Natural Food Colorant Obtained from Wild <i>Berberis vulgaris</i> L. by Ultrasound-Assisted Extraction: Optimization and Characterization by Erika N. Vega, Lorena González-Zamorano, Elena Cebadera, Lillian Barros, Tânia C. S. P. Pires, Adriana K. Molina, Tayse F. F. da Silveira, Guillermo Vidal-Diez de Ulzurrun, Javier Tardío, Montaña Cámara, Virginia Fernández-Ruiz, Patricia Morales

“…These results highlight the richness of BVFF and BVE in bioactive compounds, especially anthocyanins, underscoring their potential as natural food colorants that can be used in food product formulations instead of synthetic azo colorants.…”
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Increased population exposure to extreme droughts in Iberia due to 0.5 °C additional anthropogenic warming by Ana Russo, Virgílio A Bento, Andreia F S Ribeiro, Daniela C A Lima, João A M Careto, Pedro M M Soares, Renata Libonati, Ricardo M Trigo, Célia M Gouveia

“…This study investigates the effects of incremental global warming, specifically the transition from 1.5 °C to 2.0 °C, on drought conditions in the Iberian Peninsula (IP). …”
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Real-world survival outcomes with immune checkpoint inhibitors in large-cell neuroendocrine tumors of lung by Samuel Kareff, Jair Bar, Amir Onn, Alona Zer, Chul Kim, Stephen V Liu, Elizabeth Dudnik, Mor Moskovitz, Anastasiya Lobachov, Teodor Gottfried, Damien Urban, Ofer Rotem, Mira Wollner

“…Median OS DX was 12.4mo (95% CI 10.7 to 23.4) and 6.0mo (95% CI 4.7 to 9.4) in groups A and B, respectively (log-rank test, p=0.02). …”
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Attitudes Toward General Vaccination Mediate the Association Between Influenza Vaccination History and Pneumococcal Vaccination Intention Among Older Adults in China by Siwen Huang, Chi Ruan, Yan Jiang, Yudan Song, Yuhang Zhang, Zeying Qin, Xinyu Shi, Mengyue Zhang, Jingtao Zhou, Dingwan Chen, Yongkang Xiao, Liang Wang, Lili Tian, Rui Peng, Zongchao Peng, Sitong Luo

“…<b>Results:</b> A significant positive association was observed between influenza vaccination history and pneumococcal vaccination intention (r = 0.167, <i>p</i> < 0.001). In contrast, negative attitudes toward general vaccination, including mistrust of vaccine benefits (r = −0.253, <i>p</i> < 0.001), worries about unforeseen future effects (r = −0.180, <i>p</i> < 0.001), concerns about commercial profiteering (r = −0.360, <i>p</i> < 0.001), and a preference for natural immunity (r = −0.212, <i>p</i> < 0.001) were negatively associated with pneumococcal vaccination intention. …”
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Cost&ndash;Benefit Analysis of in vivo Reflectance Confocal Microscopy for Melanoma Diagnosis in a Real-World Clinical Setting by Bruno GM, Di Matteo S, Longo C, Stanganelli I, Farnetani F, Borsari S, Mazzoni L, Ciardo S, Raucci M, Magi S, Bassoli S, Spadafora M, Mandel VD, Casari A, Chester J, Kaleci S, Colombo GL, Pellacani G

“…Giacomo Matteo Bruno,1 Sergio Di Matteo,2 Caterina Longo,3,4,&ast; Ignazio Stanganelli,5,6,&ast; Francesca Farnetani,7 Stefania Borsari,3 Laura Mazzoni,5 Silavana Ciardo,7 Margherita Raucci,3 Serena Magi,5 Sara Bassoli,7 Marco Spadafora,3,8 Victor Desmond Mandel,9 Alice Casari,7 Johanna Chester,7 Shaniko Kaleci,7 Giorgio Lorenzo Colombo,10 Giovanni Pellacani11 1Department of Drug Sciences, University of Pavia, Pavia, Italy; 2S.A.V.E. …”
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Characteristics and spatiotemporal changes in phenotypes and genotypes of extended-spectrum β-lactamases in Escherichia coli isolated from bloodstream infections in China from 2014... by Sayyed Salman, Hao Xu, Yunbo Chen, Jinru Ji, Zhiying Liu, Yonghong Xiao

