Identification of Potential lncRNAs and miRNAs as Diagnostic Biomarkers for Papillary Thyroid Carcinoma Based on Machine Learning by Fei Yang, Jie Zhang, Baokun Li, Zhijun Zhao, Yan Liu, Zhen Zhao, Shanghua Jing, Guiying Wang

“…The regulatory network between optimal diagnostic lncRNA and mRNAs and optimal diagnostic miRNA and mRNAs was identified, followed by the construction of ceRNA network of lncRNA-mRNA-miRNA. Expression validation and diagnostic analysis of lncRNAs, miRNAs, and mRNAs were performed. …”
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Polymorphisms in Adipokines in Mexican Children with Obesity by Angélica Saraí Jiménez-Osorio, Alma Olivia Aguilar-Lucio, Helios Cárdenas-Hernández, Claudette Musalem-Younes, Jacqueline Solares-Tlapechco, Paula Costa-Urrutia, Oscar Medina-Contreras, Julio Granados, Martha Eunice Rodríguez-Arellano

“…Only both TMEM18 (rs6548238; rs7561317) polymorphisms were found associated with obesity (OR=0.5, P=0.008) and were in linkage disequilibrium (r2=0.87). The linear regression showed that the rs7561317 polymorphism of TMEM18 is negatively associated with obesity. …”
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Quantitative Validation of Hematocrit Percentage Drop Cutoff Points in Postpartum Hemorrhage: An Automated Gravimetric Approach by Venance Basil Kway, José Enrique Calacuayo Rojas, Josué Sidonio Rodríguez Cuevas, Ursula Medina Moreno, José Sergio Camacho Juárez, Jorge Francisco Ayala González, Karla Krebs Larraga, Ilse Veronica Castro Martinez, Roberto Arturo Castillo Reyther, Antonio Gordillo Moscoso, Yang Pan

“…A 14% decrease in hematocrit had an 81.7% agreement rate, with a good κ index of 0.602, a sensitivity of 82.5%, and a specificity of 80.0%. …”
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Changes in the critical nutrient content of packaged foods and beverages after the full implementation of the Chilean Food Labelling and Advertising Law: a repeated cross-sectional... by Natalia Rebolledo, Pedro Ferrer-Rosende, Marcela Reyes, Lindsey Smith Taillie, Camila Corvalán

“…Reductions in “high in” saturated fats and energy were less consistent, with the largest decreases in nuts and snacks and savory spreads (− 22.2 and − 20.0 pp, respectively, p < 0.001) and savory baked products and breakfast cereals (− 32.8 and − 25.7 pp, respectively, p < 0.001), respectively. …”
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Summer Research Internship Curriculum to Promote Self-Efficacy, Researcher Identity, and Peer-to-Peer Learning: Retrospective Cohort Study by Yulia A Levites Strekalova, Rachel Liu-Galvin, Samuel Border, Sara Midence, Mishal Khan, Maya VanZanten, John Tomaszewski, Sanjay Jain, Pinaki Sarder

“…The results of the retrospective pre-then-post survey indicated that there was a significant increase in students’ self-rated research abilities, evidenced by a significant improvement in the mean scores of the respondents when comparing reported skills self-assessment before and after the internship (improvement: median 1.09, IQR 0.88-1.65; W=52.5, P ConclusionsSummer internship programs can incorporate an academic enrichment curriculum with small-group peer learning in addition to a laboratory-based experience to facilitate increased student engagement, self-efficacy, and a sense of belonging in the research community. …”
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Integrative Omics Analysis Reveals Mechanisms of Anthocyanin Biosynthesis in Djulis Spikes by Chunmei Zheng, Wenxuan Ge, Xueying Li, Xiuzhang Wang, Yanxia Sun, Xiaoyong Wu

“…The upregulation of seven genes, including <i>chalcone synthase</i> (<i>CfCHS3_1</i>, <i>CfCHS3_2</i>, <i>CfCHS3_3</i>), <i>flavanone 3-hydroxylase</i> (<i>CfF3H_3</i>), <i>flavonoid 3′5′-hydroxylase</i> (<i>CfCYP75A6_1</i>), <i>dihydroflavonol reductase</i> (<i>CfDFRA</i>), and <i>glucosyltransferase</i> (<i>Cf3GGT</i>), promotes the formation and accumulation of delphinidin 3-sambubioside and peonidin 3-galactoside. …”
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Potentially inappropriate prescribing in hospitalised children: a retrospective, cross-sectional study at a tertiary children’s hospital in China by Linan Zeng, Lingli Zhang, Dan Yu, Huiqing Wang, Liang Huang, Siyu Li, Guo Cheng, Zhi-Jun Jia

