Factors Affecting Nonadherence to WHO’s Recommended Antenatal Care Visits among Women in Pastoral Community, Northeastern Ethiopia: A Community-Based Cross-Sectional Study by Kusse Urmale Mare, Abel Gebre Wuneh, Mubarek Shemsu Awol, Mohammed Ahmed Ibrahim, Molla Kahsay Hiluf, Setognal Birara Aychiluhm, Osman Ahmed Mohammed, Kebede Gemeda Sabo

“…Nonadherence to the recommended antenatal care visits was 57.0% (95% CI: 53.3%–60.7%). Attending primary (AOR (95% CI): 0.39 (0.22–0.72)) and secondary education and above (AOR (95% CI): 0.25 (0.08–0.77)), being married at the age of 18 years or older (AOR (95% CI): 0.48 (0.36–0.71)), and attending antenatal care at a health center (AOR (95% CI): 0.46 (0.26–0.81)) were associated decreased odds of nonadherence to the recommend visits. …”
Get full text

Mechanism of <italic>Coptis chinensis</italic> in Treatment of Type 2 Diabetes Mellitus Based on Network Pharmacology and Molecular Docking by LIU Huiling, TAN Dingying, HUANG Min, CHEN Pingping, ZHANG Wang

“…It can act on mitogen-activated proteinase 1 (MAPK1), serine/threonine protein kinase (AKT1), tumor protein p53 (TP53), transcription factor AP-1 (JUN), tumor necrosis factor (TNF), interleukin-6 (IL-6), which can regulate MAPK, AGEs-RAGE, PI3K-Akt, Toll-like receptors, HIF-1, TNF signaling pathways, etc. ④ The molecular docking results showed that, the molecular docking affinity between the active ingredients of <italic>Coptis chinensis</italic> and the above core targets was less than -7.0 kcal/mol (1 kca/mol=4.186 kJ/mol), and the binding activity was better.Conclusion<italic>Coptis chinensis</italic> may play an important role in the treatment of type 2 diabetes mellitus and its complications by regulating glucose and lipid metabolism, inflammatory response, cell proliferation and apoptosis and promoting oxidative stress, etc.…”
Get full text

Choroidal Thickness in Eyes with Band Atrophy of the Optic Nerve from Chiasmal Compression by Luiz Guilherme Marchesi Mello, Ana Claudia F. Suzuki, Giuliana Rovito de Mello, Rony Carlos Preti, Leandro C. Zacharias, Mário L. R. Monteiro

“…The pRNFL, mRNFL, and mGCC thicknesses were significantly smaller in the CCL group than in the control group (64.67 ± 10.53 μm, 29.68 ± 5.80 μm, and 80.60 ± 10.17 μm vs. 103.78 ± 12.23 μm, 39.89 ± 3.82 μm, and 105.51 ± 7.76 μm, respectively; p<0.001). …”
Get full text

Forecasting stroke and stroke-driven dementia in a rapidly ageing population: a model-based analysis of alternative projection scenarios for Ireland by Anne Hickey, Eithne Sexton, Frances Horgan, Kathleen E Bennett, Ronan Collins, Martin O'Flaherty, Suzanne Timmons, Chris Macey, David J. Williams

“…We used multiple data sources, including systematic review and observational evidence.Interventions Not applicable.Primary and secondary outcome measures We projected the incidence and prevalence of stroke (International Classification of Disease (ICD) codes I60–I61, I63–I64), poststroke dementia (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) criteria) and poststroke disability (modified Rankin Scale 3–5).Results The stable scenario indicated a projected 85 834 stroke survivors in 2046 (95% uncertainty interval (UI)=82 366–89 655), an increase of 45.7% from 2022. Assuming a high incidence decline and low case-fatality decline indicated a 5.4% increase in prevalence. …”
Get full text

Effects of Pharmacotherapy Training Course on Improving the Drug Prescription Skills of Medical Students: A Pharmacy-based Intervention by Fatemeh Taheri Asl, Mohammadhossein Taherynejad, Maryam Emadzadeh, Mina Akbari Rad, Mohammad Ali Yaghoubi, Amirreza Rostami, Sepideh Hejazi, Mitra Ahadi, Samaneh Sajjadi, Amirali Moodi Ghalibaf, Ali Moradi, Sahar Ravanshad

“…Ultimately, the pre-test and post-test scores were compared between the two groups.Results: A total of 30 interns with an average age of 24.88 ± 0.97 years were included in the study. There was no significant difference in their basic level of prescription knowledge between the two groups (p=0.314). …”
Get full text

Factors associated with retention in Quitline counseling for smoking cessation among HIV-positive smokers receiving care at HIV outpatient clinics in Vietnam. by Nam Truong Nguyen, Trang Nguyen, Giap Van Vu, Charles M Cleland, Yen Pham, Nga Truong, Reet Kapur, Gloria Guevara Alvarez, Phuong Thu Phan, Mari Armstrong-Hough, Donna Shelley

