Establishment and validation of predictive model of ARDS in critically ill patients by Senhao Wei, Hua Zhang, Hao Li, Chao Li, Ziyuan Shen, Yiyuan Yin, Zhukai Cong, Zhaojin Zeng, Qinggang Ge, Dongfeng Li, Xi Zhu

“…Based on the AUC and DCA in the validation group, the logistic model demonstrated excellent performance, achieving an AUC of 0.836 (95% CI: 0.762–0.910). For external validation, comprising 160 patients, 44 of whom developed ARDS, the AUC was 0.799 (95% CI: 0.723–0.875), significantly outperforming the LIPS score alone. …”
Get full text

Prothrombin complex concentrate for reversal of oral anticoagulants in patients with oral anticoagulation-related critical bleeding: a systematic review of randomised clinical tria... by Christian Ovesen, Jan Purrucker, Josefine Grundtvig, Theis Bech Mikkelsen, Christian Gluud, Janus Christian Jakobsen, Hanne Christensen, Thorsten Steiner

“…Among participants with VKA-related critical bleeding, meta-analyses showed no evidence of a difference between PCC versus fresh frozen plasma (FFP) when assessing all-cause mortality (risk ratio [RR] 1.05; 95% confidence interval (CI) 0.27 to 4.05; low certainty), health-related quality of life (mean difference 1.04; 95% CI − 0.94 to 3.02; very low certainty), and serious adverse events (RR 1.33; 95% CI 0.94 to 1.88; very low certainty), but information is currently sparse. …”
Get full text

Functional Analysis of DNMT1 SNPs (rs2228611 and rs2114724) Associated with Schizophrenia by Sonal Saxena, Pranay Amruth Maroju, Sumana Choudhury, Vidhya Chitta Voina, Poonam Naik, Kavitha Gowdhaman, Poornima Kkani, Kiranmai Chennoju, S. Ganesh Kumar, C. Ramasubramanian, G. Prasad Rao, Trinath Jamma, Kumar Pranav Narayan, K. Naga Mohan

“…When haplotype analysis of both loci was performed, we observed a significant association of T/T–T/T and T/T–C/T (P = 0.04) haplotypes with SZ. To gain insights into the functional effects of the two SNPs on the levels of DNMT1 transcripts, quantitative real-time PCR experiments were performed using peripheral blood monocytes from 10 individuals each with T/T–T/T (homozygous minor allele), C/T–C/T (heterozygous), and C/C–C/C (homozygous major allele) haplotypes. …”
Get full text

Model of property relations in the Soviet Lithuania village (Case of Stungiai village) by Žilvinas Kačiuška

Get full text

The burden of chronic kidney disease attributable to high sodium intake: a longitudinal study in 1990–2019 in China by Yongyao Shen, Liying Jiang, Liying Jiang, Jin Yu, Bo Chen, Aidong Liu, Yongjin Guo, Yongjin Guo

“…The estimated annual percentage change (EAPC) in age-standardized mortality rate (ASMR) and age-standardized DALYs rate (ASDR) were calculated to describe long-term trends.ResultsTotally, the number of deaths of CKD attributable to high sodium intake reached 95,000, with DALYs amounting to 2.59 million person-years in 2019, while the trends of ASMR (EAPC: -0.31, 95%CI: −0.46, −0.17%) and ASDR (−0.33, 95%CI: −0.48, −0.18%) were down during the observation period. …”
Get full text

An investigator-blinded, 24-month, parallel-group, non-inferiority study to compare aesthetic restorations in primary anterior teeth in a paediatric dental clinic: study protocol f... by Ana Paula Taboada Sobral, Elaine Marcilio Santos, Marcela Leticia Leal Gonçalves, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Sandra Kalil Bussadori, Elza Padilha Ferri, Juliana Maria Altavista Sagretti Gallo, Thais Gimenez, José Carlos Pettorossi Imparato

“…Secondary outcomes will include tooth survival, longevity of restoration, quality of life, perception and satisfaction of the participants’ parents/guardians.Ethics and dissemination This protocol has been approved by the Human Research Ethics Committee of Universidade Metropolitana de Santos (protocol number: 6.019.297. Approved 24 April 2023). Results will be submitted to international peer-reviewed journals and presented at international conferences.Trial registration number NCT05875064.…”
Get full text

