Genetic Insights Into Lipid Traits and Lipid-Modifying Drug Targets in Pregnancy Complications: A Two-Sample Mendelian Randomization Study by Shao H, Xu C, Zhang C, Li L, Wu P, Chen Z, Guan R

“…Genetic proxies for cholesteryl ester transfer protein (CETP) inhibition correlated with a decreased risk of preeclampsia (OR: 0.863, 95% CI: 0.786– 0.947, p=0.002, FDR=0.027), while genetic inhibition of HMG-CoA reductase (HMGCR) increased preeclampsia risk (OR: 1.700, 95% CI: 1.189– 2.431, p=0.004, FDR=0.036). …”
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Myostatin Levels and the Risk of Myopenia and Rheumatoid Cachexia in Women with Rheumatoid Arthritis by Fabiola Gonzalez-Ponce, Jorge Ivan Gamez-Nava, Eli Efrain Gomez-Ramirez, Melissa Ramirez-Villafaña, Heriberto Jacobo-Cuevas, Norma Alejandra Rodriguez-Jimenez, Eva Maria Olivas-Flores, Yussef Esparza-Guerrero, Alejandro Martelli-García, Aline Priscilla Santiago-Garcia, Cesar Arturo Nava-Valdivia, Alejandra Martinez-Hernandez, Sergio Antonio Gonzalez-Vazquez, Alfredo Celis, Carlos Enrique Cabrera-Pivaral, Sylvia Totsuka-Sutto, Ernesto German Cardona-Muñoz, Laura Gonzalez-Lopez

“…In the multivariable logistic regression, RA with high myostatin levels (≥17 ng/mL) was found to increase the risk of cachexia (OR=2.79, 95% CI: 1.24-6.29; p=0.01) and LSMM (OR=3.04, 95% CI: 1.17-7.89; p=0.02). …”
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Pre-CCRT 18-fluorodeoxyglucose PET-CT improves survival in patients with advanced stages p16-negative oropharyngeal squamous cell carcinoma via accurate radiation treatment planning by Tsung-Ming Chen, Wan-Ming Chen, Mingchih Chen, Ben-Chang Shia, Szu-Yuan Wu

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The association of HIV status and depressive symptoms in the Ndlovu Cohort study by Li Xiang Y. den Boer, Karine Scheuermaier, Hugo A. Tempelman, Roos E. Barth, Walter L. J. M. Devillé, Roel A. Coutinho, Diederick E. Grobbee, Francois Venter, Alinda G. Vos-Seda, Kerstin Klipstein-Grobusch

“…PLHIV were more likely to have depressive symptoms than HIV-negative participants (OR 1.34, 95% CI 1.01–1.77). This association was not statistically significant after adjusting for confounders (OR 1.22, 95% CI 0.92–1.63). …”
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Pneumonia among Under-Five Children in Northwest Ethiopia: Prevalence and Predictors—A Community-Based Cross-Sectional Study by Zewudu Andualem, Tsegaye Adane, Abiye Tigabu, Walelign Worku Yallew, Sintayehu Daba Wami, Henok Dagne, Jember Azanaw, Gebisa Guyasa, Zelalem Nigussie Azene, Mastewal Endalew

“…The prevalence of pneumonia among under-five children in the current study was found to be 12% with 95% CI: 10% to 14.4%. The presence of unpaved road within 100 m of the house (AOR=2.27, 95% CI: 1.41-3.66), living within 100 m of heavy traffic (AOR=1.94, 95% CI: 1.19-3.16), the habit of not opening doors while cooking (AOR=1.62, 95% CI: 1.01-2.62), the presence of cockroach infestation (AOR=1.98, 95% CI: 1.25-3.14), and new carpet in the house (AOR=1.75, 95% CI: 1.01-3.03) were statistically significant variables associated with childhood pneumonia. …”
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Genetic Polymorphisms in RNF138, ABCA1 and ESRRG-GPATCH2 Genes and their Role in Insulin Resistance Risk among Normal BMI Individuals in Indian Population: A Case-control Study by Sabitha Thummala, Sarah Fathima, Nithya Kruthi, Junaid Ahmed Khan Ghori, Katherine Saikia, Vivek Belde, Balamurali Andiyakkal Rajendran, Rahul Ranganathan

“…Results: Significant associations were found between IR and genetic variants rs4799327 (OR=2.74, 95% CI: 1.28-5.88, p-value=0.006) in RNF138, rs1497828 (OR=2.90, 95% CI: 1.51-5.57, p-value=0.0011) in ESRRG-GPATCH2 (dominant inheritance model), and rs2275543 (OR=3.50, 95% CI: 1.17-10.42, p-value=0.011) in ABCA1 (additive model). …”
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Advancing health equity: evaluating AI translations of kidney donor information for Spanish speakers by Oscar A. Garcia Valencia, Charat Thongprayoon, Caroline C. Jadlowiec, Shennen A. Mao, Napat Leeaphorn, Pooja Budhiraja, Nadeen Khoury, Justin H. Pham, Iasmina M. Craici, Maria L. Gonzalez Suarez, Wisit Cheungpasitporn

