Traditional herbal medicine legislative and regulatory framework: a cross-sectional quantitative study and archival review perspectives by Sileshi Dubale, Rashed Edris Usure, Yesuneh Tefera Mekasha, Gemmechu Hasen, Firdos Hafiz, Dereje Kebebe, Sultan Suleman

“…Among regulatory experts, weak performance was identified in the practical implementation of THM regulatory activities, with 70.2% of weak performance observed at the federal level and 41.7% at the regional level. Key barriers to effective regulation included a lack of research on herbal medicines (90.3%) and insufficient regulatory mechanisms (87.8%). …”
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High-Titer Rheumatoid Factor is Associated with Worse Clinical Outcomes and Higher Needs for Advanced Therapies in Rheumatoid Arthritis Under Real-Life Conditions by Victor Davi R. S. Oliveira, Ana Paula M. G. Reis, Claiton V. Brenol, Ivânio A. Pereira, Karina R. Bonfiglioli, Letícia R. Pereira, Manoel B. Bértolo, Maria de Fátima L. C. Sauma, Maria Fernanda B. R. Guimarães, Paulo Louzada-Júnior, Rina D. N. Giorgi, Sebastião C. Radominski, Licia Maria H. Mota, Cleandro P. Albuquerque, Geraldo R. Castelar-Pinheiro

“…High RF titers (compared to "non-high") were associated with tobacco use (odds ratio, OR [95% confidence interval, CI]: 2.04 [1.35, 3.08]; p < 0.001), multiraciality (OR [95% CI] 1.31 [1.03, 1.67]; p = 0.028, compared to White race), and higher body mass index (mean difference [95% CI] 0.69 [0.05, 1.33] kg/m2; p = 0.033). …”
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The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity by Tamara M Sirey, Kenny Roberts, Wilfried Haerty, Oscar Bedoya-Reina, Sebastian Rogatti-Granados, Jennifer Y Tan, Nick Li, Lisa C Heather, Roderick N Carter, Sarah Cooper, Andrew J Finch, Jimi Wills, Nicholas M Morton, Ana Claudia Marques, Chris P Ponting

“…To generate energy efficiently, the cell is uniquely challenged to co-ordinate the abundance of electron transport chain protein subunits expressed from both nuclear and mitochondrial genomes. …”
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Preparation of future teachers for innovative activities in pedagogical and technological educational environment by N. I. Naumkin, N. N. Shekshaeva, V. F. Kupryashkin, E. V. Zabrodina

“….); 6) possibility of constant monitoring and control of the implementation of the environment within its relaxation and diagnostic component; 7) use of modern educational technologies, including digital; 8) possibility of obtaining specialised knowledge and studying other disciplines within the framework of using network learning; 9) innovativeness of the environment, determined by the novelty of the approach to teaching the teachers innovation technology and its effectiveness.To teach innovation activity in this environment, a model of a methodological system for the formation of competence in innovation activity among future technology teachers has been created, combining conceptually-targeted, meaningful, instrumental-activity and reflexive-evaluative components. …”
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Risk factors associated with mortality and pathogen characteristics of bloodstream infection-induced severe sepsis in the pediatric intensive care unit: a retrospective cohort stud... by Jian Chen, Jian Chen, Haixin Huang, Ruichen Zhang, Yueqiang Fu, Chunmei Jing

“…The detection rate of carbapenem resistance (CR) in Acinetobacter baumannii (66.7%) was higher than that in Pseudomonas aeruginosa (15.4%). …”
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Metabolic reprogramming and immunological changes in the microenvironment of esophageal cancer: future directions and prospects by Zhi-Xun Guo, Jia-Li Ma, Jin-Qiu Zhang, Ling-Ling Yan, Ying Zhou, Xin-li Mao, Xin-li Mao, Xin-li Mao, Shao-Wei Li, Shao-Wei Li, Shao-Wei Li, Xian-Bin Zhou, Xian-Bin Zhou, Xian-Bin Zhou

“…We analyzed and discussed these studies, while also expressing our own insights and opinions.ResultsA total of 137 articles were included in the review: 21 articles focused on the tumor microenvironment of esophageal cancer, 33 delved into research related to glucose metabolism and tumor immunology, 30 introduced amino acid metabolism and immune responses, and 17 focused on the relationship between lipid metabolism in the tumor microenvironment and both tumor cells and immune cells.ConclusionThis article delves into metabolic reprogramming and immune alterations within the TME of EC, systematically synthesizes the metabolic characteristics of the TME, dissects the interactions between tumor and immune cells, and consolidates and harnesses pertinent immunotherapy targets, with the goal of enhancing anti-tumor immunotherapy for esophageal cancer and thereby offering insights into the development of novel therapeutic strategies.…”
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Factors associated with attention-deficit/hyperactivity disorder among Tunisian children by Asma Guedria, Asma Guedria, Asma Guedria, Mohamed Guedria, Manel Ben Fredj, Manel Ben Fredj, Randaline Ayoub, Randaline Ayoub, Randaline Ayoub, Hela Ben Abid, Hela Ben Abid, Hela Ben Abid, Ahmed Mhalla, Ahmed Mhalla, Ahmed Mhalla, Hela Slama, Hela Slama

