Tp53 determines the spatial dynamics of M1/M2 tumor-associated macrophages and M1-driven tumoricidal effects by Yi-Jing Hsiao, Min-Shu Hsieh, Gee-Chen Chang, Yin-Chen Hsu, Chia-Yu Wang, Yan-Ming Chen, Yi-Ling Chen, Pan-Chyr Yang, Sung-Liang Yu

“…This activation facilitates p53-STAT1 interactions, reduces the interaction between p53 and MDM2, and subsequently decreases p53 ubiquitination. M1 CM inhibited tumorigenesis, and silencing p53 reduced the anti-tumor efficacy of polyinosinic:polycytidylic acid (poly I:C) in vivo. …”
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Research on smoke diffusion and evacuation routes of mine fires with complex roadway networks by Menghui Xiao, Cuifeng Du, Yuan Wang, Jiuzhu Wang, Baomeng Chang

“…The results indicated that CO concentration significantly decreased at roadway corners, and both CO concentration and temperature gradually decreased with increasing depth. …”
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三七花醇提物 PNFM 对健康人血小板功能的体外作用 by 覃楠, 李卿, 左晓, 邹培斧, 马丽娟, 万建波, 杨燕, 嘉红云

“…【结果】在激动剂ADP诱导下，500μg/mL的PNFM干预组血小板聚集率从对照组的（72.00±6.08）降到了35.67±3.78（P<0.01），300μg/mL干预组同样有抑制效果；与对照组相比（30.05±6.48），PNFM干预组明显降低健康人血小板表面CD62P，其中500μg/mL组降至（2.66±0.90，P<0.001）；且均降低了PAC-1的表达，500μg/mL组（11.89±6.12）较对照组（33.37±8.12）差异显著（P<0.01）；PNFM干预组均可抑制ATP释放，500μg/mL组由对照的1.93±0.47降至0.19±0.10（P<0.001）；在血小板于纤维蛋白原上的铺展作用中，PNFM各剂量组也均显示有显著抑制作用，500μg/mL组由对照的89.57±17.34降至25.12±3.52（P<0.001）；PNFM同样抑制血小板胞浆钙离子动员，其中500μg/mL组（71.25±5.33）较对照组差异显著（183.87±11.59，P<0.001）；且均具有剂量依赖性。…”
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Family history of cardiovascular disease and death in patients with out-of-hospital cardiac arrest by Magnus Gylling, Johanna Krøll, Peder Emil Warming, Carolina Malta Hansen, Fredrik Folke, Steen M. Hansen, Lars Køber, Christian Torp-Pedersen, Rodrigue Garcia, Jacob Tfelt-Hansen, Peter E. Weeke

“…Results: Of 45,293 patients with OHCA 4,994, were eligible for inclusion (median age 50 years at OHCA, 76% male). Of these 47.7% had a family history of CVD (vs. 42.1% of controls), 68.2% of all-cause death (vs. 60.9%), 23% of premature death (vs. 15.8%) and 33.3% of cardiovascular death (vs. 27%) (p < 0.001 for all). …”
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Reverse Shoulder Arthroplasty Baseplate Stability Is Affected by Bone Density and the Type and Amount of Augmentation by Daniel Ritter, Patric Raiss, Patrick J. Denard, Brian C. Werner, Manuel Kistler, Celina Lesnicar, Micheal van der Merwe, Peter E. Müller, Matthias Woiczinski, Coen A. Wijdicks, Samuel Bachmaier

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An examination of ankle joint position sense, postural control and associated neuromuscular deficits in patients with plantar fasciitis: a cross-sectional analysis with advanced bi... by Shaker Hassan S. Alshehri, Mastour Saeed Alshahrani, Saeed Y. Al Adal, Faisal M. Alyazedi, Hani Hassan Alnakhli, Ravi Shankar Reddy

“…Pain catastrophizing was a significant predictor of AJPS in plantarflexion (β = -0.05, p = 0.001). Postural stability was negatively correlated with AJPS accuracy, particularly in mediolateral sway (r = -0.32, p = 0.037), while physical activity and quality of life had minimal effects. …”
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Association of composite dietary antioxidant index with circadian syndrome: evidence from NHANES by Chen Chen, Chenyu Zhao, Hongyu Jin, Zhiping Jiang, Wei Wang, Wen-Yang Li

