Leucine-rich alpha-2 glycoprotein in combination with C-reactive protein for predicting endoscopic activity in Crohn’s disease: a single-centre, cross-sectional study by Yoshiaki Takada, Hiroki Kiyohara, Yohei Mikami, Masataka Taguri, Ryoya Sakakibara, Yasuhiro Aoki, Kosaku Nanki, Takaaki Kawaguchi, Yusuke Yoshimatsu, Shinya Sugimoto, Tomohisa Sujino, Kaoru Takabayashi, Naoki Hosoe, Haruhiko Ogata, Motohiko Kato, Yasushi Iwao, Nobuhiro Nakamoto, Takanori Kanai

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The absolute number of circulating Treg cells is reduced in difficult-to-treat RA patients and is ameliorated by low-dose IL-2 by Huanhuan Yan, Huanhuan Yan, Huanhuan Yan, Xiaoyu Zi, Xiaoyu Zi, Xiaoyu Zi, Huer Yan, Xiaoying Zhang, Xiaoying Zhang, Xiaoying Zhang, Jie Bai, Jie Bai, Jie Bai, Chong Gao, Xiaofeng Li, Xiaofeng Li, Xiaofeng Li, Caihong Wang, Caihong Wang, Caihong Wang

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Dyssynchronous heart failure models in canines: New insights into electrocardiographic, echocardiographic and histological features by Han Jin, Shengwen Yang, Hao Huang, Sijing Cheng, Pengkang He, Sixian Weng, Min Gu, Hongxia Niu, Wei Hua, Yiran Hu, Hui Li

“…The RAP+LBBB group exhibited significant reductions in left heart compliance (LVGLS, %: RAP+LBBB −12.60 ± 0.12 to −5.93 ± 1.25; RVAP −13.28 ± 0.62 to −8.05 ± 0.63, p = 0.023; LASct, %: RAP+LBBB −15.75 ± 6.85 to −1.50 ± 1.00; RVAP −15.75 ± 2.87 to −10.05 ± 6.16, p = 0.035). Histological examination revealed more pronounced fibrosis in the left ventricular wall and left atrium in the RAP+LBBB group while the RVAP group showed more prominent fibrosis in the right ventricular myocardium. …”
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Regulatory signatures involved in the cell cycle pathway contribute to egg production heterosis in chicken by Jingwei Yuan, Yuanmei Wang, Yanyan Sun, Yunlei Li, Aixin Ni, Qin Li, Hanhan Yang, Xinying Xu, Yunhe Zong, Hui Ma, Jilan Chen

“…Then, we identified consensus co-expression modules (CMs) that showed divergent expression pattern among crossbred (WY or YW) and purebreds (WW and YY). …”
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Mineralocorticoid axis activity and cardiac remodeling in patients with ACTH-dependent Cushing’s syndrome by Peter Wolf, Simon Travers, Oliver Domenig, Stephanie Baron, Anne Blanchard, Khaoula Bouazizi, Nadjia Kachenoura, Sylvie Salenave, Marko Poglitsch, Alban Redheuil, Severine Trabado, Jacques Young, Philippe Chanson, Peter Kamenický

“…Results: Concentrations of angiotensin I and angiotensin II were comparable, but the angiotensin-converting enzyme activity was significantly lower (2.19 (1.67; 3.08) vs 4.07 (3.1; 5.6); P < 0.001) in patients compared to controls. …”
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Hepatoprotection and Phytochemistry of the Vietnamese Herbs Cleome chelidonii and Cleome viscosa Stems by Nhat Minh Phan, Thi Hong Tuoi Do, Le Thanh Tuyen Nguyen, Trong Tuan Nguyen, Quoc Luan Ngo, Trong Duc Tran, Quan Hien Nguyen, Bui Linh Chi Huynh, Diep Xuan Ky Nguyen, Trong Dat Bui, Dinh Tri Mai, Tan Phat Nguyen

“…After 72 h of treatment, at the concentrations of 25, 50, and 100 μg/mL, the methanol of C. chelidonii stems (CCSM) ranged from 18.6% to 20.8%, whereas the methanol of C. chelidonii stems (CVSM) increased from 12.3% to 17.2% cell viability. …”
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A Randomized Study to Compare the Effects of Once-Weekly Dulaglutide Injection and Once-Daily Glimepiride on Glucose Fluctuation of Type 2 Diabetes Mellitus Patients: A 26-Week Fol... by Huiqin Li, Xiaohua Xu, Jie Wang, Xiaocen Kong, Maoyuan Chen, Ting Jing, Zhiying Zhang, Guoping Yin, Xiaomei Liu, Yun Hu, Lei Ye, Xiaofei Su, Jianhua Ma

