Improvement in XIa Selectivity of Snake Venom Peptide Analogue BF9-N17K Using P2′ Amino Acid Replacements by Li Ding, Zhiping Zhai, Tianxiang Qin, Yuexi Lin, Zhicheng Shuang, Fang Sun, Chenhu Qin, Hongyi Luo, Wen Zhu, Xiangdong Ye, Zongyun Chen, Xudong Luo

“…The XIa inhibitory activity of BF9-N17K-L19D was apparently enhanced, with an IC₅₀ of 19.28 ± 2.53 nM, and its plasmin inhibitory was significantly weakened, with an IC₅₀ of 459.33 ± 337.40 nM. …”
Get full text

EIF1AX mutation in thyroid tumors: a retrospective analysis of cytology, histopathology and co-mutation profiles by Noha Elsherbini, Dong Hyun Kim, Richard J. Payne, Thomas Hudson, Véronique-Isabelle Forest, Michael P. Hier, Alexandra E. Payne, Marc P. Pusztaszeri

“…All other mutations, except one, were located at the N-terminal in exon 2. 7/31 cases (22.6%) harbored ≥ 1 co-mutation(s), including 4 RAS, 3 TP53, 1 TERT and 1 PIK3CA, with 86% of them being malignant. …”
Get full text

How to estimate the probability of a live birth after one or more complete IVF cycles? the development of a novel model in a single-center by Xiangyi Kong, Zhiqiang Liu, Chunyu Huang, Xiuyu Hu, Meilan Mo, Hongzhan Zhang, Yong Zeng

Subjects: Get full text

Prevalence and factors associated with childhood malaria and anaemia in Osun state, Nigeria: a baseline household malariometric study by Olusola Ajibaye, Semiu Adebayo Rahman, Oluwagbemiga Olanrewaju Aina, Chinazo Ujuju, Chimere Obiora Agomo, Samuel Akindele, Olakiigbe Abiodun, Tolulope Victoria Uzoka, Nnenna Ogbulafor, Olufemi Oroge, Rufai-Ahmed Garba, Michael Ekholuenetale, Kolawole Maxwell, Ridwan Akorede Awosanya, Mary Abosede Adekola, Benjamin Bukky Ilesanmi, Adekemi Ajayi, Olusola Oresanya, James K. Tibenderana, Adeola Yetunde Olukosi

“…In addition, children aged 7–12 months (aOR = 2.856; 95% CI 1.524–5.354) and those aged 13–18 months (aOR = 4.269; 95% CI 2.422–7.526) had higher odds of malaria infection, respectively, when compared with children aged 2–6 months. …”
Get full text

A meta-analysis of MHC diversity in Pan troglodytes verus by Christelle Vangenot, Alicia Sanchez‑Mazas

“…In chimpanzees both DQA1 and DQB1 are polymorphic (Bontrop et al., Comparative genetics of MHC polymorphisms in different primate species: Duplications and deletions, Hum Immunol, 2006, 67: 388-397) with DQA1 lineages shared between humans and chimpanzees. …”
Get full text

Enhancing predictive accuracy for urinary tract infections post-pediatric pyeloplasty with explainable AI: an ensemble TabNet approach by Hongyang Wang, Junpeng Ding, Shuochen Wang, Long Li, Jinqiu Song, Dongsheng Bai

“…Among the 764 pediatric pyeloplasty cases analyzed, 265 (34.7%) developed postoperative UTIs, predominantly within the first three months. …”
Get full text

Mindfulness Intervention for Health Information Avoidance in Older Adults: Mixed Methods Study by Chenyu Gu, Liquan Qian, Xiaojie Zhuo

“…Nevertheless, the results revealed a significant interaction effect between mindfulness and cyberchondria on health information avoidance (effect=‒0.357, P=.002, 95% CI ‒0.580 to ‒0.131), suggesting that mindfulness intervention effectively inhibited the transformation of cyberchondria into health information avoidance behavior. …”
Get full text

