Rationale and design of a multicentre randomised controlled trial on circulating tumour DNA-guided neoadjuvant treatment strategy for locally advanced rectal cancer (CINTS-R) by Bin Wu, Yi Xiao, Xiao Zhang, Tao Xu, Qian Liu, Wei Fu, Yang An, Yongheng Li, Guole Lin, Huadan Xue, Guoju Wu, Jiaolin Zhou, Hongwei Yao, Zhenjun Wang, Weijie Chen, Junyang Lu, Guannan Zhang, Xiaoyuan Qiu

“…The secondary endpoints include time to recurrence, 2-year overall survival, 2-year disease-free survival, clinical complete response (cCR) rate, near cCR rate and pathologically complete response rate, pathological tumour regression grade and quality of life.Ethics and dissemination This protocol has been approved by the ethics committee of Peking Union Medical College Hospital, with approval number I-23PJ157, and by the institutional review boards of all the participating centres. …”
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Cohort profile: the Viral load Cohort North-East Lesotho (VICONEL) from 2016 to 2023 – cohort description, test volumes, predictors of viraemia and the road ahead by Tracy Glass, Frédérique Chammartin, Jochen Ehmer, Thomas Klimkait, Alain Amstutz, Josephine Muhairwe, Irene Ayakaka, Blaise Lukau, Jennifer Anne Brown, Lipontso Motaboli, Malebanye Lerotholi, Maurus Kohler, Kathrin Haenggi, Moliehi Mokete, Makobefo Gladys Chakela, Mpho Kao, Mathebe Kopo, Moleboheng Mokebe, Lorena Urda, Bienvenu Lengo Nsakala, Anna Klicpera, Nadine Tschumi, Niklaus Daniel Labhardt

“…As of December 2023, it encompasses all viral load testing from 24 healthcare facilities in two districts of Lesotho.Findings to date From January 2016 to December 2023, 137 660 viral load test results were available for 29 380 participants. …”
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Vegetation height estimation based on machine learning model driven by multi-source data in Eurasian temperate grassland by Wuhua Wang, Jiakui Tang, Na Zhang, Xuefeng Xu, Anan Zhang, Yanjiao Wang, Kaihui Li, Yidan Wang

“…Throughout the year of 2001–2021, there were minor fluctuations in changes of grassland heights, ranging from 15.93 to 17.99 cm, with an overall incremental trend of 0.027 cm annually. …”
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Base de datos para Percepción de la sed durante el ejercicio y en la rehidratación ad libitum post ejercicio en calor húmedo y seco by Catalina Capitán-Jiménez, Luis Fernando Aragón-Vargas

“…Al final de la rehidratación, la percepción de calor fue mayor para el calor seco (5.3 ± 0.2ua) que para el calor húmedo (4.7 ± 0.2ua, p=0.006). La sed al final del ejercicio (85.8 ± 19.4mm) no mostró correlación significativa con la deshidratación real (3.82 ± 0.18% MC, r=-0.14, p=0.48) ni con el consumo voluntario de agua (1843 ± 587 ml, r=-0.04, p=0.85). …”
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Factores clínico-epidemiológicos asociados a litiasis residual en pacientes sometidos a litotricia láser by Saul E. Velázquez-Guerrero, Luis A. Gastélum-Félix, Julio A. Ruiz-Torres, Uziel F. Rodríguez-Muñoz, Juan A. Lugo-Machado

“…Esto también sucedió al dicotomizar las medidas de los litos en dos categorías (≤20 mm y ≥21 mm), y mediante la prueba de ji al cuadrado de Pearson se observó que el tamaño del lito tenía igualmente asociación con la litiasis residual (p = 0,017) (p ≤ 0,05). …”
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Association of Fontan Pathophysiology With Plasma Bile Acids by Ashish H. Shah, MD, MD-Research, Arun Surendran, MSc, Pedram Hassan-Tash, BSc, MD, C. Nolan Turnbull, BSc, Nicole Johnston, MSc, David Goodlett, BSc, PhD, Jun Han, PhD, Robin A. Ducas, MD, James W. Tam, MD, Eberhard Renner, MD, Todd A. Duhamel, PhD, Michel Aliani, MSc, PhD, Amir Ravandi, MD, PhD, Richard A. Krasuski, MD

