Potential value of novel multiparametric MRI radiomics for preoperative prediction of microsatellite instability and Ki-67 expression in endometrial cancer by Zhichao Wang, Yan Hu, Jun Cai, Jinyuan Xie, Chao Li, Xiandong Wu, Jingjing Li, Haifeng Luo, Chuchu He

“…For the MSI prediction task, the HMRadSum model achieved area-under-curve (AUC) value of 0.945 (95% CI 0.862-1.000) and accuracy of 0.889. For the Ki-67 prediction task, the AUC and accuracy of HMRadSum model was 0.888 (95% CI 0.743-1.000) and 0.810. …”
Get full text

Mitochondrial Quality Control Orchestrates the Symphony of B Cells and Plays Critical Roles in B Cell-Related Diseases by Wuhao Li, Peiyang Cai, Ye Xu, Weihong Tian, Licong Jing, Qiaoyi Lv, Yangjing Zhao, Hui Wang, Qixiang Shao

Get full text

A local and territorial approach to the operation of the culture economy in medium and small cities: case study of the Spanish cities of Mérida and Cuenca by Diego Antonio Barrado-Timón, Ana I. Escalona-Orcao, Carmen Hidalgo-Giralt, Carmen Vázquez-Varela, Francisca Cea-D’Ancona

“…A este fin se ha realizado una aproximación territorial a escala local con una combinación de métodos cuantitativos y cualitativos que se han aplicado a las ciudades españolas de Mérida y Cuenca, elegidas como estudio de caso. …”
Get full text

A Novel Bimodal Imaging Agent Targeting HER2 Molecule of Breast Cancer by Wei Lv, Yamei Shen, Hengli Yang, Rui Yang, Wenbin Cai, Jian Zhang, Lijun Yuan, Yunyou Duan, Li Zhang

“…The prepared IR783-NBs-Affibody presented a uniform nanoscale size around 482.7 ± 54.3 nm, good biosecurity, and stability over time. …”
Get full text

Cortical Gyrification and Cognitive Decline in the Human Brain With Type 2 Diabetes Mellitus by Weiye Lu, Yuna Chen, Zidong Cao, Zhizhong Sun, Wenbin Qiu, Limin Ge, Xin Tan, Yi Liang, Shijun Qiu

“…Results Our study found that the mean LGI of the entire brain in individuals with T2DM was lower than that of NGM, and these significant hypogyria were mainly located in the bilateral temporal lobes, including the left superior temporal cortex, left transverse temporal cortex, and bilateral temporal pole, with the greatest effect size in the left temporal pole (p = 5.7×10−7, Cohen's f2 = 0.169). In addition, the relationship between fasting blood glucose and working memory was mediated by the LGI in the right temporal pole. …”
Get full text

Prevalence and risk factors associated with prehypertension in Shunde District, southern China by Yuli Huang, Yunzhao Hu, Xiaoyan Cai, Wenke Qiu, Changhua Liu, Dingji Zhu, Jinghai Hua, Yanxian Wu, Dingli Xu

“…Multivariate logistic regression analysis showed that overweight (OR=2.84, 95% CI 1.55 to 5.20), male sex (OR=2.19, 95% CI 1.39 to 3.45), age (per 10 years, OR=1.21, 95% CI 1.02 to 1.44, p=0.03) and hyperuricaemia (OR=1.70, 95% CI 1.14 to 2.54) were independent risk factors of prehypertension.Conclusions Prehypertension is highly prevalent in southern China. …”
Get full text

Novel MFSD8 Variants in a Chinese Family with Nonsyndromic Macular Dystrophy by Qin Xiang, Yanna Cao, Hongbo Xu, Zhijian Yang, Liang Tang, Ju Xiang, Jianming Li, Hao Deng, Lamei Yuan

“…Novel compound heterozygous variants, c.1066C>T (p.Pro356Ser) and c.1102+2T>C, in the major facilitator superfamily domain containing 8 gene (MFSD8) were suspected to be involved in this family’s macular dystrophy phenotype. …”
Get full text

Comparative Analysis of the Therapeutic Effects of MSCs From Umbilical Cord, Bone Marrow, and Adipose Tissue and Investigating the Impact of Oxidized RNA on Radiation-Induced Lung... by Rui Zhai, Fumin Tai, Kexin Ding, Xin Tan, Hujie Li, Zhengyue Cao, Changhui Ge, Xiaofei Zheng, Hanjiang Fu

“…Mesenchymal stem cells (MSCs) can repair injured tissues, and the reparative potential and molecular mechanism of MSCs in treating RILI remains incompletely understood. …”
Get full text

The atherogenic index of plasma is associated with an increased risk of diabetes in non-obese adults: a cohort study by Jun Cao, Zhaohai Su, Jiangyong Yang, Bilong Zhang, Rengui Jiang, Weiling Lu, Zhenhua Huang, Zhenhua Huang, Zheng Xie

“…Adjusted analyses demonstrated a strong positive association between AIP and the risk of diabetes onset (HR 2.07; 95% CI: 1.63-2.63; p < 0.001). The risk of diabetes increased with higher AIP quartiles, especially between the highest (Q4) and lowest (Q1) quartiles (adjusted HR 1.55; 95% CI: 1.27-1.89). …”
Get full text

