Integration of clinical, pathological, radiological, and transcriptomic data improves prediction for first-line immunotherapy outcome in metastatic non-small cell lung cancer by Nicolas Captier, Marvin Lerousseau, Fanny Orlhac, Narinée Hovhannisyan-Baghdasarian, Marie Luporsi, Erwin Woff, Sarah Lagha, Paulette Salamoun Feghali, Christine Lonjou, Clément Beaulaton, Andrei Zinovyev, Hélène Salmon, Thomas Walter, Irène Buvat, Nicolas Girard, Emmanuel Barillot

“…We analyze baseline multimodal data from a cohort of 317 metastatic NSCLC patients treated with first-line immunotherapy, including positron emission tomography images, digitized pathological slides, bulk transcriptomic profiles, and clinical information. …”
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Detecting Atrial Fibrillation Using Smartwatches by Agnieszka Kulczycka-Rowicka, Julianna Podolec, Silvia Ciraolo, Joanna Wojda, Adam Sobiński, Zuzanna Kościuszko, Katarzyna Kurza, Matylda Czerwonka, Katarzyna Lesiczka-Fedoryj, Anna Walczak

“…In many cases, atrial fibrillation is paroxysmal, which makes its detection challenging and can delay the implementation of appropriate treatment. …”
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Identifying the Factors That Drive Health Service Utilization Among Healthy and Non‐Healthy Agers in a Sample of Older Ethiopians: A Cross‐Sectional Study by Amare Belachew, Nicolas Cherbuin, Nasser Bagheri, Richard Burns

“…Promoting healthy aging can be one avenue for mitigating these challenges. …”
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USP4-mediated CENPF deubiquitylation regulated tumor metastasis in colorectal cancer by Zhongdong Xie, Hanbin Lin, Yuecheng Wu, Yanan Yu, Xintong Liu, Yating Zheng, Xiaojie Wang, Jiashu Wu, Meifang Xu, Yuting Han, Qiongying Zhang, Yu Deng, Lin Lin, Yan Linzhu, Li Qingyun, Xinjian Lin, Ying Huang, Pan Chi

“…Abstract Metastasis is a major challenge for colorectal cancer (CRC) treatment. In this study, we identified autophagy activation as a prognostic indicator in CRC and observed that the expression of key autophagy proteins is elevated in metastatic and recurrent cases. …”
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Discovery of a broad-spectrum monoclonal antibody recognizing a conserved, linear epitope WFYDGYPT on VP1 protein of Enterovirus A species by Lie Fu, Wei-Ping Jin, Wen-Hui Wang, Chen Wang, Sha-Sha Qian, Meng-Jun Wang, Rui-Lun Liu, Song-Zhuang Li, Ya-Xin Du, Sheng-Li Meng, Jing Guo, Ze-Jun Wang, Xiao-Qi Chen, Shuo Shen

“…Methods In this study, a mAb 1H4 was obtained using monoclonal antibody technology by immunizing purified virus particles of Coxsackievirus A5 (CV-A5). Examined by indirect immunofluorescence and Western blotting, 1H4 detected successfully all seven selected serotypes CV-A2, CV-A4, CV-A5, CV-A6, CV-A10, CV-A16 and EV-A71 of Enterovirus A and targeted structural protein VP1. …”
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Long term safety and efficacy of ligelizumab in the treatment of Japanese patients with chronic spontaneous urticaria by Hidetoshi Takahashi, Atsushi Fukunaga, Koremasa Hayama, Takayoshi Sasajima, Ayako Fujishige, Ryohei Ichishita, Naoko Tomimatsu, Eva Hua, Vineeth Varanasi, Alis Burciu, Michihiro Hide, Thomas Severin

“…Results: From a total of 66 CSU patients (80.3% females; mean ± SD age 46.4 ± 13.2 years; mean ± SD baseline UAS7 28.7 ± 6.5) enrolled, 53 patients (80.3%) reported ≥1 TEAE during the study, with no severe or serious adverse events, no anaphylaxis events and low frequency of TEAEs leading to treatment discontinuations (6.1%). …”
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Biomechanical Performance of Mandibular Molars with Deep Mesio-Occlusal-Distal Cavities Rehabilitated with Horizontal Posts: A 3D Finite Element Analysis by Sonali Sharma, Sindhu Ramesh, Jasmine Rayapudi