“…Logistic regression revealed that the highest quartile of CDAI was inversely associated with the risk of CircS {odds ratio (OR) [95% CI = 0.69 (0.55–0.87)]} and the risk of depression [OR = 0.59 (0.48–0.72)], short sleep duration [OR = 0.54 (0.41–0.70)], elevated fasting glucose [OR = 0.80 (0.65–0.98)], elevated triglycerides (TG) [OR = 0.74 (0.59–0.92)], elevated waist circumference [OR = 0.65, (0.52–0.80)] and reduced high-density lipoprotein cholesterol (HDL-C) [OR = 0.75 (0.61–0.92)], respectively. …”
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Endovascular treatment for blood blister ⁃ like aneurysms of internal carotid artery and systematic literature review by ZHOU Lei, WANG Zhong, YANG Guo‐jun, DONG Shi‐biao, LI Nan, ZHU Wei‐wei

“…The Raymond classification showed that among the patients, there were 17 cases of grade Ⅰ occlusion, 3 cases of grade Ⅱ occlusion, and 5 cases of grade Ⅲ occlusion. …”
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Global seroprevalence of Toxoplasma gondii in pregnant women: a systematic review and meta-analysis by Nader Salari, Avijeh Rahimi, Hosna Zarei, Amir Abdolmaleki, Shabnam Rasoulpoor, Shamarina Shohaimi, Masoud Mohammadi

“…Therefore, after the continent, the highest prevalence reported was reported in Africa with 46.8% (95% CI:39.5–54.3). Also, the lowest prevalence reported based on meta-analysis was in North America with 19.7% (95% CI:8.4–39.6) and Europe with 24.6% (95% CI:17.8–32.9). …”
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Genetic Polymorphisms of IL17 and Chagas Disease in the South and Southeast of Brazil by Pâmela Guimarães Reis, Christiane Maria Ayo, Luiz Carlos de Mattos, Cinara de Cássia Brandão de Mattos, Karina Mayumi Sakita, Amarilis Giaretta de Moraes, Larissa Pires Muller, Julimary Suematsu Aquino, Luciana Conci Macedo, Priscila Saamara Mazini, Ana Maria Sell, Divina Seila de Oliveira Marques, Reinaldo Bulgarelli Bestetti, Jeane Eliete Laguila Visentainer

“…The aim of this study was to investigate possible associations between genetic polymorphisms of IL17A G197A (rs2275913) and IL17F T7488C (rs763780) with Chagas Disease (CD) and/or the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas cardiomyopathy (CCC). …”
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Lesion Topography and Clinical Features Associated With Respiratory Failure in Patients With Medullary Infarction by Na Zhao, Ran Liu, Yajing Zhang, Ling Ling, Chao Zhang, Ting Zhang, Wei Yue

“…Methods A total of 435 consecutive patients with MI within 7 days of onset in our institute were retrospectively enrolled from January 2017 to January 2024. …”
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Systemic hypotension and low perfusion pressure as risk factors for primary open-angle glaucoma progression by O.S. Myakonkaya, A.S. Sarkisyan, A.V. Seleznev, A.V. Kuroyedov, A.Yu. Brezhnev

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Factors associated with occupational injuries among bricklayers and carpenters in Building Construction: insights from a mixed methods study in Osun State, Nigeria by Temitope Olumuyiwa Ojo, Adedeji Ayodeji Onayade, Nisha Naicker

“…Factors associated with OI among bricklayers included being aged 20–39 years (AOR:6.9, 95% CI:3.1–15.3) and 40–59 years (AOR:2.9, 95% CI:1.5–5.6), earning less than N50,000 (US$67) monthly (OR:2.3, 95% CI:1.2–4.7), earning N50,000-N99,000 (US$67-US$133) monthly (AOR:2.5, 95% CI: 1.2–5.2), and handling ≥ 200 kg per day at work (AOR:2.1, 95% CI:1.3–3.5). …”
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Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study by Jong Ho Kim, Sang Soo Kim, In Joo Kim, Bo Hyun Kim, Ja Young Park, Chang Won Lee, Ji Hye Suk, Sun Hae Shin, Sung Pyo Son, Min Chul Kim, Jun Hyeob Ahn, Kwang Jae Lee, Min Jung Kwon, Soon Hee Lee, Jeong Hyun Park

