Analysis of codon usage bias in the mitochondrial genome of Pleurozia purpurea by Mengxue DU, Xin ZHANG, Jie GAO, Sheng BI, Jiewei HAO, Lina ZHANG

“…The average values for ENC and CAI are 50.29 and 0.17, indicating a preference for codons ending with A/U bases and a relatively weak CUB; 2) ENC exhibits significantly positive correlations with GCall, GC3, and the length of amino acid encoding genes, indicating significant influences of GC content and gene length on CUB; 3) Analyses including neutrality plot, ENC-plot and PR2-plot indicate that mutation pressure and natural selection jointly shaped the CUB, with mutation being the most important influencing factor; 4) A total of 23 optimal codons are selected, most of which end with A/U. …”
Get full text

Concomitant Usage of H1‐Antihistamines and Immune Checkpoint Inhibitors on Cancer Patient Survival by Yin Leung, Terry Cheuk‐Fung Yip, Grace Lai‐Hung Wong, Vincent Wai‐Sun Wong, Vicki Wing‐Ki Hui, Tony Shu‐Kam Mok, Henry Lik‐Yuen Chan, Stephen Lam Chan, Rashid Nok‐Shun Lui

“…Results A total of 1740 (65.1% male, mean age 61.9 years) were included in the landmark analysis, of which 529 (30.4%) and 307 (17.6%) had primary lung and liver malignancies. …”
Get full text

A study of impulsivity and adverse childhood experiences in a population health setting by Robert W. Read, Karen A. Schlauch, Gai Elhanan, Iva Neveux, Stephanie Koning, Takesha Cooper, Takesha Cooper, Joseph J. Grzymski, Joseph J. Grzymski

“…This analysis showed that having both high ACEs and high impulsivity confer substantial risk of MDD diagnosis (hazard ratios 2.81, 2.17, respectively). Additionally, lifetime predicted probability of MDD was approximately 40% higher for high ACEs and high impulsivity compared to no ACEs and low impulsivity. …”
Get full text

Neoadjuvant or concurrent atezolizumab with chemoradiation for locally advanced cervical cancer: a randomized phase I trial by Jyoti Mayadev, Dmitriy Zamarin, Wei Deng, Heather A. Lankes, Giulio Pesci, Hayeon Kim, Junzo P. Chino, Barbara Banbury, Ned Sherry, Elad Sharon, Sharad A. Ghamande, Catherine Ferguson, Loren Mell, Laura Holman, Cara Mathews, David O’Malley, Alexander Olawaiye, Elizabeth Hopp, Charles Leath, Larry Copeland, Robert Mannel, Roisin O’Cearbhaill, Carol Aghajanian, Russell J. Schilder

“…NRG-GY017 (NCT03738228) was a randomized phase I trial of atezolizumab (anti-PD-L1) neoadjuvant and concurrent with CRT (Arm A) vs. concurrent with CRT (Arm B) in patients with high-risk node-positive LACC. …”
Get full text

Changes in quality of life 5 years after sleeve gastrectomy: a prospective cohort study by Karl Ove Hufthammer, Tone Merete Norekvål, Grethe S Tell, Ronette L Kolotkin, Tone Nygaard Flølo, Anny Aasprang, Villy Våge, John Roger Andersen

“…We investigated 5-year trajectories in QOL and their associations with weight loss after SG.Design A prospective cohort study.Setting The study was conducted in a single Norwegian bariatric surgery centre.Participants Out of 150 operated patients, 127 were included. Mean age was 41 years, 68% were women and the follow-up rate at 1 year was 85% and 64% at 1 and 5 years, respectively.Outcome measures Data were collected preoperatively, and 1 and 5 years after surgery assessing three different levels of QOL. …”
Get full text