“…Results: Twenty Fontan patients (28.8 ± 9.8 years of age; 35% women) and 20 healthy controls (29.7 ± 6.0 years of age; 30% women) were enrolled. …”
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The Relationship between Simple Snoring and Metabolic Syndrome: A Cross-Sectional Study by Juanjuan Zou, Fan Song, Huajun Xu, Yiqun Fu, Yunyan Xia, Yingjun Qian, Jianyin Zou, Suru Liu, Fang Fang, Lili Meng, Hongliang Yi, Jian Guan, Huaming Zhu, Bin Chen, Shankai Yin

“…With regard to MetS components, simple snoring was significantly associated with increased odds for hypertension (OR=1.730, 95% CI: 1.130–2.650), abdominal obesity (OR=1.810, 95% CI: 1.063–3.083), and hyper-triglycerides (TG) (OR=1.814, 95% CI: 1.097–2.998) among all participants, with hypertension (OR=3.493, 95% CI: 1.748–6.979) among males and with abdominal obesity (OR=2.306, 95% CI: 1.245–4.270) and hyper-TG (OR=2.803, 95% CI: 1.146–6.856) among females after multivariable adjustment. …”
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The effects of citral on the intestinal health and growth performance of American bullfrogs (Aquarana catesbeiana) by Xiaoting Zheng, Qiuyu Chen, Xueying Liang, Jingyi Xie, Alfredo Loor, Hongbiao Dong, Jinlong Yang, Jiasong Zhang

“…Growth performance analysis revealed that 4 mL/kg citral supplementation significantly improved weight gain rate (WGR), specific growth rate (SGR), carcass weight (CW), and feed efficiency (FE), while survival rates declined at 16 mL/kg (P < 0.05). …”
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Mesh Migration into the Neobladder and Ileum with Complicated Fistula Formation following Incisional Hernia Repair by Masatsugu Kuroiwa, Masato Kitazawa, Yusuke Miyagawa, Futoshi Muranaka, Shigeo Tokumaru, Satoshi Nakamura, Makoto Koyama, Yuta Yamamoto, Nao Hondo, Takehito Ehara, Satoru Miyazaki, Hirokazu Tanaka, Yuji Soejima

“…An 80-year-old male who had undergone radical cystectomy 5 years ago and abdominal wall incisional hernia repair 3 years ago presented with fever and abdominal pain. Computed tomography (CT) scan revealed mesh migration into the neobladder and ileum. …”
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Comparative microbial metagenomic analysis of drinking water plants and wastewater treatment plants in Istanbul by Mehmet Demirci, Cankut Çubuk, Ferhat Dasdemir, Abdulkerim Suat Saribas, Esra Billur Balcıoglu, Dogukan Ozbey, Dogu Yorulmaz, Tugba Olmez Hanci, Safak Basa, Bekir Sami Kocazeybek, Bekir Sami Kocazeybek

“…Kraken2 tools and R scripts were used for statistical analysis and data visualization.ResultsThe microbial metagenomic analysis identified 71 phyla, 113 classes, 217 orders, 480 families, and 1,282 genera across all samples. …”
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Machine learning for predicting neoadjuvant chemotherapy effectiveness using ultrasound radiomics features and routine clinical data of patients with breast cancer by Pu Zhou, Pu Zhou, Hongyan Qian, Pengfei Zhu, Jiangyuan Ben, Jiangyuan Ben, Guifang Chen, Qiuyi Chen, Lingli Chen, Jia Chen, Ying He, Ying He