Growth performance, intestinal health, and non-specific immunity were significantly affected by feeding different compound lactic acid bacteria supplementation in sea urchin (Stron... by Yuntian Zhang, Yuntian Zhang, Rongwei Zhang, Rongwei Zhang, Yi Chen, Yi Chen, Zhixu Guo, Zhixu Guo, Xiangyu Meng, Xiangyu Meng, Yuzhe Han, Yuzhe Han, Xiaoran Zhao, Xiaoran Zhao, Tongjun Ren, Tongjun Ren

“…In this study, S. intermedius with an initial body weight of 26.47 ± 0.27 g was used as the experimental subject. …”
Get full text

Trends in depressive symptoms among high school students with and without health-risk behaviors in the United States: A population-based studyResearch in context by Tanner J. Bommersbach, Mark Olfson, Taeho Greg Rhee

“…Depressive symptoms increased more among students engaging in ≤1 risk category (BAPC = 4.6% [3.6–5.7%]) than students engaging in 4–5 risk categories (BAPC = 2.9% [2.4–3.3%]) (interaction, p = 0.037) and there was a general trend toward decreasing engagement in risk behaviors among students with depressive symptoms. …”
Get full text

Differences in patients derived from otolaryngology and other specialties with sleep apnea by Constanza Salas, Jorge Dreyse, Andrea Contreras, Gonzalo Nazar, Constanza Astorquiza, Rodrigo Cabezon, Gonzalo Labarca, Jorge Jorquera

“…Patients with OSA referred from other specialists were older than ENT patients (55 ± 13 vs 44 ± 12; p < 0.001), there was more obesity (IMC 31 ± 5.0 vs 28.7 ± 3.8; p < 0,001), a larger neck circumference (42.2 cm ± 3.7 vs 40.6 cm ± 3.0; p < 0.001) and more reported comorbidities (p < 0.001). …”
Get full text

Risk factors for COVID-19 hospitalisations and deaths in Mexican children and adolescents: retrospective cross-sectional study by Mauricio Hernandez-Avila, Libny Martínez-Valdez, Vesta Richardson López Collada, Luis Enrique Castro-Ceronio, Ángela María Rodríguez Gutiérrez, Aurora Bautista-Márquez

“…Risk analyses showed that male sex (OR 1.16–1.28), history of pneumonia (OR 29.7–65.4), immunosuppression (OR 5.3–42.9), cardiovascular disease (OR 4.4–14.6) and other comorbidities (OR 5.4–19.1), as well as age less than 1 year (OR 20.1, 95% CI 18.8 to 21.4), confer a greater risk of hospitalisation; in addition to comorbidities, age less than 1 year (OR 16.6, 95% CI 14.1 to 19.6), history of pneumonia (OR 14.1–135.1) and being an adolescent from an indigenous community (OR 2.6, 95% CI 1.23 to 5.54, p=0.012) increase the risk of death.Conclusions In Mexico, children less than 1 year old with COVID-19 have higher risk of hospitalisation and death than older children. …”
Get full text

Does the Systemic Immune Inflammation Index and Plasma Atherogenic Index Predict Poor Prognosis in Patients Undergoing Mitral Balloon Valvuloplasty? by Nergiz Aydın, Sefa Tatar, Ahmet Taha Şahin, Yakup Alsancak

“…At the third-month follow-up, SII was 7.77±7.16, and PAI was 0.47±0.25. While a statistically significant decrease was observed in SII post-procedure (p<0.001), no significant change was noted in PAI (p=0.843). …”
Get full text

Neoadjuvant Immunotherapy and De-escalation of Surgery in Locally Advanced Breast Implant-associated Anaplastic Large Cell Lymphoma by Marzia Salgarello, Jaroslaw Krupa, Rebecca Allchin, Simon Pilgrim, Fiona Miall, Arianna Di Napoli, Maurizio Martelli, Giulio Tarantino

“…The first case was a 52-year-old patient with a left breast mass-like stage III disease who underwent combined targeted immunotherapy and chemotherapy (brentuximab vedotin [BV]–cyclophosphamide, doxorubicin, prednisone [CHP]). Following a complete radiological and metabolic response, the patient underwent bilateral implant removal, right total intact capsulectomy, left en bloc capsulectomy, and skin resection from the left inframammary fold in continuity with the capsule. …”
Get full text

New strategies in management of severe alcoholic hepatitis by P. Ye. Tkachenko, I. I. Komkova, M. V. Mayevskaya, V. T. Ivashkin

“…The mean MI was 79,6±18,7. Groups were comparable by basic clinical and laboratory features. …”
Get full text

