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Inhibition of Mitochondrial Fission Reverses Simulated Microgravity-Induced Osteoblast Dysfunction by Enhancing Mechanotransduction and Epigenetic Modification
Published 2025-01-01“…Moreover, our study showed that SMG-induced chromatin remodeling and histone methylation, which are epigenetic barriers to osteogenic differentiation, can be reversed by targeting mitochondrial fission, further highlighting the significance of mitochondrial dynamics in osteoblast function in an SMG environment. …”
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4203
Electroacupuncture Mitigates Hippocampal Cognitive Impairments by Reducing BACE1 Deposition and Activating PKA in APP/PS1 Double Transgenic Mice
Published 2019-01-01“…Previous studies indicated that BACE1 initially cleaves the amyloid precursor protein (APP) and may subsequently interfere with physiological functions of proteins such as PKA, which is recognized to be closely associated with long-term potentiation (LTP) level and can effectively ameliorate cognitive impairments. …”
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4204
Discovery of new topological insulators and semimetals using deep generative models
Published 2025-01-01Get full text
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4205
Dual phase reinforced CuCrZr alloy: Synergistic improvement of mechanical properties and corrosion resistance via metallic glass and rare earth oxides
Published 2025-03-01Subjects: “…Cu-based composites…”
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4206
Lysosphingolipids in ceramide-deficient skin lipid models
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4207
Pan-genome analysis and expression verification of the maize ARF gene family
Published 2025-02-01“…Simultaneously, the structural variation also influenced the conserved domain and cis-acting elements of the gene. Further combining the transcriptome data and RT-qPCR found that, The expression levels of ARF family members in maize were higher at the early stage of embryo and grain development, and the expression levels of each member in embryo and grain were complementary, and the ARF4 plays an important role in abiotic stress. …”
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4208
Maternal age-related declines in live birth rate following single euploid embryo transfer: a retrospective cohort study
Published 2025-02-01“…Multivariable regression analysis revealed that compared with women aged ≥ 38 years, younger women had reduced risk of miscarriage (aOR = 0.371, 95% CI: 0.139–0.988 for the < 35 years group; aOR = 0.317, 95% CI: 0.106–0.954 for the 35–37 years group) and increased likelihood of live birth (aOR = 2.188, 95% CI: 1.154–4.147 for the < 35 years group; aOR = 2.239, 95% CI: 1.0103–4.548 for the 35–37 years group) after adjusting for relevant confounders. …”
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4209
Preoperative Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and CEA as the Potential Prognostic Biomarkers for Colorectal Cancer
Published 2022-01-01“…The mean follow-up duration was 32.8 ± 19.1 months (range, 0.1–67.7). Compared with the median OS, preoperative high NLR, PLR, and CEA, and low BMI had lower median OS. …”
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4210
Research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic stroke
Published 2025-01-01“…There is an urgent need to better understand the pathophysiology and pathogenesis of PSCI, as well as to identify markers that can predict PSCI early in the clinical stage, facilitating early prevention, monitoring, and treatment. …”
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Single-cell RNA sequencing reveals the heterogeneity and interactions of immune cells and Müller glia during zebrafish retina regeneration
Published 2025-12-01“…We further showed that retinal microglia can be categorized into three subtypes (microglia-1, microglia-2, and proliferative) and pseudotime analysis demonstrated dynamic changes in microglial status following retinal injury. …”
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Prognostic assessment of early-stage liver cirrhosis induced by HCV using an integrated model of CX3CR1-associated immune infiltration genes
Published 2025-01-01Subjects: Get full text
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Controlled Growth of ZnSe Nanocrystals by Tuning Reactivity and Amount of Zinc Precursor
Published 2013-01-01“…This allows that the controlled growth and excellent optical property of high-quality ZnSe nanocrystals can be achieved by combining the different reactivity and the used amount of zinc precursor, such as by using stoichiometric and reactive Zn precursor and Se precursor or by using larger amount of more unreactive Zn precursor relative to the highly reactive alkylamine-H2Se complex precursor.…”
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The value of growth differentiation factor 15 as a biomarker for peripheral artery disease in diabetes patients
Published 2025-01-01“…High GDF15 levels were associated with ABI < 0.9 (right and left mean 19.5% p = 0.80, OR:1.13; 95%CI: [0.44–2.90]). Increased age (p = 0.025 OR:1.02; 95% CI [0.13–0.87]), family history (p = 0.001 OR:1.37; 95%CI: [0.37–5.05]), heart failure (p = 0.002 OR:4.96; 95%CI: [1.76–13.97]), sodium-glucose linked transporter 2 (SGLT 2) inhibitor use (p = 0.026), estimated glomerular filtration rate (eGFR) (p = < 0.001), and uric acid (p = < 0.001) was also positively associated with high GDF15 levels. …”
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Long-Term Assessment of Soil Salinization Patterns in the Yellow River Delta Using Landsat Imagery from 2003 to 2021
Published 2024-12-01“…The salinized area increased from 538.4 km<sup>2</sup> in 2003 to 761.5 km<sup>2</sup> in 2021, particularly between 2009 and 2015, with a 47.95% increase. The main factors influencing salinization in the YRD were distance from the Bohai Sea, seasonal average potential evapotranspiration, and seasonal average normalized vegetation index, with interaction-driven effects being stronger than single-factor effects. …”
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Five Years Survival in Patients Operated from Malignant Neoplasm of Colon and Rectum
Published 2012-02-01“…<strong><br />Resultados</strong>: a supervivencia global fue de un 66,7 % a los 5 años, y las etapas I y IIb fueron las de mayor sobrevida, con un 81 a 77 %. …”
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Nanoscale ultrafast dynamics in Bi2Te3 thin film by terahertz scanning near-field nanoscopy
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