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Emergency volunteering willingness and participation: a cross-sectional survey of residents in northern China by Hong Sun, Chaojie Liu, Wei Xu, Ye Li, Qunhong Wu, Lijun Gao, Zheng Kang, Yanhua Hao, Ning Ning, Mingli Jiao, Libo Liang, Yu Cui, Mengli Shi, Chao Liang, Xiaowen Zhao, Jie Fei, Qiuyu Wei, Ming Yi

“…Higher levels of willingness to volunteer and participation in volunteering were found in those who resided in rural areas (OR=1.308 (1.064 to 1.608) for willingness; OR=1.518 (1.208 to 1.908) for participation), had stronger community attachment (OR=1.720 (1.429 to 2.069) for willingness; OR=1.547 (1.266 to 1.890) for participation), had higher recognition of responsibility (OR=1.981 (1.498 to 2.619) for willingness; OR=1.517 (1.177 to 1.955) for participation), demonstrated preparedness behaviour (OR=1.714 (1.424 to 2.064) for willingness; OR=1.391 (1.151 to 1.681) for participation) and were covered by injury insurance (OR=1.335 (1.102 to 1.619) for willingness; OR=1.822 (1.500 to 2.214) for participation). …”
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Topographical mapping of metabolic abnormalities in multiple sclerosis using rapid echo-less 3D-MR spectroscopic imaging at 7T by Eva Niess, Assunta Dal-Bianco, Bernhard Strasser, Fabian Niess, Lukas Hingerl, Beata Bachrata, Stanislav Motyka, Paulus Rommer, Siegfried Trattnig, Wolfgang Bogner

“…A strong negative association was found between NAA/tCr and EDSS in the precentral gyrus (Spearman's rank ρ=-0.58, P=.005), and a moderate positive association between mI/NAA and EDSS in the precentral and superior frontal gyri (ρ=0.47, P=.015). …”
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Direct anterior approach (DAA) vs. conventional approaches in total hip arthroplasty: A RCT meta-analysis with an overview of related meta-analyses. by Philip Lazaru, Simon Bueschges, Nikolai Ramadanov

“…We came to the following results for THA through DAA compared to THA through CAs: operation time (I2 = 92%, p<0.01; fixed: MD = 15.1, 95% CI 13.1 to 17.1; random: MD = 18.1, 95% CI 8.6 to 27.5); incision length (I2 = 100%, p<0.01; fixed: MD = -2.9, 95% CI -3.0 to -2.8; MD = -1.1, 95% CI -4.3 to 2.0); intraoperative blood loss (I2 = 87%, p<0.01; fixed: MD = 51.5, 95% CI 34.1 to 68.8; random: MD = 51.9, 95% CI -89.8 to 193.5); VAS 1 day postoperatively (I2 = 79%, p = 0.03; fixed: MD = -0.8, 95% CI -1.2 to -0.4; random: MD = -0.9, 95% CI -2.0 to 0.15); HHS 3 months postoperatively (I2 = 52%, p = 0.08; fixed: MD = 2.8, 95% CI 1.1 to 4.6; random: MD = 3.0, 95% CI -0.5 to 6.5); HHS 6 months postoperatively (I2 = 0%, p = 0.67; fixed: MD = 0.9, 95% CI -1.1 to 2.9; random: MD = 0.9, 95% CI -1.1 to 2.9); HHS 12 months postoperatively (I2 = 0%, p = 0.79; fixed: MD = 0.7, 95% CI -0.9 to 2.4; random: MD = 0.7, 95% CI -0.9 to 2.4). …”
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Novel organophosphate esters and their transformation products in offshore sediment from Eastern China: Occurrence, temporal trend, and risk assessment by Meng Gao, Yu Wang, Liman Wei, Siyuan Li, Qiuyue Zhang, Zhongkang Yang, Mohan Bai, Yiming Yao, Lei Wang, Hongwen Sun

