Comparison of GLP-1RAs vs Other Pharmacotherapy for Obesity by Andrew Overholser, Eric Czech, Linda Speer, Joel Wilson, Alex Overholser

“…Phentermine-topiramate reduced mean body weight percentage by 8.45% (95% CI, 7.89%–9.01%) after 52-56 weeks. Bupropion-naltrexone reduced mean body weight percentage by 3.01% (95% CI, 2.47%–3.54%) over 56 weeks. …”
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Levofloxacin prophylaxis omission in acute myeloid leukemia during post induction aplasia: a single center study by Irene Urbino, Chiara Frairia, Alessandro Busca, Silvia Corcione, Stefano D'Ardia, Chiara Maria Dellacasa, Valentina Giai, Carolina Secreto, Roberto Freilone, Francesco Giuseppe De Rosa, Semra Aydin, Giovannino Ciccone, Rosalba Rosato, Marco Cerrano, Ernesta Audisio

“…Fluoroquinolones (FQ) resistant pathogens were responsible for 59% of total BSIs in gA and 22% in gB (OR 5.07, 1.87 – 13.73, p=0.001); gram-negative BSIs due to multi-drug resistant organisms were 31% in gA and 36% in gB (OR 0.75, 0.15 – 3.70, p=0.727). …”
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The effect of rootstocks on morphological, physiological, and gene expression characters of citrus seedlings grown under drought condition by Nirmala Friyanti Devy, Siti Subandiyah, Sri Widyaningsih, Hardiyanto Hardiyanto, Farida Yulianti, Dita Agisimanto, Agus Sugiyatno, Mutia Dwiastuti

“…Aside from that, leaf proline and total soluble sugar levels were higher in the dryness than in the control, with the combination of KB/C (331.6 μ mol proline/g fresh weight), MP/JC, and MP/RL plants having the highest (347.9 and 337.1 μmol proline/g fresh weight). …”
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The influence of exercise modality and intensity on ventricular arrhythmia burden and perception of effort in patients with Arrhythmogenic Right Ventricular Cardiomyopathy with pla... by Fernando G. Beltrami, Kyle G. P. J. M. Boyle, Guan Fu, Corinna Brunckhorst, Firat Duru, Christina M. Spengler, Ardan M. Saguner

“…Average PVC burden during activities (including 5 min recovery) was lower for biceps curls compared with all other activities (p < 0.046), despite having the second highest level of perceived effort (13.8 ± 1.7 units). Biceps curls elicited ~20 mmHg (p < 0.001) lower peak systolic blood pressure and ~40 bpm peak lower HR (p < 0.001) compared with cycling at 120 bpm, despite similar perception of effort (12.9 ± 1.7, p = 0.818). …”
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مطالعه واکنش جوانه‌زنی بذر گیاه فراموش شده منداب (Eruca sativa Mill) به برخی عوامل محیطی by بتول نژادحسن, آسیه سیاه مرگویی, ابراهیم زینلی, فرشید قادری فر

“…تنش خشکی و شوری که باعث کاهش 50 درصد جوانه‌زنی این گیاه شد، به‌ترتیب 36/13- بار و 53/267 میلی مولار بود. حداکثر درصد جوانه‌زنی در محدوده اسیدیته 7 به میزان 98 درصد مشاهده شد و در اسیدیته‌های بالا‌تر و پایین‌تر از 7 ، درصد و سرعت جوانه‌زنی کاهش یافت. …”
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Deep-Learning-Based Reconstruction of Single-Breath-Hold 3 mm HASTE Improves Abdominal Image Quality and Reduces Acquisition Time: A Quantitative Analysis by Felix Kubicka, Qinxuan Tan, Tom Meyer, Dominik Nickel, Elisabeth Weiland, Moritz Wagner, Stephan Rodrigo Marticorena Garcia

“…<b>Results:</b> In the five healthy participants, DL-HASTE-3 mm was identified as the optimal slice (SNR 23.227 ± 3.901). Both DL-HASTE-3 mm and DL-HASTE-5 mm were assigned significantly higher overall image quality scores than standard-HASTE-5 mm (Laplacian variance, both <i>p</i> < 0.001; Likert scale, <i>p</i> < 0.001). …”
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Mental health in public safety personnel with workplace injuries requiring surgery: a longitudinal population-wide administrative data study in Manitoba, Canada by Tracie O Afifi, Jitender Sareen, Dan Chateau, Alyson Mahar, Jordan Nantais, James Bolton, Allen Kraut, Sarvesh Logsetty, Thomas Turgeon, Brenda Comaskey, Justin Gawaziuk, Rae Spiwak, Lauren Burton, Anthony Wightman, Jai Sareen, Natalie Mota