“…The overall von Mises stresses were as follows: Model 1:154.83 Mpa; Model 2: 376.877 Mpa; Model 3A: 160.221 Mpa; Model 3B: 159.488 Mpa; Model 3C: 147.231 Mpa. …”
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Increased Expression of VEGF and CD31 in Postradiation Rectal Tissue: Implications for Radiation Proctitis by G. Karamanolis, I. Delladetsima, V. Kouloulias, K. Papaxoinis, I. Panayiotides, D. Haldeopoulos, K. Triantafyllou, N. Kelekis, S. D. Ladas

“…VEGF-VI was significantly higher at the completion of radiotherapy (0.17±0.15 versus 0.41±0.24, P=0.001) declining 6 months after. …”
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Evaluación de la doble inoculación Bradyrhizobium-micorrizas y el uso de fitoterápicos de semilla en el crecimiento, eficiencia de inoculación y el rendimiento de un cultivo de soj... by A. CLUA, J. OLGIATI, J. BELTRANO

“…Se estableció un diseño experimental en bloques al azar, con cuatro repe- ticiones por tratamiento. Los tratamientos fueron: Control sin inoculación (C); Inoculación con B. japonicum (IB); Inoculación combinada Bradyrhizobium-micorrizas (IBM); Inoculación con Bradyrhizobium + curasemilla (IBC); Inoculación combinada + curasemilla (IBMC). …”
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The First Harmonic of Radial Pulse as an Early Predictor of Silent Coronary Artery Disease and Adverse Cardiac Events in Type 2 Diabetic Patients by Chi-Wei Chang, Kuo-meng Liao, Yi-Ting Chang, Sheng-Hung Wang, Ying-chun Chen, Gin-Chung Wang

“…By comparing the data of patients with C1 smaller than the first quartile and the patients with C1 greater than the third quartile, the hazard ratios were listed as follows: ACE (hazard ratio, 2.29; 95% CI, 1.55–3.37), heart failure (hazard ratio, 2.22; 95% CI, 1.21–4.09), myocardial infarction (hazard ratio, 2.44; 95% CI, 1.51–3.93), left ventricular dysfunction (Hazard ratio, 2.01; 95% CI, 0.86–4.70), and new symptoms and signs for coronary artery disease (hazard ratio, 2.03; 95% CI, 1.45–2.84). …”
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Meta-analysis to evaluate the comparative effectiveness of enzalutamide and abiraterone acetate for first-line treatment of metastatic castration-resistant prostate cancer in real-... by Armen Aprikian, Amit Bahl, Aurelius Omlin, Giulia Baciarello, Abhiroop Chakravarty, Prashanth Kondaparthi, Georgia Gourgioti, Thomas McLean, Alexis Serikoff, Andrew Chilelli

“…Among the studies reporting adjusted HRs, the pooled-effect estimate favored enzalutamide over abiraterone (reference group) in the fixed-effect model (HR: 0.90 [95% CI: 0.87–0.93]) and the random-effect model (HR: 0.90 [95% CI: 0.86–0.94]). …”
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Otologic Manifestations in Patients with Achondroplasia: A Multicenter Study by Dohee Kim, Joonsik Yoon, Myung-Whan Suh, Jun Ho Lee, Moo Kyun Park

“…Eighteen patients (25.7%) had adenoid hypertrophy, and 16 (22.9%) underwent adenoidectomy. …”
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Effectiveness of multimethod, community-based educational interventions on the knowledge and attitude to birth preparedness and complications readiness among women in southwest Nig... by Bosede B Afolabi, Ifeoma P Okafor, Mobolanle R Balogun, Adekemi O Sekoni, Duro C Dolapo, Claudia A Hawkins