鼻咽癌放疗后颈淋巴结残留与复发的疗效差异

“…残留组中RND,MRND, SND和LNR组5年累积生存率分别为29.41%,57.14%,28.68%,36.44%,无显著性差异(Log Rank统计值=2.76,P=0.4303);复发组中4种手术方式的5年累积生存率分别为51.13%,66.67%,57.14%,50.00%,差异无显著性(Log Rank统计值=1.22,P = 0.7490);3. …”
Get full text

Efficacy and Safety of an Aflibercept Treat-and-Extend Regimen in Treatment-Naïve Patients with Macular Oedema Secondary to Central Retinal Vein Occlusion (CRVO): A Prospective 12-... by Jose Garcia-Arumi, Francisco Gómez-Ulla, Navea Amparo, Enrique Cervera, Alex Fonollosa, Luis Arias, Javier Araiz, Juan Donate, Marta Suárez de Figueroa, Lucia Manzanas, Jaume Crespí, Roberto Gallego

“…Results. 24 eyes (24 patients) were included; mean (SD) age: 62.8 (15.0) years; 54.2% male; median (IQR) time since diagnosis: 7.6 (3.0, 15.2) days. Mean BCVA scores significantly improved between baseline (56.0 (16.5)) and Month 12 (74.1 (17.6)); mean (95% CI) change: 14.8 (8.2, 21.4); P=0.0001. …”
Get full text

Childhood contact with social services, self-harm and suicidal or self-harm ideation in young adulthood: a population-wide record-linkage study by S. McKenna, D. O’Reilly, E. Ross, A. Maguire

“…Even those assessed as not in need of any help or support in childhood were three times more likely to present with self-harm or ideation (OR = 3.45 [95% CI, 3.07–3.88]). Conclusions Understanding the magnitude of childhood adversity amongst adults that present to EDs with self-harm or ideation may inform clinicians’ understanding and therapeutic decision-making. …”
Get full text

Experimental and numerical assessment of water-based photovoltaic/thermal collectors with varied tubular absorber cross-sections by Shirin Rostami, Adnan Ibrahim, Amir Aziat Ishak, Ahmad Fazlizan, Ahmad Fudholi, Kamaruzzaman Sopian, Alireza Dehghani-Sanij, Amin Shahsavar, Khaled M. Al-Aribe

“…Additionally, the optimized design opens avenues for future research and can be further developed for both industrial and domestic applications.…”
Get full text

Combined mutations in nonstructural protein 14, envelope, and membrane proteins mitigate the neuropathogenicity of SARS-CoV-2 Omicron BA.1 in K18-hACE2 mice by Kotou Sangare, Shufeng Liu, Prabhuanand Selvaraj, Charles B. Stauft, Matthew F. Starost, Tony T. Wang

Subjects: “…SARS-CoV-2 variants…”
Get full text

Impact of measles vaccination strategies on vaccination rates in low-income and middle-income countries: a systematic review and meta-analysis by Andrew Hayen, Kiddus Yitbarek, Mirkuzie Woldie, Firew Tekle Bobo, Jane Frawley, Abela Mahimbo, Meru Sheel

“…The meta-analysis indicated that vaccination-targeting interventions such as vaccination reminders, cash incentives, community engagement and health education activities increase measles vaccination coverage (RR 1.19, 95% CI 1.10 to 1.27). Our analysis also indicated that interventions such as vaccine reminders, educational programmes and incentives improved timely vaccination. …”
Get full text

Codeveloping an Online Resource for People Bereaved by Suicide: Mixed Methods User-Centered Study by Edouard Leaune, Kushtrim Bislimi, Pauline Lau-Taï, Héloïse Rouzé, Benoit Chalancon, Laurène Lestienne, Pierre Grandgenevre, Margot Morgiève, Nathalie Laplace, Guillaume Vaiva, Julie Haesebaert, Emmanuel Poulet

“…Since the implementation of espoir-suicide in March 2023, a total of 19,400 connections have been recorded, 117 local resources have been registered nationwide, and 73 questions have been posted in the chat. …”
Get full text

