Single-Cell Transcriptome Analysis Reveals Different Immune Signatures in HPV- and HPV + Driven Human Head and Neck Squamous Cell Carcinoma by Simin Li, Yang Wang, Rui Sun, Debora Franceschi, Hongying Pan, Chenxuan Wei, Anthony Chukwunonso Ogbuehi, Bernd Lethaus, Vuk Savkovic, Sebastian Gaus, Rüdiger Zimmerer, Dirk Ziebolz, Gerhard Schmalz, Xiao Jiang

“…AREG and TGFBI were pDC marker genes, CXCR3 and CD27 were significantly expressed in T cell-related cells, while MS4A1 and CD19 were mainly expressed in B naïve cells. …”
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Risk Factors of Anaemia among Children under Five Years in the Hohoe Municipality, Ghana: A Case Control Study by Phyllis Atta Parbey, Elvis Tarkang, Emmanuel Manu, Hubert Amu, Martin Amogre Ayanore, Fortress Yayra Aku, Sorengmen Amos Ziema, Samuel Adolf Bosoka, Martin Adjuik, Margaret Kweku

“…Children with poor dietary diversity were 9.15 times more likely to have anaemia [AOR=9.15 (95% CI: 3.13-26.82); p< 0.001]; and children whose mothers were farmers and traders were 83% [AOR = 0.17 (95% CI: 0.05-0.60); p=0.006] and 79% [AOR=0.21 (95% CI: 0.06-0.74); p=0.014], respectively, less likely to have anaemia. …”
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Silencing hepatic PCSK9 via novel chimeric AAV8 mitigates the progression of atherosclerosis by inhibiting inflammation in ApoE−/− mice by Xiaocui Chen, Minghui Sun, Xiang Ma, Yitong Ma, Bangdang Chen

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EZSCAN风险评分在肾功能轻度损伤人群中的筛查价值 by 沈国丽, 邵敏, 蔡如意, 孙婷

“…结果经过多变量调整后，风险评分与eGFR下降的风险相关，与risk值最低组（Q1&lt;24）相比，Q2（25-27），Q3（28-47），Q4（48-75）的OR（95％CI）分别为1.84（1.54，2.20），2.47（2.08，2.94），2.41（2.05，2.83）。…”
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Deep learning-based CT radiomics predicts prognosis of unresectable hepatocellular carcinoma treated with TACE-HAIC combined with PD-1 inhibitors and tyrosine kinase inhibitors by Linan Yin, Ruibao Liu, Wei Li, Shijie Li, Xunbo Hou

“…Objective response rate (ORR) and disease control rate (DCR) was 41.0% and 55.7%, respectively. In the treatment response prediction model, the AUC for the training cohort reached 0.96, with an accuracy of 89.5%, precision of 85.6%, and F1-score of 0.896; the AUC for the testing cohort was 0.87, with an accuracy of 80.4%, precision of 74.5%, and F1-score of 0.802. …”
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The clinical implication of CD45RA+ naïve T cells and CD45RO+ memory T cells in advanced pancreatic cancer: a proxy for tumor biology and outcome prediction by Junjie Hang, Junjie Huang, Siyuan Zhou, Lixia Wu, Yingwei Zhu, Lina Zhu, Hanyu Zhou, Kequn Xu, Hua Jiang, Xuguang Yang

“…In addition, CD4+ naïve/memory ratio showed independent prognostic impact (HR 1.427, 95% CI 1.033‐1.973, P = 0.031). …”
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Remimazolam for the prevention of emergence agitation in adults following nasal surgery under general anesthesia: a prospective randomized clinical controlled trial by Yanfei Lu, Qiaomin Xu, Hong Dai, Jimin Wu, Mengting Ai, Haiyan Lan, Xiaoli Dong, Gongchen Duan

“…Trial registration The trial was registered, before patient enrollment, in the Chinese Clinical Trial Registry ( www.chictr.org.cn ) (clinical trial number: ChiCTR2300075300; Principal Investigator: Gongchen Duan; date of registration: 31 August 2023; https://www.chictr.org.cn/bin/project/edit?…”
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Evaluation of magnetic resonance thermometry performance during MR-guided hyperthermia treatment of soft-tissue sarcomas in the lower extremities and pelvis by Spyridon N. Karkavitsas, Marianne Göger-Neff, Maria Kawula, Kemal Sumser, Benjamin Zilles, Martin Wadepohl, Guillaume Landry, Christopher Kurz, Wolfgang G. Kunz, Olaf Dietrich, Lars H. Lindner, Margarethus M. Paulides

