Exploring the Impact of Systemic Inflammatory Regulators on Rosacea Risk: A Bidirectional Mendelian Randomization Analysis by Xue Q, Pan JP, Qian D, Ji J, Fei LY, Yao S, Tan X, Fan WG

“…Qiao Xue,1 Jian Peng Pan,2 Da Qian,3 Jie Ji,4 Lai Yi Fei,1 Sheng Yao,1 Xing Tan,1 Wen Ge Fan1 1Department of Dermatology, Changshu No. 1 People’s Hospital, Changshu Hospital Affiliated to Soochow University, Changshu, Jiangsu, 215500, People’s Republic of China; 2Department of Hand Surgery, Changshu No. 2 People’s Hospital, The Affiliated Changshu Hospital of Nantong University, Changshu, Jiangsu, 215500, People’s Republic of China; 3Department of Burn and Plastic Surgery-Hand Surgery, Changshu No. 1 People’s Hospital, Changshu Hospital Affiliated to Soochow University, Changshu, Jiangsu, 215500, People’s Republic of China; 4Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210000, People’s Republic of ChinaCorrespondence: Qiao Xue, Department of Dermatology, Changshu Hospital Affiliated to Soochow University, Changshu No. 1 People’s Hospital, No. 1 Shuyuan Street, Yushan Town, Changshu, Jiangsu, 215500, People’s Republic of China, Tel +86-13913657476, Email ahjk157@126.com Jian Peng Pan, Department of Hand Surgery, The Affiliated Changshu Hospital of Nantong University, Changshu No. 2 People’s Hospital, 68 South Haiyu Road, Yushan Town, Changshu, Jiangsu, 215500, People’s Republic of China, Tel +86-13814964481, Email 574161036@qq.comObjective: Rosacea is a common chronic inflammatory disorder primarily affecting the face. …”
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Dynamics of land use land cover change and its effect on urban heat island in Halaba Kulito Town by Begonet Dale, Mihret Dananto, Bisrat Kifle

“…Over the first two decades, from 1991 to 2001 and 2001 to 2011, the quantity of land under cultivation increased by 15.7 % and 14.3 %, respectively, but dropped by 59.18 % from 2011 to 2021. …”
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Genome-wide association study analysis of single nucleotide variants in L. infantum associated with IL-6 inflammatory response in visceral leishmaniasis by Amanda Miranda da Silva, Kátia Silene Sousa Carvalho, Caio Andrey Bezerra Januário, Raquel Gomes de Sena Carneiro Caldas, Bianka Lopes da Silva Paulino, Débora Cavalcante Braz, Dorcas Lamounier Costa, Gabriel da Luz Wallau, Wilson Jose da Silva Junior, Carlos Henrique Nery Costa

“…The analysis revealed that the relationship between IL-6 levels and clinical outcomes (survival vs mortality) had an area under the curve (AUC) of 0.67 (95% CI 0.52–0.81). A cut-off of 391.7 pg mL−1 for IL-6 was established to conduct a logistic regression analysis. …”
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Isothermal section of the Ni-Mn-Sb ternary system at 773K by Ao W.-Q., Yu H.-Z., Liu F.-L., Liu F.-S., Li J.-Q., Du Y., Liu S.-H., Shi C.-Y.

“…The four binary compounds Ni3Sb (Cu3Ti structure, Pmmn space group), Ni5Sb2 (Ni5Sb2-type structure, C2 space group), NiSb2 (FeS2-type structure, Pnnm space group) and Mn2Sb (Cu2Sb-type structure, P4/nmm space group) in the binary systems Ni-Sb and Mn-Sb were stoichiometric compounds, the homogeneity ranges of which were negligible. …”
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Morbilidad y mortalidad de la duodenopancreatectomía cefálica convencional en pacientes con enfermedad del confluente biliopancreático by José Alejandro Gutiérrez Aguller, Danilo Romaguera Barroso, Zenén Rodríguez Fernández, Oriol Valón Costa, Ana Lubín García, Lázaro Ibrahim Romero García

“…El estadio posoperatorio IIA fue el que prevaleció con 5 (45,5 %). El retraso del vaciamiento gástrico fue la complicación quirúrgica que prevaleció, con 7 (46,7 %) enfermos, seguida de la fístula biliar con 3 (20,0 %). …”
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Impact of Arterial Remodeling of Intermediate Coronary Lesions on Long-Term Clinical Outcomes in Patients with Stable Coronary Artery Disease: An Intravascular Ultrasound Study by Liang Geng, Peizhao Du, Yuan Yuan, Liming Gao, Yunkai Wang, Jiming Li, Qi Zhang