“…This study aims to assess ChatGPT’s translation efficacy to ensure the information provided is accurate and culturally relevant.MethodsThis study utilized ChatGPT versions 3.5 and 4.0 to translate 27 frequently asked questions (FAQs) from English to Spanish, sourced from Donate Life America’s website. …”
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Red flags to suspect inborn errors of immunity in patients with autoimmune diseases by Natalia Vélez, Juliette De Ávila, Jaime Cortés, Nelson Barrero, Leosirlay Rojas, Juan Manuel Bello, Consuelo Romero-Sánchez

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The prevalence of malaria in the five districts of Limpopo Province, South Africa, 2015 - 2017 by M T Lamola, A Musekiwa, A de Voux, C Reddy, M Morifi, P C Mutevedzi

“…However, Waterberg had the highest proportion of imported malaria cases 28.5% (437/1 532). In adjusted analyses, ages 15 - 49 years (adjusted odds ratio (aOR) 1.58, 95% confidence interval (CI) 1.48 - 1.68, p<0.001) and <1 year (aOR 1.55, 95% CI 1.37 - 0.74, p<0.001) were at higher odds of having malaria compared with ages ≥65 years. …”
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The Effect of the Concurrent Use of Angiotensin-Converting Enzyme Inhibitors or Receptor Blockers on Toxicity and Outcomes in Patients Treated with Radiotherapy: A Systematic Revie... by Wan-Chuen Liao, Hala Shokr, Corinne Faivre-Finn, Clare Dempsey, Kaye Janine Williams, Li-Chia Chen

“…ACEI users exhibited a 50% reduction in the risk of ≥grade 2 radiation pneumonitis (OR: 0.50, 95%CI: 0.32–0.77) in lung cancer and significant reductions in the odds of proctitis (80%, OR: 0.20, 95%CI: 0.12–0.33), haematuria (75%, OR: 0.25, 95%CI: 0.16–0.41), and rectal bleeding (61%, OR: 0.39, 95%CI: 0.30–0.51) in prostate cancer. …”
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Monster Radio Jet (>66 kpc) Observed in Quasar at z ∼​​​​​ 5 by Anniek J. Gloudemans, Frits Sweijen, Leah K. Morabito, Emanuele Paolo Farina, Kenneth J. Duncan, Yuichi Harikane, Huub J. A. Röttgering, Aayush Saxena, Jan-Torge Schindler

“…\limits^{{\rm{^{\prime} }}{\rm{^{\prime} }}}$ 3 resolution radio image of J1601+3102 reveals a northern and a southern radio lobe located at 9 and 57 kpc from the optical quasar, respectively. …”
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Real-Time Neuropsychological Testing for Hydrocephalus: Ultra-Fast Neuropsychological Testing During Infusion and Tap Test in Patients with Idiopathic Normal-Pressure Hydrocephalus by Ilaria Guarracino, Sara Fabbro, Daniele Piccolo, Serena D’Agostini, Miran Skrap, Enrico Belgrado, Marco Vindigni, Francesco Tuniz, Barbara Tomasino

“…To select shunt-responsive patients, infusion and tap tests can be used. Only gait is evaluated after the procedure to establish a potential improvement. …”
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Donor Small-Droplet Macrovesicular Steatosis Affects Liver Transplant Outcome in HCV-Negative Recipients by Flaminia Ferri, Quirino Lai, Antonio Molinaro, Edoardo Poli, Lucia Parlati, Barbara Lattanzi, Gianluca Mennini, Fabio Melandro, Francesco Pugliese, Federica Maldarelli, Alessandro Corsi, Mara Riminucci, Manuela Merli, Massimo Rossi, Stefano Ginanni Corradini

“…The median follow-up after LT was 7.5 years (range: 0.0-16.7). In negative recipients (n=122), graft loss was independently associated with graft Sd-MaS, in multivariable Cox regression models comprehending only pre-/intraoperative variables (HR=1.03, 95%CI=1.01-1.05; P=0.003) and when including indexes of early postoperative graft function (HR=1.04, 95%CI=1.02-1.06; P=0.001). …”
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Identification of QTL for Plant Height Traits in Single-segment Substitution Lines of Wild Rice by Xingxin DAI, Yanjie LIU, Chengxia LI, Rui TANG, Jiamei MU, Xuelin FU

“…A total of 25 QTLs related to plant height were identified in MERSSSLs, the additive effects of the QTLs ranged from -6.07 cm to 6.35 cm, and the phenotype variation explained by individual QTL was from 2.34% to 6.63%. …”
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Clinical features of early multiple sclerosis by I. Čelpačenko, R. Stankevičiūtė, M. Malciūtė, R. Balnytė

