Immune dysfunction revealed by digital spatial profiling of immuno-oncology markers in progressive stages of renal cell carcinoma and in brain metastases by Wei Wei, Michael Hurwitz, Sabina Signoretti, Lucia Jilaveanu, Toni K Choueiri, David L Rimm, Adebowale Adeniran, Sandra Martínez, Harriet M Kluger, David A Schoenfeld, Myrto Moutafi, Dijana Djureinovic, Ross D Merkin, David A Braun, Fabio Parisi

“…We profiled 76 primary tumors, 27 adjacent histologically normal kidney samples, and 86 metastases, including 24 brain metastases.Results We observed lower immune checkpoint (TIM-3 and CTLA-4), cytolytic (GZMA and GZMB), and T cell activation (CD25) protein expression in metastases compared with primary tumors in two separate cohorts. …”
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SPEC Process III. Synthesis of a Macroporous Silica-Based Crown Ether-Impregnated Polymeric Composite Modified with 1-Octanol and its Adsorption Capacity for Sr(II) Ions and Some Typical Co-Existent Metal Ions by Anyun Zhang, Chunmei Chen, Zhifang Chai, Mikio Kumagai

“…The adsorption of some fission and non-fission products contained in highly active liquid waste (HLW) such as Ru(III), Mo(VI), Pd(II), Na(I), K(I), Cs(I), Sr(II), Ba(II), La(III) and Y(III) onto (DtBuCH18C6 + Oct)/SiO 2 -P was investigated at 298 K. …”
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Caracterización de accesiones de garbanzo (Cicer arietinum L.) mediante descriptores morfo agronómicos cuantitativos en una colección del Banco de Germoplasma de la Universidad Nac... by Veronika CASTILLO, N. COLLAVINO, E. FARFAN, J. CARRERAS, A. FEKETE, M. POCOVI

“…La caracterización de las accesiones se realizó sobre cinco plantas, evaluando 17 descriptores morfo agronómicos. Los resultados de los estadísticos simples revelaron que las variables número de vainas por planta y peso de 100 semillas presentaron valores altos de CV. …”
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Modelling of structural, mechanical, electronic, and optical properties of Rb2TlXF6 (X = Ir, Rh) double perovskite compounds through density functional theory by Wasi Ullah, Nasir Rahman, Mudasser Husain, Wafa Mohammed Almalki, Khamael M. Abualnaja, Ghaida Alosaimi, Soufyane Belhachi, Bashar.M. Al-Khamiseh, Vineet Tirth, Ahmed Azzouz-Rached, Hanan A. Althobaiti, Farooq Ali

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Effects of Nitrate Stress on Physiological and Biochemical Characteristics of Canna generalis Bailey at Seedling Stage by Zhaohu GU, Shuxin ZHAO, Wenwei WU, Huini XU, Kunzhi LI

“…【Result】After treatment with 0 (CK), 10, 50, 100 and 150 mmol/L nitrate solutions for 5 weeks, the total nitrate uptake amounts of Canna generalis Bailey was 0, 411.7, 676.9, 554.6 and 516.4 mg/plant, the plant height increased by -0.27, 5.25, 4.25, 0.05 and -10.32 cm, and the fresh weight increased by 10.3, 32.7, 31.6, 20.3 and -11.0 g/plant, respectively. …”
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ASPECTOS PSICOJURÍDICOS DA SÍNDROME ALCOÓLICA FETAL by Eduardo Jorge Sant'Ana Honorato, Dalila Azevedo da Silva, Eunice Braga Borges dos Santos, Alice Sobral, Daniel Cerdeira de Sousa

“…Este estudo teve como objetivo realizar uma reflexão a cerca dos aspectos psicológicos e jurídicos da Síndrome Alcoólica Fetal – SAF com a intenção de construir um artigo científico. …”
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The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis by Peiye Zhu, Yunrui Jin, Jiya Sun, Xia Zhou

