Randomised controlled trial of topical kanuka honey for the treatment of rosacea by James Fingleton, Mark Weatherall, Richard Beasley, Irene Braithwaite, Janwillem Kocks, Mark Holliday, Andrew Corin, Colin Helm, Davitt Sheahan, Barney Montgomery, Judith Riley, Anna Hunt, Christopher Tofield

“…The VAS-CS at week 2 was 9.1 (95% CI 3.5 to 14.7), p=0.002, and at week 8 was 12.3 (95% CI 5.7 to 18.9)¸ p<0.001 for Honevo compared to control.Conclusions Honevo is an effective treatment for rosacea.Trial registration number This trial was registered in the Australian and New Zealand Clinical Trials Registry ACTRN12614000004662.…”
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肝动脉灌注氟尿苷优化结直肠癌肝转移患者的化疗方案的探索性研究

“…【目的】 评价mFOLFOX全身化疗的基础上联合肝动脉灌注氟尿苷(FUDR)治疗不可手术切除的结直肠癌肝转移患者的临床疗效和安全性【方法】 2006年 7月至2010年5月,入组48例患者行DSA导引下的经皮肝动脉药盒植入,导管头端置于肝固有动脉,每日用FUDR 0.1 ~ 0.2 mg/kg,同时加入地塞米松2 mg,持续经药盒泵入肝动脉灌注14 d;奥沙利铂85 mg/m2,静滴2 h,第115天;亚叶酸钙200 mg/m2,静滴2 h,第115天;5-氟尿嘧啶1400 mg/m2,持续静滴22 h,第1,15天;每28天重复化疗方案按美国癌症研究所常见毒性判定标准3.0版评价不良反应每2个治疗周期后按实体瘤的疗效评价标准(RECIST)评价客观疗效,并按照同时性或异时性肝转移既往化疗史,动脉灌注FUDR的剂量进行分层分析【结果】可评价疗效的48例患者均接受大于1周期的联合化疗,中位随访13个月后,全组病例的CR 0例,PR 36例(75%),SD 9例(18.7%)各分层亚组的客观有效率均大于63%(63%~85%)其中12例(25%)患者转化为可手术切除和/或接受局部射频消融治疗病例中常见不良反应为1~2度的血小板减少,白细胞减少,恶心呕吐和腹泻,外周感觉神经毒性;Ⅲ级不良反应发生率8.3%治疗过程中病情未进展的45例患者生活质量得到改善(P < 0.01)【结论】 mFOLFOX全身化疗联合肝动脉灌注FUDR治疗不可手术切除的结直肠癌肝转移患者疗效确切, 具有较高的客观有效率,不良反应可耐受, 能保障患者的生活质量,是值得推广验证的新联合化疗方案…”
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Effect of daily alcohol intake on sex hormone levels among postmenopausal breast cancer survivors on aromatase inhibitor therapy: a randomized controlled crossover pilot study by Elizabeth Mostofsky, Julie E. Buring, Steven E. Come, Nadine M. Tung, Cancan Zhang, Kenneth J. Mukamal

“…Compared to daily grape juice, daily wine led to decreases in total estradiol (11.1%, 95%confidence interval[CI] -49.8%,57.2%), free estradiol index (0.7%, 95%CI -2%,0.7%), and free estradiol concentration (7.7%, 95%CI -48%, 63.9%) but increases in estrone (13.8%, 95%CI -9.5%,43.1%), dehydroepiandrosterone sulfate (DHEAS; 11.4%, 95%CI -3.3%,28.4%), and testosterone (12.6%, 95%CI -0.8%,27.7%) and decreased sex hormone-binding globulin (SHBG; -2.7%, 95%CI -21.9%,21.2%). …”
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Synthesis of acrylonitrile functionalized hydroxymethylfurfural derivatives with Mg(OH)$_{{2}}$ under solvent-free conditions by Mancipe, Sonia, Coca, Valentina, Castillo, Juan-Carlos, Rojas, Hugo, Brijaldo, María Helena, Castañeda, Claudia, Martínez, José Jobanny, Romanelli, Gustavo Pablo

“…Hydroxymethylfurfural (HMF) derivatives that contain an acrylonitrile group result in interesting scaffold molecules that can be obtained from biomass. However, the synthesis of these types of molecules has not been extensively studied. …”
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Efforts to strengthen anatomic pathology diagnostic services for cancer in sub-Saharan Africa: a scoping review protocol by Katherine Van Loon, Elia John Mmbaga, Marcia Edelweiss, Dianna L. Ng, Asteria Herman Kimambo, Edda Vuhahula, Beatrice Paul Mushi, Omolade Adegoke, Johanna Goldberg, Pendo M. Ibrahim, Zainab Illonga, Julia Jackman, Luisa Jamisse