“…The Jaccard coefficient quantified pretreatment motion; receiver operating characteristic analysis assessed its predictability for acceptable precision (<1 °C) during HT.Results Compared to the built-in dual-echo approach, single-echo thermometry improved the mean temporal precision from 1.32 ± 0.40 °C to 1.07 ± 0.34 °C (pelvis) and from 0.99 ± 0.28 °C to 0.76 ± 0.23 °C (lower extremities). …”
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Association between weight-adjusted-waist index and long-term prognostic outcomes in cardiovascular disease patients: results from the NHANES 1999–2018 study by Hanbin Li, Wen Zhong, Hongxin Cheng, Shiqi Wang, Ran Li, Lu Wang, Chengqi He, Quan Wei

“…In the fully adjusted model, the highest quartile (WWI > 12.05 cm/√ kg) showed a higher all-cause mortality rate compared with the lowest quartile (WWI < 11.03 cm/√ kg) (HR = 1.37, 95% CI: 1.03, 1.82, P < 0.05). …”
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Real-World Life Analysis of a Continuous Glucose Monitoring and Smart Insulin Pen System in Type 1 Diabetes: A Cohort Study by Paola Pantanetti, Giovanni Cangelosi, Sara Morales Palomares, Gaetano Ferrara, Federico Biondini, Stefano Mancin, Gabriele Caggianelli, Mauro Parozzi, Marco Sguanci, Fabio Petrelli

“…Results: This study included 21 participants with a mean age of 51.5 years, a mean BMI of 24.7, and a mean duration of T1D of 21.9 years. The transition from a traditional MDI system to the Smart MDI system resulted in significant improvements in key glycemic parameters: mean Sensor Glucose (SG) decreased from 171.0 mg/dL to 153.5 mg/dL (<i>p</i> = 0.035), Time In Range (TIR) increased from 58.0% to 64.4% (<i>p</i> = 0.005), and time above range (TAR; >180 mg/dL) decreased from 39.0% to 34.2% (<i>p</i> = 0.015). …”
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The effect of prednisolone ingestion and acute exercise on lipocalin-2 and its variants in young men: a pilot randomised crossover study by Carlie Bauer, Rhiannon K. Patten, Qiyang Sun, Haoyun Li, Daniels Konja, Mary Woessner, Xuzhu Lin, Andrew Garnham, David L. Hare, Peter R. Ebeling, Marc Sim, Joshua R. Lewis, Yu Wang, Lewan Parker, Itamar Levinger

“…C87A, but not LCN2 or its other variants, remained elevated at 180 min post-ex (p = 0.007). …”
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Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study by Taylor Roh, Sungeun Ju, So Young Park, Yeonghwan Ahn, Jiyun Chung, Miyako Nakano, Gyoungah Ryu, Young Jae Kim, Geumseo Kim, Hyewon Choi, Sung-Gwon Lee, In Soo Kim, Song-I Lee, Chaeuk Chung, Takashi Shimizu, Eiji Miyoshi, Sung-Soo Jung, Chungoo Park, Sho Yamasaki, Seung-Yeol Park, Eun-Kyeong Jo

“…Additionally, Mincle, a C-type lectin receptor, interacts with Fu-Hp to amplify the inflammatory responses and signaling. …”
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ASB1 engages with ELOB to facilitate SQOR ubiquitination and H2S homeostasis during spermiogenesis by Jinxing Lv, Tiantian Wu, Jiajia Xue, Cong Shen, Wenxin Gao, Xia Chen, Yueshuai Guo, Mingxi Liu, Jun Yu, Xiaoyan Huang, Bo Zheng

“…Mechanistically, ASB1 interacts with ELOB to induce the instability of sulfide-quinone oxidoreductase (SQOR) by enhancing its K48-linked ubiquitination on residues K207 and K344, consequently triggering proteasomal degradation. …”
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Distribution of Major HLA-A, -B, -DR, and -DQ Loci Potentially Associated with Multiple Sclerosis in a Healthy Population from Southern Morocco by Abir Fguirouche, Fatimazahra Ouahmani, Ikram Brahim, Raja Hazime, Nissrine Louhab, Najib Kissani, Mohamed Chraa, Brahim Admou

“…HLA class I typing was executed using the CDC (complement dependent cytotoxicity) technique (OneLambda™, Los Angeles CA, USA), and HLA class II typing was performed by either PCR-SSP (sequence-specific primer, OneLambda) or PCR-SSO (sequence-specific oligonucleotides) using the Luminex Xmap (Lifecodes, Immucor, Peachtree, Corners, GA, USA) system. …”
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Характеристика яловичини, отриманої від бугайців української чорно-рябої молочної породи за різного покриву туш жировою тканиною... by Крук О.П., Угнівенко А.М.