“…However, no significant difference was observed in improving interleukin-6 levels (SMD = -1.35, 95%CI(-2.75, -0.05), P = 0.06; Level of evidence: very low), tumor necrosis factor α levels (SMD = -3.30, 95%CI(-7.47, 0.87), P = 0.12; Level of evidence: very low), superoxide dismutase levels (SMD = 0.39, 95%CI(-0.26, 1.04), P = 0.24; Level of evidence: very low), total antioxidant capacity levels (SMD = 0.39, 95%CI(-0.23, 1.00), P = 0.21; Level of evidence: very low) and malondialdehyde levels (SMD = -3.36, 95%CI(-10.30, 3.09), P = 0.29; Level of evidence: very low).ConclusionResveratrol improved inflammation and oxidative stress in T2DM patients to some extent. …”
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Nutrition and Antioxidant Potential of Three Cauliflower (Brassica oleracea L. Var. Botrytis) Cultivars Cultivated in Southern Part of Bangladesh by Mousumi Jahan Sumi, Sharmin Akter Serity, Tusar Kanti Roy, Keya Akter, Shishir Rasul, Mostofa Jaman Depro, Md. Masum Abdullah, Md. Nesar Uddin

“…This study aimed to evaluate the biochemical and nutritional profiles of three cauliflower cultivars—Valentena, Carotena, and Snow White—focusing on chlorophyll, carotenoids, anthocyanins, vitamin C, flavonoids, phenolics, and antioxidant activity. …”
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Prevalence, Characterization, and Proteomic Relatedness Among β-Lactam-Resistant Bacteria Throughout the Poultry Production Chain in Greece by Anestis Tsitsos, Alexandros Damianos, Konstantinos Kiskinis, Vasilios Tsiouris, Ilias Tirodimos, Nikolaos Soultos, Anna Papa, Vangelis Economou

“…The prevalence of <i>Acinetobacter</i> spp. and <i>E. coli</i> on farmers’ skin was 16.7% (n = 2 strains) and 8.3% (n = 1 strain), correspondingly. …”
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Ultrasound-guided vs. fluoroscopy-guided percutaneous leverage reduction for severely displaced radial neck fractures in children: a comparative analysis of clinical and radiologic... by Xing Wu, Jingdong Xia, Xiongtao Li, Xiaoliang Chen, Si Wang, Xiantao Shen

“…Additionally, the US group had a significantly lower number of FL images and radiation dose (3.59 ± 1.57 times, 9.56 ± 6.08 mGy) than the FL group (22.26 ± 8.07 times, 69.68 ± 34.70 mGy; P < 0.001). …”
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A Comparison of hs-CRP Levels in New Diabetes Groups Diagnosed Based on FPG, 2-hPG, or HbA1c Criteria by Yildiz Tutuncu, Ilhan Satman, Selda Celik, Nevin Dinccag, Kubilay Karsidag, Aysegul Telci, Sema Genc, Halim Issever, Jaakko Tuomilehto, Beyhan Omer

“…In HbA1c, 2-hPG, and FPG based new-onset DM people, cut-off levels of hs-CRP in women were 2.9, 2.1, and 2.5 mg/L [27.5, 19.7, and 23.5 nmol/L] and corresponding values in men were 2.0, 1.8, and 1.8 mg/L (19.0, 16.9, and 16.9 nmol/L), respectively (sensitivity 60–65% and specificity 54–64%). …”
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CLEC11A-Driven Molecular Mechanisms in Intervertebral Disc Degeneration: A Comprehensive Multi-Omics Study by Jiang N, Wang Q, Hu Z, Tian X

“…Mediation MR analysis further indicated that CLEC11A might significantly elevate IVDD risk by upregulating the inflammatory mediator ARTN and the uncharacterized serum metabolites X-12731 and X-18901 (ARTN: OR=1.078, 95% CI: 1.004– 1.158, P=0.038; X-12731: OR=0.906, 95% CI: 0.852– 0.960, P=0.043; X-18901: OR=1.090, 95% CI: 1.007– 1.179, P=0.034). …”
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Exploring the relationship between established HIV risk factors and depressive symptoms amongst young women without HIV in two sites in South Africa. by Zanenhlanhla Gumbi, Celia Mehou-Loko, Lindi Masson, Makhosazana Mdladla, Nokuthula Maphumulo, Jo-Ann Passmore, Sanele Mbeje, Linda Gail Bekker, Disebo Potloane, Heather Jaspan, Nina Radzey, Andrea Abrahams, Rushil Harryparsad, Pamela Mkhize, Hilton Humphries

