Real-world data of dacomitinib as first-line treatment for patients with EGFR-mutant non-small-cell lung cancer by Ji Eun Shin, Hyun Ae Jung, Sehhoon Park, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Byoung Yong Shim

“…The median follow-up duration was 16.9 months, with a median PFS of 16.7 months (95% CI, 14.4 to 25.2). Based on the type of EGFR mutation, the median PFS was 18.1 months (95% CI, 14.5 to NE) in patients with exon 19 deletion, and 15.9 months (95% CI, 12.5 to NE) in patients with L858R mutation. …”
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Incidence, trends and patterns of female breast, cervical, colorectal and prostate cancers in Antigua and Barbuda, 2017–2021: a retrospective study by Andre A. N. Bovell, Thendo Ramaliba, Sekeena O. Goodwin, Joycelyn C. Phillip, Jabulani Ncayiyana, Themba G. Ginindza

“…Overall mean age at presentation was 61.5 (± 12.9) years, ranging from 24 to 94 years, age-standardized incidence rate 65.2 (95% CI: 58.7–71.6) per 100,000 population. Age-standardized incidence rate for female breast cancer was 49.9 (95% CI: 42.2–57.8), annual percentage change in incidence a low of -0.2%. …”
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Optimizing risk in action: Differences between fixated aim points and movement outcomes in throwing by Stephan Zahno, Damian Beck, Ralf Kredel, André Klostermann, Ernst-Joachim Hossner

“…Trends in Cognitive Sciences, 12(8), 291–297. https://doi.org/10.1016/j.tics.2008.04.010 …”
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间充质干细胞抑制MEK/ERK信号通路改善盲肠结扎穿孔所致急性肺损伤中肺泡Ⅱ型上皮细胞的凋亡

“…摘 要: 【目的】 研究间充质干细胞(MSC)可通过抑制MEK/ERK信号通路改善脓毒症所致急性肺损伤(ALI)中肺泡Ⅱ型上皮细胞(AECⅡ)凋亡水平? 【方法】 本研究取30只balb/c雄性小鼠,随机抽取其中20只通过盲肠结扎穿孔(CLP)建立小鼠脓毒症所致急性肺损伤的模型,CLP术后6h随机分成2组,每组10只,通过尾静脉分别注射间充质干细胞(MSC)?…”
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The Role of Prosocial (Politicized) Identity and Prejudice in Collective Action Intentions to Help Women and Men Suffered from Domestic Violence by O.A. Ananyeva, I.S. Prusova

“…</strong> Adapted to Russian scales of the in-group identification developed by C. Leach, the ambivalent sexism and ambivalence towards men inventories by P. …”
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Date pomace polysaccharides-capped selenium nanoparticles: Biosynthesis, optimization, physicochemical characterization, biological activities, stability and gut microbiota modulation by Gafar Babatunde Bamigbade, Athira Subhash, Mohammed Abdin, Hebah Jarusheh, Basim Abu-Jdayil, Shao-Quan Liu, Giovanni Palmisano, Abdelmoneim Ali, Afaf Kamal Eldin, Mutamed Ayyash

“…The MPS-NPS were well-stabilized, spherical particles averaging 65.4 nm in size, with PDI (0.032), zeta potential (–21.07 mV) and notable antioxidant activity (82.7 % DPPH, 68.9 % ABTS, 491.0 µg/mL FRAP, and 961.2 µg/mL TAC at 100 mg/L). …”
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NKAPL facilitates transcription pause-release and bridges elongation to initiation during meiosis exit by Zhenlong Kang, Chen Xu, Shuai Lu, Jie Gong, Ruoyu Yan, Gan Luo, Yuanyuan Wang, Qing He, Yifei Wu, Yitong Yan, Baomei Qian, Shenglin Han, Zhiwen Bu, Jinwen Zhang, Xian Xia, Liang Chen, Zhibin Hu, Mingyan Lin, Zheng Sun, Yayun Gu, Lan Ye