“…Smokers living with HIV aged 35 or older (OR = 5.53, 95% CI 1.42-21.52), who had a very low/low tobacco dependence level (OR = 2.26, 95% CI 1.14-4.51), had a lower score of perceived importance of quitting cigarettes (OR = 0.87, 95% CI 0.76-0.99), had a household ban or partial ban on cigarettes smoking (OR = 2.58, 95% CI 1.39-4.80), and had chosen a quit date during the Quitline counseling (OR = 3.0, 95% CI 1.63-5.53) were more likely to retain in the Quitline counseling than those smokers living with HIV whose ages were less than 35, who had a high/very high tobacco dependence level, had a higher score of perception of the importance of quitting cigarettes, did not have a household ban on cigarettes smoking, and did not choose a quit date during counseling.…”
Get full text

Cluster randomised controlled trial to examine medical mask use as source control for people with respiratory illness by Abrar Ahmad Chughtai, Chandini Raina MacIntyre, Yi Zhang, Quanyi Wang, Bayzidur Rahman, Haiyan Zhang, Holly Seale, Daitao Zhang, Yanhui Chu

“…Since 43 index cases in the control arm also used a mask during the study period, an as-treated post hoc analysis was performed by comparing outcomes among household members of index cases who used a mask (mask group) with household members of index cases who did not use a mask (no-mask group).Main outcome measure Primary outcomes measured in household members were clinical respiratory illness, ILI and laboratory-confirmed viral respiratory infection.Results In an intention-to-treat analysis, rates of clinical respiratory illness (relative risk (RR) 0.61, 95% CI 0.18 to 2.13), ILI (RR 0.32, 95% CI 0.03 to 3.13) and laboratory-confirmed viral infections (RR 0.97, 95% CI 0.06 to 15.54) were consistently lower in the mask arm compared with control, although not statistically significant. …”
Get full text

DANCR在人胚胎干细胞向内胚层分化中的调控功能 by 邓家成, 彭丽妹, 石颖鹏, 钟小敏

“…干扰DANCR表达使分化早期的原条分子标志物Brachyury （T），EOMES，MIXL1和GSC，以及分化后期的DE分子标志物 SOX17和FOXA2 的mRNA表达水平相比对照组显著降低（全部<italic>P </italic>&lt; 0.05）。…”
Get full text

The Identification of Molecular Ploidy Status of Abnormal Pronuclear Zygotes Reveals a Significant Number of Euploid Blastocysts Available for Conception by Blair R. McCallie, Mary E. Haywood, Lauren N. Henry, Rachel M. Lee, William B. Schoolcraft, Mandy G. Katz-Jaffe

“…In contrast, 50% of the 3PN blastocysts (<i>n</i> = 172) showed the presence of a third set of 23 parental chromosomes and were confirmed to be triploid (69XXY = 59.3% and 69XXX = 40.7%), with 41.9% identified as aneuploid and, interestingly, a small percentage (8.1%) confirmed to be diploid with normal fertilization. …”
Get full text

Burden of esophageal cancer in global, regional and national regions from 1990 to 2021 and its projection until 2050: results from the GBD study 2021 by Chengcheng Zhang, Linzhi Chen, Yuqi Xiu, Hongling Zhang, Yuejuan Zhang, Wenjuan Ying

“…By 2050, the ASIR is projected to decrease to 6.17 per 100,000, and the ASDR to 5.23 per 100,000, though the absolute number of cases and deaths is expected to rise.ConclusionsThe global burden of EC remains significant, with ongoing challenges in regions such as Africa and East Asia. …”
Get full text

Hubungan Umur, Jenis Kelamin dan Perlakuan Penatalaksanaan dengan Ukuran Tonsil pada Penderita Tonsilitis Kronis di Bagian THT-KL RSUP DR. M. Djamil Padang Tahun 2013 by Annisa Oktaria Shalihat, Novialdi , Lili Irawati

“…Ukuran tonsil dan adenoid cenderung kecil pada usia &lt;7 tahun, bertambah besar pada usia 7-15 tahun dan cenderung mengecil pada usia tua. …”
Get full text

Association between early dietary patterns and cardiometabolic health at age 8: a confirmatory analysis of the European Childhood Obesity Project by Mariona Gispert-Llauradó, Joaquin Escribano, Natalia Ferré, Veit Grote, Berthold Koletzko, Gina Ambrosini, Elvira Verduci, Dariusz Gruszfeld, Annick Xhonneux, Veronica Luque

