大蒜素对神经母细胞瘤生长的抑制作用

“…【目的】 探讨大蒜素对神经母细胞瘤生长的影响及相关机制65377;【方法】 MTT法测定不同浓度大蒜素对神经母细胞瘤细胞生长的影响;建立裸鼠人神经母细胞瘤皮下移植瘤模型24只(n = 8),随机分为对照组65380;大蒜素Ⅰ组(1 mg8226;kg-18226;d-1)和大蒜素Ⅱ组(10 mg8226;kg-18226;d-1),观察其对肿瘤生长的影响,荧光定量PCR法测定大蒜素对裸鼠皮下移植瘤VEGF mRNA表达的影响;ELISA法测定裸鼠血浆VEGF浓度;免疫组化法观察肿瘤微血管密度65377;【结果】 不同浓度的大蒜素均能抑制神经母细胞瘤细胞的生长,高浓度的大蒜素能直接杀死肿瘤细胞;大剂量和小剂量大蒜素对裸鼠神经母细胞瘤皮下移植瘤均有抑制作用65377;对照组65380;大蒜素Ⅰ组和Ⅱ组的肿瘤体积为(2143 ± 127) mm365380;(1041 ± 89) mm3和(904 ± 65) mm3 (P < 0.05);大蒜素能下调神经母细胞瘤VEGF mRNA转录,对照组65380;大蒜素Ⅰ组和Ⅱ组VEGF mRNA表达量分别为(8.4 ± 0.8)65380;(6.1 ± 0.7)和(5.1 ± 0.5);大蒜素能够抑制肿瘤细胞VEGF的表达,对照组65380;大蒜素Ⅰ组和Ⅱ组裸鼠血VEGF浓度分别为(78 ± 10)65380;(45 ± 8)和(35 ± 7) pg/mL;大蒜素可以减少神经母细胞瘤的微血管密度65377;【结论】 大蒜素在体内和体外均可抑制神经母细胞瘤细胞的生长,其机制与大蒜素抑制肿瘤细胞增殖和下调神经母细胞瘤VEGF mRNA的转录和蛋白表达有关65377;…”
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The Upregulation of COX2 in Human Degenerated Nucleus Pulposus: The Association of Inflammation with Intervertebral Disc Degeneration by Chang Liu, Guoyan Liang, Zhantao Deng, Jing Tan, Qiujian Zheng, Feng-Juan Lyu

“…The IOD and number of COX2-positive cells were divided by the total cell number to obtain COX2 expression density (IOD/cell) and COX2 positivity (cell+/cell). …”
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Increasing Health Burdens Driven by Global Trade Induced Air Pollution by Ruifei Li, Yu Luo, Xu Zhu, Jin Zhang, Pei Hua, Zhenyu Wang, Wenyu Yang, Qiuwen Chen, Hui Li

“…Results show that consumption transferred more primary PM2.5 emissions (2.2 Mt, 23.5%) and caused more additional mortality (241,000 deaths) through international trade than primary input (emission: 1.1 Mt, 12.3%, mortality: 167,000 deaths) in 2015. Top three key sectors contributed to more than half of emission flow driven by consumption (commercial, construction, electrical and machinery) and primary inputs (commercial, petroleum, and mining). …”
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Thapsigargin对心肌细胞钙释放和肌浆网钙容量的时问效应 by 沈建新, 王世强, 程和平, 韩太真

“…（结果 l TC对ACT峰值（可衡虽钙瞬变的大小）的时间效应如下： 0 min,5. 55土0. 28 (单位为标准钙荧光强度即Fl Fo, 凡为静息钙荧光强度）； 10 min, 4. 89士0. 36; 17 min, 2. 58土0.38; 25 min, 2. 11士0.19; 35 min, 2. 22士0.17;50 min, 2. 27士0.27。 …”
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Total Phenolic, Flavonoid, Tomatine, and Tomatidine Contents and Antioxidant and Antimicrobial Activities of Extracts of Tomato Plant by Norma Patricia Silva-Beltrán, Saul Ruiz-Cruz, Luis Alberto Cira-Chávez, María Isabel Estrada-Alvarado, José de Jesús Ornelas-Paz, Marco Antonio López-Mata, Carmen Lizette Del-Toro-Sánchez, J. Fernando Ayala-Zavala, Enrique Márquez-Ríos

