Concomitant exposure to benzodiazepines during pembrolizumab-based therapy for advanced non-small-cell lung cancer: a propensity-score matched analysis of monitoring agency data by Fabrizio Nelli, Enzo Maria Ruggeri, Antonella Virtuoso, Diana Giannarelli, Armando Raso, Federica Natoni, Gloria Pessina, Daniele Remotti, Mario Giovanni Chilelli, Carlo Signorelli, Agnese Fabbri

“…After a median follow-up of 16.3 [95% confidence interval (CI) 13.1–19.7] months, univariate analysis revealed no significant differences in terms of progression-free survival (PFS) or overall survival (OS) between BZD cohorts. …”
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The Use of Biopsy and “No-Biopsy” Approach for Diagnosing Paediatric Coeliac Disease in the Central European Region by Petra Riznik, Márta Balogh, Piroska Bódi, Luigina De Leo, Jasmina Dolinsek, Ildikó Guthy, Judit Gyimesi, Ágnes Horváth, Ildikó Kis, Martina Klemenak, Berthold Koletzko, Sibylle Koletzko, Ilma Rita Korponay-Szabó, Tomaz Krencnik, Tarcisio Not, Goran Palcevski, Éva Pollák, Daniele Sblattero, István Tokodi, Matej Vogrincic, Katharina Julia Werkstetter, Jernej Dolinsek

“…Data from 653 children (63.9% female, median age: 7 years, range: 7 months-18.5 years) from Croatia, Hungary, Germany, Italy, and Slovenia were analysed. …”
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Associations of Pretransplant Patient-Reported Outcomes Measurement Information System Physical Function Score With Kidney Transplant Outcomes by Junji Yamauchi, Amy M. Cizik, Katalin Fornadi, Dominik Thomas, Divya Raghavan, Duha Jweehan, Suayp Oygen, Silviana Marineci, Michelle Buff, Motaz Selim, Michael Zimmerman, Istvan Mucsi, Istvan Mucsi, Miklos Z. Molnar

“…However, a lower PROMIS-PF score was significantly associated with a higher risk of emergency room visits [adjusted odds ratios compared to normal: mild, 1.68 (95% confidence interval, 0.76–3.83); moderate/severe, 3.23 (1.34–7.79)] and rehospitalization [adjusted odds ratios: mild, 2.61 (1.16–5.90); moderate/severe, 2.53 (1.07–6.00)] within 1 month posttransplant. …”
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Protocolized approach saves the limb in peripheral arterial injury: A decade experience by Pratyusha Priyadarshini, Supreet Kaur, Komal Gupta, Abhinav Kumar, Junaid Alam, Dinesh Bagaria, Narender Choudhary, Amit Gupta, Sushma Sagar, Biplab Mishra, Subodh Kumar

“…Median ischemia time was 4 h (interquartile range 2–7 h). Brachial artery (28.5%) was the most common injured vessel followed by popliteal artery (17.5%) and femoral artery (17.3%). …”
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Artificial intelligence for quantifying immune infiltrates interacting with stroma in colorectal cancer by Jing Yang, Huifen Ye, Xinjuan Fan, Yajun Li, Xiaomei Wu, Minning Zhao, Qingru Hu, Yunrui Ye, Lin Wu, Zhenhui Li, Xueli Zhang, Changhong Liang, Yingyi Wang, Yao Xu, Qian Li, Su Yao, Dingyun You, Ke Zhao, Zaiyi Liu

“…In the primary cohort, survival analysis showed a significant difference in 5-year survival rates between score 4 and score 1 groups: 87.4% vs. 58.2% (Hazard ratio for score 4 vs. score 1 0.27, 95% confidence interval 0.15–0.48, P < 0.001). …”
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Associations between Children’s Exposure to PM2.5 and their Serum Inflammatory Responses in Taiwan by Wei-Jung Tseng, Jian-He Lu, How-Ran Chao, Ming-Hsien Tsai, Yu-Ting Chang, Liang-Jen Wang, Chih-Cheng Chen, Wan-Nurdiyana-Wan Mansor, Juliana Jalaludin, Chih-Lung Wang, Ying-I Tsai

“…Schoolchildren (n = 183) between the ages of 6 and 12 years living in southern Taiwan were recruited to measure their serum inflammation including interferon-γ (IFN-γ), IFN-α2, interleukin 1b (IL-1b), IL-2, IL-6, IL-10, IL-13, IL-17, monocyte chemotactic protein (MCP)-l, and tumor necrosis factor (TNF-α). …”
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Effects of effluent recirculation on two-stage anaerobic digestion in treatment of biodegradable municipal solid waste by P.V. Dinh, T. Fujiwara, A.N. Peni, C.K. Tran