“…Results. HbA1c of the dulaglutide group was reduced from 8.38±0.93% to 6.68±0.73% after the treatment (P<0.05); similarly, it was reduced from 7.91±0.98% to 6.67±0.74% (P<0.05) in the glimepiride group. …”
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Agronomic and Nutritional Evaluation of INIA 910—Kumymarca Ryegrass (<i>Lolium multiflorum</i> Lam.): An Alternative for Sustainable Forage Production in Department of Amazonas (NW... by Héctor V. Vásquez, Leandro Valqui, Leidy G. Bobadilla, Enrique Meseth, Milton J. Trigoso, Luis H. Zagaceta, Lamberto Valqui-Valqui, David Saravia-Navarro, Elgar Barboza, Jorge L. Maicelo

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New multilocus sequence typing scheme for Enterococcus faecium reveals sequential outbreaks of vancomycin-resistant E. faecium ST1162 and ST610 in a Japanese tertiary medical cente... by Masaki Karino, Masashi Yanagihara, Tetsuya Harada, Megumi Sugo, Mizuki Karino, Hirofumi Ohtaki, Hiroyuki Hanada, Toru Takano, Masaya Yamato, Shigefumi Okamoto

“…Simpson’s index of diversity values were 0.635, 0.317, and 0.648 for PFGE, the original scheme, and the Bezdíček scheme, respectively. …”
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A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins by Xiuxiu Lu, Monika Chandravanshi, Venkata R. Sabbasani, Snehal Gaikwad, V. Keith Hughitt, Nana Gyabaah-Kessie, Bradley T. Scroggins, Sudipto Das, Wazo Myint, Michelle E. Clapp, Charles D. Schwieters, Marzena A. Dyba, Derek L. Bolhuis, Janusz W. Koscielniak, Thorkell Andresson, Michael J. Emanuele, Nicholas G. Brown, Hiroshi Matsuo, Raj Chari, Deborah E. Citrin, Beverly A. Mock, Rolf E. Swenson, Kylie J. Walters

“…Abstract Proteasome subunit hRpn13 is partially proteolyzed in certain cancer cell types to generate hRpn13Pru by degradation of its UCHL5/Uch37-binding DEUBAD domain and retention of an intact proteasome- and ubiquitin-binding Pru domain. …”
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Comparative Analysis of Carbon Density Simulation Methods in Grassland Ecosystems: A Case Study from Gansu Province, China by Luyao Wu, Jiaqiang Du, Xinying Liu, Lijuan Li, Xiaoqian Zhu, Xiya Chen, Yue Gong, Yushuo Li

“…The main conclusions are as follows: (1) The overall estimation results demonstrate that the GWR model is the optimal choice for inverting AGBC, DOMC, and SOC, with coefficients of determination (<i>R</i>²) of 0.67, 0.60, and 0.92, respectively. In contrast, the MGWR model is best suited for BGBC, with an <i>R</i>² value of 0.73. (2) The stratified estimation results suggest that the optimal inversion models for AGBC and BGBC are predominantly the MGWR and RF models selected through the recursive feature elimination algorithm. …”
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Therapeutic potential of rutin in premenstrual depression: evidence from in vivo and in vitro studies by Xiangjun Wang, Xiaowen Xia, Xianliang Song, Yi Zhou, Mingyu Ma, Yashuang Ren, Xitai Chen, Zenghui Xia, Yinghui Guo, Chunhong Song

“…The Kd of rutin with the GABAA receptor (α1β2γ2) was 1.17 ± 0.89 μM. Rutin competed with [H3]-flunitrazepam for the GABAA receptor benzodiazepine site and inhibited the inward flow of chloride ions (P &lt; 0.05). …”
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Gravitational wave luminosity distance for Starobinsky gravity in viscous cosmological models by Jia-nan Chi, Ya-Bo Wu, Yu Sang, Xue Zhang, Yi-liang Hu, Wen-zhong Liu, Bo-hai Chen

“…European Physical Journal C: Particles and Fields…”
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İntörn Hemşirelere Verilen Akılcı İlaç Uygulamaları Eğitiminin İlaç Uygulamaları ile İlgili Tıbbi Hata Eğilimlerine Etkisi by Derya Suluhan, Emine Öksüz, Gamze Sarıkoç, Sibel Yılmaz Şahin, Hatice Ayhan, Gülşah Kök, Tülay Başak, Dilek Yıldız, Gülden Güvenç, Öznur Kavaklı, Emine İyigün

