Designing multi-epitope vaccines against Echinococcus granulosus: an in-silico study using immuno-informatics by Jadoon Khan, Asma Sadiq, May M. Alrashed, Nosheen Basharat, Syed Nadeem Ul Hassan Mohani, Tawaf Ali Shah, Kotb A. Attia, Aamer Ali Shah, Hayat Khan, Ijaz Ali, Arif Ahmed Mohammed

“…Abstract Cystic echinococcosis (CE) is a worldwide zoonotic public health issue. …”
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Adjunctive diagnostic tool for histopathological classification of congenital mesoblastic nephroma based in molecular genetic findings by Hiroshi Hamada, Kenichi Kohashi, Takeshi Iwasaki, Mikiko Hashisako, Yuko Hino, Masahiro Fukuhara, Amane Kamouchi, Naonori Kawakubo, Tatsuro Tajiri, Yoshinao Oda

“…Gene ontology analysis of the highly expressed genes in the EGFR-ITDs tumor group revealed enrichment related to the mitogen-activated protein kinase (MAPK) signaling pathway. p-Mek1/2 and p-Erk1/2 immunoreactivity was significantly increased in the EGFR-ITDs tumor group (p = 0.018 and p = 0.017, respectively). EGFR immunoreactivity is not a useful marker for CMN with EGFR-ITD. …”
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Stool immunoassay for identification of colorectal cancer and other significant gastrointestinal diseases risk groups by N. S. Sergeeva, Nina V. Marshutina, Ye. V. Zenkina

“…Content of hHb, hHb/ Hp and fTu M2-PK was investigated by solid-phase immunoenzyme tests in stool samples of 447 patients: 157 primary CRC cases, 121 stomach cancer (SC) patients, 64 ulcerative colitis (UC), 20 colonic polyps (CP) patients and 85 healthy donors. …”
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Exploring survival rates in HIV-infected Ethiopian children receiving HAART: a retrospective cohort study by Yimam Getaneh, Yared Dejene, Birhanemeskel T. Adankie, Siti Qamariyah Khairunisa, Dominicus Husada, Kuntaman Kuntaman, Maria Inge Lusida

“…There was a high risk of mortality among female (adjusted HRs (AHRs) (95% CI) =1.35 (1.14 to 1.65)), those with poor adherence (AHR (95% CI) =1.29 (1.13 to 1.35)), CD4 count of ≤200 cells/mm3 (AHR (95% CI) =1.75 (1.33 to 2.30)) and baseline haemoglobin≤12 g/dL (AHR (95% CI) =1.8 (1.66 to 1.98)).Conclusion The significant drop in the survival rate as of the 6th year follow-up and the high loss rate to follow-up call for programme attention. …”
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Effects of clinical stage, behavioral and psychological symptoms of dementia, and living arrangement on social distance towards people with dementia. by Kae Ito, Shuji Tsuda

“…<h4>Background</h4>Dementia presents significant challenges, including social exclusion, which can be exacerbated by public stigma. This study aimed to clarify how social distances, a common measure of public stigma, towards people living with dementia and its associated factors vary with clinical stage, presence of behavioral and psychological symptoms of dementia (BPSD), and living arrangements.…”
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The use of emergency medical services for palliative situations in Western Cape Province, South Africa: A retrospective, descriptive analysis of patient records by C Gage, B Spies, K Crombie, L Gwyther, W Stassen

“…All patient records of those who arrived at the hospitals between 1 January 2020 and 31 December 2020 via EMS conveyance leading to palliative care provision were included in the study. Results. In total, 1 207 unique patients received palliative care services at both hospitals during the study period. …”
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Highly Aggressive CD4-Positive Mast Cell Leukaemia (Leukaemic Variant) Associated with Isolated Trisomy 19 and Hemophagocytosis by Neoplastic Mast Cells: A Case Report with Challenging Experience and Review by Dina Sameh Soliman, Ahmad Al-Sabbagh, Feryal Ibrahim, Amna Gameil, Mohamed Yassin, Halima El-Omri