“…Following a PQ-DP at both ages 2 and 8 was associated with higher triglycerides (β = 0.061, p = 0.049), systolic and diastolic BP (β = 13.019, p < 0.001 & β = 7.612, p = 0.014, respectively) and altered levels of HOMA-IR (OR = 3.1, p = 0.037, 95% CI = 1.1–9.1) at 8 years, compared to children with an HC-DP at both ages, after adjusting for confounders. …”
Get full text

Human Factors Studies to Assess the Usability of the Faricimab Prefilled Syringe by Barakat MR, Kwong Jr HM, Marcon G, O'Leary OE, Paris LP, Schneider P, Tang Y, Graff JM

“…Mark R Barakat,1,2 Henry M Kwong Jr,2,3 Gelson Marcon,4 Olivia E O’Leary,4 Liliana P Paris,5 Petrick Schneider,4 Yannan Tang,5 Jordan M Graff2,6,7 1Retina Macula Institute of Arizona, Scottsdale, AZ, USA; 2Department of Ophthalmology, University of Arizona College of Medicine – Phoenix, Phoenix, AZ, USA; 3Associated Retina Consultants, Phoenix, AZ, USA; 4F. …”
Get full text

Effectiveness of Cognitive Behavioral Therapy Provided Through a Web Application for Subthreshold Depression, Subthreshold Insomnia, and Subthreshold Panic: Open-Labeled 6-Arm Rand... by Kayoko Taguchi, Mirai Miyoshi, Yoichi Seki, Shiori Baba, Eiji Shimizu

“…In the SI group, the difference in the PSQI score change was also significant (difference=0.53, 95% CI 0.11-0.94, P=.01). However, in the SP group, the difference in the PAS score change was not significant (difference=0.07, 95% CI –2.00 to 2.15, P=.94). …”
Get full text

Apoptosis induction and tumor growth suppression by hydroxyapatite nanoparticles–cisplatin combined treatment in Ehrlich solid carcinoma-bearing mice by Shaymaa M. Eissa, Asmaa M. Mahfouz, Saad M. El-Gendy, Al-shimaa Zakaria, Heba Effat, Hanan R. H. Mohamed

“…Conclusion Hydroxyapatite nanoparticles can provoke DNA damage and regulate apoptosis, selectively eliminating tumor cells. …”
Get full text

The Impact of Hyperoxia on Outcome of Patients Treated with Noninvasive Respiratory Support by Seyhan Pala Cifci, Yasemin Urcan Tapan, Bengu Turemis Erkul, Yusuf Savran, Bilgin Comert

“…The results from the recent clinical researches about hyperoxia indicate that hyperoxia can be related to worse outcomes than expected in some critically ill patients. …”
Get full text

Socio-economic inequalities in access to COVID-19 tests in France in 2020: evidence from the EPICOV socio-epidemiological cohort by Pierre-Yves Geoffard, Pierre-Yves Geoffard, Florence Jusot, Antoine Sireyjol, Josiane Warszawski, Nathalie Bajos

“…Individuals holding a university degree were (1.08 [1.04–1.12]) more likely than those who only completed high school to be tested, as well as those in one of the three top income deciles with reference to the bottom decile (OR 1.07, [1.02–1.13] for the top decile). Ethno-racial status was not significantly associated with testing. …”
Get full text

Blood absolute lymphocyte count and trajectory are important in understanding severe COVID-19 by Catharine I. Paules, Jacqueline A. Nordwall, Kathryn Shaw-Saliba, Judith A. Aberg, Edward M. Gardner, Anna L. Goodman, N. Kumarasamy, Shikha Vasudeva, David M. Vock, Crystal M. North, Jens Lundgren, Neil R. Aggarwal, for the STRIVE Network and TICO Trial Study Group

Subjects: Get full text

Eficiencia de remoción eimpacto delsistema de tratamiento de aguas residuales del sector urbano y rural de la Provincia de Santa Elena by JUAN JOSÉ HUMANANTE CABRERA, Lucrecia Cristina Moreno Alcivar, Ana Grijalva Endara, Ricardo Williams Saldoya Tinedo, Joan Alberto Suárez Tomalá

Get full text

Feasibility and Preliminary Effects of Acupuncture for Cognitive Dysfunction in Diverse Cancer Survivors: A Pilot, Randomized, Placebo-Controlled Trial by Xiaotong Li, Kaitlin Lampson, Tim A. Ahles, James C. Root, Q. Susan Li, Yuelin Li, Anam Ahsan, Jun J. Mao, Kevin T. Liou

“…From baseline to week 10, the RA group (n = 19) reported a clinically meaningful 17.3-point increase in FACT-Cog PCI (95% confidence interval [CI] 12.5 to 22.1), compared to 9.7 points (95% CI 2.8 to 16.7) in the SA group (n = 9), and 6.8 points (95% CI −3.7 to 17.2) in the WLC group (n = 4). …”
Get full text