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Prediction of long-term drug-free outcomes in ACPA-positive and ACPA-negative rheumatoid arthritis by combined clinical and ultrasound assessment of residual disease: a 5-year pros... by Carlomaurizio Montecucco, Garifallia Sakellariou, Claudia Alpini, Catherine Klersy, Serena Bugatti, Ludovico De Stefano, Emanuele Bozzalla Cassione, Antonio Manzo, Blerina Xoxi, Terenzj Luvaro, Ylenia Sammali

“…Whole-cohort multivariate Cox regression identified anti-citrullinated protein antibody (ACPA) positivity (HR: 4.20, 95% CI 2.37 to 7.44) and hands’ joints with grey scale (US-GS) alterations (GS&gt;1; HR: 2.18, 95% CI 1.20 to 3.93) as independent predictors. …”
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48例原因不明矮身材儿童临床特征和致病基因分析 by 侯乐乐, 林少汾, 李晓娟, 刘祖霖, 欧辉, 张丽娜, 孟哲, 梁立阳

“…结果纳入患儿48例（男性30例，女性18例），年龄（7.73±3.97）岁，身高标准差分值为-3.63±1.67；临床表现：特殊面容33例（68.8%），体型或骨骼系统异常31例（64.6%），围产期异常26例（54.2%，其中61.5%为小于胎龄儿），内分泌系统异常24例（50.0%，其中87.5%生长激素（GH）峰值低于正常），矮身材家族史21例（43.8%）；实验室检查：GH激发试验峰值（9.72±7.25）ng/mL，IGF-1 标准差分值为-0.82±1.42，骨龄与年龄差值（-0.93±1.39）岁；WES共发现相关基因变异者25例，其中14例（56.0%）为致病变异，6例（24.0%）为可能致病变异，5例（20.0%）为意义未明变异；评价为致病及可能致病变异的基因共14个，其中影响细胞内信号通路10个（<italic>PTPN11、RAF1、RIT1、ARID1B、ANKRD11、CSNK2A1、SRCAP、CUL7、SMAD4</italic>和<italic>FAM111A</italic>），影响细胞外基质（ECM）4个（<italic>ACAN、FBN1、COL10A1</italic>和<italic>COMP</italic>）。…”
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Integrating the GRACE Score with the Ceramide Risk Score Enhances the Predictive Accuracy of Major Adverse Cardiac Events in Patients with Acute Coronary Syndrome Undergoing Percut... by Xiaofei Wang, Chengzhe Liu, Fu Yu, Zizhuo Zhang, Jiale Wang, Xiaoyu Shi, Tianyou Xu, Qiang Deng, Liping Zhou, Wanyue Sang, Hong Jiang, Lilei Yu

“…Clinical Trial Registration: Registration number: ChiCTR2300068491 (https://www.chictr.org.cn/showproj.html?…”
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Comparison of safety and effectiveness of medical adhesive and metal spring coil in preoperative localization of peripheral pulmonary nodules by Yifei Wang, Zhenhua Yue, Xiaoqian Shi, Guozhan Xia, Linlin Qin, Qi Sun, Yiling Huang, Rong Chen, Xuewei Zhao, Mingdong Wang

“…The immediate pain score (2.32 ± 0.79) of the medical adhesive positioning group 15 min after positioning was significantly lower than that of the metal spring coil positioning group (3.97 ± 0.54) (P &lt; 0.001). The incidence of complications such as pneumothorax [15.7% (13/83) vs 5.4% (11/205), P = 0.004], pulmonary hemorrhage/hemoptysis [20.5% (17/83) vs 4.9 (10/205), P &lt; 0.001] was significantly higher in the metal coil positioning group than in the medical adhesive positioning group.ConclusionPreoperative medical adhesive positioning for pulmonary nodules is safe, reliable, and effective. …”
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Assessment of post-partum physical exercise practice and its associated factors among women in postpartum period, in West Wollega zone, Oromia, Ethiopia by Tegegne Yadeta, Daniel Belema, Seifedin Ahmad, Nurye Sirage, Abubeker Seid Ali, Kedir Ali, Ali Yimer

