The impact of urolithiasis on urology services in a high-prevalence region: A multicenter study by Wissam Khalid Kamal, Musab M. Alghamdi, Raed A. Azhar, Ahmad Bugis, Mohammed Abuzenada, Majed Alharthi, Saeed Bin Hamri, Yahya Ghazwani, Yasser A. Noureldin, Hassan Aljifri, Abdulaziz Alamri, Hatem Hamed Althubiany, Mansour Alnazari, Badr Alharbi, Abdulrahman Al Own, Mohanad Jebril Bosily, Mohammed Almansour, Abdullah Alfakhri, Ibrahim Alowidah, Ali Abdel Raheem

“…Overall, the total cost of treatments has been estimated to be about 192.1 million SAR from 2017 to 2022 with an increase by 107% (47.7 million SAR in 2022 vs. 23.0 million SAR in 2017). …”
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结构性MRI测量对脊髓小脑共济失调3型的诊断价值 by 曾文婷, 赵静, 胡曼诗, 丘海珊, 吴超, 初建平

“…HCs、pre-SCA3和sym-SCA3三组的双侧小脑上、中、下脚、脑桥及脊髓前后径（除颈5椎体上缘水平）分别依次减小并具有统计学差异（<italic>P</italic>&lt;0.017）。ROC示左侧小脑中脚对pre-SCA3的诊断价值最高（AUC=0.911），其敏感度、特异度和cut-off值分别为85.7%，95.5%和10.15 mm，而右侧小脑上脚对sym-SCA3的诊断价值最高（AUC=0.999），其临界值为 2.62 mm， 敏感度和特异度分别是100%和98.3%。…”
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Development of an innovative intravaginal model of probiotic inoculation in dairy ovine flocks: positive effects on the vaginal microbiota, vaginitis and fertility by M. Toquet, J. Gomis, E. Jiménez-Trigos, E. Bataller, M. Barba, A. Sánchez, P. González-Torres, Á. Gómez-Martín

“…Specifically, increases in the percentages of pregnant sheep in flocks 1 and 4 (10.7 and 5.7% respectively; P > 0.05) and flock 3 (27.3%; P < 0.05) were observed in inoculated ewes. …”
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Health risk assessment through probabilistic sensitivity analysis of carbon monoxide and fine particulate transportation exposure by E. Ernyasih, A. Mallongi, A. Daud, S. Palutturi, S. Stang, R. Thaha, E. Ibrahim, W. Al Madhoun

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Contrastive learning with transformer for adverse endpoint prediction in patients on DAPT post-coronary stent implantation by Fang Li, Zenan Sun, Ahmed abdelhameed, Tiehang Duan, Laila Rasmy, Xinyue Hu, Jianping He, Yifang Dang, Jingna Feng, Jianfu Li, Yichen Wang, Tianchen Lyu, Naomi Braun, Si Pham, Michael Gharacholou, DeLisa Fairweather, Degui Zhi, Jiang Bian, Cui Tao

“…Our approach demonstrated superior predictive performance for both ischemic and bleeding events across prediction windows of 1, 2, 3, 6, and 12 months, with time-dependent concordance (Ctd) index values ranging from 0.88 to 0.80 and 0.82 to 0.77, respectively. …”
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Diagnosis and treatment of disorders of intracranial pressure: consensus statement of the Spanish Society of Neurology’s Headache Study Group by J. García-Ull, N. González-García, M. Torres-Ferrús, D. García-Azorín, I.F.J. Molina-Martínez, I. Beltrán-Blasco, S. Santos-Lasaosa, G. Latorre, A.B. Gago-Veiga, J.M. Láinez, J. Porta-Etessam, C. Nieves-Castellanos, A. Mínguez-Olaondo, A. López-Bravo, S. Quintas, N. Morollón, S. Díaz-Insa, R. Belvís, P. Irimia