“…BM biopsy was diffusely infiltrated with many atypical mast cells positive for CD45, CD117, mast cell tryptase, CD25, and CD4 with partial positivity for CD7 and CD30. …”
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Harnessing natural polymers and nanoparticles: Synergistic scaffold design for improved wound healing by Anitha S, Nandini Robin Nadar, Srividya Shivakumar, Sharma S C, Siddharth P, Surekha Varalakshmi V, Rajesh Lenka, Rajadurai S

“…Conventional wound healing products do not heal wounds adequately and can cause scarring, suggesting the possibility of new biomaterials. …”
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A comparative machine learning study of schizophrenia biomarkers derived from functional connectivity by Victoria Shevchenko, R. Austin Benn, Robert Scholz, Wei Wei, Carla Pallavicini, Ulysse Klatzmann, Francesco Alberti, Theodore D. Satterthwaite, Demian Wassermann, Pierre-Louis Bazin, Daniel S. Margulies

“…To this end, we leveraged data of 936 individuals from three large open-access datasets: COBRE, LA5c, and SRPBS-1600. We developed a pipeline which allows us to aggregate over a million different features and assess their predictive potential in a single, computationally efficient experiment. …”
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Shift from chronic to episodic migraine frequency in a long-term phase 3 study of galcanezumab by Hans-Christoph Diener, Kathleen A. Day, Sarah Lipsius, Sheena K. Aurora, Nada A. Hindiyeh, Holland C. Detke

“…Ability to convert patients from chronic migraine frequency to episodic migraine (EM) frequency is a clinically relevant and desirable outcome when prescribing preventive treatments to patients with CM. Methods Patients aged 18–65 years with an ICHD-3β diagnosis of CM were randomized 2:1:1 to receive monthly injections of placebo (N = 558), galcanezumab 120 mg with a 240-mg loading dose (N = 278), or galcanezumab 240 mg (N = 277) during a 3-month double-blind period of the phase 3 REGAIN trial. …”
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Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria D... by Saverio Massimo Lepore, Valeria Maria Morittu, Marilena Celano, Francesca Trimboli, Manuela Oliverio, Antonio Procopio, Carla Di Loreto, Giuseppe Damante, Domenico Britti, Stefania Bulotta, Diego Russo

“…We have synthesized a peracetylated derivative of Ole (Ac-Ole) which has shown in vitro antioxidant and growth-inhibitory activity higher than the natural molecule. In this study, male C57BL/6JOlaHsd mice were fed with a standard (std), cafeteria (caf) diet, and caf diet supplemented with Ole (0.037 mmol/kg/day) and Ac-Ole (0.025 mmol/kg/day) for 15 weeks. …”
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Tumor Size Is a Critical Factor in Adjuvant Chemotherapy for T3-4aN0M0 Gastric Cancer Patients after D2 Gastrectomy by Shi Chen, Li-Ying Ou-Yang, Run-Cong Nie, Yuan-Fang Li, Jun Xiang, Zhi-Wei Zhou, Ying-Bo Chen, Jun-Sheng Peng

“…For patients with tumors larger than 5 cm, univariate analysis revealed that tumor location (p=0.007), Borrmann type (p=0.039), postoperative chemotherapy (p=0.003), and pathological T stage (p<0.001) were significant prognostic factors. …”
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Soil moisture characteristics of four artificial plant communities in aerial seeding afforestation area and their response to different levels of rainfall by Tiejun Zhang, Tiejun Zhang, Yanping Liu, Yanping Liu, Jianying Guo, Jianying Guo, Guodong Tang, Guodong Tang, Zhenqi Yang, Zhenqi Yang