“…Then, the liquid part was collected and pumped into the methane reactor at an organic loading rate of 7.64 grams of total solids per liter per day at 36 degrees Celsius. …”
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Plasma EphA2 level is a superior biomarker to Del-1 for sepsis diagnosis and prognosis by Eun Hye Lee, Mi Hwa Shin, Se Hyun Kwak, Ji Soo Choi, Ah Young Leem, Su Hwan Lee, Kyung Soo Chung, Young Sam Kim, Sang-Guk Lee, Moo Suk Park

“…Hence, we examined their potential as biomarkers of sepsis.MethodsIn total, 117 participants, including 20 healthy controls, 21 patients with systemic inflammatory response syndrome (SIRS), and 76 patients with sepsis, were enrolled in this study. …”
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Egg freshness during storage: the effect of laying hen age and shelf life prediction using a novel hybrid modeling method by Yifeng Lu, Jing Li, Zihao He, Linyun Chen, Huixin Tian, Chen Xu, Xinglian Xu, Minyi Han

“…The tuning process of hyperparameters such as learning rate, training function, and transfer function was presented in detail. Results show that CS-BP-AdaBoost had satisfactory performance on the test set with root mean square error (RMSE) and coefficient of determination (R2) of 0.68 and 0.97, respectively. …”
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A New Smartphone-Based Cognitive Screening Battery for Multiple Sclerosis (icognition): Validation Study by Stijn Denissen, Delphine Van Laethem, Johan Baijot, Lars Costers, Annabel Descamps, Ann Van Remoortel, Annick Van Merhaegen-Wieleman, Marie D’hooghe, Miguel D'Haeseleer, Dirk Smeets, Diana M Sima, Jeroen Van Schependom, Guy Nagels

“…Test performance was comparable between people with MS and healthy participants for all cognitive tests, both in icognition (Symbol Test: U=4431; P=.42; Dot Test: U=3516; P=.32; vBDS: U=3708; P=.27) and the gold standard paper-and-pencil tests (Symbol Digit Modalities Test: U=4060.5, P=.82; 10/36 Spatial Recall Test: U=3934; P=.74; auditory Backward Digit Span: U=3824.5, P=.37). …”
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High prevalence of overweight/obesity and central obesity among women in a rural district of Nepal in 2012–2013: a population-based study by Chandra Yogal, Chandra Yogal, Astrid Kamilla Stunes, Astrid Kamilla Stunes, Sunila Shakya, Biraj Karmarcharya, Rajendra Koju, Mats P. Mosti, Mats P. Mosti, Miriam K. Gustafsson, Miriam K. Gustafsson, Bjørn Olav Åsvold, Bjørn Olav Åsvold, Berit Schei, Unni Syversen, Unni Syversen

“…Height, weight, and waist circumference (WC) were measured, and body mass index (BMI) calculated. WHO cut-offs for Asians were used to assess the prevalence of overweight (23.0–27.4 kg/m2), obesity (≥ 27.5 kg/m2) and central obesity (WC ≥ 80 cm). …”
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Hypoglycemic effects of black brick tea with fungal growth in hyperglycemic mice model by Wei Xu, Yang Zhou, Ling Lin, Dongyin Yuan, Yingqi Peng, Li Li, Wenjun Xiao, Zhihua Gong

“…These regulatory steps were followed by high activities of glutathione peroxidase and superoxide dismutase and low content of malondialdehyde. These teas can promote blood glucose transport and absorption by upregulating the protein and mRNA expression of insulin receptor substrate-1 and glucose transporter-2 and stimulate glycolysis by upregulating the protein and mRNA expression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. …”
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Сравнение методик пункционно-дилатационной трахеостомии Фрова и Григгс у пациентов с избыточной массой тела и ожирением: рандомизированное контролируемое исследование... by Николай Михайлович Кругляков, Н. Э. Альтшулер, О. В. Карпова, А. Е. Кукленко, К. В. Киселёв, К. А. Попугаев

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Efecto de la concentración de silicio en suelo sobre el rendimiento agrícola en cultivos de frutilla Fragaria × ananassa (Duchesne ex Weston) Duchesne ex Rozier en Areguá, Pirayú, Capiatá y J. Augusto Saldívar, Paraguay by Fernando Garcete, Luz Bóveda, María Leticia Montiel, Jonny Toledo, Ana Aguilar Rabito, Daisy Ramírez, Boris Michajluk Barboza

“…La cuantificación del silicio en el suelo se realizó mediante la técnica de análisis por activación neutrónica empleando una fuente isotópica de neutrones de Americio-Berilio con flujo de neutrones de 5,0.107 ns-1cm-2, un detector de centelleo de ioduro de sodio de 2” x 2” acoplado a una tarjeta multicanal Accuspec y un estándar de silicio de procedencia alemana, con 97,5% de pureza. …”
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Effects of Eleclazine (GS6615) on the proarrhythmic electrophysiological changes induced by myocardial stretch by Francisco J. Chorro, Francisco J. Chorro, Francisco J. Chorro, Luis Such-Miquel, Luis Such-Miquel, Samuel Cuñat, Oscar Arias-Mutis, Oscar Arias-Mutis, Patricia Genovés, Patricia Genovés, Manuel Zarzoso, Manuel Zarzoso, Antonio Alberola, Antonio Alberola, Luis Such-Belenguer, Luis Such-Belenguer, Irene Del Canto, Irene Del Canto