“…El diagnóstico y tratamiento de ambas entidades ha presentado un avance destacable en los últimos años; por lo que desde el Grupo de Estudio de Cefaleas de la Sociedad Española de Neurología (GECSEN) consideramos necesaria la elaboración de este documento de consenso con la inclusión de algoritmos diagnósticos y terapéuticos para mejorar su manejo en la práctica diaria.Este documento ha sido redactado por un comité de expertos del GECSEN tras realizar una revisión sistemática de la bibliografía, incorporando la experiencia de los participantes y estableciendo unas recomendaciones prácticas con niveles de evidencia y grados de recomendación.…”
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Bioassays for the evaluation of the attractiveness of attractive targeted sugar bait (ATSB) against Anopheles mosquitoes in controlled semi-field systems by Frank S. C. Tenywa, Ummi A. Kibondo, Julian Entwistle, Osward Dogan, Mapipi Haruna, Restuta P. Phisoo, Jason Moore, Jane J. Machange, Haji Makame, Frederic Tripet, Pie Müller, Mathias Mondy, Derric Nimmo, Jennifer C. Stevenson, Sarah J. Moore

“…Of the four prototypes tested, the latest iteration, ASB prototype v1.2.1, showed the highest intrinsic attraction of both Anopheles species, attracting 91.2% [95% CI 87.9–94.5%]. Relative to ATSB v1.1.1, the latest prototype, v.1.2.1, had higher attraction (OR = 1.19 [95% CI 1.07–1.33], P < 0.001) and higher feeding success (OR = 1.71 [95% CI 1.33–2.18], P < 0.001). …”
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Identification and Potential Clinical Utility of Common Genetic Variants in Gestational Diabetes among Chinese Pregnant Women by Claudia Ha-ting Tam, Ying Wang, Chi Chiu Wang, Lai Yuk Yuen, Cadmon King-poo Lim, Junhong Leng, Ling Wu, Alex Chi-wai Ng, Yong Hou, Kit Ying Tsoi, Hui Wang, Risa Ozaki, Albert Martin Li, Qingqing Wang, Juliana Chung-ngor Chan, Yan Chou Ye, Wing Hung Tam, Xilin Yang, Ronald Ching-wan Ma

“…These included three previously reported loci for GDM and type 2 diabetes mellitus (T2DM) at MTNR1B (rs7945617, odds ratio [OR], 1.64; 95% confidence interval [CI], 1.38 to 1.96), CDKAL1 (rs7754840, OR, 1.33; 95% CI, 1.13 to 1.58), and INS-IGF2-KCNQ1 (rs2237897, OR, 1.48; 95% CI, 1.23 to 1.79), as well as a novel genome-wide significant locus near TBR1-SLC4A10 (rs117781972, OR, 2.05; 95% CI, 1.61 to 2.62; Pmeta=7.6×10-9), which has not been previously reported in GWAS for T2DM or glycaemic traits. …”
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Effectiveness of late and very late antivenom administration on recovery from snakebite-induced coagulopathy in French Guiana: a population-based studyResearch in context by Jean Marc Pujo, Stephanie Houcke, Guy Roger Lontsi Ngoulla, Vivian Laurent, Boubacar Signaté, Rémi Mutricy, Alexis Frémery, Flaubert Nkontcho, Ibtissem Ben Amara, José María Gutiérrez, Dabor Resiere, Hatem Kallel

“…The median time from SB to AV was 8.5 h (IQR: 6.9–10) in the late AV group and 21.1 h (IQR: 16.7–27.4) in the very late AV group (p < 0.001). …”
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Effectiveness and safety profile of mesenchymal stem cell secretome as a treatment for severe cases of COVID-19: a randomized controlled trial [version 2; peer review: 1 approved,... by Hary Sakti Muliawan, Erlina Burhan, Mia Elhidsi, Heri Wibowo, Triya Damayanti, Jeanne Adiwinata Pawitan, Isabella Kurnia Liem, Ismail Hadisoebroto Dilogo, Mira Yulianti, Adityo Susilo, Irandi Putra Pratomo, Raden Rara Diah Handayani, Rahyussalim -, Murdani Abdullah, Cosphiadi Irawan, Robert Sinto, Dita Aditianingsih

