improving Pain mAnagement for childreN and young people attendeD by Ambulance (PANDA): protocol for a realist review. [version 3; peer review: 2 approved, 1 approved with reservati... by Paul Leighton, Georgette Eaton, Georgie Nicholls, Kacper Sumera, Marishona Ortega, Jessica Hodgson, Michael Baliousis, Aloysius Niroshan Siriwardena, Despina Laparidou, Bill Lord, Sarah Redsell, Gregory Adam Whitley, Tatiana Bujor

“…This realist review will aim to understand how ambulance clinicians can provide improved prehospital acute pain management for CYP. …”
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تاثیر کودهای زیستی و شیمیایی بر تغییرات فیتو هورمونی و جذب عناصر غذایی در دورهای مختلف آبیاری سورگوم... by امین عباسی, زهرا صیادی آذر, فریبرز شکاری, عبداله جوانمرد

“…عوامل مورد بررسی در این تحقیق شامل، تیمار اصلی آبیاری با سه دور آبیاری (با فاصله 7 روز، با فاصله آبیاری 14 روز و با فاصله آبیاری 21 روز) و تیمارهای کودی شامل 5 سطح کودی (100 درصد کود زیستی، 100 درصد کود شیمیایی، 100 درصد کود زیستی + 75 درصد شیمیایی، 100 درصد زیستی+ 50 درصد شیمیایی، 100 درصد زیستی+ 25 درصد شیمیایی) بود. …”
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Reduced Glutathione Promoted Growth Performance by Improving the Jejunal Barrier, Antioxidant Function, and Altering Proteomics of Weaned Piglets by Zhimei Tian, Yiyan Cui, Miao Yu, Dun Deng, Zhenming Li, Xianyong Ma, Mingren Qu

“…A total of 180 weaned piglets were randomly allotted to 5 groups: a basal diet (CON), and a basal diet supplemented with antibiotic chlortetracycline (ABX), 50 (GSH1), 65 (GSH2), or 100 mg/kg GSH (GSH3). …”
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Validity of a machine learning estimation of blood volumes during altitude training by Basile Moreillon, Bastien Krumm, Lena Mettraux, Julian Wackernell, James Spragg, Martin Faulhaber, Raphael Faiss

“…Conversely, a significant increase in hematocrit (+2.7 + 2.2%pt ; p<0.001) and hemoglobin concentration ([Hb], +0.63 + 0.75 g×dL-1; p<0.01). …”
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Hábitos de salud, estilos de vida y comorbilidades asociadas a la sarcopenia en las personas mayores by Eduardo Guzmán-Muñoz, María José Carreño Oñat, Fernanda Marilaf Adasme, Sergio Orellana Arellano, Marylin Gutiérrez Muñoz, Yeny Concha-Cisternas, Ricardo Riquelme, Pablo Luna-Villouta, Miguel Alarcón-Rivera

“…Se utilizó la prueba de ji cuadrado para asociar la presencia de sarcopenia con hábitos de salud, estilos de vida y comorbilidades. …”
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Genotype-environment interactions on growth and inner shell color variation in Hyriopsis cumingii cultured in different iron-level substrates by Xuefeng Lv, Zhiyan Wang, Quanzhi Bao, Changzhi Li, Tingting Lu, Yuyang Wu, Chuntong Liu, Zhiyi Bai

“…Heritability estimates for growth and inner shell color traits ranged from 0.07 to 0.25 across the experimental population. …”
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Temporal trends and differences of SARS-CoV-2-specific antibody responses in symptomatic and asymptomatic subjects: a longitudinal study from Umbria in Italy by Iosief Abraha, Paolo Eusebi, Marta Micheli, Antonella Germani, Erica Pasquarelli, Sofia Pascolini, Rossana Antonietti, Sandro Argenti, Alessandra Fioravanti, Elisa Martini, Luana Aristei, Paola Mancinelli, Maria Letizia Ottaviani, Martina Roselli, Milena Barzacca, Erika Belardinelli

“…SARS-CoV-2 serological testing for antibodies targeting the Nucleocapside and Spike proteins were determined.Results Of 184 eligible subjects, 149 were available for evaluation: 17 were classified as oligo/asymptomatic, 107 as symptomatic, 25 as hospital admitted. …”
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Effect of Rifaximin and a Multi-Strain Probiotic on the Intestinal Microbiome and Cardiovascular Risk Indicators in Patients with Coronary Heart Disease by E. A. Kashukh, E. A. Poluektova, A. V. Kudryavtseva, G. S. Krasnov, V. I. Kazey, P. D. Sobolev, P. V. Gremyakova, V. T. Ivashkin

