miR‐130a‐3p regulated TGF‐β1‐induced epithelial‐mesenchymal transition depends on SMAD4 in EC‐1 cells by Xiaokang Tian, Qian Fei, Mingyu Du, Hongming Zhu, Jinjun Ye, Luxi Qian, Zhiwei Lu, Wenjun Zhang, Yan Wang, Fanyu Peng, Jie Chen, Baoling Liu, Qian Li, Xia He, Li Yin

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Gender differences in robotic surgery for rectal cancer: A retrospective study by Muhammad Ali, Wei Wang, Liuhua Wang, Bin Liu, Jun Ren, Daorong Wang

“…While males had longer operative times (177 ​min vs. 160 ​min for females), this was not statistically significant. …”
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Understanding the Molecular Mechanisms of Incomptine A in Treating Non-Hodgkin Lymphoma Associated with U-937 Cells: Bioinformatics Approaches, Part I by Fernando Calzada, Normand García-Hernández, Elihú Bautista, José Manuel Sánchez-López, Miguel Valdes, Claudia Velázquez, Elizabeth Barbosa

“…<b>Objectives</b>: In this research, we reviewed the altered levels of proteins present in the lymph nodes of male Balb/c mice inoculated with U-937 cells and treated with <b>IA</b> or methotrexate, as well as mice only inoculated with cancer cells. …”
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Spatiotemporal Variation of Water Use Efficiency and Its Responses to Climate Change in the Yellow River Basin from 1982 to 2018 by Jie Li, Fen Qin, Yingping Wang, Xiuyan Zhao, Mengxiao Yu, Songjia Chen, Jun Jiang, Linhua Wang, Junhua Yan

“…The region of significant increase in WUE in 2000–2018 (45.35%, Slope > 0, <i>p</i> < 0.05) was higher than that of 1982–2000 (8.23%, Slope > 0, <i>p</i> < 0.05), which was 37.12% higher in comparison. (2) Forest WUE (1.267 gC·kg⁻¹·H₂O) > Cropland WUE (0.972 gC·kg⁻¹·H₂O) > Grassland WUE (0.805 gC·kg⁻¹·H₂O) under different land cover types. …”
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Electrocardiographic signs of cardiac ischemia at rest and during exercise in patients with COPD traveling to 3,100 m: data from a randomized trial of acetazolamide by Marla Christen, Marla Christen, Aline Buergin, Aline Buergin, Maamed Mademilov, Maamed Mademilov, Laura Mayer, Laura Mayer, Simon R. Schneider, Simon R. Schneider, Mona Lichtblau, Mona Lichtblau, Talant M. Sooronbaev, Talant M. Sooronbaev, Silvia Ulrich, Silvia Ulrich, Konrad E. Bloch, Konrad E. Bloch, Michael Furian, Michael Furian

“…The incidence of a post-exercise ST elevation (STE) ≥0.3 mm in aVR (J + 80 ms) was the main outcome.ResultsAt 760 m, 3 of 49 (6%) patients randomized to placebo and 3 of 50 (6%) randomized to acetazolamide showed a post-exercise STE. …”
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Impact of diabetes on clinical outcome of patients with heart failure undergoing ICD and CRT procedures: results from the German Device Registry by Elif Kaya, Jochen Senges, Matthias Hochadel, Lars Eckardt, Dietrich Andresen, Hüseyin Ince, Stefan G. Spitzer, Thomas Kleemann, Sebastian S.K. Maier, Werner Jung, Christoph Stellbrink, Tienush Rassaf, Reza Wakili

“…Subgroup analysis were performed for ICD and CRT implantations. Median follow‐up was 15.7 (12.9; 20.0) and 16.2 (12.8; 21.2) months in DM and non‐DM patients. …”
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Exploring the synergistic effect of rose distillation waste and biostimulant beside other organic amendments onRosa damascena seedlings’ growth by Soumia El Malahi, Lahcen Irahoui, Wafaa Mokhtari, Mounia Ennami, Houda Taimourya, Jamaa Zim, Abdallah Zayani, Bahija Zakeri, Khalid Dhassi, Mimoun Mokhtari, Lalla Mina Idrissi Hassani

“…This in turn can foster a circular economy, minimizing waste disposal and promoting a green economy. …”
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The chromosome-level genome provides insights into the adaptive evolution of the visual system in Oratosquilla oratoria by Daizhen Zhang, Xiaoli Sun, Lianfu Chen, Lianyu Lin, Chijie Yin, Wenqi Yang, Jun Liu, Qiuning Liu, Huabin Zhang, Senhao Jiang, Yongxin Li, Boping Tang, Gang Wang

