Hydrogen-oxygen mixture inhalation as an adjunctive treatment to home-based exercise in older patients with knee osteoarthritis: an open-label, blinded-endpoint, randomized control... by Chenhui Wang, Mengwei Yan, Yuru Li, Lei Han, Hongqian Wang, Shufeng Jia, Xingchen Liu, Yang Liu, Fan Wu, Baoguo Wang

“…The between-group mean difference in the WOMAC total score was −5.2 (95% CI −12.1 to 1.7, P = 0.140) at week 12, with Group H showing an improvement of −22.9 (95% CI −26.3 to −19.6, P < 0.001) and Group C showing an improvement of −19.4 (95% CI −22.7 to −16.0, P < 0.001) compared to baseline, revealing a significant group × time interaction (F (3, 356.034) = 14.425, P < 0.001). …”
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Care coordination across healthcare systems: development of a research agenda, implications for practice, and recommendations for policy based on a modified Delphi panel by Aneesa Motala, Susanne Hempel, Michelle Wong, Maria Bolshakova, Ning Fu, David Ganz, Sonali Saluja, Timothy Kim, Carolyn Turvey, Kristina Cordasco, Aashna Basu, Tonya Page, Reshma Mahmood, Jenny Barnard, Isomi M Miake-Lye

“…Agreed practice recommendations included educating external professionals about issues specific to the patients in the main healthcare system, educating professionals within the main healthcare system about the roles and responsibilities of all involved parties, and helping patients better understand the pros and cons of within-system and out-of-system care. Policy recommendations included supporting time for professionals with high overlap in patients to engage regularly and sustaining support for care coordination for high-need patients.Conclusions Recommendations from the stakeholder panel created an agenda to foster further research, practice and policy innovations in cross-system care coordination.…”
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Exploring the Dynamics of Brent Crude Oil, S&P500 and Bitcoin Prices Amid Economic Instability by Adela Bara, Irina Alexandra Georgescu, Simona-Vasilica Oprea, Marian Pompiliu Cristescu

“…The most appropriate GARCH-type model for Dubai crude oil is TGARCH(1,1) Skewed Student, with a VaR coverage of 0.17. Both WTI oil and Dubai crude oil have a coverage that exceeds 5%, implying a more conservative approach to estimating potential losses. …”
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Efficacy of biocompost from pineapple waste coupled with indigenous fungi strains Trichoderma spp. on soil fertility, nutrients uptake, growth, and yield of Ananas comosus (L.) M... by Nguyen Quoc Khuong, Truong Thi Kim Chung, Le Thi My Thu, Tran Chi Nhan, Lieu Mong Ca, Le Thanh Quang, Ly Ngoc Thanh Xuan, Ngo Thanh Phong

“…The treatments with the TC123 biocompost correspondingly increased plant height, leaf number, D-leaf length, peduncle height, fruit length, and fruit width by 1.9, 31.8, 16.7, 5.4, 7.8, and 12.1%, in comparison with the treatments with the positive control. …”
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Assessing Prevention Protocols by a Brief Questionnaire in the Infectious Respiratory Diseases Pandemics: An Application in Pedestrian Population in COVID-19 Pandemic by Ali Jafari-Khounigh, Alireza Razzaghi, Hamid Sharifi, Shahram Habibzadeh, Seyed Taghi Heydari, Rasool Entezarmahdi, Mostafa Farahbakhsh, Alireza Ansari Moghaddam, Mahdi Rezaei, Mohammad Saadati, Ehsan Sarbazi, Morteza Haghighi, Mina Golestani, Homayoun Sadeghi-Bazargani

“…The mean age (SD) of participants was 41.5 (16.7). The CVR values resulted in the elimination of two questions. …”
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Phytochemical investigation and evaluation of antioxidant and antidiabetic activities in aqueous extracts of Cedrus atlantica by Idrissi Amine Mounadi, Mahraz Mohamed Adil, Drioua Soufiane, Assouguem Amine, Ali Essam A., Ibrahim Mohamed A., Mehta Chandra Mohan, Lahlali Rachid, Tlemcani Sara, Moussaoui Fatima, En-nabety Ghizlan, Eloutassi Noureddine, Lahkimi Amal

“…The CA extract showed potent α-amylase inhibition (IC50 307 ± 0.02 μg/mL) and remarkable α-glucosidase inhibition (IC50 70 ± 0.04 μg/mL), outperforming the FA and EA extracts. …”
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Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls by Niraj S. Patel, Michael R. Peterson, Grace Y. Lin, Ariel Feldstein, Bernd Schnabl, Ricki Bettencourt, Ekihiro Seki, Claude B. Sirlin, Rohit Loomba