Economic burden of chronic obstructive pulmonary disease and post-tuberculosis sequelae in low- and middle-income countries: a database compiled from a systematic review and meta-a... by Fabrizio Tediosi, Klaus Reither, Olivia Keiser, Alexandra Walker, Yuling Lin, Marguerite Batta, Sierra Ottilie-Kovelman, Anna Duchenko, Curdin Brugger, Robert S Wallis, Marina Antillon

“…The data collected are presented in the Cost Database of COPD and Post-TB (CD-CPTB). The majority of studies were from Asia, Eastern Europe and Latin America, with a few from other middle-income countries. …”
Get full text

Improved primary stability and load transfer of a customized osseointegrated transfemoral prosthesis compared to a commercial one by Giulia Galteri, Valentina Betti, Domenico Alesi, Stefano Zaffagnini, Marco Palanca, Emanuele Gruppioni, Luca Cristofolini

“…Discussion and conclusion These results support the hypothesis that the OsteoCustom stem can offer better primary stability and load distribution compared to commercial implants. …”
Get full text

Diagnostic efficacy of dual-energy CT virtual non-calcium technique in the diagnosis of bone marrow edema of sacroiliac joints in ankylosing spondylitis by Hongyue Lu, Zhi Li, Ziheng Liang, Yuqi Liu

“…The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of visual qualitative assessment for BME by Physicians A and B were as follows: iliac facet [(92.5%, 88.6%, 88.1%, 92.9%, 90.5%), (90.0%, 90.9%, 90.0%, 90.9%, 90.5%)], sacral facet [(88.4%, 87.8%, 88.4%, 87.8%, 88.1%), (90.7%, 85.3%, 86.7%, 89.7%, 88.1%)].In terms of objective quantitative analysis, the CT values of the edematous areas on the iliac and sacral surfaces were (-41.4 ± 15.9) Hu and (-38.8 ± 19.7) Hu, respectively, while the CT values of normal bone marrow areas were (-79.6 ± 18.2) Hu and (-72.8 ± 14.8) Hu, respectively. …”
Get full text

Changes in the shape of the lumbar curve during growth: a geometric morphometric approach by Ruth Pelleg-Kallevag, Sarah Borgel, Einat Kedar, Nathan Peled, Hila May

Subjects: Get full text

Influência da caminhada na cognição e composição corporal de mulheres idosas by Rafael Afonso de Oliveira, Vinícius Nagy Soares, Ricardo Aurélio Carvalho Sampaio, Paula Teixeira Fernandes

“…O grupo de intervenção melhorou o desempenho no teste Códigos WAIS-III (Δ = 8,68; IC95%: 6,7; 10,7) e reduziu os tempos de execução dos testes CTT-A (Δ = -7,94; IC95%: -13,1; -2,8) e CTT-B (Δ = -18,59; IC95%: -31,4; -5,8). …”
Get full text

Systemic therapy of skin metastatic melanoma with BRAF gene mutation by Yu. S. Shakh-Paronyants, S. V. Cheporov, N. P. Shiryaev, A. V. Ukgarskiy, P. V. Nesterov, N. S. Korzina

“…Progression–free survival in the group of patients with targeted therapy was 8.7 months, in the immunotherapy group – 9.8 months. …”
Get full text

A Novel PET Imaging Using 64Cu-Labeled Monoclonal Antibody against Mesothelin Commonly Expressed on Cancer Cells by Kazuko Kobayashi, Takanori Sasaki, Fumiaki Takenaka, Hiromasa Yakushiji, Yoshihiro Fujii, Yoshiro Kishi, Shoichi Kita, Lianhua Shen, Hiromi Kumon, Eiji Matsuura

“…We confirmed that 64Cu-labeled 11-25 mAb highly accumulated in MSLN-expressing tumors as compared to MSLN-negative ones. …”
Get full text

Relationship Between a Heavy Rainfall and Gravity Wave in Sichuan Basin by Xu Yizhou, Li Guoping, Zhang Xiaoyu, Xie Xin, Dong Yuanchang

Get full text