SRC enhanced cisplatin resistance in bladder cancer by reprogramming glycolysis and pentose phosphate pathway by Yuwen Gong, Dongyang Gao, Yibo Shi, Guangrui Fan, Xiaoquan Yu, Enguang Yang, Hui Cheng, Junqiang Tian, Hui Ding, Shanhui Liu, Shengjun Fu, Yan Tao, Yuan Shui, Liang Cheng, Lanlan Li, Zhiping Wang

“…This phenomenon was effectively reversed by knockout of SRC and inhibition of SRC activity by the SRC inhibitor, eCF506. Moreover, we constructed Cell-derived xenograft (CDX) and Patient-derived xenograft (PDX) from cisplatin-resistant bladder cancer patient. eCF506 exhibited excellent anti-tumor effects and effectively enhanced cisplatin-sensitivity. …”
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Evaluation of the WRF-CMAQ Model Performances on Air Quality in China with the Impacts of the Observation Nudging on Meteorology by Jiali Li, Shaocai Yu, Xue Chen, Yibo Zhang, Mengying Li, Zhen Li, Zhe Song, Weiping Liu, Pengfei Li, Min Xie, Jia Xing

“…The results of regional O3 over China revealed that the Nudging case reproduced the spatial patterns of observed mean O3 concentrations in the 367 cities very well with the NMB value of 0.97%, much lower than –5.67% in the base case. …”
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Molecular testing stratifies the risk of structural recurrence in high risk differentiated thyroid cancer: a retrospective cohort study by Jie Liu, Wensi Gao, Xiong Zheng, Shuping Wu, Yi Shi, Feng Wang, Yu Wu

“…Multivariate COX regression analysis confirmed that molecular characterize groups (HR: 5.77, 95% CI: 2.18-15.23, p < 0.001) and tumor size (HR: 1.32, 95% CI: 1.00-1.74, p = 0.047) independently predicted recurrence-free survival.ConclusionATA-RSS high-risk differentiated thyroid cancer often presents with late-hit genetic alterations, which are strongly associated with increased likelihood of structural recurrence. …”
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INCREASED PULMONARY BLOOD FLOW IN NEWBORNS WITH CYANOTIC CONGENITAL HEART DEFECTS AND DUCTUS-DEPENDENT PULMONARY BLOOD FLOW: RESULTS AND FEATURES OF OUTPATIENT POSTOPERATIVE FOLLOW... by Anzhelika Mykhailovska, Olga Borodinova, Raad Tammo

“…In contrast, there was no early (30-day) postoperative mortality in the PDA st. group, and late mortality accounted for 7,4% (2/27). Before the subsequent stage of surgical correction, sufficient growth of pulmonary artery branches was noted (Nakata index increased from 156.9±33.3 mm2/m2 to 277±35.9 mm2/m2 in the SPAS group and from 142.7±55.2 mm2/m2 to 289.1±149.2 mm2/m2 in the PDA st. group, and the left ventricular end-diastolic dimension index increased from 51.2±32.4 mm2/m2 to 67.5±15.5 mm2/m2 in the SPAS group and from 50.8±24.9 mm2/m2 to 56.7±28.5 mm2/m2 in the PDA st. group. …”
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Sewage pollution from onsite sewage disposal systems and an offshore wastewater treatment plant outfall in coastal waters of Keaukaha, Hawaiʻi Island by Shayla M.P. Waiki, Steven L. Colbert, Tracy N. Wiegner, Noelani Puniwai, Joseph W.P. Nakoa, III, Nicolas M. Storie, Craig E. Nelson, Ashlynn N. Overly, Karla J. McDermid, Devon K. Aguiar

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Анатомічні та функціональні результати двох варіантів слінгових оперативних втручань для хірургічної корекції стресового нетримання сечі в жінок... by K.V. Chaika, K.I. Bohadelnikova, V.A. Shamrai, I.L. Kukuruza, N.M. Homon, P.P. Slobodian, O.O. Hryshchenko

“…Натомість встановлено, що методика TVT дає змогу досягти більшої частоти випадків повного утримання сечі через 2 роки після операції - 87,9% проти 67,9% у групі TVT-O, а також меншої кількості ургентних позивів та епізодів ургентного нетримання протягом доби через 1 рік (р=0,047 та р=0,03, відповідно) і 2 роки (р=0,012 та р=0,02, відповідно) після встановлення слінга. …”
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Specific detection of pigeon parvovirus with TaqMan real-time PCR technology by Cuiteng Chen, Chunhua Zhu, Shuyu Chen, Zhen Chen, Huanru Fu, YuYi Chen, Mengyan Zhang, Wenyu Zhang, Yu Huang, Longfei Cheng, Chunhe Wan

