Overall Survival of Patients with Metastatic Renal Cell Carcinoma Following the Introduction of Targeted and Immunotherapies: A Norwegian Retrospective, Real-World Registry Data St... by Puco K, Notland CS, Szulkin R, Jonasson C, Beisland C, Johannesen TB, Solli O, Oldenburg J, Heinrich D

“…Katarina Puco,1 Cathrine S Notland,2 Robert Szulkin,3,4 Christian Jonasson,5 Christian Beisland,6,7 Tom B Johannesen,8 Oddvar Solli,9 Jan Oldenburg,10,11 Daniel Heinrich12 1Department of Oncology, Hematology and Palliative Care, Lovisenberg Diaconal Hospital, Oslo, Norway; 2Department of Medical Affairs, Pfizer AS, Oslo, Norway; 3SDS Life Science, Stockholm, Sweden; 4Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Solna, Sweden; 5Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; 6Department of Urology, Haukeland University Hospital, Bergen, Norway; 7Department of Clinical Medicine, University of Bergen, Bergen, Norway; 8Cancer Registry of Norway, Norwegian Institute of Public Health, Oslo, Norway; 9Health and Value, Pfizer AS, Oslo, Norway; 10Department of Oncology, Akershus University Hospital HF, Lørenskog, Norway; 11Faculty of Medicine, University of Oslo, Oslo, Norway; 12Department of Radiotherapy and Oncology, Innlandet Hospital Trust HF, Division Gjøvik/Lillehammer, NorwayCorrespondence: Katarina Puco, Department of Oncology, Hematology and Palliative Care, Lovisenberg Diaconal Hospital, Oslo, Norway, Tel +47  416 86 298, Email katarina.puco@lds.noPurpose: In Norway, 5-year survival rates of patients with renal cell carcinoma (RCC) are increasing. …”
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Pre-immunotherapy alters stereotactic ablative radiotherapy-induced systemic T cell responses in early-stage NSCLC by Chao Liu, Yanjuan Chen, Xiaohui Li, Zhijie Bai, Meilin Jiang, Dongsheng Sheng, Wenxue Zou, Rui Huang, Qingyu Huang, Fuhao Wang, Jingyang Zhu, Huiru Sun, Bing Liu, Zongcheng Li, Bing Sun

“…Results We uncovered distinct T cell response patterns induced by these treatments: while terminal effector CD8+ T cells showed increased cytotoxic and inhibitory scores, and upregulated immune-activated pathways post-SABR, the reverse responses occurred post-icSABR. …”
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Efficacy and Safety Outcomes of Intravitreal Dexamethasone Implant Therapy for the Treatment of Adult Coats’ Disease by Qingshan Chen, Saying Liang, Xizhen Wang, Chenli Hu, Jieting She, Zi Li

“…No significant difference of baseline characteristics including BCVA, CRT, IOP, and follow-up time can be defined between DEX (+) and DEX (−) groups. …”
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Comprehensive analysis of metabolomics and transcriptomics reveals varied tepal pigmentation across Gloriosa varieties by Yue Sun, Pinli Hu, Yanan Jiang, Zhenzhen Wang, Jiaxing Chang, Yiwei Zhou, Haojing Shao

“…Weighted gene co-expression network analysis (WGCNA) revealed significant co-expression patterns between 217 transcription regulatory factors (TFs) and 8 carotenoid biosynthesis genes, and between 194 TFs and 41 anthocyanin biosynthesis genes. qRT-PCR verified the expression patterns of four carotenoid biosynthesis-related genes, eight anthocyanin biosynthesis-related genes, and three transcription regulatory factors. …”
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A Regional Gravimetric and Hybrid Geoid Model in Northern Greece from Dedicated Gravity Campaigns by Georgios S. Vergos, Dimitrios A. Natsiopoulos, Elisavet G. Mamagiannou, Eleni A. Tzanou, Anastasia I. Triantafyllou, Ilias N. Tziavos, Dimitrios Ramnalis, Vassilios Polychronos

“…After the deterministic fit, a std to the GNSS/leveling data of 10.1 cm has been achieved, with 54.8% and 83.1% of the absolute height differences being below the 1 cm and 2 cm per square root km of baseline length. …”
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YEARS clinical decision rule for diagnosing pulmonary embolism: a prospective diagnostic cohort follow-up study in primary care by Frans H Rutten, Menno V Huisman, Jeanet Blom, Rosanne van Maanen, Frederikus A Klok, Geert-Jan Geersing, Karel Moons, Hannah M la Roi-Teeuw, Melchior Nierman, Tuur Egbers