Spatial distribution and determinants of improved shared sanitation facilities among households in Ethiopia: Using 2019 mini-Ethiopian Demographic and Health Survey. by Baye Tsegaye Amlak, Daniel Gashaneh Belay

“…Community-level characteristics such as residing in urban areas [AOR = 7.60; 95% CI: 3.47, 16.67], the metropolitan region [AOR = 25.83; 95% CI: 10.1, 66.3], and periphery regions [AOR = 5.01; 95% CI: 2.40, 10.48] were also associated with the use of shared toilet facilities.…”
Get full text

Etiology of Hospital-Acquired Pneumonia (HAP) and Ventilator-Associated Pneumonia (VAP) in Tertiary-Care Hospitals in Thailand: A Multicenter, Retrospective Cohort Study by Rongrungruang Y, Plongla R, Pleumkanitkul S, Hantrakun V, Khawcharoenporn T

“…Medical records of patients with a documented diagnosis of nosocomial pneumonia (NP) were systematically reviewed to collect data on demographic, clinical, microbiological, and 30-day readmission due to NP.Results: A total of 240 patients were included in the study, comprises patients with VAP (62.9%), HAP (36.7%), and ventilated HAP (vHAP) (0.4%). All of the patients had late-onset NP, occurring after five days of hospitalization with median time to NP of 13 days (interquartile range [IQR] 6– 25 days) from admission. …”
Get full text

Drug-drug interaction between ensitrelvir and tacrolimus in a patient undergoing treatment for COVID-19: a case report by Yuki Miyata, Ryo Yamaguchi, Takehito Yamamoto, Toshiyuki Kishida, Kazuhiko Ikeuchi, Hiroaki Harada, Takeya Tsutsumi, Keishi Fujio, Tappei Takada

“…Abstract Background Ensitrelvir is a novel SARS-CoV-2 3-chymotrypsin-like protease inhibitor, similar to nirmatrelvir/ritonavir. …”
Get full text

Ten Machine Learning Models for Predicting Preoperative and Postoperative Coagulopathy in Patients With Trauma: Multicenter Cohort Study by Xiaojuan Xiong, Hong Fu, Bo Xu, Wang Wei, Mi Zhou, Peng Hu, Yunqin Ren, Qingxiang Mao

“…Trial RegistrationChinese Clinical Trial Registry ChiCTR2300078097; https://www.chictr.org.cn/showproj.html?…”
Get full text

Impact of Pre-existing Type 2 Diabetes Mellitus and Cardiovascular Disease on Healthcare Resource Utilization and Costs in Patients With COVID-19 by Chi Nguyen, Christopher L. Crowe, Effie Kuti, Bonnie Donato, Rachel Djaraher, Leo Seman, Nancy Graeter, Thomas P. Power, Rinku Mehra, Vincent J. Willey

“…**Results:** In all, 321 232 COVID-19 patients were identified (21 651 with T2DM + CVD, 28 184 with T2DM only, and 271 397 with neither T2DM/CVD). …”
Get full text

Delay of innate immune responses following influenza B virus infection affects the development of a robust antibody response in ferrets by Thomas Rowe, Ashley Fletcher, Melissa Lange, Yasuko Hatta, Gabriela Jasso, David E. Wentworth, Ted M. Ross

“…Inoculation of ferrets, with over 1,500 human clinical influenza isolates (1998–2019) resulted in lower antibody responses (HI <1:160) to 86% (387 out of 448) influenza B viruses (IBVs) compared to 2.7% (30 out of 1,094) influenza A viruses (IAVs). …”
Get full text

CHA2DS2-VASc Score Is Associated With Prognosis in Patients With Acute Ischemic Stroke Without Atrial Fibrillation by Mingjuan Song, MM, Xu Chen, MD