“…Most respondents in both groups had a positive attitude to BP/CR, the intervention had no significant influence on this in the IG (p=0.504).Predictors of adequate knowledge of BP/CR included being of Yoruba tribe, (adjusted OR (AOR) 2.83, 95% CI 1.06 to 7.54), being employed, (AOR 1.31; 95% CI 1.04 to 5.87) and having a baby 6 months prior to the study (AOR 2.62; 95% CI 1.31 to 5.24).Conclusion Findings have implications for the design and implementation of relevant policy and community interventions to reduce maternal mortality. …”
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Nutritional Analysis of Three Commonly Consumed Varieties of Sorghum (<i>Sorghum bicolor L.</i>) in Bauchi State, Nigeria by Z.S. Mohammed, A.H. Mabudi, Y. Murtala, S. Jibrin, S. Sulaiman, J. Salihu

“… Three sorghum samples (yellow, red, and white sorghums) were analyzed for their proximate, vitamin (B1, B3, B6) and mineral element (Mg, Na, K, Ca, Fe, Zn, Cu and Mn) compositions. Vitamins and mineral compositions were determined using HPLC and AAS respectively. …”
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Antibodies Against β2-Glycoprotein I Complexed With an Oxidised Lipoprotein Relate to Intima Thickening of Carotid Arteries in Primary Antiphospholipid Syndrome by P. R. J. Ames, J. Delgado Alves, L. R. Lopez, F. Gentile, A. Margarita, L. Pizzella, J. Batuca, G. Scenna, V. Brancaccio, E. Matsuura

“…In PAPS, IgG anti-2GPI−oxLig-1 independently predicted PONa (p = 0.02) and IMT of B (p = 0.003), CC, (p = 0.03) and of IC (p = 0.04). In PAPS, PONa inversely correlated to the IMT of B, CC and IC (p = 0.01, 0.02 and 0.003, respectively). …”
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Study on the impact parameters of convective heat transfer in industrial-scale Siemens reactor by Xingping Yuan, Dan Zhao, Yanqing Hou, Ni Yang, Wenhui Ma, Fengyang Chen, Gang Xie

“…Consequently, the established forced CHT model and correlation equation can effectively predict CHT in industrial-scale Siemens reactors. …”
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Acceptance of artificial intelligence clinical assistant decision support system to prevent and control venous thromboembolism among healthcare workers: an extend Unified Theory of... by Jingxian Wang, Yun Zhou, Yun Zhou, Kai Tan, Zhigang Yu, You Li

“…Top management support was an antecedent of performance expectancy (β = 0.41 , P &lt; 0.001), social influence (β = 0.57, P &lt; 0.001), effort expectancy (β = 0.61, P &lt; 0.001), and information quality (β = 0.59, P &lt; 0.001). …”
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Design and fabrication of {111}-textured nanotwinned silver coating for enhancing surface wear resistance of depleted uranium by Kunming Yang, Xiaobo Wang, Shengfa Zhu, Yawen Zhao, Qingdong Xu, Yiyun Wei, Chao Lu, Zhiyuan Wen, Tongxiang Fan, Mingyu Gong, Anyi Yin, Wenhua Luo

“…Microstructural characterizations showed that at the optimized bias voltage of −400 V, the sputter-deposited Ag coating exhibited {111}-oriented texture with high-density nanoscale twins and also well-bonded Ag/DU interface with an UO2 interlayer, thus endowing the Ag coating highly stable wear resistance with low mass wear rate of ∼1.37 × 10−7 g/(N·s). The present findings may shed lights on microstructural and interface design of surface anti-wear coatings on U and its alloys.…”
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ALCAM is an entry factor for severe community acquired Pneumonia-associated Human adenovirus species B by Yusang Xie, Hong Mei, Wei Wang, Xiao Li, Pengfei Hu, Xingui Tian, Rong Zhou, Jia Liu, Jieming Qu

“…Abstract Human adenovirus (HAdV) is a widely spread respiratory pathogen that can cause infections in multiple tissues and organs. …”
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Model Prognosis Masa Pengobatan Pasien Tuberkulosis Dengan Metode C4.5 by Rusdah Rusdah, Brian Agni Bregastantyo

“…The patient's habit factor and the patient's time to take medication must be closely monitored so that the treatment period can be shortened. Pulmonary Specialists try to reduce the Drop Out rate of Tuberculosis patients by monitoring their schedule with good management. …”
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