“…Group 3 comprised CHD patients receiving rifaximin for 7 days followed by addition of the multi-strain probiotic under test for 21 days. …”
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Traditional herbal medicine legislative and regulatory framework: a cross-sectional quantitative study and archival review perspectives by Sileshi Dubale, Rashed Edris Usure, Yesuneh Tefera Mekasha, Gemmechu Hasen, Firdos Hafiz, Dereje Kebebe, Sultan Suleman

“…Among regulatory experts, weak performance was identified in the practical implementation of THM regulatory activities, with 70.2% of weak performance observed at the federal level and 41.7% at the regional level. Key barriers to effective regulation included a lack of research on herbal medicines (90.3%) and insufficient regulatory mechanisms (87.8%). …”
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High-Titer Rheumatoid Factor is Associated with Worse Clinical Outcomes and Higher Needs for Advanced Therapies in Rheumatoid Arthritis Under Real-Life Conditions by Victor Davi R. S. Oliveira, Ana Paula M. G. Reis, Claiton V. Brenol, Ivânio A. Pereira, Karina R. Bonfiglioli, Letícia R. Pereira, Manoel B. Bértolo, Maria de Fátima L. C. Sauma, Maria Fernanda B. R. Guimarães, Paulo Louzada-Júnior, Rina D. N. Giorgi, Sebastião C. Radominski, Licia Maria H. Mota, Cleandro P. Albuquerque, Geraldo R. Castelar-Pinheiro

“…High RF titers (compared to "non-high") were associated with tobacco use (odds ratio, OR [95% confidence interval, CI]: 2.04 [1.35, 3.08]; p < 0.001), multiraciality (OR [95% CI] 1.31 [1.03, 1.67]; p = 0.028, compared to White race), and higher body mass index (mean difference [95% CI] 0.69 [0.05, 1.33] kg/m2; p = 0.033). …”
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The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity by Tamara M Sirey, Kenny Roberts, Wilfried Haerty, Oscar Bedoya-Reina, Sebastian Rogatti-Granados, Jennifer Y Tan, Nick Li, Lisa C Heather, Roderick N Carter, Sarah Cooper, Andrew J Finch, Jimi Wills, Nicholas M Morton, Ana Claudia Marques, Chris P Ponting

“…To generate energy efficiently, the cell is uniquely challenged to co-ordinate the abundance of electron transport chain protein subunits expressed from both nuclear and mitochondrial genomes. …”
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Preparation of future teachers for innovative activities in pedagogical and technological educational environment by N. I. Naumkin, N. N. Shekshaeva, V. F. Kupryashkin, E. V. Zabrodina

“….); 6) possibility of constant monitoring and control of the implementation of the environment within its relaxation and diagnostic component; 7) use of modern educational technologies, including digital; 8) possibility of obtaining specialised knowledge and studying other disciplines within the framework of using network learning; 9) innovativeness of the environment, determined by the novelty of the approach to teaching the teachers innovation technology and its effectiveness.To teach innovation activity in this environment, a model of a methodological system for the formation of competence in innovation activity among future technology teachers has been created, combining conceptually-targeted, meaningful, instrumental-activity and reflexive-evaluative components. …”
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Risk factors associated with mortality and pathogen characteristics of bloodstream infection-induced severe sepsis in the pediatric intensive care unit: a retrospective cohort stud... by Jian Chen, Jian Chen, Haixin Huang, Ruichen Zhang, Yueqiang Fu, Chunmei Jing

“…The detection rate of carbapenem resistance (CR) in Acinetobacter baumannii (66.7%) was higher than that in Pseudomonas aeruginosa (15.4%). …”
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Metabolic reprogramming and immunological changes in the microenvironment of esophageal cancer: future directions and prospects by Zhi-Xun Guo, Jia-Li Ma, Jin-Qiu Zhang, Ling-Ling Yan, Ying Zhou, Xin-li Mao, Xin-li Mao, Xin-li Mao, Shao-Wei Li, Shao-Wei Li, Shao-Wei Li, Xian-Bin Zhou, Xian-Bin Zhou, Xian-Bin Zhou

“…We analyzed and discussed these studies, while also expressing our own insights and opinions.ResultsA total of 137 articles were included in the review: 21 articles focused on the tumor microenvironment of esophageal cancer, 33 delved into research related to glucose metabolism and tumor immunology, 30 introduced amino acid metabolism and immune responses, and 17 focused on the relationship between lipid metabolism in the tumor microenvironment and both tumor cells and immune cells.ConclusionThis article delves into metabolic reprogramming and immune alterations within the TME of EC, systematically synthesizes the metabolic characteristics of the TME, dissects the interactions between tumor and immune cells, and consolidates and harnesses pertinent immunotherapy targets, with the goal of enhancing anti-tumor immunotherapy for esophageal cancer and thereby offering insights into the development of novel therapeutic strategies.…”
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Factors associated with attention-deficit/hyperactivity disorder among Tunisian children by Asma Guedria, Asma Guedria, Asma Guedria, Mohamed Guedria, Manel Ben Fredj, Manel Ben Fredj, Randaline Ayoub, Randaline Ayoub, Randaline Ayoub, Hela Ben Abid, Hela Ben Abid, Hela Ben Abid, Ahmed Mhalla, Ahmed Mhalla, Ahmed Mhalla, Hela Slama, Hela Slama