“…NKAPL binds to promoter-associated nascent transcripts and co-localizes with DNA-RNA hybrid R-loop structures at GAA-rich loci to enhance R-loop formation and facilitate Pol II pause-release. …”
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北方汉族31个X染色体短串联重复片段突变及遗传多态性研究 by 徐妍, 刘岩, 郝世诚, 张金佩, 刘革新, 陶玉婷, 王显众, 袁丽

“…平均排除概率在三联体和二联体中分别为0.312 7-0.912 4、0.193 5-0.844 6。累积平均排除概率在三联体和二联体中分别为1-2.281 9×10^-17、1-2.509 0×10^-12。…”
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Оптимизация параметров биобаллистики для трансформации мягкой пшеницы Triticum aestivum L. линии Велют by Нестеров М.А., Киселёва А.А., Тимонова Е.М., Сергеева Е.М., Салина Е.А.

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“Subtype-precise” therapy leads diagnostic and therapeutic innovations: a new pattern for precision treatment of breast cancer by ZHANG Siwei, MA Ding, JIANG Yizhou, SHAO Zhimin

“…They deeply analyzed the molecular characteristics of TNBC, leading to the development of a “Fudan subtype” closely related to clinical outcomes: luminal androgen receptor subtype (LAR), which can be targeted with anti-HER2 and CDK4/6 inhibitors; the immunomodulatory subtype (IM), suitable for immunotherapy; basal-like immune-suppressed subtype (BLIS), which can be treated with platinum-based drugs or poly (ADP-ribose) polymerase (PARP) inhibitors; and mesenchymal-like subtype (MES), which can be treated with anti-cancer stem cell and anti-angiogenic therapies. …”
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Mutational Landscape of Bone Marrow CD19 and CD138 Cells in Waldenström Macroglobulinemia (WM) and IgM Monoclonal Gammopathy of Undetermined Significance (IgM MGUS) by Alessandra Trojani, Alessandro Beghini, Luca Emanuele Bossi, Marta Rachele Stefanucci, Cassandra Palumbo, Antonino Greco, Annamaria Frustaci, Barbara Di Camillo, Roberto Cairoli

“…Moreover, sequencing evaluation revealed recurrently frameshift or missense mutations involving NFKB2 (L473Afs) in 60% of IgM MGUS and 20% of WM/sWM, PTPN13 (P1546Tfs) in 20% of IgM MGUS and 7% of WM/sWM, CARD11 (S622del) in 20% of IgM MGUS and 20% of WM/sWM, KMT2C (I823T) in all IgM MGUS and 93% of WM/sWM, and ATM in 20% of IgM MGUS and 47% of WM/sWM patients. …”
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Perioperative SARS-CoV-2 Infection in Patients Undergoing Elective Surgery in Gynecology Clinic: Tertiary Center Experience by Gulnihal Reyhan Toptas, Eylem Unlubilgin, Tugba Kinay, Ali Riza Dogan, Mehmet Akif Akgul, Sitare Aslanova, Emel Ebru Ercan, Vakkas Korkmaz, Sezin Erturk Aksakal, Yaprak Ustun

“… OBJECTIVE: The objective of this study was to determine the incidence of perioperative “severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)” infection among women, operated during Coronavirus disease-2019 (COVID-19) era. …”
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Vaccine Prophylaxis of Pneumococcal Infections in Children under Conditions of Severe Flood in the Amur River Basin by Aleksandr G. Chuchalin, Gennadiy G. Onishchenko, Victor P. Kolosov, Olga P. Kurganova, Tatiana A. Zaitseva, Leonid G. Manakov, Galina N. Kholodok, Juliy M. Perelman, Roman S. Kozlov, Natalia M. Ivakhnishina, Olga E. Trotsenko, Albina P. Bondarenko

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How does the ground reaction force affect the 6 second sprint performance? by Baris Gurol, İlker Yılmaz, İzzet Kırkaya