“…Araştırmanın örneklemini 97 intörn hemşire oluşturdu. Okulun intörn oryantasyon programı içerisinde yer alan “Akılcı İlaç Uygulamaları Eğitimi” orta gerçeklik simülasyon uygulamalarından biri olan rol play yöntemi ile verildi. …”
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Construction of a Practical Oriented Tool for Evaluating the Ability of Community Medical Staff to Provide Hospice Care Services and Its Reliability and Validity by SHA Jingjing, JING Limei, DING Tongjiu, XIN Yurong, TANG Lan, LI Shuijing

“…The Delphi expert consultation method invited a total of 15 authoritative experts in Shanghai who study and carry out hospice services, in which the expert authority coefficient was 0.87, and the Kendall harmony coefficient of the overall index system was 0.624 (P&lt;0.01), and the evaluation tools for the 50 entries were finally formed after two rounds of Delphi expert consultation. …”
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活性氧激活的脊髓星形胶质细胞参与瑞芬太尼诱发的 痛觉过敏

“…【方法】 72只SD大鼠随机分成6组,每组12只:对照组(C)?瑞芬太尼组(R)?瑞芬太尼+腹腔注射生理盐水组(R+Si.p)?瑞芬太尼+腹腔注射活性氧清除剂N-叔丁基-α-苯基硝酮(PBN)组(R+PBN)?…”
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Facing migration under adverse conditions: challenges and resilience in the Colombo-Venezuelan border area by Gloria Omaira Bautista, Axel Kroeger, Nelly Rosero Castillo, Eduardo Gabriel Osorio Sanchez, Dianne Sofía Gonzales Escobar, Rafael Olarte, Sonia Diaz Monsalve

“…The survey included 412 migrant families, comprising 1656 individuals, and 317 Colombian neighbour families, totalling 1077 individuals. …”
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Alpha/beta values in pediatric medulloblastoma: implications for tailored approaches in radiation oncology by Danny Jazmati, Dennis Sohn, Juliane Hörner-Rieber, Nan Qin, Edwin Bölke, Jan Haussmann, Rudolf Schwarz, Niklas David Niggemeier, Arndt Borkhardt, Florian Babor, Triantafyllia Brozou, Melissa Felek, Balint Tamaskovics, Patrick Melchior, Thomas Beez, Beate Timmermann, Marc Remke, Stefanie Corradini, Rémi Till Schulz, Ronja-Linda Preugschas, Wilfried Budach, Christiane Matuschek

“…Furthermore, differences in alpha/beta values cannot be correlated with molecular subgroups (p = 0.07) or radiosensitivity (SF2). Conclusion These in vitro findings strongly recommend normofractionated or hyperfractionated radiotherapy for paediatric medulloblastoma cases due to consistently high alpha/beta values across subgroups. …”
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Nitidine chloride inhibits the progression of hepatocellular carcinoma by suppressing IGF2BP3 and modulates metabolic pathways in an m6A-dependent manner by Dan-dan Xiong, Zhen-dong Chen, Jian-di Li, Yu-long Deng, Rong-quan He, Zhi-guang Huang, San-qi An, Yi-wu Dang, Gang Chen

“…Subsequently, employing RNA sequencing, RT-qPCR, WB, molecular docking, MD simulation, SPR, and CCK8 off-target assays, we pinpointed IGF2BP3 as a direct target of NC. …”
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Mechanical response characteristics and damage mechanism of water-containing mudstone under low strain rate dynamic loading by Guichen LI, Sen YANG, Yuantian SUN, Jinghua LI, Haoran HAO, Zeyu SHAO

“…The results show that: ① low strain rate dynamic loading still has a weakening effect on the strength of mudstone, the ability of mudstone to resist the disturbance of dynamic loading decreases with the increase of water content, dynamic loading rate, and strength, and the strength damage reaches the maximum of 28.47%, 59.76%, and 31.56%, respectively. ② The acoustic emission characteristic parameter law shows that during the loading process, the mudstone has gone through four fracture evolution stages: initial damage, damage intensification, damage quiescence (exacerbation), and damage development, and the Kaiser effect is more obvious at the lower level of each factor in the dynamic loading perturbation stage, and the Felicity effect is more significant at the higher level of each factor. ③ The loading strain and plastic strain of the mudstone under the initial dynamic load disturbance are the largest, and the time of the second significant damage of the mudstone is advanced at higher levels of each factor. …”
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