“…Logistic regression results showed that PIP was more likely to occur in male patients (OR 1.128, 95% CI 1.059 to 1.202) and younger patients (&lt;2 years old; OR 1.974; 95% CI 1.739 to 2.241), and in those with more comorbidities (≥11 types; OR 4.181; 95% CI 3.671 to 4.761), concomitant drugs (≥11 types; OR 22.250; 95% CI 14.468 to 34.223) or longer hospital stay (≥30 days; OR 8.130; 95% CI 6.727 to 9.827).Conclusions Medications for long-term hospitalised young children with multiple comorbidities should be minimised and optimised, to avoid PIP, reduce adverse drug reactions and ensure children’s medication safety. …”
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Clinicopathological relationship between PM2.5 exposure and acute exacerbations of chronic obstructive pulmonary disease by Anfeng Cui, Yingying Shao, Yang Wang, Haodong Wang, Jiayi Song, Caiji Liu, Ningning Shen, Zhiqing Yang, Wangliang Zhang, Tiane Luo, Chen Wang

“…Inflammatory markers (leukocyte and neutrophil counts, eosinophil percentages, C-reactive protein), D-dimer levels, PaCO2, and pulmonary fibrosis indicators showed positive correlations with PM2.5 levels, whereas Pulmonary Function measures (FEV1/ FVC, FEV1 %) and PaO2 showed inverse correlations. …”
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The impact of same‐day and rapid ART initiation under the Universal Health Coverage programme on HIV outcomes in Thailand: a retrospective real‐life cohort study by Sirinya Teeraananchai, David C. Boettiger, Cheewanan Lertpiriyasuwat, Rattaphon Triamwichanon, Patchara Benjarattanaporn, Nittaya Phanuphak

“…The median (IQR) pre‐ART CD4 count was 233 (76–420) cells/mm3. ART initiation occurred within 7 days for 25% (17% on the same day, 8% in 2–7 days), 24% in 8 days to <1 month, 23% in 1–3 months and 28% in >3 months. …”
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Gender differences in use of cigarette and non-cigarette tobacco products among adolescents aged 13–15 years in 20 African countries by Israel T. Agaku, Rose Sulentic, Adriana Dragicevic, Gibril Njie, Candace K. Jones, Satomi Odani, Tina Tsafa, Joy Gwar, Constantine I. Vardavas, Olalekan Ayo-Yusuf

“…Among boys, perceived social acceptability of smoking at parties was associated with an increased likelihood of cigarette smoking (APR=2.27; 95% Cl: 1.20–4.30). Conclusions The prevalence of cigarette smoking among boys was higher than that of girls in many countries. …”
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The Modulation of Laser Refractive Surgery on Sensory Eye Dominance of Anisometropia by Hongting Liu, Qi Chen, Fangfang Lan, Yan Luo, Enwei Lin, Wuqiang Luo, Ming Kong, Jiangxia Wang, Fengju Zhang

“…In experiment one, the mean ODI in the nonanisometropic group and the anisometropic group was 1.48 ± 0.63 and 1.95 ± 1.07, respectively. The ODI values of the anisometropic group were significantly higher than those of the nonanisometropic group (Mann–Whitney U test, P<0.001). …”
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Utilization of partograph and associated factors among obstetric caregivers in Ethiopia: a systematic review and meta-analysis by Mulat Ayele, Eyob Shitie Lake, Gizachew Yilak, Getinet Kumie, Biruk Beletew Abate, Alemu Birara Zemariam, Befkad Derese Tilahun

“…Factors such as partograph training [adjusted odds ratio (AOR) = 3.63, 95% CI: 2.57–5.25], good knowledge about partograph (AOR = 2.63, 95% CI: 1.62–4.26), a favorable attitude toward partograph (AOR = 1.95, 95% CI: 1.35–2.82), partograph availability (AOR = 0.89, 95% CI: 2.24–6.61), and being in the midwifery profession (AOR = 0.09, 95% CI: 1.78–5.25) were significantly associated with partograph utilization.ConclusionThe pooled prevalence of partograph utilization in Ethiopia was low. …”
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Correlations of Cancer-Related Fatigue with Clinicopathological Features and Quality of Life in Gastric Cancer by Dong Liu, A-Dong Xia, Yue-Long Xing, Kai Zhang, Dan Chen