“…The Pitenza variety extracts inhibited the growth of pathogens such as E. coli O157:H7, Salmonella Typhimurium, Staphylococcus aureus, and Listeria ivanovii, yielding inhibition halos of 8.0 to 12.9 mm in diameter and MIC values of 12.5 to 3.125 mg/mL. …”
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Analysis of Changes in Retinal Thickness in Type 2 Diabetes without Diabetic Retinopathy by Jing Jiang, Yan Liu, Yingchao Chen, Bo Ma, Yiwen Qian, Zhenzhen Zhang, Dongqing Zhu, Zhiliang Wang, Xiaofang Xu

“…Regression analysis revealed that decreased retinal thickness of the temporal perifovea was associated with a higher HbA1c level (>8.7%) (p=0.04). Conclusion and Relevance. …”
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Global prevalence of platelet-type von Willebrand disease by Omid Seidizadeh, Andrea Cairo, Maha Othman, Flora Peyvandi

“…Methods: We used available exome and genome sequencing data of 807,162 (730,947 exomes and 76,215 genomes) subjects from the Genome Aggregation Database (gnomAD-v4.1). …”
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Pretransplant Immune- and Apoptosis-Related Gene Expression Is Associated with Kidney Allograft Function by Dorota Kamińska, Katarzyna Kościelska-Kasprzak, Paweł Chudoba, Oktawia Mazanowska, Mirosław Banasik, Marcelina Żabinska, Maria Boratyńska, Agnieszka Lepiesza, Agnieszka Gomółkiewicz, Piotr Dzięgiel, Marian Klinger

“…In a prospective study, we analyzed pretransplant peripheral blood gene expression in87 renal transplant candidates with real-time PCR on custom-designed low density arrays (TaqMan). …”
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Characterization and Removal of Condensable Particulate Matter in Flue Gas Studied with Cold Electrode Electrostatic Precipitator by Wenting Liu, Bowen Zhao, Xin Wang, Jianyi Lu

“…The removal rate can reach up to 93%. The average CPM concentration after removal was 2.8 mg Nm−3, and the CE-ESP had a significant removal effect on SO42−, Ca, As, esters, and olefins from CPM. …”
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Le mutilazioni genitali femminili e l’ostetrica: uno studio osservazionale tra formazione e competenza by Chaymae Ahnou, Rosanna De Serio, Chiara Gatti, Fabia Pioli, Gloria D'Angelo, Tania Miconi, Renato Rocchi, Stefano Marcelli

“…CONCLUSIONI: Sarebbe opportuno creare dei corsi di approfondimento che affrontino la tematica per formare le persone che non hanno avuto modo di farlo nel passato, e aggiornare chi invece ha avuto l’opportunità di approfondirla già …”
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Newcastle disease virus genotype VII.1.1 identified from backyard chickens with low antibody titer: Jimma Zone, Southwest Ethiopia. by Bezina Arega Emeru, Haregawi Tesfaye Desta, Yosef Deneke

“…Nucleotide-sequenced isolates were nearly identical (99.7%) to each other and identified as velogenic based on the F-gene cleavage site (RRQKRF) with genotype VII.1.1. …”
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Mucosa-Associated Escherichia coli in Colorectal Cancer Patients and Control Subjects: Variations in the Prevalence and Attributing Features by Roghayeh Nouri, Alka Hasani, Kourosh Masnadi Shirazi, Mohammad Reza Alivand, Bita Sepehri, Simin Sotoudeh, Fatemeh Hemmati, Afshin Fattahzadeh, Babak Abdinia, Mohammad Ahangarzadeh Rezaee