“…In total, 603 patients were classified as ‘PE ruled-out’ by the YEARS algorithm (532 with zero YEARS items and a D-dimer<1000 ng/mL and 71 with≥1 positive YEARS item and a D-dimer<500 ng/mL), resulting in an efficiency of 80.6% (603/748 patients, 95% CI 77.6% to 83.4%). Of these patients, three patients had a diagnosis of non-fatal PE during 3 months follow-up, all three with zero YEARS items and D-dimer between 500 and 1000 ng/mL, resulting in an overall diagnostic failure rate of 0.50% (3/603 patients, 95% CI 0.13% to 1.57%). …”
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High Human Immunodeficiency Virus (HIV) Viral Load and Coinfection with Viral Hepatitis Are Associated with Liver Enzyme Abnormalities among HIV Seropositive Patients on Antiretrov... by Shabani Iddi, Caroline A. Minja, Vitus Silago, Asteria Benjamin, Jastine Mpesha, Shimba Henerico, Benson R. Kidenya, Stephen E. Mshana, Mariam M. Mirambo

“…ASAT levels were significantly high among patients with high HIV viral load (P= 0.002) while ALAT levels were significantly high among those coinfected with hepatitis C virus (P=0.017) and hepatitis B virus (P<0.001). …”
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Co-Delivery of Dacarbazine and miRNA 34a Combinations to Synergistically Improve Malignant Melanoma Treatments by Ding B, Li M, Zhang J, Zhang X, Gao H, Gao J, Shen C, Zhou Y, Li F, Liu A

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CHI study: protocol for an observational cohort study on ageing and mental health in community-dwelling older adults by Lei Feng, Lieng Hsi Ling, Qiushi Feng, Rachael Zhi Yi Lee, Junhong Yu, Iris Rawtaer, Patrick Finbarr Allen, Zhiming Bao, Jeong Kyu Lee, Chin Tat Lim, Leng Leng Thang, Thet Naing, D Y Wang, Kai Zhen Yap, EH Kua, Rathi Mahendran

“…Results from the cohort will enable future studies to identify at-risk groups and develop interventions to improve the physical and mental health and quality of life of older adults.Ethics and dissemination Approval of the cohort study by the National University of Singapore Institutional Review Board (NUS-IRB Reference code: H-17-047) was obtained on 12 October 2017. Written consent will be obtained from all participants. …”
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Body Composition in Crohn’s Disease and Ulcerative Colitis: Correlation with Disease Severity and Duration by Dawesh P. Yadav, Saurabh Kedia, Kumble Seetharama Madhusudhan, Sawan Bopanna, Sandeep Goyal, Saransh Jain, Naval K. Vikram, Raju Sharma, Govind K. Makharia, Vineet Ahuja

“…In both UC/CD, disease severity was associated with nonsignificant decline in BMI (UC: 22.1±4.9 versus 20.2±3.2 versus 19.9±3.2 kg/m2, p=0.23; CD: 22.1±4.2 versus 19.9±2.3 versus 19.7±4.2 kg/m2, p=0.18) and fat mass (UC: 10.9±8.9 versus 8.1±5.9 versus 5.7±3.6 kg, p=0.14; CD: 11.2±7 versus 7.9±4.4 versus 7.2±5.9 kg, p=0.16), and disease duration was associated with significant decline in FFMI (p<0.05). …”
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Extraction of collagen from by-products of Amazonian fish tambaqui, Colossoma macropomum and pirarucu Arapaima gigas by Alexandre Augusto Barai, Antônio José Inhamuns, Tiago Cabral Nóbrega, Cristiane Cunha Guimarães, Lígia dos Santos Mourão, Antonio Fabio Lopes de Souza, Fagnaldo Braga Pontes, Flávia Dayane Félix Farias, Joana Maia Mendes, João Paulo Ferreira Rufino, Adriano Teixeira de Oliveira

“…The collagen extraction yields for C. macropomum and A. gigas were 2.97 % and 1.48 % for T1, and 1.51 % and 0.85 % for T2, respectively. …”
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Mixed methods evaluation of the Getting it Right First Time programme in elective orthopaedic surgery in England: an analysis from the National Joint Registry and Hospital Episode... by Stephen Morris, James Mason, Rosalind Raine, Peter Martin, Naomi J Fulop, Elena Pizzo, Andrew Hutchings, Helen Barratt, Jean Ledger, Raj Mehta, Sarah Jasim, Fiona Aspinal, Rafael Gafoor

“…Between 2012 and 2018, there were reductions in procedures by low volume surgeons (ORs (95% CI) hips 0.58 (0.53 to 0.63), knees 0.77 (0.72 to 0.83)); uncemented hip prostheses in &gt;65 s (OR 0.56 (0.51 to 0.61)); knee arthroscopies before surgery (OR 0.48 (0.41 to 0.56)) and mean length of stay (hips −0.90 (−1.00 to -0.81), knees −0.74 days (−0.82 to −0.66)). …”
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ارائه یک روش مبتنی بر یادگیری ماشین برای تلفیق محصولات آئروسل سنجندۀ مادیس جهت بهبود تخمین PM2.5، به‌عنوان یکی از مهم‌ترین مخاطرات زیست‌محیطی در شهر تهران... by علی میرزایی, حسین باقری, مهران ستاری