“…Negative remodeling lesions had the smallest minimum lumen area (4.16 ± 1.03 mm2 vs. 5.05 ± 1.39 mm2 vs. 4.85 ± 1.76 mm2; P<0.01), smallest plaque burden (63.45 ± 6.13% vs. 66.12 ± 6.82% vs. 71.17 ± 6.45%; P<0.01), and highest area stenosis rate (59.32% ± 10.15% vs. 54.61% ± 9.09% vs. 51.67% ± 12.96%; P<0.01). …”
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Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa by Frank Phoya, Claire Butters, Timothy F. Spracklen, Timothy F. Spracklen, Hanna L. Kassa, Hamza van der Ross, Chris Scott, Kate Webb, Kate Webb

Subjects: “…MIS-C (multisystem inflammatory syndrome in children)…”
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Increased aqueous humor levels of endothelin-1 in patients with open angle glaucoma by Adam Hedberg-Buenz, Erin A. Boese, Angela W. Nyunt, Nathan C. Sears, Andrew E. Pouw, Kai Wang, John H. Fingert

“…Analysis of covariance indicated neither age nor sex was associated with ET-1 level (p = 0.60 and p = 0.27), respectively. Controlling for age and sex had minimal influence on the comparison of ET-1 levels in the POAG versus control cohort (p = 0.018) and nominal influence on the comparisons between the NTG (p = 0.089) or XFG cohort (p = 0.15) relative to the control. …”
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Clinical Utility of the Trajectory of Serum Bilirubin and International Normalized Ratio Values in Hepatitis B Virus-Related Acute-on-Chronic Liver Failure by Song YQ, Fu XY, Yan SY, Qi RB, Zhou YJ, Liang JW, Zhang JQ, Ye LP, Mao XL, Li SW

“…Artificial liver support did not improve short-term prognosis for the stable group; instead, it was a risk factor (OR 2.16, 95% CI [0.23– 3.79], P=0.007). Subgroup analysis showed no interaction between predictive models and trajectory groups. …”
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The Prechtl’s General Movement Assessment, Hammersmith Infant Neurological Examination and Sensory Profile-2 in Prediction of Cerebral Palsy at Two Years of Age in High-risk Infant... by Hatice ADIGÜZEL, Halil İbrahim ÇELİK, Yusuf Ünal SARIKABADAYI, Nevin ERGUN, Bülent ELBASAN

“…In order to diagnose CP, it was important to consider the predictive values of the GMA (absent FMs) (sensitivity: 100%; specificity: 96.15%, p<0.001; 95% confidence interval: 80.36-99.9), HINE (sensitivity: 87.5%; specificity: 80.77%; p=0.004), and the combination of both GMA and HINE (sensitivity: 87.5%; specificity: 100%; p<0.001). …”
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Comparative safety of transvenous and leadless pacemakers in patients with cardiovascular diseases: A meta-analysis study by Cedric Mhasseb, Mayassa Kiwan, Marie-Elie Merhi, Nicolas Moussallem, Jana Moussalli, Maroun Abou Zeid, Sarah Abou Daher, Ghassan Nabbout, Sami Azar, Amjad Kanaan, Frederic Harb

“…Relative risks (RR) and odds ratio (OR) were used to evaluate the outcomes with a 95 % confidence interval (CI). Results: Nineteen studies met the inclusion criteria and were analyzed, in which the overall effect estimate showed increased risk of major complications in the TVP group (LogOR = −0.27, 95 % CI: [-0.63, 0.10]) compared to the LP group. …”
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Assessing the efficacy of iso-mukaadial acetate and betulinic acid against selected Plasmodium falciparum glycolytic pathway proteins: in silico and in vitro studies by Lindiwe Khumbuzile Zuma, Ofentse Jacob Pooe, Nonduduzo Hlengiwe Mabaso, John Alake, Vincent A. Obakachi, Sinethemba Yakobi, Nothando Gasa, Rajshekhar Karpoormath, Mthokozisi Simelane

“…Parasite inhibition studies confirmed potent antimalarial activity against the P. falciparum NF54 strains, with BA and IMA showing IC50 values of 1.27 µg/ml and 1.03 µg/ml against the asexual stage of P. falciparum, respectively. …”
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Narrow Linewidth All-Optical Microwave Oscillator Based on Torsional Radial Acoustic Modes of Single-Mode Fiber by Wen Wang, Wenjun He, Xinyue Fang, Yi Liu, Yajun You, Mingxing Li, Lei Yu, Qing Yan, Yafei Hou, Jian He, Xiujian Chou