“…The viruses of the Parvoviridae family can infect both vertebrate and invertebrate animals. …”
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Prevalence of carbapenemase-encoding genes carriage in patients admitted to multidisciplinary hospital in Moscow by Ni O.G., Shifman E.M., Yakovlev S.V., Bykov A.O., Gorbacheva A.A., Kruglov A.N., Belotserkovskiy B.Z., Matyushkov N.S., Galata A.A., Protsenko D.N.

“…Genes blaKPC and blaOXA-51 were detected with the same frequency (14.7%). The other genes were less common, from 0.6% (blaIMP) to 10.3% (blaOXA-51). …”
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Effectiveness of small-sided games on change of direction speed in youth soccer players: a systematic review and meta-analysis by Ioan Neag, Ion Mihaila, Leonard Julien Fleancu, Alexandru Acsinte, Corina Daniela Popescu, Maura Stancu, Vladimir Potop, Gabriel Trandafirescu, Ilie Mihai

“…The analysis showed no significant differences between SSGs and running-based methods in change of direction speed (ES = –0.04, 95% CI = –0.30 to 0.21, p = 0.74). Significant improvements were observed within groups for both running-based methods (ES = –0.61, 95% CI = –0.89 to –0.33, p < 0.001) and SSG interventions (ES = –0.67, 95% CI = –0.91 to –0.44, p < 0.01). …”
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A combined diagnostic model including middle rectal artery visualization for predicting lateral lymph node metastasis in rectal cancer by Ning Wang, Yiping Li, Yiping Li, Yiping Li, Kun Lu, Kaikai Wei, Shize Jia, Shuhong Fan, Donglin Ren, Donglin Ren, Donglin Ren, Yuanji Fu, Yuanji Fu, Yuanji Fu, Zhimin Liu, Zhimin Liu, Zhimin Liu

“…Enhanced computed tomography (CT) was used to determine whether MRA was visible. …”
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Applying evidence-based cross-disciplinary concepts helps to explain the heterogeneity in pain, function, and biological measures in individuals with knee pain with/at risk of oste... by Angela M. Mickle, Jared J. Tanner, Udell Holmes, III, Ahmed Rashid, Olivier Barolette, Brittany Addison, Nicola Sambuco, Cynthia Garvan, Song Lai, Christoph Seubert, Siegfried Schmidt, Roland Staud, Jeffrey C. Edberg, David Redden, Burel R. Goodin, Catherine C. Price, Roger B. Fillingim, Kimberly T. Sibille

“…One hundred seventy-three individuals participated in the study. Of those, 117 had protective dispositional traits (81 above poverty/36 in poverty), and 56 had vulnerable dispositional traits (24 above poverty/32 in poverty). …”
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Dengue virus IgG and neutralizing antibody titers measured with standard and mature viruses are protective by Camila D. Odio, Jedas Veronica Daag, Maria Vinna Crisostomo, Charlie J. Voirin, Ana Coello Escoto, Cameron Adams, Lindsay Dahora Hein, Rosemary A. Aogo, Patrick I. Mpingabo, Guillermo Raimundi Rodriguez, Saba Firdous, Maria Abad Fernandez, Laura J. White, Kristal An Agrupis, Jacqueline Deen, Aravinda M. de Silva, Michelle Ylade, Leah C. Katzelnick

“…ELISA IgG≥3 was associated with reduced dengue probability relative to naïve children (3% vs. 10%, p = 0.007). Serotype-specific antibodies binding EDIII or NS1 had no association with dengue risk. …”
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Characterization of the colostrum proteome of primiparous Holstein cows and its association with colostrum immunoglobulin G concentrations by Ezequias Castillo-Lopez, Patrick Biber, Arife Sener-Aydemir, Karin Hummel, Ebrahim Razzazi-Fazeli, Nicole Reisinger, Qendrim Zebeli, Susanne Kreuzer-Redmer, Thomas Hartinger

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Comparison of Oncological Outcomes After Curative Resection for Right-side Colon Cancer and Left-side Colon Cancer: a Retrospective Observational Study by Mehmet Torun, Orhan Uzun, Mustafa Duman, Erdal Polat, Aziz Serkan Senger, Mürşit Dinçer, Ömer Özduman, Selçuk Gülmez, Ahmet Orhan Sunar