“…نتایج حاصل از تلفیق نشان داد که دقت تخمین PM2.5 محصول تلفیقی در هر سه شاخص RMSE، MAE و  نسبت به حالت‌هایی که محصولات به‌صورت منفرد استفاده شدند، بهتر است (0.77= ، 7.00 MAE = ، 9.59 RMSE=). علاوه بر افزایش دقت، روش پیشنهادی ساده و از نظر محاسباتی کم‌هزینه است. …”
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Accurate phenotype-to-genotype mapping of high-diversity yeast libraries by heat-shock-electroporation (HEEL) by Marcus Wäneskog, Emma Elise Hoch-Schneider, Shilpa Garg, Christian Kronborg Cantalapiedra, Elena Schäfer, Michael Krogh Jensen, Emil Damgaard Jensen

“…Our findings demonstrate that the longstanding trade-off between the size and quality of transformed yeast libraries can be overcome. By employing the HEEL method, large DNA libraries can be transformed into yeast with high-efficiency, while maintaining high library quality, essential for successful mutant screenings. …”
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Identification of a 5-Gene-Based Scoring System by WGCNA and LASSO to Predict Prognosis for Rectal Cancer Patients by He Huang, Shilei Xu, Aidong Chen, Fen Li, Jiezhong Wu, Xusheng Tu, Kunpeng Hu

“…Brown and yellow modules (including 77 DEGs) were identified to be preserved for RC. …”
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A first study on sperm sexing in water buffalo through magnetic nanoparticles by Syed Murtaza Hassan Andrabi, Muhammad Hammad Fayyaz, Muhammad Shafiq Haider, Ghulam Muhammad Ali

“…Three ali-quots (sexed groups) were incubated with 0.67 ml of negatively charged MNPs suspension. The fourth aliquot was incubated without MNPs (called “control group”). …”
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Peroral Endoscopic myotomy (POEM) in pediatric achalasia: a retrospective cohort on institutional experience and quality of life by Thijs Kuipers, Carlijn Mussies, Aaltje Lei, Gwen M.C. Masclee, Marc A. Benninga, Paul Fockens, Barbara A.J. Bastiaansen, Albert J. Bredenoord, Michiel P. van Wijk

“…Patients with an Eckardt score > 3 had a significantly worse general (Kidscreen-52: physical score 44.7 vs. 52.4; p = 0.011; mental score: 42.5 vs. 51.3; p = 0.038) and disease specific (35 vs. 16; p = 0.017) quality of life compared to those with an Eckardt ≤ 3. …”
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Rehabilitation success and related costs following stroke in a regional hospital: a retrospective analysis based on the Australian National Subacute and Non-Acute Patient (AN-SNAP)... by Fan He, George Mnatzaganian, Michael Njovu, David Rutherford, Tara Alexander, Irene Blackberry

“…A longer delay in starting rehabilitation was associated with a lower likelihood of achieving RFG success [Odds Ratio (OR): 0.85, 95% confidence interval (CI): 0.78–0.93, P < 0.001] and FIM efficiency success (OR: 0.89, 95% CI: 0.82–0.97, P = 0.010). …”
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Association of lower-limb strength with different fall histories or prospective falls in community-dwelling older people: a systematic review and meta-analysis by Ringo Tang-Long Zhu, Jenny Jing-Jing Zuo, Ke-Jing Li, Freddy Man Hin Lam, Arnold Yu Lok Wong, Lin Yang, Xue Bai, Man Sau Wong, Timothy Kwok, Yong-Ping Zheng, Christina Zong-Hao Ma

“…Moderate quality of evidence showed that the lower average leg-press power (SMD & 95% CI: -0.17 [-0.23, -0.12]; OR & 95% CI: 0.84 [0.79, 0.89]) and lower peak sit-to-stand power (Cohen’s d = 0.41) could predict prospective falls in older adults, especially the injurious/recurrent falls. …”
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The Forgotten Hemodynamic (PCO2 Gap) in Severe Sepsis by Zouheir Ibrahim Bitar, Ossama Sajeh Maadarani, AlAsmar Mohammed El-Shably, Ragab Desouky Elshabasy, Tamer Mohamed Zaalouk

“…Patients with a persistent or rising PCO2 gap larger than 0.8 kPa at T = 6 and 12 hours had a higher mortality change (n = 6; in-hospital mortality was 21.4%) than patients with a PCO2 gap of less than 0.8 kPa at T = 6 (n = 1; in-hospital mortality was 3%); this odds ratio was 5.3 (95% CI 0.9–30.7; P=0.08). The PCO2 gap had no relation with the chest ultrasound pattern. …”
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