“…The main ring cavity provides forward stimulated Brillouin scattering gain and utilizes a nonlinear polarization rotation effect to achieve TR_2,7 mode locking. By combining the sub ring cavity with the main ring cavity and utilizing the Vernier effect, the TR_2,7 mode microwave photonic single longitudinal mode (SLM) output can be ensured. …”
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Repurposing of phosphodiesterase-5 inhibitor sildenafil as a therapeutic agent to prevent gastric cancer growth through suppressing c-MYC stability for IL-6 transcription by Zhenzhan Zhang, Wuqing Huang, Donghua Huang, Zhou Xu, Qingfeng Xie, Xin Tan, Wenjun He, Weihao Yang, Guoxin Li, Jianguang Ji, Hao Liu

“…A total of 161 Swedish GC patients from a nationwide population-based cohort who received post-diagnostic PDE5 inhibitors demonstrated lower cancer-specific mortality compared to the controls (HR = 0.66, 95% CI = 0.47-0.92, P = 0.016). Functionally, the PDE5 inhibitor sildenafil exhibited the suppressive ability to prevent oncogenic growth in GC. …”
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Detection of Cervical Cancer and High Grade Neoplastic Lesions by a Combination of Liquid‐Based Sampling Preparation and DNA Measurements Using Automated Image Cytometry by Xiao Rong Sun, Jian Wang, David Garner, Branko Palcic

“…If DNA assisted cytology were to be used instead, and all cases having 3 or more cells with DNA amount greater than 5c were to be referred to colposcopy and biopsy, then 50 lesions that had to be removed would have been discovered (10 CIN2, 15 CIN3/CIS and 25 cancers) for the sensitivity of 54.3±6.2% at specificity of 96.9±0.6%. …”
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Augmentation index as a predictor of right ventricular dysfunction in coronary artery disease: a cross-sectional study by Arash Rahimi, Babak Geraiely, Hamed Vahidi, Mohammadreza Eftekhari, Ramyar Rahimi Darehbagh, Somayeh Mohammadi, Golrokh Ghaffari, Meysam Khoshavi

“…AIx correlated negatively with TAPSE (r=-0.421), FAC (r=-0.376), RVLS (r=-0.428), and RV S’ (r=-0.355) (all P < 0.001), and positively with pulmonary artery systolic pressure (r = 0.467, P < 0.001) and pulmonary vascular resistance (r = 0.297, P = 0.001). …”
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A High-Salt Diet Disturbs the Development and Function of Natural Killer Cells in Mice by Xiaokang Zeng, Yan Li, Weibiao Lv, Xinhuai Dong, Chong Zeng, Liming Zeng, Zibo Wei, Xu Lin, Yanning Ma, Qiang Xiao

“…Further, the development of NK cells in mice was evaluated, and it was found that HSD reduced the effective NK cell subset (CD27+CD11b-). Moreover, it was also found that the ability of NK cells to secrete CD107a and IFN-γ in HSD-fed mice was decreased following stimulation with RMA-S and YAC-1 tumor cells. …”
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Reduced white matter integrity and disrupted brain network in children with type 2 and 3 spinal muscular atrophy by Huirong Nie, Shasha Lan, Huan Wang, Pei Xiang, Mengzhen Yan, Yang Fan, Wanqing Shen, Yijuan Li, Wen Tang, Zhiyun Yang, Yujian Liang, Yingqian Chen

“…Results In total, 42 patients (mean age, 10.86 ± 4.07 years; 23 men) were included. TBSS analysis revealed widespread white matter changes in SMA patients. …”
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Kombucha Versus Vegetal Cellulose for Affordable Mucoadhesive (nano)Formulations by Ioana Popa-Tudor, Naomi Tritean, Ștefan-Ovidiu Dima, Bogdan Trică, Marius Ghiurea, Anisoara Cimpean, Florin Oancea, Diana Constantinescu-Aruxandei

“…VNC reduced the amount of reactive oxygen species (ROS) by about 23% (105.5 ± 2.2% of C−) in comparison with the positive control, whereas the ROS level was slightly higher (120.2 ± 3.9% of C−) following the BNC hydrogel treatment. …”
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Malva neglecta essential oil: A promising approach for bio-preserving mayonnaise and assessing variable correlations through principal component analysis and heat map by Amin Abbasi, Hedayat Hosseini, Hadi Pourjafar, Samaneh Moradi, Saeedeh Shojaee-Aliabadi

“…The MNEO-based bio-preservation strategy efficiently diminished microbial growth (S. aureus > E. coli O157:H7 > P. aeruginosa > S. enteritidis) and augmented the mayonnaise sample's shelf life (>40 days). …”
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