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Coupling genome-wide continuous perturbation with biosensor screening reveals the potential targets in yeast isopentanol synthesis network by Qi Xiao, Jingjing Shi, Lixian Wang, Guoping Zhao, Yanfei Zhang

“…In addition, we validated the knockout or overexpression of key co-DEGs. Our results confirmed the critical roles of HOM3 and DIP5 in isopentanol production, along with genes associated with the aerobic respiratory chain (SDH3, CYT1, COX7, ROX1, and ATG41) and cofactor balance (BNA2 and NDE1). …”
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Semaglutide and laparoscopic sleeve gastrectomy in an adolescent with congenital adrenal hyperplasia due to 21-hydroxylase: a case report by Alaina P. Vidmar, Linus Kaiser, Matthew J. Martin, Stuart Abel, Aimee G. Kim, Madeleine Weitzner, Cynthia E. Muñoz, Lynda K. Fisher, Mimi S. Kim, Kamran Samakar

“…Owing to ongoing metabolic dysregulation, he underwent laparoscopic sleeve gastrectomy at the age of 17 years. The surgery was well tolerated, with careful intraoperative glucocorticoid management. …”
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Evaluating the efficacy of carbetocin versus oxytocin for preventing intraoperative blood loss, early postpartum hemorrhage, and maintaining a favorable hemodynamic profile in lowe... by Bisma Fayaz, Raja Suhail Shounthoo, Ajaiz Rasool, Saima Wani, Showkat Ahmad Gurcoo

“…Results: On comparing the data between carbetocin group and oxytocin group, the carbetocin group had less incidence of hypotension and tachycardia (P<0.001), less intraoperative blood loss (Group C: Group O, mean±SD mL; 328.7±72.59:435.9±99.08 [P<0.001]), and minimal use of additional uterotonic agents (P<0.001); however, the requirement of blood transfusion was comparable between the two groups (P=0.157). …”
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Association of Genetic Variants of KCNJ11 and KCNQ1 Genes with Risk of Type 2 Diabetes Mellitus (T2DM) in the Indian Population: A Case-Control Study by Vasiuddin Khan, Amit Kumar Verma, Deepti Bhatt, Shahbaz Khan, Rameez Hasan, Yamini Goyal, Sowmya Ramachandran, Mohammed A. Alsahli, Arshad Husain Rahmani, Ahmad Almatroudi, M. Y. Shareef, Babita Meena, Kapil Dev

“…KCNJ11 rs5210 and KCNQ1 rs2237895 variants were found to be significantly associated with risk of T2DM in dominant (KCNJ11: OR, 2.07; 95% CI, 1.30–3.27; p−0.001; KCNQ1: OR, 2.33; 95% CI, 1.46–3.70; p−0.0003) and codominant models (KCNJ11: OR, 1.76; 95% CI, 1.09–2.84; p−0.020; KCNQ1: OR, 1.85; 95% CI, 1.16–2.95; p−0.009). …”
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Effect of Traditional Process Methods on the Physicochemical and Functional Properties of a Traditional Food Salt (Nikkih) Obtained from Waste Biomass Peels of Musa paradisiaca and... by Pride Ndasi Ngwasiri, Vivian Akah Adanmengwi, Wilson Agwanande Ambindei, Noumo Thierry Ngangmou, Dobgima John Fonmboh, Ngwa Martine Ngwabie, Martin Benoit Ngassoum, Ejoh Richard Aba

“…Alkaline content ranged from 61.7 ± 0.141% to 52.8 ± 0.141%, with boiled M. acuminate combusted at 3500C having the highest value and the lowest from raw M. paradisiaca combusted at 2500C. …”
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Оцінювання ефективності фізичних вправ для ліквідації діастазу прямих м’язів живота в жінок у постпартумі... by N.M. Kinash, I.V. Levytskyi, I.V. Kravchuk, D.S. Martyniuk

“…У жінок обох груп у термін 7-8 місяців після пологів спостерігали статистично значуще зменшення ширини білої лінії. …”
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A Green Approach to Landfill Remediation: The Efficacy of Indigenous Zygophyllum coccineum L. and Leptadenia pyrotechnica L. in Phytoremediating a Heavy Oil Flay Ash-contaminated L... by Samir G.M. Al-Solaimani, Abdulrahman Alkurashi, Refaat A. Abohassan, Omer H.M. Ibrahim, Magdi A.A. Mousa

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Effects of music training on executive functions in preschool children aged 3–6 years: systematic review and meta-analysis by Yanan Lu, Lin Shi, Lin Shi, Ahmad Faudzi Musib