“…Programmed stimulation and high-resolution mapping techniques were applied using multiple epicardial electrodes.ResultsAt baseline, both the ventricular refractory period measured at a fixed cycle length (250 m) and its surrogate obtained during ventricular fibrillation (VF) decreased significantly during stretch (baseline 128 ± 15 vs. stretch 110 ± 14 m; n = 15; p &lt; 0.001, and baseline 52 ± 13 vs. stretch 44 ± 9 m; n = 11; p &lt; 0.05), while the VF dominant frequency (DF) increased significantly (DF baseline 13 ± 3 vs. stretch 17 ± 5Hz; n = 11; p &lt; 0.01). Eleclazine 1.4 μM prolonged refractoriness, diminished both DF and conduction velocity during the arrhythmia, and avoided the stretch induced variations in refractoriness (baseline 148 ± 19 vs. stretch 150 ± 23 m; n = 15; ns, and baseline 73 ± 15 vs. stretch 77 ± 15 m; n = 11; ns) and in DF (baseline 12 ± 5 vs. stretch 12 ± 3 Hz; ns). …”
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The used of chopped banana Musa paradisiaca stem for stimulating immune responses and streptococcosis resistance of Nile tilapia Oreochromis niloticus by Lilis Nurjanah, Sri Nuryati, Alimuddin Alimuddin, Kukuh Nirmala

“…Selain itu, perlakuan ini memiliki nilai tertinggi pada aktivitas fagositik (36,6%), respiratory burst (0,58 pada O.D. 630 nm) dan aktivitas lisozim (72,7 Unit/mL) setelah hari ke‒4 uji tantang dengan bakteri S. agalactiae.   …”
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کالای عمومی ملی؛ مطالعه موردی رفاه اجتماعی در ایران و انطباق اسناد بالادستی نظام با تعریف آمارتیا سن از رفاه اجتماعی... by گلزار آقایی, کرم اله دانش فرد, غلامرضا معمارزاده

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Posttraumatic Stress Disorder Is Associated With Endothelial Dysfunction in Women With HIV by Nishant Vatsa, MD, Alireza Rahbar, MD, Tanveer Kauser, MPH, Ariel Kirksey, BS, Daniel A. Gold, MD, Vardhmaan Jain, MD, Matthew E. Gold, MD, Heqiong Wang, MD, MPH, Christina Mehta, PhD, MSPH, Caitlin A. Moran, MD, Alicia K. Smith, PhD, Kimbi Hagen, EdD, Med, Ighovwerha Ofotokun, MD, MSc, Cecile D. Lahiri, MD, MS, Laurence Sperling, MD, Viola Vaccarino, MD, PhD, Puja K. Mehta, MD, Arshed A. Quyyumi, MD, Gretchen N. Neigh, PhD, Vasiliki Michopoulos, PhD

“…Both PTSD severity (β per 10-point increase: −0.72% [95% CI: −1.22 to −0.21], P = 0.01) and PTSD status (β: −2.51% [95% CI: −4.21 to −0.77], P = 0.01) were independently associated with lower FMD in WWH but not in those without HIV. …”
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Physicochemical and functional properties of cassava flour produced by controlled fermentation using mixed culture from various bacteria and yeast by Sri Widowati, Misgiyarta, Nurdi Setyawan, Heny Herawati, Widaningrum, Sintha Suhirman, Kartika Noerwijati, Rohmad Budiono, Santi Dwi Astuti, Rudy Tjahjohutomo, Astu Unadi, Uning Budiharti

“…The results showed that cassava flour contained 7–8 % moisture content, 1.39–2.22 % ash, 0.82–1.65 % fat, 0.81–2.17 % protein, 86.9–89.3 % carbohydrates, 54–76 % starch, 21–24 % amylose, and 1.0–1.9 % crude fiber. …”
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Acceptability, feasibility, and effectiveness of internet-based cognitive behavior therapy for obsessive–compulsive disorder (OCD-NET): a naturalistic pilot trial during the COVID-... by Elisabeth Kohls, Sabrina Baldofski, Julia Scholl, Oskar Flygare, Lina Lundström, Ursula Beyrich-Kolbus, Marc Steinbrecher, Christian Rück, Christine Rummel-Kluge

“…In ITT analyses, the OCI-R decreased significantly with a within-group effect size of d = 1.13 (95% CI 0.88 – 1.38). At post-treatment, n = 17 (29.8%) participants showed a treatment response on the OCI-R (≥ 40% reduction). …”
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