“…However, the multivariate model conducted to determine the variables independently associated with ADD/ADHD revealed only three determining factors: passive smoking during pregnancy (OR = 4.60 [2.14, 9.94]; p &lt; 0.001), acute fetal distress (OR = 5.08 [1.47, 17.52]; p = 0.01), and familial psychiatric history (OR = 9.37 [2.46, 35.59]; p = 0.001).DiscussionThe recognition of factors involved in the genesis of ADHD within different ethnic populations may help understanding and broaden our knowledge of this disorder to develop targeted strategies for prevention and early intervention. …”
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Assessing Mental Illness Referral Request Acceptance: A Nationwide E-Referral Data From Saudi Arabia by Alharbi AA, Aljerian NA, Alghamdi HA, Binhotan MS, Alsultan AK, Arafat MS, Aldhabib A, Aloqayli AI, Alwahbi EB, Horner RD

“…Life-saving referrals showed the highest acceptance (aOR = 2.60; 95% CI = 1.51– 4.48), while psychiatrist availability significantly influenced acceptance rates (aOR = 1.36; 95% CI = 1.17– 1.58). …”
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Uncovering Molecular Mechanisms of Feed Efficiency in Pigs Through Multi-Omics Analysis of the Jejunum by Saixian Zhang, Yue Xiang, Yaobang Jian, Qiulin Zhao, Jiahui Sun, Yi Huang, Jing Xu, Xiaolong Qi, Jingjin Li, Zhuqing Zheng, Liangliang Fu, Yuwen Liu, Xinyun Li

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Immune Modulation Effect of Administration of Rice Bran Extract with Increased Solubility Fermented by <i>Lentinus edodes</i> UBC-V88 in Cyclophosphamide-Treated Mice Model by Gi-Jung Kim, Yelim Jang, Ji-Yoon Hong, Kyoung-Tae Kwon, Dae-Weon Kim, Dae-Jung Kang, Sung-Joo Hwang, Jung-Yun Lee, Emmanouil Apostolidis, Young-In Kwon

“…The potential immunomodulatory effect of fermented rice bran (FRB) and processed rice bran (RB) was evaluated using male BALB/c mice whose immunity was lowered by Cyclophosphamide (CY). …”
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Feasibility and usefulness of Gini coefficients of primary care visits as a measure of service inequality: preliminary findings from a cross-sectional study using region-wide elect... by Xin Yang, Jing Chai, Jing Cheng, DeBin Wang, XingRong Shen, Rong Liu, ManMan Lu, Jia Xu, Ningjing Yang, Guocheng Li

“…The study also produced topographic maps of the GPVs for nine selected diseases.Setting All primary healthcare facilities within the 105 townships or communities randomly selected from Anhui province, China.Participants All practising doctors working with and all patients presenting to the above sampled facilities during the 27-month study period.Results The overall rate of primary healthcare visits during the 27-month period was estimated at 147.78%, with intra-regional variation coefficients by all-cause and system-specific disease ranging from 49.02% to 68.96%, and women were more likely than men to seek primary healthcare. …”
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Infections, autoimmunity and immunodeficiencies are the leading etiologies of non-cystic fibrosis bronchiectasis in adults from the southwest of Colombia. by Andrés F. Zea-Vera, Carlos Andrés Rodríguez, Sebastián Giraldo, Mario Alejandro Chacón, Luis Fernando Guerrero, Ricardo Mosquera, Raúl Andrés Vallejo, Fabio Samir Vargas, María Andrea García, María A. Rengifo, Anilza Bonelo, Maximiliano Parra

“…Postinfectious (34.6%) and immune disorders (25.3%), represented by autoimmunity (13.6%) and immunodeficiency (11.7%), were the leading causes. Gender differences were noted in autoimmune (females: 18.8% versus males: 6.1%, p = 0.021) and immunodeficiency-related bronchiectasis (males: 21.2% versus females 5.2%, p = 0.002). …”
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Cardiovascular disease risk in cancer survivors: a population-based cohort study from the UK Biobank, and meta-analysis of cohort studies by Hong Li, Yazhou He, Zubing Mei, Hong Wu, Yang Shen, Ziqiang Wang, Jichun Zhao, Chuan Xu, Yanhong Zhou, Chi Shu, Botao Yu, Xiran Wang, Changtao Li, Yiqiang Liu

“…We found a 1.34-fold increased CVD risk among patients with cancer (95% CI 1.22 to 1.47, p&lt;0.001). …”
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Harnessing deep learning to detect bronchiolitis obliterans syndrome from chest CT by Mateusz Koziński, Doruk Oner, Jakub Gwizdała, Catherine Beigelman-Aubry, Pascal Fua, Angela Koutsokera, Alessio Casutt, Argyro Vraka, Michele De Palma, John-David Aubert, Horst Bischof, Christophe von Garnier, Sahand Jamal Rahi, Martin Urschler, Nahal Mansouri

