9–1.5, p < 0.001) clinical trials. …”
Get full text

Annexin A8 deficiency delays atherosclerosis progression by Carmen Gutiérrez‐Muñoz, Rafael Blázquez‐Serra, Irene San Sebastian‐Jaraba, Sandra Sanz‐Andrea, Maria J. Fernández‐Gómez, Gonzalo Nuñez‐Moreno, Pablo Mínguez, Joan Carles Escolá‐Gil, Paula Nogales, Veronique Ollivier, Jose L. Martín‐Ventura, Benoit Ho‐Tin Noe, Ursula Rescher, Nerea Méndez‐Barbero, Luis M. Blanco‐Colio

“…Plaques of ApoE−/−AnxA8−/− were characterized by lower lipid and inflammatory content, smaller necrotic core, thicker fibrous cap and less apoptosis compared with those in ApoE−/−AnxA8+/+. …”
Get full text

Angiographic Complete versus Clinical Selective Incomplete Percutaneous Revascularization in Heart Failure Patients with Multivessel Coronary Disease by Chieh-Yu Chang, Chun-Chi Chen, I-Chang Hsieh, Ming-Jer Hsieh, Cheng-Hung Lee, Dong-Yi Chen, Ming-Lung Tsai, Ming-Yun Ho, Jih-Kai Yeh, Yu-Chang Huang, Yu-Ying Lu, Chao-Yung Wang, Shang-Hung Chang, Ming-Shien Wen

“…However, patients who failed CR had a significantly greater incidence of 5-year MACEs than those in the other two groups (failed CR: 46.4% vs. selective IR: 27.7% vs. successful CR: 27.8%, p<0.001). …”
Get full text

Construction of feature selection and efficacy prediction model for transformation therapy of locally advanced pancreatic cancer based on CT, 18F-FDG PET/CT, DNA mutation, and CA199 by Liang Qi, Xiang Li, Jiayao Ni, Yali Du, Qing Gu, Baorui Liu, Jian He, Juan Du

Subjects: Get full text

Clinical study on the treatment of chronic heart failure with a novel D‐shant atrium shunt device by Xiaoke Shang, Mei Liu, Yucheng Zhong, Xueli Wang, Song Chen, Xiaojuan Fu, Ming Sun, Mingxing Xie, Yuhe Ke, Ying Guan, Changdong Zhang, Nianguo Dong

“…Echocardiography revealed that the left ventricular diameter decreased significantly from 6.40 ± 0.57 mm to 5.03 ± 0.73 mm (P < 0.05). There was an obvious decrease in mitral regurgitation. …”
Get full text

Symptom management practice of 232 patients with liver malignant tumors undergoing radiofrequency ablation based on symptom evaluation by using MDASI-TCM (基于MDASI-TCM的232例肝脏恶性肿瘤射频消... by ZHANG Ying (张莹), KANG Dongqin (亢东琴), WANG Yun (王云), SUN Hong (孙红)

“…方法 应用肿瘤常见症状及中医症状调查量表(MDASI-TCM)对科室2018年7月—2022年11月收治的232例肝脏恶性肿瘤患者在射频消融术后进行评估, 对筛查出的症状按照科室制订的症状管理流程系统地有针对性的进行干预和管理, 在出院前对患者再次采用MDASI-TCM进行症状管理的效果评价。…”
Get full text

Impact of liver graft steatosis on long-term post-transplant hepatic steatosis and fibrosis via magnetic resonance quantification by Lung-Yi Mak, Lung-Yi Mak, James Fung, James Fung, James Fung, James Fung, Gladys Lo, Christine Shing-Yen Lo, Trevor Kwan-Hung Wu, Matthew Shing-Hin Chung, Tiffany Cho-Lam Wong, Tiffany Cho-Lam Wong, Wai-Kay Seto, Wai-Kay Seto, Albert Chi-Yan Chan, Albert Chi-Yan Chan, Man-Fung Yuen, Man-Fung Yuen

“…MRI performed at a median of 12.2 years post-LT identified PTHS in 27.4 and 10.6% of patients. PTHS was independently associated with SLG (OR 2.067, 95% CI 1.082–3.951), central obesity (OR 3.952, 95% CI 1.768–8.832), and hypertension (OR 2.510, 95% CI 1.268–4.966). …”
Get full text