“…The prevalence of postpartum physical exercise practice among the participants was determined to be 19.5% (95% CI: 12.03–22.50). Several factors were independently associated with postpartum physical exercise practice: Women with a college education or higher had nearly three times greater odds of engaging in postpartum physical exercise (AOR = 2.97, 95% CI: 1.14, 7.80). …”
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MRI-T2*检测β-重型地中海贫血心、肝、胰铁沉积的临床价值 by 黄静文, 苏赟, 黎继昕, 杨绮华, 梁碧玲

“…结果109例β-TM患者的心肌、肝脏、胰腺T2*中位数分别为27.7（3.2~45.4）ms 、1.8（0.7~18.6）ms及6.1（1.1~42.9）ms；诊断心肌铁沉积（T2*&lt;20 ms）34例（31.2%），肝脏铁沉积（T2*&lt;6.3 ms）101例（92.7%），胰腺铁沉积（T2*&lt;26 ms）92例（84.4%）；诊断心肌铁沉积最小年龄7岁，肝脏和胰腺铁沉积最小年龄均为5岁。…”
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Retrospective analysis of the occurrence, potential risk factors and medical significance of pulmonary complications after total shoulder arthroplasty from the National Inpatient S... by Mengning Dong, Huitong Liang, Jinlang Fu, Zeying Guo, Hao Xie, Qinfeng Yang, Qingmei Yu, Xiaomin Hou

“…Infections, such as pneumonia, respiratory failure or PE, complicated 1.4% (95% CI, 1.52%–1.64%) of TSA operations. The ailments at this period that were most likely to result in pulmonary problems were ulcer (adjusted odds ratio [AOR] = 9.43; 95% CI, 4.99–46.91), pulmonary circulation disorders (AOR = 9.01; 95% CI, 4.56– 31.92), weight loss (AOR = 4.84; 95% CI, 2.15–10.88), fluid and electrolyte disorders (AOR = 3.55; 95% CI, 2.55–4.95), alcohol abuse (AOR = 1.56; 95% CI, 1.08–2.26), congestive heart failure (AOR = 3.09; 95% CI, 1.83–5.24), chronic pulmonary disease (AOR = 2.45; 95% CI, 1.60–3.75), deficiency anaemia (AOR = 1.56; 95% CI, 1.08–2.26), depression (AOR = 1.47; 95% CI, 1.03–2.11) and obesity (AOR = 1.46; 95% CI, 1.01–2.11). …”
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ECG‐based epileptic seizure prediction: Challenges of current data‐driven models by Sotirios Kalousios, Jens Müller, Hongliu Yang, Matthias Eberlein, Ortrud Uckermann, Gabriele Schackert, Witold H. Polanski, Georg Leonhardt

“…In pseudo‐prospective classification, the ROC‐AUC was 0.569 (±0.17), and 86 (49.4%) seizures were classified with IoC. …”
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基于加速传感器评估达到孕期活动推荐量的步数阈值分析 by 陈汉青, 张嘉鹏, 明伟杰, 王子莲