“…We found a strong correlation between hepatic and pancreatic MRI-PDFF (Spearman correlation, P = 0.57, P value <0.001). Participants with increased insulin resistance determined by homeostatic-model-of-insulin-resistance (HOMA-IR) greater than 2.5 had higher pancreatic (7.3% versus 4.5%, P value =0.015) and liver (13.5% versus 4.0%, P value <0.001) MRI-PDFF. …”
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Magnetic resonance imaging -based radiomics of the pituitary gland is highly predictive of precocious puberty in girls: a pilot study by Michele Maddalo, Maddalena Petraroli, Francesca Ormitti, Alice Fulgoni, Margherita Gnocchi, Marco Masetti, Eugenia Borgia, Benedetta Piccolo, Emanuela C. Turco, Viviana D. Patianna, Nicola Sverzellati, Susanna Esposito, Susanna Esposito, Caterina Ghetti, Maria E. Street, Maria E. Street

“…BackgroundThe aim of the study was to explore a radiomic model that could assist physicians in the diagnosis of central precocious puberty (CPP). A predictive model based on radiomic features (RFs), extracted form magnetic resonance imaging (MRI) of the pituitary gland, was thus developed to distinguish between CPP and control subjects.Methods45 girls with confirmed diagnosis of CPP (CA:8.4 ± 0.9 yr) according to the current criteria and 47 age-matched pre-pubertal control subjects (CA:8.7 ± 1.2 yr) were retrospectively enrolled. …”
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Contribution of type 2 diabetes to major adverse cardiovascular events (MACE) in a long-term observational study with different stages of atherosclerosis by Arthur Mader, Dario Haeberli, Barbara Larcher, Jörn F. Dopheide, Christoph H. Saely, Christine F. Heinzle, Peter Amann, Marc Schindewolf, Andreas Festa, Heinz Drexel

“…Further, MACE occurred more frequently in group III (58.1%), than group II (34.1%) or group I (19.1%) (group I vs. group II vs. group III, p < 0.001). In a cox-regression-model, T2DM was a significant predictor of MACE in univariate analyses (HR = 2.43 [1.88–3.14], p < 0.001) and after multivariate adjustment for cardiovascular risk factors, as well as the different grades of atherosclerosis (HR = 1.37 [1.02–1.84], p = 0.034). …”
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Efficacy of non-invasive brain stimulation interventions on cognitive impairment: an umbrella review of meta-analyses of randomized controlled trials by Minmin Wu, Wenjing Song, Xue Wang, Lili Teng, Jinting Li, Jiongliang Zhang, Xinyue Li, Donghui Yu, Huanhuan Jia, Binhan Wang, Qiang Tang, Luwen Zhu

“…Repetitive transcranial magnetic stimulation (rTMS) significantly enhanced short-term global cognition (standardized mean difference [SMD], 0.44; 95% CI 0.02–0.86), language (SMD, 1.64; 95% CI 1.22–2.06), executive function (SMD, 1.64; 95% CI 0.18–0.83), and long-term global cognition (SMD, 0.29; 95% CI 0.07–0.50). …”
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Performance of zero water discharge (ZWD) system with nitrifying bacteria Bacillus megaterium and microalgae Chaetoceros calcitrans components in super intensive pacific white shri... by Rahim Rahim, Gede Suantika, Harish Muhammad

“…The experiment used three treatments, (a) shrimp reared without any addition of microbial agent with water exchange conducted every week as much as10–20% of total rearing volume as control (K); (b) ZWD systems with the applications of nitrifying bacteria, (C. calcitrans and B. megaterium) without water discharge  (P1); and (c) ZWD system with the application of microalgae C. calcitrans and B. megaterum without water discharge (P2). …”
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Genomic epidemiology of third-generation cephalosporin-resistant Escherichia coli from companion animals and human infections in Europe by Adrien Biguenet, Benoit Valot, Farid El Garch, Xavier Bertrand, Didier Hocquet

“…The blaCTX-M-15 gene was more frequent in humans (49.24 %) than in companion animals (17.9 %) (p < 0.001). …”
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An innovative approach to prioritizing soil conservation areas under diverse scenarios by leveraging the complementary roles of soil retention services and soil erosion indicators by Eshetu Shifaw, Jinming Sha, Xiaomei Li, Peng Zhao, Jianwan Ji, Hao Zhang, Ashenafi Yimam Kassaye, Shuhui Lai, Zhonglin Ji, Yusheng Yang

“…The total values of AE, ST, SL, and SE ranged from 11.98 to 12.49 billion, 2.07–2.15 billion, 660.41–684.06 million, and 102.35–105.75 million tons/year, respectively. …”
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Evaluation of three-dose fosfomycin tromethamine in the treatment of patients with urinary tract infections: an uncontrolled, open-label, multicentre study by Shan Chen, Yong Yang, Bo Yang, Ming Chen, Kai Zhang, Yi Wang, Lu-Dong Qiao, Bo Zheng, Hong-Feng Guo, Yuan-Jie Niu, Ben-Kang Shi, Wei-Min Yang, Xiao-Kun Zhao, Xiao-Feng Gao