“…The patients were divided into the following age groups: 28 (20.3%) patients aged 18-30 years (mean 24.89±3.725), 58 (42.0%) aged 31-50 years (mean 40.43±6.093), and 52 (37.7%) 50 years and older (mean 57.83±5.498). 49 (35.5%) patients converted to MS and 89 (64.5%) patients were diagnosed with other diseases than MS. …”
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Synthesizing Local Capacities, Multi-Source Remote Sensing and Meta-Learning to Optimize Forest Carbon Assessment in Data-Poor Regions by Kamaldeen Mohammed, Daniel Kpienbaareh, Jinfei Wang, David Goldblum, Isaac Luginaah, Esther Lupafya, Laifolo Dakishoni

“…The Kruskal–Wallis test (<i>p</i> = 1.37 × 10⁻¹³) and Dunn post-hoc analysis revealed significant differences in carbon stock potential among tree species, with <i>Afzelia quanzensis</i> (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mover accent="true"><mrow><mi>x</mi></mrow><mo>~</mo></mover><mtext> </mtext></mrow></semantics></math></inline-formula>= 12 kg/ha, P-holm-adj. = 0.05) and the locally known species <i>M’buta</i> (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mover accent="true"><mrow><mi>x</mi></mrow><mo>~</mo></mover></mrow></semantics></math></inline-formula> = 6 kg/ha, P-holm-adj. = 5.45 × 10⁻⁹) exhibiting a significantly higher median AGC. …”
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Interplay of PNPLA3 and HSD17B13 Variants in Modulating the Risk of Hepatocellular Carcinoma among Hepatitis C Patients by Carla De Benedittis, Mattia Bellan, Martina Crevola, Elena Boin, Matteo Nazzareno Barbaglia, Venkata Ramana Mallela, Paolo Ravanini, Elisa Ceriani, Stefano Fangazio, Pier Paolo Sainaghi, Michela Emma Burlone, Rosalba Minisini, Mario Pirisi

“…A single-nucleotide polymorphism causing a C to G change in the PNPLA3 gene (rs738409) is associated with disease severity and development of hepatocellular carcinoma (HCC) in nonalcoholic fatty liver disease; the insertion variant rs72613567:TA of the 17β-hydroxysteroid dehydrogenase type 13 (HSD17B13) mitigates this detrimental effect. …”
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Risk of hemorrhagic fever with renal syndrome associated with meteorological factors in diverse epidemic regions: a nationwide longitudinal study in China by Nan Chang, Wenzhong Huang, Yanlin Niu, Zhihu Xu, Yuan Gao, Tingting Ye, Zihao Wang, Xiaohui Wei, Yuming Guo, Qiyong Liu

“…Results The exposure-response relationships between meteorological factors and HFRS incidence revealed significant heterogeneity across epidemic regions, as evidenced by Cochran’s Q test for temperature (Q = 324.40, P < 0.01) and relative humidity (Q = 30.57, P < 0.01). The optimal daily average temperature for HFRS transmission in Rattus-dominant epidemic regions (− 6.6 °C), characterized by spring epidemics, was lower than that observed in Apodemus-dominant epidemic regions (13.7 °C), where primary cases occurred during autumn and winter months. …”
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Associations between WASH-related violence and depressive symptoms in adolescent girls and young women in South Africa (HPTN 068): a cross-sectional analysis by Ruvani T Jayaweera, Kathleen Kahn, Sheri A Lippman, Torsten B Neilands, Rhian Twine, Jennifer Ahern, Ryan G Wagner, Audrey Pettifor, Dana Goin

“…Adjusted prevalence of depression was also higher among those who reported violence when collecting water (PD 11.9%, 95% CI: 6.7% to 17.2%), and who worried about violence when using the toilet (PD 12.8%, 95% CI: 7.9% to 19.8%), as compared with those who did not report these experiences. …”
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Determination of HLA Tissue Type According to the Etiology of Patients with Chronic Renal Failure by Burcu KARAKUS TURAN, Fahri UCAR, Vural Taner YILMAZ, Yahya KILINC, Sule DARBAŞ ARAS, Huseyin KOCAK, Nurten SAYIN EKINCI, Bulent AYDINLI, Habibe Sema ARSLAN

“…In our study, B*08, B*49, B*50 alleles in the HLA B locus (p=0.002, p=0.012 p=0.009) and DRB1*03, *04 alleles in the HLA DRB1 locus (p&lt;0.001, p&lt;0.001) were found positively associated with CKD. A*02, A*11, A*74 alleles at the HLA A locus (p=0.003, p&lt;0.001, p=0.009) and B*27, B*39, B* alleles at the HLA B locus 40, B*59 (p&lt;0.001, p&lt;0.001, p&lt;0.001, p=0.009), DRB1*07, *08, *09, *13, *16 (p&lt;0.001, p=0.012, p=0.007, p&lt;0.001, p&lt;0.001) alleles were determined as negatively associated with the disease. …”
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