“…Notably, the DNN shows comparable performance on standard- and high-resolution CT scans. It also demonstrates the ability to predict BOS in at-risk patients (FEV1 between 80% and 90% of best FEV1) with a ROC-AUC of 0.87 (95% CI: 0.735–0.974). …”
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Restorative Neurostimulation Therapy Compared to Optimal Medical Management: A Randomized Evaluation (RESTORE) for the Treatment of Chronic Mechanical Low Back Pain due to Multifid... by Frank Schwab, Nagy Mekhail, Kiran V. Patel, Meredith Langhorst, Robert D. Heros, Jonathan Gentile, Sherif Costandi, Gregory Moore, Christopher Gilmore, Smith Manion, Krishnan Chakravarthy, S. Craig Meyer, Justin V. Bundy, Jordan L. Tate, Rebecca Sanders, Sandeep Vaid, Oszkar Szentirmai, Johnathan Goree, Vikas V. Patel, Jeff Lehmen, Mehul J. Desai, Jason E. Pope, Anthony Giuffrida, Salim Hayek, Sohrab Singh Virk, Richard Paicius, William R. Klemme, Robert Levy, Christopher Gilligan, the RESTORE investigators

“…The primary endpoint was a statistically significant demonstration of a clinically relevant mean improvement in the Oswestry Disability Index (ODI) between restorative neurostimulation and OMM arms: ODI (−19.7 ± 1.4 vs. −2.9 ± 1.4; p < 0.001). Additionally, improvements in both the numeric rating scale (NRS) (−3.6 ± 0.2 vs. −0.6 ± 0.2; p < 0.001) and EuroQol Five-Dimension (EQ-5D-5L) (0.155 ± 0.012 vs. 0.008 ± 0.012; p < 0.001) were statistically and clinically significant in the restorative neurostimulation arm compared to the OMM arm. …”
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Reactive agility training to prevent frailty in older adults – a randomized controlled trial. by Eric Lichtenstein, Martin Keller, Ralf Roth, Sebastian Ludyga, Oliver Faude

“…After controlling for age, sex, and BMI, the analysis revealed, on average, at least small effects in favor of the AT group for Go/No-Go task parameters (0.18 < d < 0.47), perceived stress (d = 0.42), psychosocial well-being (d = 0.33), social relationships (d = 0.26), as well as single-task gait speed (d = 0.34). …”
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Sexual and reproductive health awareness and practices among adolescents and adults in a rural farming community in Baja California, Mexico: a quantitative and qualitative cross-se... by Cristina Espinosa da Silva, Margarita Santibanez, Adrienne RS Lee, Lorena S Pacheco, Stephanie Brodine, Miguel A Fraga, Taylor B Desmarais, Noe C Crespo, Javier Martínez Hernandez, Marianne McKennett, Richard S Garfein

“…Participants in the quantitative phase of our study (n = 217) were a median age of 30 years, 71% were female, and those with children reported having a median of three (range = 1–11). …”
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Successful Management of Peri-Implantitis around Short and Ultrashort Single-Crown Implants: A Case Series with a 3-Year Follow-Up by Giorgio Lombardo, Mauro Marincola, Andrea Cicconetti, Miguel Angel Simancas-Pallares, Jacopo Pighi, Jeffrey Lehrberg, Annarita Signoriello, Giovanni Corrocher, Xiomara Serpa-Romero, Luis Armando Vila Sierra, Luisa Arevalo-Tovar, Pier Francesco Nocini

“…At the 3-year follow-up, the CSR was 100%, the mean mBI was 0.88 (average reduction: −1.47), the mean PD was 3.35 mm (mean PD reduction: 4.77 mm), and the mean bone defect was reduced by 1.74 mm, with a mean bone fill of 55%. …”
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Study of height-spread sporadic-E layers observed in the South American Magnetic Anomaly by Juliano Moro, Juliano Moro, Jiyao Xu, José Valentin Bageston, Lígia Alves da Silva, Lígia Alves da Silva, Laysa Cristina Araújo Resende, Laysa Cristina Araújo Resende, Clezio Marcos De Nardin, Vânia Fátima Andrioli, Vânia Fátima Andrioli, Angela Machado Santos, Angela Machado Santos, Giorgio Arlan da Silva Picanço, Hui Li, Liu Zhengkuan, Chi Wang, Nelson Jorge Schuch

“…The analysis is based on Digisonde data obtained at the Santa Maria station (29.7° S, 53.8° W, ∼22.000 nT) in Brazil over 1 year (2019/2020). …”
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Mesure de la digestibilité <em>in vivo</em> de résidus de récolte de quatre variétés améliorées de sorgho à double usage sur les moutons de race Djallonké by Souleymane Ouédraogo, Lassina Sanou, Issaka Gnegne, Modou Sere, Myriam Adam, Patrice Savadogo, Chantal Yvette Kaboré Zoungrana

“…La plus faible dMS a été observée avec la variété Djiguikala (37,3 %) et les plus faibles dMO et dMAT avec la variété Fadda (35,8 % et 24,7 % respectivement). …”
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