“…Зі збільшенням розвитку підшкірного жиру на туші складається тенденція до: насичення кольору підшкірної жирової тканини на 2,7 %, сухожилок і зв’язок на 0,2 пункту і міцності бульйону із вивареного м’яса на 8,7 %; зменшення живої маси тварин після голодного витримування на 2,7 %, забійного виходу (туш) на 0,9 пункту, жирової тканини у туші на 1,3 пункту, вмісту м’язової тканини першого сорту на 0,5 пункту; погіршення мармуровості м’яса на 27,7 % і утримання води в ньому на 5,3 пункти, придатності м’яса до зберігання на 0,5 пункту; зменшення у м’ясі загального вмісту вологи на 2,1 пункту і загальної маси золи на 0,3 пункту, основних складових сенсорного оцінювання яловичини – ніжності на 6,7 % та соковитості на 3,0 %. …”
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Genome skimming provides evidence to accept two new genera (Apiaceae) separated from the Peucedanum s.l. by Bo-Ni Song, Chang-Kun Liu, Chang-Kun Liu, Jiao-Jiao Deng, Wei-Yan Tan, Song-Dong Zhou, Xing-Jin He

“…Meanwhile, obvious recognized features for morphology, plastome, and chromosome number for each clade were detected: dorsally compressed and glabrous mericarps with filiform dorsal ribs, winged lateral ribs, numerous vittae in commissure and each furrow, IRa/LSC border falling into rpl23 gene, an overall plastome size of 152,288-154,686 bp, and chromosome numbers of 2n=20 were found in clade A; whereas dorsally compressed and pubescent mericarps with filiform dorsal ribs, winged lateral ribs, numerous vittae in commissure and each furrow, IRa/LSC border falling into the ycf2 gene, an overall plastome size of 146,718-147,592 bp, and chromosome numbers of 2n=22 were discovered in clade B. …”
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Liver Radioembolization: a New Chapter in Russian Oncology by A. D. Kaprin, S. A. Ivanov, V. V. Kucherov, A. P. Petrosyan, K. V. Mayorov, N. V. Markov, L. O. Petrov, G. A. Davydov, M. A. Sigov, N. K. Silantieva, T. P. Berezovskaya, A. Yu. Usacheva, D. B. Sanin

“…Annually, over 200 thousand patients with inoperable primary liver cancer and over 270 thousand patients with inoperable metastatic liver cancer are registered globally, for whom radioembolization is considered as the most suitable treatment method. 90Y is a pure beta emitter without its own gamma line, which is characterized by a small average particle path in the tissue of 2.5 mm (the maximum level is 11 mm), a maximum beta particle energy of 2.27 MeV (average energy of 0.937 MeV) and a half-life of 64.1 hours. …”
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Regulatory problems and developmental psychopathology within the first 2 years of living—a nested in cohort population-based study by Janni Ammitzbøll, Janni Ammitzbøll, Anne Lise Olsen, Susanne Landorph, Christian Ritz, Anne Mette Skovgaard, Anne Mette Skovgaard

“…Children with RP of feeding and eating showed an increased risk of overall mental disorder, adjusted OR 1.4 (95% CI: 0.7–2.4), and specifically, feeding and eating disorders, adjusted OR 6.0 (95% CI: 1.6–21.7), disorders of behavior and emotions, adjusted OR 2.2 (95% CI: 0.9–5.8), as well as DC:0-3R regulatory disorders, adjusted OR 1.6 (1.0–7.5). …”
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Survival of common carp carrying Cyca-DAB1*05 post-challenged with Aeromonas hydrophila by Laode Muhammad Arsal, Munti Yuhana, Sri Nuryati, , Alimuddin

“…Masing-masing ikan diinfeksikan A. hydrophila secara intramuskuler pada dosis 0,1 mL, kepadatan 108 cfu/mL. Uji tantang dilakukan selama 14 hari, dan sampel darah ikan diambil pada hari ke-0, tiga, tujuh dan 14. …”
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Healthcare provision for displaced people in transit: Analyses of routinely collected data from INTERSOS clinics at the Ukrainian border with Moldova and Poland by Saleh Aljadeeah, Seyed-Moeen Hosseinalipour, Nataliia Khanyk, Eszter Szocs, Aliki Traianou, Ana Tomas, Chrysanthi Tatsi, Elżbieta Czapka, Alessandro Verona, Tessa van Boekholt, Ion Chesov, Apostolos Veizis

“…The majority of the adult population seeking healthcare were females (76.5 %), 26.1 % were children and 18.7 % were older individuals. Noncommunicable diseases (NCDs) were the primary reason for seeking healthcare at these clinics, with 23.3 % of the study population being diagnosed with at least one chronic disease, and 3.4 % of people having multimorbidity. …”
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