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Clinical and Mycobacterium tuberculosis strain characteristics of tuberculosis patients with diabetes mellitus in Changping District, Beijing, China
Published 2025-01-01“…The DST results showed the highest resistance rates to isoniazid and streptomycin, both at 8.2% (6/73), with approximately one-quarter of the strains resistant to at least one anti-TB drug, and about half (47.1%, 8/17) resistant to first-line drugs. The study demonstrated good specificity but suboptimal sensitivity in predicting phenotypic drug resistance based on genotypic resistance. …”
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La fecundidad en Cuba. Miradas a diferentes contextos
Published 2020-08-01“…La fecundidad cubana se caracteriza por una trayectoria decreciente en niveles por debajo del reemplazo, con una estructura temprana y predominio de los hijos de primer orden, mientras se reafirmó un creciente aporte de las adolescentes. …”
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4764
MicroRNA-451a is a candidate biomarker and therapeutic target for major depressive disorder
Published 2024-02-01“…Background Increasing evidence supports the role of microRNAs (miRNAs) in major depressive disorder (MDD), but the pathophysiological mechanism remains elusive.Aims To explore the mechanism of microRNA-451a (miR-451a) in the pathology and behaviours of depression.Methods Abnormal miRNAs such as miR-451a reported previously in the serum of patients with MDD were screened and then confirmed in a mouse model of depression induced by chronic restraint stress (CRS). Eight-week-old male C57BL/6 mice had miR-451a overexpression in the medial prefrontal cortex (mPFC) via adeno-associated virus serotype 9 vectors encoding a pri-mmu-miR-451a-GFP fusion protein followed by behavioural and pathological analyses. …”
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4765
Green coal and lubricant via hydrogen-free hydrothermal liquefaction of biomass
Published 2025-01-01“…In this work, we report a non-hydrogenated refinery paradigm for nearly complete valorization (~90%), via co-generating green coal and bio-lubricant. The obtained green coal has higher heating values comparable to commercial coals, with a lower fuel ratio and reduced ash content. …”
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4766
Selective activation of SIGMAR1 in anterior cingulate cortex glutamatergic neurons facilitates comorbid pain in depression in male mice
Published 2025-01-01“…Chemogenetic activation of these neurons can induce depression and pain, while chemogenetic blockade can reverse such depression-induced pain. …”
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Optimizing strength and corrosion resistance of the metastable β-alloy Ti–35Nb–7Zr–5Ta alloy by equal-channel angular pressing
Published 2025-03-01“…Controlling the microstructure of the Ti–35Nb–7Zr–5Ta alloy is fundamental for enhancing its strength and corrosion resistance in biomedical applications. …”
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Predictors of Poor Outcome of Anti-MDA5-Associated Rapidly Progressive Interstitial Lung Disease in a Chinese Cohort with Dermatomyositis
Published 2020-01-01“…Out of 213 patients with DM and clinically amyopathic dermatomyositis (CADM), 20.7% (44/213) of patients were identified as aMDA5-DM. …”
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The role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment options
Published 2025-02-01“…Therefore, the changes of oxidative stress caused by ICH on these markers can be used to evaluate and diagnose ICH, predict its prognosis, and guide preventive treatment to turn to antioxidant based treatment as a new treatment alternative.…”
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Clinical application of 3D slicer reconstruction and 3D printing localization combined with neuroendoscopy technology in VPS surgery
Published 2025-01-01“…At the same time, our team has newly developed a puncture point (“Cai’s point”), which has a puncture path in a non-vascular area and can reduce the risk of puncture bleeding. …”
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A Systematic Review and Network Meta-Analysis of Biomedical Mg Alloy and Surface Coatings in Orthopedic Application
Published 2022-01-01“…MAO demonstrated the best capability for new bone formation, followed by Ca-P coating. Ca-P coating exhibited the highest overall performance. …”
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4773
Probiotic administration aggravates dextran sulfate sodium salt-induced inflammation and intestinal epithelium disruption in weaned pig
Published 2025-01-01“…The pigs were orally challenged (DCON, DA) or not (CON, CA) with DSS from day 9 to the end of the experiment and slaughtered on day 16. …”
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A Dual Active Black Hole Candidate with Mass Ratio ~7:1 in a Disk Galaxy
Published 2025-01-01“…Here we report the evidence of a dual AGN candidate with mass ratio ~7:1 located in an undisturbed disk galaxy. We identify the central BH with mass of 9.4 × 10 ^6 M _⊙ from its radio emission as well as AGN-driven galactic-scale biconical outflows. …”
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Association of iron deficiency with kidney outcome and all-cause mortality in chronic kidney disease patients without anemia
Published 2025-01-01“…Compared with patients with TSAT level of > 20%, those with TSAT level of ≤ 20% had significantly higher risks of CKD progression (adjusted hazard ratio [aHR]: 1.66, 95% confidence intervals [CI]: 1.16–2.37; P = 0.005) and all-cause mortality (aHR: 2.21, 95% CI: 1.36–3.57; P = 0.001). …”
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Effects of dietary curcumin supplementation on the liver health of juvenile channel catfish (Ictalurus punctatus) fed high-starch diet
Published 2025-03-01Subjects: Get full text
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