“…<h4>Results</h4>The cohort consisted of 274 adolescent girls, 38.6% from the WC site and 61.4% from the KZN site. Overall, 15.7% (43/274) of AGYW reported depressive symptoms. …”
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Co-obligate symbioses have repeatedly evolved across aphids, but partner identity and nutritional contributions vary across lineages by Manzano-Marín, Alejandro, Coeur d’acier, Armelle, Clamens, Anne-Laure, Cruaud, Corinne, Barbe, Valérie, Jousselin, Emmanuelle

“…Lastly, patterns of Buchnera genome evolution reveal that small losses affecting a few key genes can be the onset of these dual systems, while large gene losses can occur without any co-obligate symbiont acquisition. …”
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Psychometric properties of the Iranian version of the polycystic ovary syndrome quality of life questionnaire for married and unmarried women with PCOS: PCOSQoL-47 and PCOSQoL-42 by Fatemeh Bazarganipour, Seyed Abdolvahab Taghavi, Ali Montazeri, Fazlollah Ahmadi, Zahra Derakhshideh, Zahra Asadikalameh

“…Following the linguistic validation of the Iranian adaptation of the PCOSQoL-47 and PCOSQoL-42, a panel of experts reviewed the items through an evaluation of the content validity index (CVI) and content validity ratio (CVR). …”
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Structural and iron content changes in subcortical vascular mild cognitive impairment: a combined voxel-based morphometry and quantitative susceptibility mapping study by Yushuang Liu, Yingqi Lu, Liyu Hu, Jinping Xu, Xingchen Liu, Nan Yang, Shangjie Chen, Zhongling Zhang

“…In addition, the susceptibility in left middle cingulate cortex and paracingulate gyrus was positively correlated associated with MoCA scores (r = 0.538 p < 0.001), and the susceptibility in the right middle frontal gyrus was negatively correlated with MoCA scores (r = -0.418 p < 0.007). …”
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Major Adverse Cardiovascular Events in Primary Aldosteronism After Adrenalectomy or Mineralocorticoid Receptor Antagonist Treatment: A Systematic Review and Meta‐Analysis by Chien‐Wei Huang, Tse‐Ying Huang, Ya‐Fei Yang, Li‐Yang Chang, Yu‐Kang Tu, Vin‐Cent Wu, Jui‐Yi Chen

“…Patients with PA after adrenalectomy had a lower MACE incidence rate (2.00/100 patient‐years [95% CI, 1.40–2.60]) compared with those undergoing MRA treatment (3.30/100 patient‐years [95% CI, 2.40–4.10], P=0.017). …”
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Predicting the reduction in heatstroke and heart disease-related mortality under urban modification scenarios using machine learning by Yukitaka Ohashi, Ko Nakajima, Yuya Takane, Yukihiro Kikegawa, Tomohiko Ihara, Kazutaka Oka

“…The results showed that in July–August 2018, the ground surface greening case effectively decreased the outdoor surface air temperature by 0.28 °C (50-percentile), 0.37 °C (90-percentile), and 0.56 °C (Max) in all grids resolved at 1 km. …”
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Pathomorphological features of the proximal femur in crowe IV hips and their implication on stem selection during total hip arthroplasty by Kaveh Gharanizadeh, Elham Mohammadyahya, Mohammad Reza Bahaeddini, Shayan Amiri, Sajad Noori Gravand, Sepideh Pezeshki, Amir Aminian, Arvin Eslami, Hamed Tayyebi, Mansour Abolghasemian

“…The LT base width index was larger in the case group (P < 0.001). CFI was smaller at the LT level in dysplastic hips (P < 0.001), but the values were similar with a cut 1.5 cm above the LT (P = 0.67). …”
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Turismo e infraestructura urbana: la refuncionalización de la estación del ferrocarril de Gualeguaychú como atractivo turístico by Diego Kuper, Rodolfo Bertoncello

“…Las tendencias actuales del turismo se asocian con la valorización de los más diversos atractivos y, de esta forma, provocan la multiplicación de lugares de destino turístico. …”
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