“…The total concentrations of Σ15TOPEs, Σ3NOPEs, Σ9Di-OPEs, and Σ7OH-OPEs in surface sediments were 3.16–73.4, n.d.–16.3, 4.48–21.4, and 0.14–0.42 ng g−1, respectively. …”
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Structural Model of Factors Affecting the Use of Organic Fertilizers by Rice Farmers during Rice (Oryza sativa) Cultivation in Dezful County by Zahra Eskanadari, Moslem Saavri, Masoud Yazdanpanah

“…This is despite the fact that the perceived obstacles variable did not have a significant effect in this section. In addition, it can be said that the variables of the health belief framework could explain 67% of the variance of the dependent variable of the research (the use of organic fertilizers in rice cultivation). …”
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Beyond first-line therapy: efficacy and safety outcomes of continuing immunotherapy in extensive stage small cell lung cancer after PD-L1 inhibitor progression by Jianfeng Peng, Xueying Zhai, Xiaomei Liu, Zhaoqin Huang, Yimeng Wang, Peizhu Wu, Ran Gao, Xiangjiao Meng

“…The median overall survival (OS) in the IBP group was also longer than that in the non-IBP group (11.2 months vs. 9.0 months, HR=0.68, 95%CI 0.47-0.98, p=0.042). Subgroup analyses revealed a significant survival advantage with IBP treatment in patients presenting with baseline liver metastases, less than three metastatic organs, and those who were nonsmokers. …”
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Spatial Analysis of Building Density and Liquefaction Spread in Izmit Bay and its Surroundings by Arzu Erener, Metin Aşcı, Gül Gülsoy, Aydın Üstün, Muhammed Ali Güvenaltın, Erman Şentürk, Sefa Yalvaç, Fatma Canaslan Çomut, T. Serkan Irmak, Haluk Konak, Pakize Küreç Nehbit, Efdal Kaya, Burak Kotan, Selin Öye

“…Since December 2017, with the support of Kocaeli Metropolitan Municipality and with the leadership of Kocaeli University Geomatic Department, TÜBİTAK project numbered 117Y155 and titled “Monitoring of Vertical Displacements in East Marmara (Izmit Bay) with Multi-Band InSAR and GNSS Techniques, Investigation of the Relationship Between Ground Collapse and Building Density and Liquefaction" studies have been initiated to determine the risks in the Izmit Bay area. …”
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Knowledge, Attitude, and Practice (KAP) Survey toward Skin Cancer among Ecuadorian Population by Victor H. Pinos-León, César Sandoval, Franklin Cabrera, Esmeraldas Terán, Ana Garnica, Ana Kellendonk, Mery Alvear, Carla Rosero, Lorena Vaca, Jorge Bonifaz, Anita Buestán, Claudia Armas, Raquel Trujillo, Patricio Freire, Tamara León, Giselle Erazo, Liliana García, Marcela Alzate, Vicente Toapanta, Myriam Ortega, Daniela Caicedo, Alicia Pereira, Lenin Gómez-Barreno, Juan S. Izquierdo-Condoy, Merry Charlie, Esteban Ortiz-Prado, Katherine Simbaña-Rivera

“…Concerning sunscreen, 76.7% knew the reason for using it. The female group was 1.68 times more likely to get a higher score than the male group, and the groups between 61–70 and 71–80 years were 0.30 and 0.17 times less likely to get a higher score compared with the less than 20-years-old group, respectively. …”
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Collagen turnover biomarkers to predict outcome of patients with biliary cancer by Leonard Kaps, Muhammed A. Genc, Markus Moehler, Stephan Grabbe, Jörn M. Schattenberg, Detlef Schuppan, Rasmus Sund Pedersen, Morten A. Karsdal, Philipp Mildenberger, Annett Maderer, Nicholas Willumsen

“…Patients with high levels (cohort separated by median split) of PRO-C8 (HR 2.85, 95% CI 1.42; 5.73) followed by C3M (HR 2.33, 95% CI 1.2; 4.5), PRO-C3 (HR 3.09, 95% CI 1.5; 6.36) and CA 19–9 (HR 2.52, 95% CI 1.37; 4.64) as reference biomarker had a shorter OS. …”
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