“…Multivariate Cox regression models indicated that, compared with a CHA2DS2-VASc score of 0 or 1, the hazard ratio (HR) of MACE occurrence was 3.22 (95% CI, 1.93-5.37; P < .01) for a CHA2DS2-VASc score greater than 2 and 1.92 (95% CI, 1.24-2.98; P < .01) for a CHA2DS2-VASc score of 2. …”
Get full text

Are Saudi Radiological Sciences Students Prepared for Emergencies? Exploring Knowledge, and Attitudes Towards Basic Life Support and Cardiopulmonary Resuscitation by Alshamrani KM, Alkhayyat AA, Arif RN, Alahmadi AAS, Aldahery ST, Alsharif WM, Qurashi AA

“…Descriptive statistics were generated, and chi-square test examined associations between categorical variables and Basic Life Support (BLS) training status.Results: Out of 367 students contacted, 261 participated (71.1% response rate). …”
Get full text

Subtyping Social Determinants of Health in the "All of Us" Program: Network Analysis and Visualization Study by Suresh K Bhavnani, Weibin Zhang, Daniel Bao, Mukaila Raji, Veronica Ajewole, Rodney Hunter, Yong-Fang Kuo, Susanne Schmidt, Monique R Pappadis, Elise Smith, Alex Bokov, Timothy Reistetter, Shyam Visweswaran, Brian Downer

“…While many studies have identified strong associations between specific SDoH and health outcomes, little is known about how SDoH co-occur to form subtypes critical for designing targeted interventions. …”
Get full text

Understanding Health-Related Discussions on Reddit: Development of a Topic Assignment Method and Exploratory Analysis by Garrett J Chan, Mark Fung, Jill Warrington, Sarah A Nowak

“…STIs comprised 7.44% (5876/78,980) of posts, and anxiety comprised 5.43% (4289/78,980) of posts. …”
Get full text

Impact of the Smarter Safer Homes Solution on Quality of Life and Health Outcomes in Older People Living in Their Own Homes: Randomized Controlled Trial by Wei Lu, David Silvera-Tawil, Hwan-Jin Yoon, Liesel Higgins, Qing Zhang, Mohanraj Karunanithi, Julia Bomke, Joshua Byrnes, Jennifer Hewitt, Vanessa Smallbon, Jill Freyne, Deepa Prabhu, Marlien Varnfield

“…In comparison to the control group, the intervention group had a higher ASCOT score at the 6-month assessment (mean difference 0.045, 95% CI 0.001 to 0.089; Cohen d=0.377). However, this difference did not persist at the 12-month assessment (mean difference 0.031, 95% CI –0.014 to 0.076; Cohen d=0.259). …”
Get full text

Osteoarthritis and Degree of Fatigue are Associated with Pain Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study of 394 Patients by Wang Z, Lan T, Zhang Y, Guo Z, Yu H, Sun G, Wang Z, Yan Z, Tao Q, Xu Y

“…An interaction analysis based on the main regression model was performed to examine the interaction between OA and degree of fatigue.Results: Among the FMS patients, the presence of OA was identified as a risk factor associated with higher pain-VAS scores (OR=2.777, 95% CI=1.377– 5.601, P=0.004); furthermore, higher degree of fatigue scores on the FS-14 were found to be significantly associated with high pain level (OR=1.145, 95% CI=1.054– 1.243, P=0.001). …”
Get full text

Effects of Environmental Factors on Carbon Stocks of Dry Evergreen Afromontane Forests of the Choke Mountain Ecosystem, Northwestern Ethiopia by Fikirte Asrat, Teshome Soromessa, Tesefaye Bekele, Rama Mohan Kurakalva, Sravya Sai Guddeti, David Russel Smart, Kristine Steger

“…For lower, medium, and higher altitudes, the total carbon stock variation along an altitudinal gradient was 289.67 t·ha−1, 347.93 t·ha−1, and 414.89 t·ha−1 in Anshirava forest and 270.99 t·ha−1, 204.24 t·ha−1, and 224.82 t·ha−1 in Ziba forest, respectively. …”
Get full text