Influence of Mountain Wildfires on the Insulation Properties of Air Gaps in Power Grids by Fangrong Zhou, Hao Geng, Gang Wen, Yutang Ma, Yi Ma, Guofang Wang, Jun Cao, Jiaze Xu, Hongwei Mei

Get full text

Machine Learning–Based Risk Factor Analysis and Prediction Model Construction for the Occurrence of Chronic Heart Failure: Health Ecologic Study by Qian Xu, Xue Cai, Ruicong Yu, Yueyue Zheng, Guanjie Chen, Hui Sun, Tianyun Gao, Cuirong Xu, Jing Sun

“…Validation on the training and validation sets through 10-fold cross-validation gave an AUC of 0.97, an accuracy of 91.27%, a precision of 0.94, a sensitivity of 0.92, and an F1-score of 0.94. …”
Get full text

Effects of Simvastatin on Glucose Metabolism in Mouse MIN6 Cells by Jieqiong Zhou, Weihua Li, Qiang Xie, Yuxi Hou, Shaopeng Zhan, Xi Yang, Xiaofeng Xu, Jun Cai, Zhengrong Huang

“…Real-time PCR and western blotting were performed to measure the mRNA and protein levels of inward rectifier potassium channel 6.2 (Kir6.2), voltage-dependent calcium channel 1.2 (Cav1.2), and glucose transporter-2 (GLUT2), respectively. …”
Get full text

An Interpretable Prediction Method for Tobacco Drying Process Based on CGTNN by Wencai Wang, Chen Yang, Wenwei Niu, Sidi Lin, Qiang Gao, Zhe Cao, Jianning Chen, Jianzhong Li, Zhengkui Li

“…Experiments with production data show that the model accurately predicts moisture content with a Mean Absolute Error (MAE) of 0.016%, Root Mean Squared Error (RMSE) of 0.024%, and an Explainable variance (R2) of 0.987, outperforming other models. This approach significantly reduces delays and errors in moisture monitoring, enhancing accuracy and reliability in practical applications.…”
Get full text

Corrigendum: Effects of rosemary extract and its residue on production, immune performance, and gut microbiota in geese by Yuzhi Huang, Lanmeng Xu, Hang He, Lijuan Peng, Qinfeng Liao, Kun Wan, Simeng Qin, Lijing Cao, Jie Zhang

Get full text

Deciphering Gas Dynamics and Star Formation in a z = 1.1 Main-sequence Spiral Galaxy with ALMA and JWST by Zhaoran Liu, Tadayuki Kodama, Takahiro Morishita, Kianhong Lee, Fengwu Sun, Mariko Kubo, Zheng Cai, Yunjing Wu, Zihao Li

“…We present a joint analysis of high-resolution CO(2–1) and Paschen- α (Pa α ) emission lines to trace gas dynamics and spatially resolved star formation in ASPECS-LP.3 mm.06, a z = 1.1 main-sequence galaxy. …”
Get full text

Modeling and simulation for toxicity assessment by Cristina Anton, Jian Deng, Yau Shu Wong, Yile Zhang, Weiping Zhang, Stephan Gabos, Dorothy Yu Huang, Can Jin

“…Using stability analysis and numerical simulations, we determine the lowest concentration of toxin that can kill the cells. This information can be used to better design experimental studies for cytotoxicity profiling assessment.…”
Get full text

The effects of aerobic exercise on goal-directed attention and inhibitory control in individuals with high trait anxiety: an EEG study by Mengyang He, Jinxia Guo, Shunyao Yu, Hao Lian, Ruijie Zhan, Rongrong Luo, Zhifei Shi, Zhidong Zhuang, Wenpeng Cai

“…In Experiment 1, goal-directed attention was assessed using a cue-object paradigm, and in Experiment 2, inhibitory control was evaluated through a visual search task. …”
Get full text

ALDH2 Overexpression Alleviates High Glucose-Induced Cardiotoxicity by Inhibiting NLRP3 Inflammasome Activation by Ruiping Cao, Dian Fang, Jiahui Wang, Ying Yu, Hongwei Ye, Pinfang Kang, Zhenghong Li, Hongju Wang, Qin Gao

“…The purpose of this study was to investigate the changes of NLRP3 inflammasome and pyroptosis in high glucose-induced H9C2 cardiac cell injury and investigate whether overexpression of mitochondrial aldehyde dehydrogenase 2 (ALDH2) can reduce the occurrence of pyroptosis. …”
Get full text

Secondary Metabolites from the Mangrove Ecosystem-Derived Fungi <i>Penicillium</i> spp.: Chemical Diversity and Biological Activity by Guojun Zhou, Jin Cai, Bin Wang, Wenjiao Diao, Yu Zhong, Shaodan Pan, Weijia Xiong, Guolei Huang, Caijuan Zheng

“…Among these natural products, the plausible biosynthetic pathways of 37 compounds were also proposed; 11 compounds have novel skeleton structures, and 26 compounds contain halogen atoms. …”
Get full text

Biosynthesis inhibition of miR-142-5p in a N 6-methyladenosine-dependent manner induces neuropathic pain through CDK5/TRPV1 signaling by Jinshi Li, Yang Guo, Chen Zhu, Dongxu Wang, Yuan Li, Xiaotong Hao, Linyan Cao, Yiting Fan, Bo Fang

Subjects: Get full text