Different expression of circulating microRNA profile in tibetan OSAHS with metabolic syndrome patients by Xue-feng Shi, Xiang He, Ze-rui Sun, Jie Duo, Hao Yang

“…We identified IKBKB, PIK3R1, and MAP2K1 as the target genes most associated with Mets pathogenesis in OSAHS, regulated by miR-503-5p, miR-497-5p, and miR-497-5p, respectively. Additionally, the target genes of differentially expressed miRNAs between Tibetan OSAHS patients with MetS and healthy individuals are regulated by transcription factors such as NR2C1, STAT3, STAT5a, HIF1a, ETV4, NANOG, RELA, SP1, E2F1, NFKB1, AR, and MYC. …”
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Dissociated response and treatment outcome with immune checkpoint blockade in advanced cancer by Yaping Guan, Yu Cui, Yanhong Gong, Xiuju Liang, Xinyue Han, Yingcui Chen, Hong Xie, Yuekai Zhang, Baocheng Wang, Xin Ye, Jun Wang

“…The pantumor cohort included 177 patients. DR were observed in 12 (6.8%) patients. …”
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Comparison of Ziziphus jujube Mill. Syrup versus polyethylene glycol in children with functional constipation: a randomized clinical trial by Fatemeh Keihanian, Shohreh Maleknejad, Amin Saeidinia, Soheil Soltanipour, Amir Pirooz

“…The mean age of the subjects was 4.31 ± 1.97 years. There was no significant difference between the two groups in terms of age (P = 0.181), gender (P = 0.218), age at onset of constipation (P = 0.083), and weight (P = 0.199). …”
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Effect of different clay additions to concrete on its ultrasonic acoustic parameters and compressive strength by Wenxiang Wu, Shunchao Chen, Yong Wu, Xiangyang Zhang, Debiao Kong, Jifeng Wen

“…Specifically, as $$\:{\gamma\:}_{Mc}$$ increases, there is a non-linear relationship between compressive strength and $$\:{\gamma\:}_{Mc}$$ (R²=0.97); When $$\:{\gamma\:}_{Mc}$$ is greater than 10%, the sound velocity and sound time values change significantly, and both show linear and nonlinear relationships with the mud content; As $$\:{\gamma\:}_{Mc}$$ increases, the amplitude also exhibits a nonlinear relationship with $$\:{\gamma\:}_{Mc}$$ (R²=0.91);When $$\:{\gamma\:}_{Mc}$$ is greater than 20%, the frequency value changes significantly and shows a linear relationship with $$\:{\gamma\:}_{Mc}$$ (R²=0.95).In addition, concrete with higher mud content has a longer first wave period, larger waveform spacing, and faster signal attenuation.…”
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Quelques observations sur l’alimentation des bonobos en semi-liberté au sanctuaire « Tasok » de Kinshasa by Paul N ’ Lemvo Budiongo

“…Les jeunes indépendants ont perdu 0,4 kg en moyenne par individu. En effet, ces derniers se disputaient la nourriture avec les grands car ils étaient servis dans les mêmes bacs à aliments alors que ceux qui étaient nourris par les mères adoptives ne connaissaient pas de compétition alimentaire. …”
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Developing a Transparent Anaemia Prediction Model Empowered With Explainable Artificial Intelligence by Muhammad Sajid Farooq, Muhammad Hassan Ghulam Muhammad, Oualid Ali, Zahid Zeeshan, Muhammad Saleem, Munir Ahmad, Sagheer Abbas, Muhammad Adnan Khan, Taher M. Ghazal

“…The model simulation results are showing promising results in terms of the accuracy (98.13%) and the miss-rate (1.87%) which are the superior performance compared to the previous published approaches.…”
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Smoking Cessation in Chinese Patients Undergoing Thoracic Surgery: A Multicenter Prospective Observational Study by Jianxing He, Dingpei Han, Kun Qian, Weijie Guan, Ge Zhang, Weiqing Lu, Hecheng Li, Xiuyi Zhi

“…PCs occurred in 13.8% of patients, with similar proportions in smokers (14.1%) and quitters (12.7%). PPCs occurred in 9.8% of patients with no significant differences between smokers and quitters (9.4% vs 11.1%, p=0.70). …”
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The relationship between gallstone disease and the genetic variants of the sterol transporter adenosine triphosphate–binding cassette G8 and G5 in Egyptians by Menna A. Hassan, Salwa M. Abo El-Khair, Noha M. Mesbah, Dina M. Abo-Elmatty, Asmaa R. Abdel-Hamed

“…Results Between patients with gallstone disease and healthy controls, there were statistically significant differences in the distribution of these genes polymorphisms. Q604E CC genotype (OR = 15.2; P = 0.004) and C allele (OR = 2; P = 0.007) in ABCG5 (rs6720173) as well as D19H GC genotype (OR = 2.9; P = 0.002) and C allele (OR = 2; P = 0.004) in ABCG8 (rs11887534) were significantly more frequent in gallstone patients. …”
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Beyond BRAFV600E: Investigating the Clinical and Genetic Spectrum of Langerhans Cell Histiocytosis in Children by Xue Tang, Ju Gao, Xia Guo, Zhi Wan, Jing‐jing Sun