“…Enteropathogenic Escherichia coli (EPEC) was also found in 23% of CRC strains and 7.1% of control strains (p<0.05). …”
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Data-Driven Model for the Prediction of Total Dissolved Gas: Robust Artificial Intelligence Approach by Mohamed Khalid AlOmar, Mohammed Majeed Hameed, Nadhir Al-Ansari, Mohammed Abdulhakim AlSaadi

“…Lastly, for USGS 14181500 station, the statistical measures for ELM (SVR) were, respectively, reported as R2 of 0.991 (0.991), MAE of 0.338 (0.396), and U95 of 0.832 (0.837). In addition, ELM’s training process computational time is stated to be much shorter than that of SVM. …”
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Association between Optical Coherence Tomography Measurements and Clinical Parameters in Idiopathic Intracranial Hypertension by Priscilla Fernandes Nogueira, Gustavo Coelho Caiado, Carolina P. B. Gracitelli, Fernando Meister Martins, Felipe Chaves Duarte Barros, Sandro Luis De Andrade Matas, Sérgio Henrique Teixeira, Luciana da Cruz Noia, Danilo Andriatti Paulo

“…There was a significant association between GCC thickness and optic disc pallor (p=0.016) and between edema and visual acuity (p=0.037). No significant difference was found in RNFL thickness between patients and controls. …”
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姜酚肟对谷氨酸诱导PC12细胞损伤的保护作用 by 杜瑞, 王辉, 黄雪松, 郭国庆, 沈伟哉

“…谷氨酸(5 mmol/L)能诱导PC12细胞凋亡，处理24 h 后细胞凋亡率为20.1﹪, 经姜酚肟(3.125、6.25、12.5、25 μg/ml )预处理后，细胞凋亡率明显降低，分别为3.5﹪(P<0.01), 2.8﹪(P<0.01), 9.6﹪(P<0.01), 17.7﹪(P<0.05)。【结论】谷氨酸能诱导PC12细胞凋亡，较低浓度的姜酚肟能有效保护PC12细胞免受谷氨酸诱导的细胞损伤，其中6.25 μg/ml的姜酚肟效果最好。…”
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Pengaruh Pemberian Tablet Zink dan Besi terhadap Kadar Hemoglobin dan Feritin pada Ibu Hamil Anemia Defisiensi Besi by Desi Wildayani, Yusrawati Yusrawati, Hirowati Ali

“…Hasil penelitian didapatkan ibu hamil yang diberikan tablet zink dan besi rata-rata selisih kadar hemoglobinnya lebih tinggi (1,07 g/dl) dibandingkan dengan ibu hamil yang mendapatkan tablet besi saja (0,81 g/dl), dengan nilai p = 0,190. …”
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The Efficacy of Parenteral Nutrition and Enteral Nutrition Supports in Traumatic Brain Injury: A Systemic Review and Network Meta-Analysis by Yan Qin, Maoxia Liu, Fengbao Guo, Du Chen, Peng Yang, Xionghui Chen, Feng Xu

“…No effects on in-hospital mortality (Median RR = 1.06, 95% Crl = 0.12 to 1.77) and the value of 0-1 days of serum albumin were found between the included regimens. …”
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Effect of bleaching and repolishing on whiteness change and staining susceptibility of resin-based materials by Sultan Aktuğ Karademir, Samet Atasoy, Beyza Yılmaz

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骨髓间充质干细胞对高氧肺损伤大鼠的治疗作用 by 张红珊

“…C组, P < 0.05),RAC值明显增加(9.2 ± 0.7 vs. 7.4 ± 0.4,A组 vs. …”
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Impact of a potential Chlamydia vaccine in the USA: mathematical modelling analyses by Hiam Chemaitelly, Laith J Abu-Raddad, Houssein H Ayoub, Susanne F Awad, Monia Makhoul

“…Number of vaccinations needed to avert one infection was 17.7 for VES=50%, 26.5 for VEI=50%, 33.4 for VEP=50% and 12.0 for VES=VEI=VEP=50%. …”
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