Feasibility study of pilot scale vegetable waste composting project for Kundasang community’s waste management program by Noorafizah Murshid, Abu Zahrim Yaser, Junidah Lamaming, Mariani Rajin, Sariah Saalah, Mariana Taliban

“…Results of the final compost (on a dry matter basis) showed that the moisture content is 62 ± 0.2% WM, the pH level is 7.6 ± 0.1, the electrical conductivity is 1.8 ± 0.4 mS/cm, and the N, P, and K values are 0.58 ± 0.10% DM, 0.04 ± 0.02% DM, and 0.17 ± 0.04% DM, respectively. …”
Get full text

Molecular Characterization, Oxidative Stress-Mediated Genotoxicity, and Hemato-Biochemical Changes in Domestic Water Buffaloes Naturally Infected with <i>Trypanosoma evansi</i> Und... by Waqas Ahmad, Muhammad Yasin Tipu, Muti ur Rehman Khan, Haroon Akbar, Aftab Ahmad Anjum, Muhammad Ovais Omer

“…Noteworthily, a comet assay revealed a significantly (<i>p</i> < 0.0001) higher mean genetic damage index in the infected buffaloes (0.7 ± 0.04) compared with the healthy ones (0.196 ± 0.004). …”
Get full text

Thermography in posterior scleritis by A. Kawali, S. Sanjay, P. Mahendradas, R. Shetty

“…At presentation, Δt was maximum in all PS patients and reduced unequally after starting treatment. Mean ampΔt was 1.21 °C (1.47–1.04 °C) in PS group and 0.44 °C (0.13–0.63 °C) in the control group. 3 out 6 PS patients were diagnosed with recurrences as demonstrated by OST spikes compared to previous measurements.…”
Get full text

پهنه‌بندی خطر وقوع فرونشست زمین در دشت هشتگرد بر اساس رویکرد تلفیقی تصمیم‌گیری چند معیار: WOI-BWM by شبنم مهرنور, مریم رباطی, میرمسعود خیرخواه زرکش, فروغ فرساد, شهرام بیک پور

“…نتایج روش BWM نشان داد عوامل برداشت از آب زیرزمینی (219/0)، نوع سازند زمین‌شناسی (157/0)، افت سطح آب زیرزمینی (079/0) و عمق آب زیرزمینی (078/0) اهمیت بیشتری بر پتانسیل خطر فرونشست در منطقه موردمطالعه دارند. …”
Get full text

Levels of generalized anxiety, moral distress, and moral courage among nurses: A comparative study in COVID-19 and non-COVID-19 wards by Seyede Fatemeh Gheiasi, Ahmad Reza Abedi, Mahboobeh Khosravani, Fatemeh Rafiei, Andrew Fournier, Maryam Ebrahimabadi

“…Results: The majority of participants in the study were female (66%) and married (54.7%). There was no statistically significant difference in the mean (SD) generalized anxiety score between nurses in COVID-19 and non-COVID-19 wards [5.51 (2.53) vs. 4.83 (2.50), p=0.168]. …”
Get full text

Surgical treatment after neoadjuvant systemic therapy for HER2-positive invasive breast cancer in the Netherlands: 10-Year trends and the influence an accompanying DCIS component by Roxanne A.W. Ploumen, Thiemo J.A. van Nijnatten, Loes F.S. Kooreman, Adri C. Voogd, Kristien B.M.I. Keymeulen, Sabine Siesling, Marjolein L. Smidt

“…Percentage of ypT0 was significantly lower in patients with IBC+DCIS (38.7 %), compared to IBC only (47.3 %, p < 0.001) Multivariable logistic regression analyses showed presence of DCIS (OR 1.69, 95%CI 1.47–1.95, p < 0.001) to be independently associated with mastectomy. …”
Get full text

Dose-dependent incidence of agranulocytosis in patients treated with methimazole and propylthiouracil by Jaeduk Yoshimura Noh, Kosuke Inoue, Nami Suzuki, Ai Yoshihara, Miho Fukushita, Masako Matsumoto, Hideyuki Imai, Shigenori Hiruma, Masahiro Ichikawa, Masakazu Koshibu, Akiko Sankoda, Rei Hirose, Natsuko Watanabe, Kiminori Sugino, Koichi Ito

“…The incidence of agranulocytosis according to dose in the MMI group was 0.13% at 10 mg/day, 0.20% at 15 mg/day, 0.32% at 20 mg/day, and 0.47% at 30 mg/day, revealing a significant dose-dependent increase. …”
Get full text