“…However, the multivariate model conducted to determine the variables independently associated with ADD/ADHD revealed only three determining factors: passive smoking during pregnancy (OR = 4.60 [2.14, 9.94]; p &lt; 0.001), acute fetal distress (OR = 5.08 [1.47, 17.52]; p = 0.01), and familial psychiatric history (OR = 9.37 [2.46, 35.59]; p = 0.001).DiscussionThe recognition of factors involved in the genesis of ADHD within different ethnic populations may help understanding and broaden our knowledge of this disorder to develop targeted strategies for prevention and early intervention. …”
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Path Analysis of Morphological Traits on Weight Traits of Breeding Mya japonica by Xiaoyan XU, Meirong DU, Tinghao WANG, Zengjie JIANG

“…Using the multiple regression analysis method, the optimal regression equation of shell size trait to weight trait was established as Y1=0.295X1+ 1.73X2+1.128X3–72.554, R2=0.954; Y2=0.117X1+0.56X2+0.219X3–19.240, R2=0.927; Y3=0.055X1+ 0.362X2+0.082X3–9.402, R2=0.891. …”
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تأثیرهشت هفته تمرینات فال­-پروف بر خطر سقوط، شادکامی و تاب آوری در سالمندان by ماهرخ دهقانی, عارفه مختاری ملک آبادی, محمود پیررسول زاده

“…جامعه آماری این پژوهش کلیه سالمندان شهرستان اردبیل بودند که از بین آنان 30 نفر (15 نفر گروه تمرین (سن: 5/66±70/25 سال، قد: 10/44±175/12 سانتی­متر، وزن: 9/48±78/36 کیلوگرم، شاخص توده بدنی: 6/15±26/98 کیلوگرم­بر­مترمربع و وضعیت شناختی: 2/35±25/12) و 15 نفر گروه کنترل (سن: 7/87±69/58 سال، قد: 7/45±177/32 سانتی­متر، وزن: 7/36±77/31 کیلوگرم، شاخص توده بدنی: 5/48±25/63 و وضعیت شناختی: 1/89±24/89)) به روش نمونه ­گیری در دسترس انتخاب شدند. …”
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Assessing Mental Illness Referral Request Acceptance: A Nationwide E-Referral Data From Saudi Arabia by Alharbi AA, Aljerian NA, Alghamdi HA, Binhotan MS, Alsultan AK, Arafat MS, Aldhabib A, Aloqayli AI, Alwahbi EB, Horner RD

“…Life-saving referrals showed the highest acceptance (aOR = 2.60; 95% CI = 1.51– 4.48), while psychiatrist availability significantly influenced acceptance rates (aOR = 1.36; 95% CI = 1.17– 1.58). …”
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Uncovering Molecular Mechanisms of Feed Efficiency in Pigs Through Multi-Omics Analysis of the Jejunum by Saixian Zhang, Yue Xiang, Yaobang Jian, Qiulin Zhao, Jiahui Sun, Yi Huang, Jing Xu, Xiaolong Qi, Jingjin Li, Zhuqing Zheng, Liangliang Fu, Yuwen Liu, Xinyun Li

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激活TGR5缓解肾缺血再灌注后肾脏纤维化损伤 by 李蒙, 隆罗莎, 梁柏恩, 徐龙, 赵晓朵, 王蔚东, 李春凌

“…目的探讨激活胆汁酸受体TGR5在单肾缺血再灌注损伤合并对侧肾摘除（uIRIx）模型诱导的肾脏纤维化中的作用。方法体内实验：将C57BL/6J小鼠随机分成假手术（Sham）组、uIRIx组及uIRIx+石胆酸（LCA）组，每组6只，使用uIRIx模型诱导肾脏纤维化，通过血和尿生化指标评估肾脏功能，利用HE染色评估肾脏损伤程度，使用Masson染色及免疫组化对肾脏纤维化程度进行评估，并用Western Blotting检测肾脏皮质纤维化相关指标蛋白表达；分别在<italic>TGR5</italic>^+/+小鼠及<italic>TGR5</italic>^-/-小鼠中设置Sham组及uIRIx组，每组6只，利用Western Blotting检测各组肾脏纤维化程度。…”
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