“…Significant improvements were seen for working memory following music training having a duration of ≥12 weeks (SMD = 0.42, 95% CI: 0.18–0.65), occurring &lt;3 times per week (SMD = 0.49, 95% CI: 0.06–0.93), occurring ≥3 times per week (SMD = 0.28, 95% CI:0.1–0.47), and lasting 20–30 min per session (SMD = 0.39, 95% CI: 0.16–0.54). …”
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Investigating the impact of oligo-chitosan on the growth dynamics and yield traits of Oryza sativa L. ‘BRRI dhan29’ under subtropical conditions by Afrina Rahman, Rayhan Ahammed, Jayanta Roy, Md Liton Mia, Mohammad Abdul Kader, Mubarak A. Khan, Md Harun Rashid, Uttam Kumer Sarker, Md Romij Uddin, Md Shafiqul Islam

“…In vegetative characters, the highest plant height became (87.3 cm), number of tiller hill−1 (13.7), Total dry matter (12.9), leaf area index (1.35), and chlorophyll content (57.73). …”
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Reference values for the 1-minute sit-to-stand test to assess functional capacity and short-term mortality in people with idiopathic pulmonary fibrosis and fibrotic connective tiss... by Meng-Yun Tsai, Kuo-Tung Huang, Chiann-Yi Hsu, Yi-Hsuan Yu, Pin-Kuei Fu

“…Results Of the 150 F-ILD patients, 37 (24.6%) had idiopathic pulmonary fibrosis (IPF), and 113 (75.4%) had connective tissue disease-related ILD (CTD-ILD). …”
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Plastome data provides new insights into population differentiation and evolution of Ginkgo in the Sichuan Basin of China by Liyun Nie, Fangling Liu, Meixia Wang, Zhuying Jiang, Jiali Kong, Luke R. Tembrock, Shenglong Kan, Penghao Wang, Jie Wang, Zhiqiang Wu, Xiaoli Liu

“…While nuclear genomic studies have revealed population structure across China, the evolutionary patterns reflected in maternally inherited plastomes remain unclear, particularly in the Sichuan Basin - a potential glacial refugium that may have played a crucial role in Ginkgo’s persistence. Results Analysis of 227 complete plastomes, including 81 newly sampled individuals from the Sichuan Basin, revealed three distinct maternal lineages differing from known nuclear genome patterns. …”
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Changes in Uterine Cancer Incidence Rates in Egypt by Saad Alshahrani, Amr S. Soliman, Ahmed Hablas, Mohamed Ramadan, Jane L. Meza, Steven Remmenga, Ibrahim A. Seifeldein, Robert M. Chamberlain

“…The crude rate (CR) was 1.95, 95% CI (1.64–2.25) in 1999–2002; 2.9, 95% CI (2.5–3.2) in 2003–2006; and 3.5, 95% CI (3.1–3.9) in 2007–2010. …”
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The Effect of Intravascular Imaging-Guided Percutaneous Coronary Intervention on Coronary Artery Perforation by Yuichi Sawayama, MD, Kenta Sasaki, MD, Narumi Taninobu, MD, Akihiro Ikuta, MD, Kohei Osakada, MD, Shunsuke Kubo, MD, Takeshi Tada, MD, Yasushi Fuku, MD, Hiroyuki Tanaka, MD, Yoshihisa Nakagawa, MD, Kazushige Kadota, MD

“…IVI-guided PCI showed a significant association with a lower risk of the overall incidence of CAP (adjusted OR: 0.78; 95% CI: 0.61-0.99; P = 0.047). …”
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Influence of Synthesis Conditions on the Capacitance Performance of Hydrothermally Prepared MnO₂ for Carbon Xerogel-Based Solid-State Supercapacitors by Vania Ilcheva, Victor Boev, Mariela Dimitrova, Borislava Mladenova, Daniela Karashanova, Elefteria Lefterova, Natalia Rey-Raap, Ana Arenillas, Antonia Stoyanova

“…The sample obtained at 160 °C exhibited the highest specific surface area (approximately 157 m²/g). …”
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Urinary NGAL and RBP Are Biomarkers of Normoalbuminuric Renal Insufficiency in Type 2 Diabetes Mellitus by Aimei Li, Bin Yi, Yan Liu, Jianwen Wang, Qing Dai, Yuxi Huang, Yan Chun Li, Hao Zhang

“…The patients were classified into two groups, NO-CKD (eGFR≥60 ml/min per 1.73 m2, n=165) and NA-DKD (eGFR<60 ml/min per 1.73 m2, n=44). …”
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