“…The microbiological efficacy rates (day 15) were 97.65% (83/85), 94.44% (34/36) and 83.87% (26/31), respectively. …”
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Crystalloid resuscitation is associated with decreased treatment delays and improved systolic blood pressures in a blood-constrained setting by Melissa Carvalho, Alain Chichom-Mefire, Catherine Juillard, S Ariane Christie, Rasheedat Oke, Thompson Kinge, Jean-Gustave Tsiagadigui, Mbiarikai A Mbianyor, Mark T Yost, Matt Driban, Fanny Nadia Dissak Delon, Richard Njock, Daniel Nkusu

“…Median time to treatment was lower for CB than BL (12 vs 131 min, p&lt;0.01). Multivariate logistic regression adjusted for injury severity found no association between resuscitation type and mortality (CB adjusted OR (aOR) 1.28, p=0.82; BL aOR 1.05, p=0.97).Conclusions CB was associated with faster treatment, greater SBP elevation, and similar survival compared with BL in Cameroonian patients with trauma with hemorrhagic shock. …”
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Profiles of innovative behavior and associated predictors among clinical nurses: a multicenter study using latent profile analysis by Husheng Li, Yue Qiao, Tianxiang Wan, Chun Hua Shao, Fule Wen, Xiaoxin Liu

“…Results Among the respondents, individuals aged 25 to 35 accounted for 55.9%, and females comprised 94.6%. IB of clinical nurses can be identified into 3 groups: low-level (n = 108, 30.51%), moderate-level (n = 149, 42.09%), and high-level (n = 97, 27.40%) groups. …”
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Blastic plasmacytoid dendritic cell neoplasm: a Swiss case series of a very rare disease and a structured review of the literature by Ramona Meier-Lienhard, Cosima Suter, Thomas Pabst, Felicitas Hitz, Jakob R. Passweg, Olivier Spertini, Nathan Cantoni, Daniel Betticher, Lucas Simeon, Michael Medinger, Stefanie Hayoz, Adrian Schmidt

“…Newly diagnosed women were significantly younger than men (median: 62 vs 67 years, mean: 53.4 vs 59.3 years, p = 0.027) and less often had bone marrow infiltration and affected lymph nodes. …”
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Development of an Alternative Protocol to Study Muscle Fatigue by Daniela A. Alambarrio, Benjamin K. Morris, R. Benjamin Davis, Emily B. Grabarczyk, Kari K. Turner, John M. Gonzalez

“…Semitendinosus ATP concentration decreased (<i>p</i> < 0.01) post-EMS compared to ST pre- and BF pre- and post-EMS (<i>p</i> ≥ 0.29), but BF and ST concentration tended to differ pre-EMS (<i>p</i> = 0.07). The data indicated that EMS is a valuable tool for replicating ambulatory movement or physical activity, but super-contraction is not a means to accelerate postmortem muscle fatigue onset. …”
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Virulence of Five Root-Knot Nematodes (<i>Meloidogyne</i> spp.) on Nine Industrial Hemp (<i>Cannabis sativa</i> L.) Varieties and Nematicidal Potential of Hemp Seed Extracts Agains... by Dionysios Ntinokas, Ioannis Roussis, Antonios Mavroeidis, Panteleimon Stavropoulos, Antigolena Folina, Ioanna Kakabouki, Emmanuel A. Tzortzakakis, Dimitrios Bilalis, Ioannis O. Giannakou

“…In the current research, a greenhouse experiment was developed to evaluate the infection effect of five RKN species (<i>Meloidogyne javanica</i>, <i>M. incognita</i>, <i>M. arenaria</i>, <i>M. hapla</i>, and <i>M. luci</i>) in nine industrial hemp varieties (Fedora 17, Ferimon 12, Futura 75, Santhica 27, Santhica 70, KC Dora, KC Zuzana, Zenit, and USO 31), as was a laboratory experiment to evaluate the nematicidal activity of aqueous and water extracts of hemp seeds against second-stage juveniles (J2s) of <i>M. javanica</i>. …”
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Impacts of drought on respiratory mortality in the upper midwest United States: a population subgroup assessment by Yeongjin Gwon, Yuanyuan Ji, Jesse D Berman, Azar M Abadi, Ronald D Leeper, Jared Rennie, Jesse E Bell

“…Our study suggests that the risks differs by subgroups: elevated risks in elderly (higher 14.4% and 9.8% for 6 and 12 month), White (15.1% and 9.0% higher for 6 and 12 month), males (12.7% and 5.1% higher for 6 and 12 month), females (15.8% and 11.1% higher for 6 and 12 month), urban 15.8% and 8.8% higher for 6 and 12 month), and rural (13.6% and 9.9% higher for 6 and 12 month) communities. …”
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