“…Statistical analyses were performed using the chi-squared test, Fisher’s exact test, Mann-Whitney U test, the Kaplan-Meier method, and Cox regression analysis. …”
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CD8+T cells and monocytes were associated with brain alterations in human immunodeficiency virus-infected individuals with cognitive impairment by Xin Zhang, Zhen Li, Jiahao Ji, Yundong Ma, Guangqiang Sun, Xue Chen, Ling Zhang, Tong Zhang, Yulin Zhang, Yang Zhang

“…The amplitude of low frequency fluctuations in a specific brain region of frontal-middle lobe was negatively correlated with the frequencies of non-classical monocytes (nCM) and their subpopulations (CCR2lownCM, CD57lownCM and CD127+nCM), and positively associated with the plasma interleukin 25 and transforming growth factor-α levels. …”
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From structure prediction to function: defining the domain on the African swine fever virus CD2v protein required for binding to erythrocytes by Ana Luisa Reis, Anusyah Rathakrishnan, Vlad Petrovan, Muneeb Islam, Lynnette Goatley, Katy Moffat, Mai Tuyet Vuong, Yuan Lui, Simon J. Davis, Shinji Ikemizu, Linda K. Dixon

“…A combination of protein structure modeling and extensive mutagenesis was used to identify residues mediating binding of transiently expressed CD2v to erythrocytes. The N-terminal Ig-like domain AGFCC′C″ β sheet was identified as the putative CD2v erythrocyte-binding area. …”
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Differentiating Liver Metastases from Primary Liver Cancer: A Retrospective Study of Imaging and Pathological Features in Patients with Histopathological Confirmation by Laura Andreea Ghenciu, Mirela Loredana Grigoras, Luminioara Maria Rosu, Sorin Lucian Bolintineanu, Laurentiu Sima, Octavian Cretu

“…Primary liver cancers were more likely to be solitary (72.7% vs. 17.5%, <i>p</i> < 0.001), have smooth margins (63.6% vs. 21.4%, <i>p</i> = 0.002), exhibit arterial phase hyperenhancement (81.8% vs. 23.8%, <i>p</i> < 0.001), and portal venous washout (72.7% vs. 19.0%, <i>p</i> < 0.001). …”
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Effects of biologic therapy on novel indices of lung inhomogeneity in patients with severe type-2 high asthma by Nayia Petousi, Nick P Talbot, Ian Pavord, Peter A Robbins, Nicholas M J Smith, Graham Richmond, Asma Alamoudi, Lorenzo Petralia, Haopeng Xu, Dominic Sandhu, Grant AD Ritchie

“…Following biologics, improvements in σlnCl were significantly dependent on BEC (LME regression coefficient +0.19, 95% CI (0.11, 0.27), p&lt;0.001) whereas improvements in FEV1 % predicted related to both BEC and ACQ-5 responses (LME coefficients: BEC −10.8 % pred, 95% CI (−16.1,–5.5); ACQ-5 –3.5 % pred, 95% CI (−5.1 to –1.9), p&lt;0.001). …”
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Malignancies in people living with HIV: A 25-years observational study from a tertiary hospital in Italy by Antonio Anastasia, Walter Mazzucco, Luca Pipitò, Santo Fruscione, Roberta Gaudiano, Marcello Trizzino, Maurizio Zarcone, Antonio Cascio

“…No statistical difference was found between the mean values of zenith HIV-RNA and CD4 count in HIV outpatients with cancer and in those without cancer, while a statistically significant difference was found between the HIV-RNA zenith in HIV outpatients with ADC as compared with NADC (10.2 copies/mL versus 8.1 copies/mL; p-value= 0.007). …”
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Hurdle Approach to Simulate Corn Wet Milling Inactivation of Undesirable Microorganisms: A Pilot Scale Microbial Challenge Study Using Salmonella Surrogate Enterococcus faecium by Erin Kealey, Madeline Shick, Minho Kim, Ruben Chavez, Gordon Shetley, David Stenger, Kirk A. Perreau, Allison Cooke, Cecil Barnett-Neefs, Matthew J. Stasiewicz

“…Flash drying had a reduction range from 1.7 to 2.7 log CFU/g. There was also no biologically meaningful change (<1 log CFU/g reduction) of E. faecium counts during an 8-week survival study of the dried final product. …”
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