“…Different loads of GRF have been analysed for seeing effect of the increasing ground reaction force. 8 female sportswomen (age=24.7±6.2year; body weight=61.27±8.79kg; height=172.4±11.37m) of Anadolu University Youth and Sport Club that competes in the second division of Turkey Women’s Basketball participated in this study. 6s. sprint kinematical analysis of the participants was made with two fast filming cameras (A602f, Basler, Germany) that are able to record up to 500 Hz and a software program (SIMI 7.3, Germany) that is able to record the scenes simultaneously into computer in 60 Hz. …”
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Randomized controlled trial on effect of different routes of dexmedetomidine on Haemodynamics in patients undergoing saphenectomy under epidural anaesthesia by Sisi Zeng, Jixiang Wan, Xuechao Li, Na Wang, Jiabei Li, Luyue Gao, Zhen Yang, Fangjun Wang

“…Compared with those in the NS group, the SBP at T3 − 7 and DBP at T4 − 5,7 were significantly lower in the ED group (P = 0.008, 0.001, 0.001, 0.001, 0.038 and P = 0.017, 0.006, 0.044, respectively), and the SBP and DBP at T1 − 8 were lower in the VD group (P < 0.001, 0.001, 0.001, 0.001, 0.004 and P < 0.001, 0.001, 0.001, 0.002, 0.001, 0.001, 0.001, 0.036, respectively). …”
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Development and Validation of a Machine Learning Model for the Prediction of Bloodstream Infections in Patients with Hematological Malignancies and Febrile Neutropenia by Antonio Gallardo-Pizarro, Christian Teijón-Lumbreras, Patricia Monzo-Gallo, Tommaso Francesco Aiello, Mariana Chumbita, Olivier Peyrony, Emmanuelle Gras, Cristina Pitart, Josep Mensa, Jordi Esteve, Alex Soriano, Carolina Garcia-Vidal

“…Cluster 2 (28.4% of episodes) and Cluster 3 (43.7%) exhibited higher BSI rates of 26.7% and 37.6% and GNB BSI rates of 13.4% and 19.3%, respectively. …”
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Associations of Tea Consumption With the Risk of All‐Cause and Cause‐Specific Mortality Among Adults With Type 2 Diabetes: A Prospective Cohort Study in China by Lifeng Wang, Xikang Fan, Jian Su, Yu Qin, Zhongming Sun, Yan Lu, Shujun Gu, Chong Shen, Jinyi Zhou, Hao Yu, Ming Wu

“…Compared with nonconsumers, regular tea consumption (≥ 3 times/week, 1 cup/day, > 30 years) was associated with reduced all‐cause mortality risk in T2DM, with HRs (95% CIs) of 0.82 (0.74, 0.91), 0.80 (0.72, 0.89), and 0.77 (0.68, 0.86). …”
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Life cycle assessment of agricultural waste recycling for sustainable environmental impact by S. Sumiyati, B.P. Samadikun, A. Widiyanti, M.A. Budihardjo, S. Al Qadar, A.S. Puspita

“…The study also examines cutting-edge technologies, such as anaerobic digestion and biomass-to-energy conversion, highlighting their potential to manage agricultural waste and being a sustainable energy source. …”
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Protective role of ginsenoside Rg1 in the dynamic progression of liver injury to fibrosis: a preclinical meta-analysis by Lijuan Dan, Xiuyan Li, Shuanglan Chen, Xiaojie You, Dong Wang, Tianyuan Wang, Jia Li, Wenping Liu, Jie Mu, Quansheng Feng, Quansheng Feng

“…Time-dose interval analysis revealed that the effective dose range of ginsenoside Rg1 was between 4 and 800 mg/kg/d.ConclusionRg1 at a dose of 4–800 mg/kg/d mitigates the progression of liver injury to fibrosis via anti-inflammatory, antioxidative, and anti-apoptotic pathways.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD 42024557878.…”
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Structural and functional features of phytoene synthase isoforms PSY1 and PSY2 in pepper Capsicum annuum L. cultivars by E. A. Dyachenko, M. A. Filyushin, G. I. Efremov, E. A. Dzhos, A. V. Shchennikova, E. Z. Kochieva

“…In this work, the complete PSY1 and PSY2 genes were identified in nine C. annuum cultivars, which differ in ripe fruit colour. …”
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