Effectiveness of ertugliflozin during Ramadan fasting in patients with type 2 diabetes mellitus: a real-world study (ErtuRamadan study) by Md Faruque Pathan, Nazma Akter, Marufa Mustari, M. Saifuddin, Mirza Sharifuzzaman, Mohammad Motiur Rahman, Mohammed Ripon, S. M. Mohiuddin, A. B. M. Kamrul-Hasan, Mohammad Abdul Hannan, Muhammad Shah Alam, Samira Mahjabeen, Faria Afsana, Muhammed Abu Bakar, Tahniyah Haq, Afsar Ahammed, Samir Kumar Talukder, Sourav Sarkar, Shahjada Selim

“…The primary endpoints were changes in HbA1c levels, body weight, body mass index (BMI), and the incidence of hypoglycemia during Ramadan fasting.ResultsThe mean age of the study participants was 50.37 ± 11.14 (SD) years, with 40.6% male and 58.7% female. …”
Get full text

Dynamics of HDL-Cholesterol Following a Post-Myocardial Infarction Cardiac Rehabilitation Program by Carlos Bertolín-Boronat, Héctor Merenciano-González, Víctor Marcos-Garcés, María Luz Martínez-Mas, Josefa Inés Climent Alberola, Nerea Pérez, Laura López-Bueno, María Concepción Esteban-Argente, María Valls Reig, Ana Arizón Benito, Alfonso Payá Rubio, César Ríos-Navarro, Elena de Dios, Jose Gavara, Juan Sanchis, Vicente Bodi

“…Conversely, higher HDL-C before CRP (HR = 1.15, 95% CI, 1.07–1.23, p < 0.001) and increased lipoprotein (a) (HR = 1.01, 95% CI, 1–1.02, p = 0.04) predicted failure to increase HDL-C levels. …”
Get full text

Impact of healthy lifestyle on diabetes incidence among adults of different socioeconomic status in Guizhou province: a prospective cohort study by Yiying WANG, Min CHEN, Lieqiang ZHANG, Xin WANG, Wei ZHAN, Yunxi PAN, Xiaodeng ZHAO, Tao LIU

“…Among adults with SES scores of 9 – 11, those with 3, 4, and ≥ 5 healthy lifestyle factors had 42.0% (HR = 0.580, 95%CI: 0.397 – 0.848), 36.6% (HR = 0.634, 95%CI: 0.424 – 0.947), and 78.0% (HR = 0.220, 95%CI: 0.094 – 0.514) lower diabetes risk, respectively. …”
Get full text

Wild grasses as the reservoirs of infection of rust species for winter soft wheat in the Northern CaucasusWild grasses as the reservoirs of infection of rust species for winter sof... by E. I. Gultyaeva, L. A. Bespalova, I. B. Ablova, E. L. Shaydayuk, Zh. N. Khudokormova, D. R. Yakovleva, Yu. A. Titova

“…Potentially, an autumn infection on grasses can serve as a source for infection of winter soft wheat cultivars sown in October. …”
Get full text

The Impact of Ageing on Diaphragm Function and Maximal Inspiratory Pressure: A Cross-Sectional Ultrasound Study by Toru Yamada, Taro Minami, Takahiro Shinohara, Shuji Ouchi, Suguru Mabuchi, Shunpei Yoshino, Ken Emoto, Kazuharu Nakagawa, Kanako Yoshimi, Mitsuko Saito, Ayane Horike, Kenji Toyoshima, Yoshiaki Tamura, Atsushi Araki, Ryoichi Hanazawa, Akihiro Hirakawa, Takeshi Ishida, Takuma Kimura, Haruka Tohara, Masayoshi Hashimoto

“…<b>Results</b>: The study involved 230 individuals with a mean age of 55.5 years (older adults (65 years and over), <i>n</i> = 117; non-older adults, <i>n</i> = 113). In older adults, the diaphragm was thicker (2.1 vs. 1.7 mm, <i>p</i> < 0.001), and TF was lower (88.7% vs. 116.0%, <i>p</i> < 0.001), with no significant difference in DE. …”
Get full text

Characteristics and drainage modes of coalbed methane resources in closed coal mines in Yangquan and Jincheng Mining Areas by Yang WANG, Jie XIANG, Yong QIN, Shangbin CHEN, Yanming ZHU, Manli HUANG, Ying SHI

“…The porosity of No.15 coal seam is between 3.69%～5.45%, the specific surface area of micropores is 97.58～120.76 m2/g, and the volume of micropores ranges from 0.017～0.022 cm3/g, indicating that micropores are the most developed. …”
Get full text