“…线性相关分析显示孕期每日步数与日常总活动量呈正相关（妊娠早期、妊娠中期和妊娠晚期的相关系数<italic>r</italic>分别为0.87，0.83和0.86，<italic>P</italic>均＜0.001）；与轻度活动有正相关（妊娠早期、妊娠中期和妊娠晚期的相关系数<italic>r</italic>分别为0.79，0.72和0.77，<italic>P</italic>均＜0.001）；与中等强度活动也有正相关（妊娠早期、妊娠中期和妊娠晚期的相关系数<italic>r</italic>分别为0.62，0.53和0.55，<italic>P</italic>均＜0.001）。…”
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Prevalence and Molecular Characterization of Carbapenemase-Producing Multidrug-Resistant Bacteria in Diabetic Foot Ulcer Infections by Mohd Saleem, Soha Abdallah Moursi, Tahani Nasser Almofeed Altamimi, Mohammed Salem Alharbi, Alwaleed Mohammad Alaskar, Sahar Adly Hassan Hammam, Ehab Rakha, Ozair Ilyas Syed Muhammad, Hamoud Abdulmohsin Almalaq, Metab Nasser Alshammari, Azharuddin Sajid Syed Khaja

“…<b>Results:</b> Among the isolates, 51.7% were confirmed to be carbapenemase producers. …”
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Rationale, design, and methodology of My Body Is Fit and Fabulous at school (MyBFF@school) study: a multi-pronged intervention program to combat obesity among Malaysian schoolchild... by Abdul Halim Mokhtar, Ruziana Mona Wan Mohd Zin, Abqariyah Yahya, Fuziah Md. Zain, Rusidah Selamat, Zahari Ishak, Muhammad Yazid Jalaludin

“…The mean (SD) characteristics for the participating primary and secondary schoolchildren were: BMI z-score, + 2.29 (± 0.81) and + 2.10 (± 0.71); waist circumference, 75.06 (± 9.6) cm and 85.5 (± 10.9) cm; percentage body fat, 37.8% (± 6.5%) and 39.2% (± 7.3%); and muscle mass, 14.7 (± 2.9) and 23.1 (± 5.2) kg respectively. …”
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Establishing a baseline for surgical care in Mongolia: a situational analysis using the six indicators from the Lancet Commission on Global Surgery by Raymond R Price, Ali Jalali, Anudari Zorigtbaatar, Sarnai Erdene, Sergelen Orgoi, Andrea Davis, Jonathan Nellermoe, Jade M Nunez, Simon Ruhnke, Battsetseg Gonchigjav, Nomindari Bat-Erdene, Kevin Bagley, Micah Katz, Hannah Pioli, Batsaikhan Bat-Erdene, Ganbold Lundeg

“…Secondary outcomes include regional access; surgeons, anaesthesiologists and obstetricians (SAO) density; surgical volume; and perioperative mortality.Results In 2016, 80.1% of the population had 2-hour access to essential surgery, including 60% of those outside the capital. SAO density was 47.4/100 000 population. A coding change increased surgical volume to 5784/100 000 population, and in-hospital mortality decreased from 0.27% to 0.14%. …”
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Seroprevalence of Human Herpesvirus Infections in Newly Diagnosed HIV-Infected Key Populations in Dar es Salaam, Tanzania by Doreen Kamori, Agricola Joachim, Mucho Mizinduko, Godfrey Barabona, Macdonald Mahiti, Upendo Kibwana, Mtebe Majigo, Salim Masoud, Ambele M. Mwandigha, Takamasa Ueno, Elia Mmbaga, Eligius Lyamuya

“…The overall seropositivity of HHV IgG was 92% (95% CI: 87.7–95.3%). HHV IgM was not detected in any of the samples. …”
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Variations in the diagnostic performance of transurethral resection of bladder tumor with photodynamic diagnosis according to surgical experience: A retrospective, single-center st... by Shuhei Suzuki, Yoshiyuki Nagumo, Kosuke Kojo, Atsushi Ikeda, Bunpei Isoda, Akane Yamaguchi, Kozaburo Tanuma, Satoshi Nitta, Masanobu Shiga, Takashi Kawahara, Shuya Kandori, Akio Hoshi, Hiromitsu Negoro, Bryan J. Mathis, Hiroyuki Nishiyama

“…Multivariate analysis identified urological experience as a significant factor improving accuracy rate (odds ratio [OR] 2.14) while tangential effects substantially reduced accuracy rate (OR 0.37). Notably, combining both PDD and WL resulted in a sensitivity exceeding 94 %, even in first-year urology residents and tangential effect areas. …”
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