“…Additionally, patients with the BRAF exon 15 mutation and MAP2K1 exon 2 mutation had higher rates of LCH onset before age 3 compared with patients carrying the BRAF exon 12 mutation and MAP2K1 exon 3 mutation (p = 0.037; p = 0.0015). Patients carrying the BRAF mutation in exon 15 had higher rates of liver involvement compared with patients carrying the exon 12 (p = 0.042). …”
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The Combination of Shading and Potassium Application Regulated the Bulb Active Ingredients Accumulation in <i>Fritillaria thunbergii</i> Miq. by Affecting Rhizosphere Microecology by Leran Wang, Bingbing Liang, Jia Liu, Huizhen Jin, Zixuan Zhu, Siyu Hao, Shumin Wang, Xiaoxiao Sheng, Xinshu Zhou, Honghai Zhu, Ning Sui

“…Shading increased the content of active ingredients in bulbs by approximately 11.7% while decreasing bulb biomass by approximately 11.3%. …”
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Phenotypic Characterization and Antibiotic Resistance Patterns of Extended-Spectrum β-Lactamase- and AmpC β-Lactamase-Producing Gram-Negative Bacteria in a Referral Hospital, Saudi Arabia by Mutasim E. Ibrahim, Mohammed Abbas, Abdullah M. Al-Shahrai, Bahaeldin K. Elamin

“…Associations with outcome measures were determined by simple descriptive statistics and a chi-square test. Results. Out of 311 GNB isolates, the frequency of ESBL and AmpC β-lactamase producers was 84 (27%) and 101 (32.5%), respectively. …”
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PPAR Gamma Expression Levels during Development of Heart Failure in Patients with Coronary Artery Disease after Coronary Artery Bypass-Grafting by Izabela Wojtkowska, Andrzej Tysarowski, Katarzyna Seliga, Janusz A. Siedlecki, Zbigniew Juraszyński, Milosz Marona, Lidia Greszata, Anna Skrobisz, Karol Kaminski, Robert Sawicki, Janina Stępińska

“…Sensitivity of PPARγ expression in Ao above 1.1075 in detection of HF was 20.5% (AUC 0.531, 95% CI 0.442–0.619). Positive predictive value (Ppv) was 85.7%. …”
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D. I. BLOKHINTSEV – SCIENTIST AND TEACHER. THE SPIRITUAL FOUNDATIONS OF SCIENTIFIC WORK by V. N. Pervushin

“…On the other hand, the pedagogics is an art which methods, unlike scientific methodologies, can’t be acquired by formal and logical schemes. …”
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Comparative Study on the Clinical Efficacy and Safety of Acitretin and MTX in the Treatment of Pustular Psoriasis by TLR7/MyD88/CXCL16 Pathway by Jiajing Lu, Yu Wang, Ying Li, Yu Gong, Yangfeng Ding, Yuling Shi

“…The incidence of adverse reactions in the four groups was 16.2%, 8.1%, 10.3%, and 14.7%, respectively. The high-dose group had a higher incidence of adverse reaction than the low-dose group (P<0.05). …”
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Gambaran Angka Kejadian Gangguan Anxietas pada Warga Batu Busuk Kelurahan Padang Besi Kecamatan Lubuk Kilangan Kota Padang Akibat Banjir Bandang 24 Juli 2012 by Rigo Junaidi, Adnil Edwin Nurdin, Rosfita Rasyid

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Smoking habits, awareness and support needs for cessation among people with multiple sclerosis in Australia: findings from an online survey by Roshan das Nair, Ron Borland, Claudia H Marck, Isabelle Weld-Blundell, Lisa Grech, Sarah L White

“…Awareness of the harms of smoking on MS onset (n=68, 24.3%) and progression (n=116, 41.6%) was low. Almost a quarter (n=67, 23.8%) of participants were regularly exposed to passive smoke, and awareness of associated harm was also low (n=47, 16.8%). …”
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Apoio social e prática de atividade física no lazer em adolescentes: um estudo de base populacional by Márcio Botelho Peixoto, Alan Goularte Knuth, Inácio Crochemore Mohnsam da Silva, Pedro Curi Hallal

“…A proporção de ativos no lazer foi de 28,2% (IC 95%: 24,6-31,3). Meninos com maior apoio social de amigos apresentaram uma probabilidade de 112% (IC 95%: 41,0-183,0) maior de serem ativos em comparação a seus pares com menor apoio social. …”
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Sustainable CO₂ Capture: N,S-Codoped Porous Carbons Derived from Petroleum Coke with High Selectivity and Stability by Jiawei Shao, Yingyi Wang, Mingyang Che, Ya Liu, Yongfu Jiang, Qiang Xiao, Muslum Demir, Linlin Wang, Xin Hu

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Factors associated with risk analysis for asymptomatic left ventricular diastolic dysfunction in nondialysis patients with chronic kidney disease by Yajuan Gao, Shengnan Chen, Jiani Fu, Cui Wang, Yali Tang, Yongbai Luo, Xiaozhen Zhuo, Xueying Chen, Yan Shen

“…Therefore, dynamic monitoring of these factors associated with risk, timely diagnosis and treatment of ALVDD can delay the progression to symptomatic HF, which is of great importance for reducing CVD mortality, and improving the prognosis and quality of life in CKD patients.…”
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Three-dimensional linkage analysis with digital PCR for genome integrity and identity of recombinant adeno-associated virus by Tam Duong, Michele Firmo, Chien-Ting Li, Bingnan Gu, Peng Wang

“…Particularly, we rigorously tested our algorithms by conducting experiments involving the mixing of seven DNA fragments to represent various AAV viral genome populations, including 3 single partials, 3 double partials, and 1 full-length genomes. Across all 37 tested scenarios, we validated the accuracy of our workflow’s output for the percentages of 3D linkage by comparing to the known percentages of input DNA. …”
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