“…Conclusions: MSC secretome can control inflammation in patients with severe COVID-19 and has a good safety profile. …”
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Virological and serological outcomes in people with HIV-HBV coinfection who had discontinued tenofovir-containing antiretroviral therapy: Results from a prospective cohort study by Amir M. Mohareb, Patrick Miailhes, Julie Bottero, Caroline Lascoux-Combe, Julie Chas, Sarah Maylin, Audrey Gabassi, Hayette Rougier, Emily P. Hyle, Constance Delaugerre, Karine Lacombe, Anders Boyd

“…Results: Among 192 participants, 161 (83.9 %) were on continuous tenofovir, 22 (11.5 %) discontinued tenofovir, and 9 (4.7 %) never initiated tenofovir during a median follow-up of 14.5 years (IQR = 10.5–14.8). …”
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Integrating 16S rDNA and metabolomics to uncover the therapeutic mechanism of electroacupuncture in type 2 diabetic rats by Zhang Yue, Wang Xiang, Deng Duping, Gong Yuanyuan, Chen Xuanyi, Li Juan, Li Juan, Hong Xiaojuan

“…GLP-1 was positively correlated with acetic acid (R = 0.487, p = 0.001), butyric acid (R = 0.586, p = 0.000), isovaleric acid (R = 0.374, p = 0.017), valeric acid (R = 0.535, p = 0.000), and caproic acid (R = 0.371, p = 0.018). …”
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بررسی تنوع ژنتیکی کلکسیون لوبیا سبز بانک ژن by مهرزاد احمدی, علی اکبر قنبری, حمید رضا فنایی, سیمین طاهری اردستانی, معصومه پوراسماعیل, فرنگیس قنواتی

“…داده‌ها با استفاده از نرم‌افزارهای آماری SPSS و SAS مورد تجزیه و تحلیل قرار گرفت و ضمن محاسبه همبستگی، گروه‌بندی ژنوتیپ‌ها با استفاده از تجزیه کلاستر انجام شد.یافته‌ها بیشترین ضریب تغییرات (CV) به ارتفاع بوته (70 درصد)، وزن بذر تک بوته (47 درصد)، تعداد غلاف در بوته (40 درصد) اختصاص داشت، در میان صفات کیفی مورد بررسی بیشترین شاخص شانون به ترتیب در صفات درجه انحنای غلاف(28/1)، رنگ بذر(23/1) و شکل برش عرضی غلاف(17/1) مشاهده شد. …”
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Global, regional, and national burden of esophageal cancer: a systematic analysis of the Global Burden of Disease Study 2021 by Weiqiu Jin, Kaichen Huang, Ziyin Ding, Mengwei Zhang, Chongwu Li, Zheng Yuan, Ke Ma, Xiaodan Ye

“…Results Despite global reductions in EC ASRs, with ASIR, ASDR, and ASDALYR in 2021 of 6.65 [5.88, 7.45] (95% uncertainty interval), 6.25 [5.53, 7.00], and 148.56 [131.71, 166.82], decreasing by 24.9%, 30.7%, and 36.9% in 1990–2021, respectively, the absolute burden numbers were increased from 1990 to 2021, probably because of population growth and aging. …”
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Development of a zoonotic influenza distribution assessment and ranking system (ZIDAR): Technical application in Nepal to support cross-sectoral risk-based surveillance by Adam Charette-Castonguay, Dipendra Gautam, Binay Shrestha, Hemant Chandra Ojha, Barun Kumar Sharma, Mukul Upadhayaya, Sujan Rana, Roshika Shrestha, Lok Bandu Chaudhary, Bhawana Kandel, Rudra Prasad Marasini, Sharmila Chapagain, Tulsi Ram Gompo, Surendra Karki, Apsara Poudel, Saugat Shrestha, Avinash Sunny Kayastha, Arun Kumar Govindakarnavar, Reuben Samuel, Allison Gocotano, Pushpa Ranjan Wijesinghe, Nilesh Buddha, Edwin Ceniza Salvador, Manish Kakkar, Ricardo J. Soares Magalhães