“…Results We generated a chromosome-level genome assembly for O. oratoria (2.97 Gb, 44 pseudo-chromosomes) using combination sequencing strategies. …”
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Identification of Southeast Asian Anopheles mosquito species with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using a cross-correlation approach by Victor Chaumeau, Sunisa Sawasdichai, Thu Zar Ma Ma Moe Min, Thithiwarada Kularbkeeree, Naw Jaruwan, Naw Gloria, Naw Yu Lee, Muesuwa Trackoolchengkaew, Monticha Phanaphadungtham, Patcharamai Rongthong, Aritsara Inta, Wanitda Watthanaworawit, François Nosten

“…Results With one spot and a threshold value of −14 for the cross-correlation index on the log scale, the sensitivity was 0.99 [95% credible interval (CrI): 0.98–1.00], the predictive positive value was 0.99 (95% CrI: 0.98–0.99), and the accuracy was 0.98 (95% CrI: 0.97–0.99). …”
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Clinical integration of germline findings from a tumor testing precision medicine program by Maria Carolina Sanabria-Salas, Nina C. Anggala, Brittany Gillies, Kirsten M. Farncombe, Renee Hofstedter, Larissa Peck, Helia Purnaghshband, Laura Redondo, Emily Thain, Wei Xu, Peter Sabatini, Philippe L. Bedard, Raymond H. Kim

“…A total of 127 TGVs were assessed in these 83 cases, of which 44 (34.6%) were considered germline relevant. …”
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Impact of Mandatory Preoperative Dental Screening on Infective Endocarditis in Patients Undergoing Surgical Valve Replacement by Lytfi Krasniqi, MD, Poul Erik Mortensen, MD, Emil Johannes Ravn, MD, Marlene Tofterup, MD, Henrik Nissen, MD, PhD, Christian Juhl Terkelsen, MD, PhD, DMSCi, Niels Holmark Andersen, MD, PhD, DMSCi, Ivy Modrau, MD, DMSCi, Kasper Stokbro, DDS, PhD, Jonas A. Povlsen, MD, PhD, Oke Gerke, MSc, PhD, DMSCi, Jesper Hallas, MD, DMSCi, Marie-Annick Clavel, DVM, PhD, Lars Peter Schødt Riber, MD, PhD, DMSCi, Jordi Sanchez Dahl, MD, PhD, DMSCi

“…Mortality rate was higher in MPDS (2-year mortality: 6.2% (95% CI: 4.7-8.1) vs 2.8% (95% CI: 1.6-5.0). Differences in IE rates, all-cause mortality but not composite endpoint were abolished in 370 propensity score-matched patients. …”
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One Year Duration of Immune Response Following a 3rd Booster Dose of mRNA Vaccine Against COVID‐19 in 292 Patients With Hematological Malignancies in University Hospital Ostrava, C... by Ondrej Šušol, Barbora Šušolová, Ondřej Klempíř, Milan Navrátil, Jaromír Gumulec, Zdeněk Kořístek, Juraj Ďuraš, Michal Kaščák, Jana Mihályová, Lukáš Stejskal, Tomáš Jelínek, Petra Richterová, Lenka Szeligová, Hana Plonková, Jana Zuchnická, Barbora Dluhošová, Ivo Demel, David Buffa, Katarína Hradská, Tereza Popková, Ludmila Muroňová, Martin Lachnit, Klára Lančová, Roman Hájek

“…Lowest seroconversion was observed in CLL cohort (20/41, 48.8%), patients who received anti‐CD20 therapy < 6 months before vaccination (8/30, 26.7%) and BTK inhibitors (3/6, 50.0%). …”
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Social-ecological perspective on the suicidal behaviour factors of early adolescents in China: a network analysis by Xueying Zhang, Yuan Li, Juan Chen, Peiying Li, Mengyuan Yuan, Yonghan Li, Gengfu Wang, Puyu Su

“…Notably, the network also showed unique correlates of suicidal ideation (sex, weight=0.60; impulsivity, weight=0.24; family violence, weight=0.17; relationship with teachers, weight=−0.03; school-bullying perpetration, weight=0.22), suicidal plans (social support, weight=−0.15) and suicidal attempts (relationship with mother, weight=−0.10; parental mental illness, weight=0.61).Conclusions This study identified the correlates of suicidal ideation, plans and attempts, and provided practical implications for suicide prevention for young adolescents in China. …”
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Evaluating the radiosensitivity of the oral microbiome to predict radiation-induced mucositis in head and neck cancer patients: A prospective trial by Andreas R. Thomsen, Elsa Beatriz Monroy Ordonez, Michael Henke, Benedikt Luka, Jörg Sahlmann, Henning Schäfer, Vivek Verma, Nadine Schlueter, Anca-Ligia Grosu, Tanja Sprave