“…The objective of this study was to investigate whether PSP with traumatic physical workplace injuries requiring surgery with anaesthetic have higher post-injury rates of mental disorders compared with the general population with similar non-workplace injuries.Design Retrospective longitudinal cohort study.Setting Population-based study using linked anonymised administrative data for PSP and the general population in Manitoba, Canada.Participants This study compared two groups hospitalised for a traumatic physical injury requiring surgery with anaesthetic between 1 January 2002 and 31 December 2018: (1) PSP (n=293) injured in the workplace and matched 1:5 on sex, age, geographical region and surgical procedure code with (2) individuals in the general population (GenPop) injured outside the workplace (no Workers Compensation Board claim) (n=1198).Primary and secondary outcomes and measures As planned in the study protocol, the prevalence of mental disorders including anxiety, depression and substance use was measured in the cohorts 2 years pre- and post-injury.Results This study found an elevated unadjusted risk of depression in PSP compared with the general population in the 2 years post-injury, adjusting for pre-injury mental health (rate ratio, 1.49; 95% CI, 1.02 to 2.17; p&lt;0.0001). After adjusting, there were no significant differences in rates between the two cohorts; however, the significant group × care interaction term for depression suggests a greater risk for PSP compared with GenPop over time.Conclusions Our findings indicate that, compared with a matched cohort, PSP have an increased risk of depression from the pre-injury to post-injury period following a traumatic physical workplace injury. …”
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Injectable Hierarchical Bioactive Hydrogels with Fibroblast Growth Factor 21/Edaravone/Caffeic Acid Asynchronous Delivery for Treating Parkinson's Disease by Junpeng Xu, Peng Dai, Chen Zhang, Na Dong, Caiyan Li, Chonghui Tang, Zhihao Jin, Shih‐Ho Lin, Luyang Ye, Tianmiao Sun, Yukai Jin, Fenzan Wu, Lihua Luo, Ping Wu, Shengcun Li, Xiaokun Li, Shan‐hui Hsu, Dawei Jiang, Zhouguang Wang

“…The hydrogel with caffeic acid‐grafted polymer main chain is crosslinked using a micellar nanocrosslinker, with sufficient modulus (≈167 Pa), antioxidant activity (> 50%), injectability (30‐gauge syringe needle), and shape‐adaptability. …”
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Efficacy of TIPS plus extrahepatic collateral embolisation in real-world data: a validation study by Chao Chen, Feng Zhang, Hao Wu, Wei Wu, Hui Xue, Yuzheng Zhuge, Chunqing Zhang, Guangchuan Wang, Zhengjie Li, Qiong Wu, Bo Wei, Jun Tie, Xiubin Sun, Lianhui Zhao, Yifu Xia, Jiao Xu, Peijie Li

“…TIPS+E demonstrated a significant reduction in rebleeding (HR 0.77; 95% CI 0.59 to 0.99; p=0.04), HE (HR 0.82; 95% CI 0.68 to 0.99; p=0.04) and FDC (HR 0.85; 95% CI 0.73 to 0.99; p=0.04), comparing to TIPS. …”
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Promising Directions in Chemical Processing of Methane from Coal Industry. Part 4. Long-term Stability Test by Е.V. Matus, O.V. Tailakov, O.B. Sukhova, A.V. Salnikov, O.A. Stonkus, M.A. Kerzhentsev, S.R. Khairulin, Z.R. Ismagilov

“…Gas chromatographic analysis of coal mine gas showed that it contains the following components with an average concentration, vol.%: CH4 – 40.18, N2 – 36.30, H2O – 12.90, O2 – 9.77, CO2 – 0.88, C2H6 – 0.25 and C3H8 – 0.04. …”
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Impact of Enhanced Recovery After Surgery Protocol Compliance on Outcome After Pancreatic Surgery: Results From a Certified ERAS Center by Alina S. Ritter, MD, Thilo Welsch, MD, FACS, MBA, Freya Brodersen, MSc, Julia Auinger, MD, Parisa Moll-Khosrawi, MD, Mara R. Goetz, MD, Jan Bardenhagen, MD, Christine Nitschke, MD, Tobias Schneider, BSc, Björn Wellge, MD, Anna Suling, PhD, Faik G. Uzunoglu, MD, Asmus Heumann, MD, Felix Nickel, MD, Thilo Hackert, MD, Jakob R. Izbicki, MD

“…In total, 594 patients who underwent PD (44.8%), distal pancreatectomy (14.6%), total pancreatectomy (17.8%), or other pancreatic resections (22.7%) were included. …”
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Association of Sociodemographic Factors With Overtriage, Undertriage, and Value of Care After Major Surgery by Tyler J. Loftus, MD, Matthew M. Ruppert, MS, Benjamin Shickel, PhD, Tezcan Ozrazgat-Baslanti, PhD, Jeremy A. Balch, MD, Kenneth L. Abbott, MD, Die Hu, MS, Adnan Javed, MD, Firas Madbak, MD, Faheem Guirgis, MD, David Skarupa, MD, Philip A. Efron, MD, Patrick J. Tighe, MD, William R. Hogan, MD, Parisa Rashidi, PhD, Gilbert R. Upchurch, Jr, MD, Azra Bihorac, MD