“…The ZIDAR Nepal model's predictive accuracy, determined by the area under the receiver operating characteristic curve, demonstrated strong performance: 0.87 and 0.85 for the wildlife and animal components, respectively. …”
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Cognitively Stimulating Activities: Effects on Cognition across Four Studies with up to 21 Years of Longitudinal Data by Meghan B. Mitchell, Cynthia R. Cimino, Andreana Benitez, Cassandra L. Brown, Laura E. Gibbons, Robert F. Kennison, Steven D. Shirk, Alireza Atri, Annie Robitaille, Stuart W. S. MacDonald, Magnus Lindwall, Elizabeth M. Zelinski, Sherry L. Willis, K. Warner Schaie, Boo Johansson, Roger A. Dixon, Dan M. Mungas, Scott M. Hofer, Andrea M. Piccinin

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Dynamics of Somatic and Comorbid Mental Disorders (Distress, Anxiety, Somatisation and Depression) in Patients with Irritable Bowel Syndrome during Therapy with Alimemazine: Result... by V. T. Ivashkin, O. Z. Okhlobystina, M. V. Mayevskaya, O. S. Shifrin, Z. A. Mamieva, Yu. E. Azimova

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Evaluation of circulating tumor DNA as a prognostic and predictive biomarker in BRAF V600E mutated colorectal cancer—results from the FIRE‐4.5 study by Susanne Klein‐Scory, Alexander Baraniskin, Wolff Schmiegel, Thomas Mika, Roland Schroers, Swantje Held, Kathrin Heinrich, David Tougeron, Dominik P. Modest, Ingo Schwaner, Jan Eucker, Rudolf Pihusch, Martina Stauch, Florian Kaiser, Christoph Kahl, Meinolf Karthaus, Christian Müller, Christof Burkart, Sebastian Stintzing, Volker Heinemann

“…No BRAF V600E mutations were detected in 26% (17/66) of patients and was associated with a significantly longer progression‐free survival (PFS: 13.2 vs 6.5 months; HR 0.47; P = 0.014) and overall survival (OS: 36.8 vs 13.2 months; HR 0.35; P = 0.02) as compared to ctDNA mutant patients. …”
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تفکیک سهم تغییر اقلیم و فعالیت‌های انسانی بر تغییرات دبی رودخانه با استفاده از رویکرد تحلیل حساسیت هیدرولوژیکی مبتنی بر فرضیه بودیکو مطالعه موردی: شوره‌زار دشت قزوین... by سارا حشمتی, بیژن نظری, محمد رضا نیکو

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Incidence of type 2 diabetes and metabolic syndrome by Occupation – 10-Year follow-up of the Gutenberg Health Study by Juliane Bauer, Janice Hegewald, Karin Rossnagel, Sylvia Jankowiak, Michaela Prigge, Julian Chalabi, Matthias Nübling, Alice Freiberg, Merle Riechmann-Wolf, Pavel Dietz, Philipp S. Wild, Thomas Koeck, Manfred E. Beutel, Norbert Pfeiffer, Karl J. Lackner, Thomas Münzel, Konstantin Strauch, Philipp Lurz, Oliver Tüscher, Julia Weinmann-Menke, Stavros Konstantinides, Andreas Seidler

“…The highest incidence of type 2 diabetes was observed in the occupational group “food production and processing” (20.7%) with a threefold increased incidence (SIR = 3.0, 95% CI 1.8–4.7) compared to the total working population of the GHS. …”
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