“…The coefficient of variation of soil moisture content in C. mongolicum community was the largest, which was 22.7%, and the coefficient of variation of soil moisture content in H. scoparium-C. mongolicum community was the smallest, which was 19.4%. …”
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A Comparative Analysis of Spatial Resolution Sentinel-2 and Pleiades Imagery for Mapping Urban Tree Species by Fabio Recanatesi, Antonietta De Santis, Lorenzo Gatti, Alessio Patriarca, Eros Caputi, Giulia Mancini, Chiara Iavarone, Carlo Maria Rossi, Gabriele Delogu, Miriam Perretta, Lorenzo Boccia, Maria Nicolina Ripa

“…Pléiades imagery demonstrated superior classification accuracy, achieving an overall accuracy (OA) of 89% and a Kappa index of 0.84 in Villa Ada Savoia, compared to Sentinel-2’s OA of 66% and Kappa index of 0.47. Specific tree species, such as Pinus pinea (Stone Pine), reached a user accuracy (UA) of 84% with Pléiades versus 53% with Sentinel-2. …”
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Improvement in soil properties and soil water content due to the application of rice husk biochar and straw compost in tropical upland by Junita Barus, Rr Ernawati Rr Ernawati, Nila Wardani, Yulia Pujiharti, Nandari Suretno, Slameto Slameto

“…The changes in soil chemical properties like pH, C, N, CEC, P, K, Mg, Ca, Na, and physical properties including soil bulk density, particle density, total porosity, macropores, micropores, permeability, and soil water content at various pressures were measured. …”
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经食道-胸壁电刺激建立兔心脏骤停模型

“…在心肺复苏开始时心电图表现为室颤的比例为73.3%（11/15），无脉性电活动的比例为26.7%（4/15）。心肺复苏用时200.07±136.00s，除颤次数1.00±0.76次，静脉注射肾上腺素次数2.40±1.12次，自主循环恢复率93.3%（14/15），自主循环恢复后机械通气时间40.46±17.05min。…”
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The Commonly Encountered Bacterial Agents and their Antibiotic Sensitivity in the Neonatal Intensive Care Units of Cairo University Children Hospitals: An Observational Study by Dina Khedr, Peter Samaan, Abdulrahman Abdulrazek, Noha Adel Yassin

“…Of all cultures performed, multidrug resistant (MDR) Klebsiella pneumoniae was the most frequently isolated organism among 37 (27%) cases, that was mostly sensitive to polymyxin B was, followed by coagulase-negative Staphylococcal aureus (CoNS) in 32 cases, which was the most sensitive to vancomycin. …”
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Clinical usefulness of patient-reported-outcome-measurement information system in Pediatric Crohn’s Disease: a cross-sectional study by Sara Azevedo, Maria Miguel Oliveira, Paulo Nogueira, Ana Isabel Lopes

“…Pediatric CD patients (aged 8–17 years) were enrolled prospectively over eight months from an outpatient pediatric gastroenterology center. …”
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Relationship between effective blood flow rate and clinical outcomes in maintenance hemodialysis patients: a single-center study by Zhoucang Zhang, Jiarui Li, Jiaxiang Ding, Shenglei Zhang, Mei Wang, Jinsheng Xu

“…Continuous Cox models demonstrated each 20 ml/min increase in eBFR linked to a 63% decrease in the risk of all-cause mortality (HR: 0.37, 95% CI: 0.23–0.59) and a 38% decrease in the occurrence of new MACE (HR: 0.62, 95% CI: 0.46–0.84). …”
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Revalidation and adaptation of the Menstrual Practice Needs Scale (MPNS) in a cross-sectional survey to measure the menstrual experiences of adult women working in Mukono District,... by Julie Hennegan, Kellogg J Schwab, Natalie G Exum, Simon P S Kibira, Fredrick E Makumbi, Justine N Bukenya, Petranilla Nakamya

“…Higher scores reflected more positive menstrual experiences and were associated with well-being (total score r=0.24, p&lt;0.001), not missing work due to the last menstrual period (total score OR=2.47 95% CI 1.42 to 4.30) and confidence to manage menstruation.Conclusions The MPNS offers a valid and reliable way to assess menstrual health needs. …”
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