“…Tubes with the cell suspension were placed within the irradiation chamber of a 137Cs Gammacell 40 Exactor (Best Theratronics, Canada) and exposed to 0, 2, 4, 6, or 8 Gy at a dose rate of 0.63 Gy min−1. …”
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Fifteen-second bouts of hyperoxia improve 5-minute time-trial performance in acute hypoxic conditions by Martin Faulhaber, Sina Schneider, Linda K. Rausch, Tobias Dünnwald, Verena Menz, Hannes Gatterer, Michael D. Kennedy, Wolfgang Schobersberger

“…Out study aimed to test the effects of repeated bouts of hyperoxia, each lasting fifteen seconds, on maximal 5-minute cycling performance under acute hypoxic conditions. Methods 17 healthy and recreationally trained individuals (7 females, 10 males, age 27 ± 4 years) participated in this randomized placebo-controlled cross-over trial. …”
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Discontinuation of immune checkpoint inhibitors for reasons other than disease progression and the impact on relapse and survival of advanced melanoma patients. A systematic review... by Konstantinos Lallas, Eftychia Chatziioannou, Derya Durak, Georg Frey, Lina Maria Serna-Higuita, Marie-Lena Rasch, Athanassios Kyrgidis, Eleni Timotheadou, Zoe Apalla, Ulrike Leiter, Lukas Flatz, Lukas Flatz, Aimilios Lallas, Teresa Amaral, Teresa Amaral

“…Rechallenge with ICI resulted in 57.3% DCR and 28.6% pooled CR rates (n=22, CR rate 28.6%, 95%CI 17.1 – 40.2, I2 68%). …”
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Discovery of Novel Nav1.7-Selective Inhibitors with the 1H-Indole-3-Propionamide Scaffold for Effective Pain Relief by Gaoang Wang, Hang Wu, Yingying Wang, Xiangying Liu, Shuijiao Peng, Wenxing Wang, Meijing Wu, Yifei Liu, Ercheng Wang, Zhe Wang, Lei Xu, Xiaojian Wang, Wei Yang, Haiyi Chen, Xi Zhou, Tingjun Hou

“…Molecular dynamics simulations and experimental findings reveal that the R configuration of WN2 (WN2-R) is the preferred form (IC50 = 24.7 ± 9.4 nM) within the VSDIV pocket of Nav1.7. …”
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Folic acid alleviates the negative effects of dexamethasone induced stress on production performance in Hyline Brown laying hens by Xi Sun, Chaohui Wang, Sijing Li, Xiaoying Liu, Yun Li, Yumeng Wang, Yuxin Niu, Zhouzheng Ren, Xin Yang, Xiaojun Yang, Yanli Liu

“…Folic acid (FA) is an antioxidant compound that can improve oocyte function and regulate gut microbiota composition. …”
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Association of sodium–glucose cotransporter-2 inhibitors with mortality across the spectrum of myocardial infarction: a systematic review and meta-analysis by Michele Maremmani, Ramin Ebrahimi, Marco Centola, Felice Achilli, Valentina Capone, Eduardo Bossone, Christian Templin, Davide Di Vece

“…SGLT2 inhibitors reduced all-cause mortality following MI (HR 0.79, 95% CI [0.68, 0.91]; p = 0.001; I2 = 59%). Stratified analysis demonstrated consistent effects in both early (HR 0.76, 95% CI [0.59, 0.98]; p = 0.03; I2 = 65%) and delayed (HR 0.81, 95% CI [0.67, 0.98]; p = 0.03; I2 = 60%) treatment. …”
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Potential pharmacological effect of Quercetin Phytosome™ in the management of hyperuricemia: results from real-life clinical studies by Francesco Di Pierro, Francesco Di Pierro, Francesco Di Pierro, Fazle Rabbani, Meherullah Tareen, Roohi Nigar, Amjad Khan, Nicola Zerbinati, Maria L. Tanda, Massimiliano Cazzaniga, Alexander Bertuccioli, Alexander Bertuccioli, Paolo Falasca, Gabriele Damiani, Nicola Villanova

“…Cohort 1 consisted of 164 healthy participants (87 QP-treated, 77 probiotic Streptococcus salivarius (S. salivarius) K12-treated) who were monitored for 90 days. …”
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