“…Overtriage was associated with increased total direct costs [$16.2K ($11.4K–$23.5K) vs $14.1K ($9.1K–$20.7K), P < 0.001] and low value of care; undertriage was associated with increased hospital mortality (1.5% vs 0.7%, P = 0.002) and hospice care (2.2% vs 0.6%, P < 0.001) and low value of care. …”
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Establishing a radiomics model using contrast-enhanced ultrasound for preoperative prediction of neoplastic gallbladder polyps exceeding 10 mm by Dong Jiang, Yi Qian, Yijun Gu, Ru Wang, Hua Yu, Zhenmeng Wang, Hui Dong, Dongyu Chen, Yan Chen, Haozheng Jiang, Yiran Li

“…This model, derived from machine learning frameworks including Support Vector Machine (SVM), Logistic Regression (LR), Multilayer Perceptron (MLP), k-Nearest Neighbors (KNN), and eXtreme Gradient Boosting (XGBoost) with fivefold cross-validation, showed AUCs of 0.95 (95% CI: 0.90–0.99) and 0.87 (95% CI: 0.72–1.0) in internal validation. …”
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اثر سمیت یونی کلرید سدیم بر برخی خصوصیات فیزیولوژیکی و بیوشیمیایی گیاه نعناع سبز(Mentha spicata L.) by زهرا صفری محمدیه, محمد مقدم, بهرام عابدی, لیلا سمیعی

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Assessment of Environmental Hazards and Vulnerability of The Rud–E-Shur, Rud-E-Shirin and Rud-E-Minab International Wetland Using the DPSIR Model by Hengameh Safa Eisini, Saber Ghasemi, Afshin Danehkar, Mohsen Dehghani Ghanateghestani, Hossein Parvaresh

“…Also, oil smuggling, destruction of habitat, and transmission of shrimp farming effluent into Wetland, was classified as 1, 0.87, 0.75 respectively, ranking in the first to third risk factors.Discussion: According to the amount of Cli, two factors of oil smuggling and destruction of habitats are categorized in intolerable risks. …”
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Implications of prognostic nutritional index in predicting adverse outcomes of uncontrolled diabetic patients: a cohort study of the national health and nutrition examination surve... by Fei Liu, Zhili Jiang, Wei Luo, Yunxiao Yang, Shuai Guo, Jiayi Yi, Geng Shen, Wei Li, Lin Wang, Xiuhuan Chen, Zhaogong Zhi, Tian Liu, Xuedong Zhao, Chen Li, Hai Gao

“…During a median follow-up of 77 months, 247 DM-related deaths and 205 cardiovascular deaths occurred. …”
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Sustainable Skincare Innovation: Cork Powder Extracts as Active Ingredients for Skin Aging by Ana Silva, Cláudia Pinto, Sara Cravo, Sandra Mota, Liliana Rego, Smeera Ratanji, Clara Quintas, Joana Rocha e Silva, Carlos Afonso, Maria Elizabeth Tiritan, Honorina Cidade, Teresa Cruz, Isabel F. Almeida

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ارزیابی استفاده توأم اکسین و چند ترکیب شیمیایی جهت انگیزش ریشه در قلمه‌های زیتون by مهدی علیزاده, طاهره یونس آبادی, اسماعیل سیفی, مرتضی صادقی

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First aid intervention in the adult population: the Yorkshire Health Study and its implications for first aid education

“…Background: First aid can reduce death, injury and suffering, but little is known about the characteristics of those who actually give and receive it. …”
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Predicting prognosis using stroke-heart indicator: brain natriuretic peptide in patients with aneurysmal subarachnoid hemorrhage by Jionghao Xue, Jionghao Xue, Fa Lin, Fa Lin, Minghao Liu, Minghao Liu, Wenxiong Song, Wenxiong Song, Runting Li, Runting Li, Yu Chen, Yu Chen, Jun Yang, Jun Yang, Heze Han, Heze Han, Yitong Jia, Yitong Jia, Xiaolin Chen, Xiaolin Chen, Rong Wang, Rong Wang, Yuanli Zhao

“…After accounting for confounding factors, elevated BNP levels remained a significant independent risk factor of a poor prognosis (p = 0.047, OR = 1.49, 95%CI = 1.01–2.20). Nevertheless, BNP’s predictive value alone might not warrant its inclusion in a prognostic model.ConclusionElevated BNP levels independently forecast unfavorable prognosis in patients with aSAH, even though the cutoff value is lower than the cardiology standards. …”
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