“…A univariate analysis revealed that maximal baPWV was significantly associated with both the ACR (r=0.297, P<0.001) and eGFR (r=−0.220, P<0.001). A multivariate analysis adjusted for significant clinical variables and eGFR showed that baPWV remained significantly correlated with the ACR (r=0.150, P<0.001). …”
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Безпечність токолітичної терапії в різних гестаційних термінах by S.S. Leush, D.О. Govsіeіev, O.S. Zahorodnia

“…Протягом тижня після токолізу гексопреналіном понад 48 год у групах ЕПП і РПП вижили відповідно 80,0% і 90,9% новонароджених, після токолізу ніфедипіном - відповідно 66,7% і 92,9%. У групі ЕПП виживання після гексопреналіну становило 80,0%, ніфедипіну - 66,7%. …”
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Extracellular matrix turnover in severe COVID-19 is reduced by corticosteroids by Janesh Pillay, Antine W. Flikweert, Matijs van Meurs, Marco J. Grootenboers, Simone van der Sar-van der Brugge, Peter H. J. van der Voort, Morten A. Karsdal, Jannie M. B. Sand, Diana J. Leeming, Janette K. Burgess, Jill Moser

“…Abstract Background Severe and critical COVID-19 is characterized by pulmonary viral infection with SARS-CoV-2 resulting in local and systemic inflammation. …”
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Comparative Evaluation of Different Mint Species Based on Their In Vitro Antioxidant and Antibacterial Effect by Ameni Sfaxi, Szilvia Tavaszi-Sárosi, Kovács Flórián, Katalin Patonay, Péter Radácsi, Ákos Juhász

“…The least effective oil in the case of Gram-negative bacteria was bergamot mint (inhibition zone: 7.67–8.67 mm, MIC: 2.00, >2.00 <i>v</i>/<i>v</i>%, IC₅₀: 0.11–0.25 <i>v</i>/<i>v</i>%, MBC: 2.00, >2.00 <i>v</i>/<i>v</i>%), while in the case of Gram-positive bacteria, oils containing dihydrocarvone as the main compound possessed the weakest antibacterial effect (inhibition zone: 9.00–10.00 mm, MIC: 1.00–2.00 <i>v</i>/<i>v</i>%, IC₅₀: 0.22–0.37 <i>v</i>/<i>v</i>%, MBC: >2.00 <i>v</i>/<i>v</i>%). …”
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Structural, magnetic, and optical characteristics of undoped and chromium, iron, cobalt, copper, and zinc doped nickel oxide nanopowders by Farzaneh Asaldoust, Khosro Mabhouti, Akbar Jafari, Maryam Taleb-Abbasi

“…In this regard, the preparation of pristine NiO and Ni0.95 × 0.05O (X = Cr, Fe, Co, Cu, and Zn) powders was successfully achieved through the co-precipitation method. …”
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Game-thinking; utilizing serious games and gamification in nursing education – a systematic review and meta-analysis by Mats Nylén-Eriksen, Marko Stojiljkovic, Daniela Lillekroken, Katrin Lindeflaten, Elisabeth Hessevaagbakke, Tone Nygaard Flølo, Olav Johannes Hovland, Ada Marie Svarstad Solberg, Sylvia Hansen, Ann Kristin Bjørnnes, Christine Tørris

“…The meta-analysis suggested that game-thinking could be beneficial in nursing education, notably improving students’ academic achievement (Pooled ES = 0.99, [95%CI 0.53, 1.44]). The most significant effect of game-thinking on academic achievement was observed in the academic knowledge performance of nursing students (Pooled ES = 1.06, [95%CI 0.55, 1.57]), followed by academic skill performance (Pooled ES = 0.54, [95%CI 0.06, 1.03]). …”
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A Novel, Patient-Specific Mathematical Pathology Approach for Assessment of Surgical Volume: Application to Ductal Carcinoma in situ of The Breast by Mary E. Edgerton, Yao-Li Chuang, Paul Macklin, Wei Yang, Elaine L. Bearer, Vittorio Cristini

“…We then corroborated our hypothesis by comparing the predicted size of each tumor based on our model with the actual size of the pathological specimen after tumor excision (R2 = 0.74—0.88). In addition, for the 17 cases studied, both histological grade and mammography were not found to correlate with tumor size (R2 = 0.08—0.47). …”
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