“…Pearson’s correlation analysis revealed a positive correlation between patient emotions and the CRF BFI score (r=0.443, P=0.001). Patients with mild, moderate, and severe CRF showed statistically significant differences in physical functioning (83.34±21.12 vs. 65.23±21.14 vs. 32.25±17.29, F=15.382, P<0.001), role emotional (72.53±21.21 vs. 67.33±27.56 vs. 54.37±26.45, F=14.483, P<0.001), fatigue (49.12±18.44 vs. 54.61±26.64 vs. 67.51±14.27, F=13.581, P<0.001), bodily pain (56.56±25.12 vs. 76.43±21.71 vs. 80.32±12.39, F=14.582, P<0.001), appetite reduction (57.45±25.47 vs. 69.51±16.21 vs. 76.23±27.58, F=14.592, P<0.001), and overall health status and quality of life (67.21±19.45 vs. 53.43±22.32 vs. 43.43±12.52, F=16.494, P<0.001). …”
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Uncovering the Hidden Physical Structures and Protostellar Activities in the Low-metallicity S284-RE Region: Results from ALMA and JWST by O. R. Jadhav, L. K. Dewangan, Aayushi Verma, N. K. Bhadari, A. K. Maity, Saurabh Sharma, Mamta

“…Overall, the study investigates a massive protostar candidate, driving the ∼2.7 pc H _2 outflow olc1 and undergoing episodic accretion.…”
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Programmed Cell Death Ligand 1 (PD-L1) and major Histocompatibility Complex Class I (MHC Class I) Expression Patterns and Their Pathologic Associations in triple-Negative Breast Ca... by Kaewkedsri P, Intarawichian P, Jessadapattarakul S, Kunprom W, Koonmee S, Thanee M, Somintara O, Wongbuddha A, Chadbunchachai P, Nawapun S, Aphivatanasiri C

“…However, high MHC class I expression was strongly associated with improved OS (HR = 0.469, 95% CI: 0.282– 0.780, p=0.004). Patients with negative PD-L1 and high MHC class I expression had the most favorable prognosis, with significant OS for CPS ≥ 1 (HR = 0.447, 95% CI: 0.236– 0.846, p=0.013) and CPS ≥ 10 (HR = 0.516, 95% CI: 0.307– 0.869, p=0.013).Conclusion: These findings support the potential of PD-L1 and MHC class I expression as prognostic markers for TNBC, offering insights to guide treatment decisions and improve patient outcomes.Keywords: triple-negative breast cancer, TNBC, programmed cell death ligand 1, PD-L1, major histocompatibility complex class I, MHC class I, immunohistochemistry, prognosis…”
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Flexible and wireless metasurface coils for knee and elbow MRI by Daniel M. Düx, Robert Kowal, Lucas Knull, Simon Schröer, Othmar Belker, Dominik Horstmann, Moritz Gutt, Holger Maune, Oliver Speck, Frank Wacker, Bennet Hensen, Marcel Gutberlet

“…If universal MC designs can achieve image quality comparable to those of standard coils and simultaneously be utilized across multiple body areas, the technology may revolutionize future musculoskeletal MRIs. …”
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The association of gut microbiota, immunocyte dynamics, and protein–protein ratios with tuberculosis susceptibility: a Mendelian randomization analysis by Hanxin Wu, Weijie Ma, Liangyu Zhu, Li Peng, Xun Huang, Lei Zhong, Rui Yang, Bingxue Li, Weijiang Ma, Li Gao, Xinya Wu, Jieqin Song, Suyi Luo, Fukai Bao, Aihua Liu

“…The results showed that 19 gut microbiotas were associated with tuberculosis. An7 indirectly affected tuberculosis through immunocyte (CD4 on CM CD4+), with a masking effect ratio of 0.008, demonstrating immune cells’ mediating role in the association between gut microbiota and tuberculosis. …”
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Metabolic Alterations in Different Stages of Hypertension in an Apparently Healthy Nigerian Population by M. A. Charles-Davies, A. A. Fasanmade, J. A. Olaniyi, O. E. Oyewole, M. O. Owolabi, J. R. Adebusuyi, O. Hassan, M. T. Ajobo, M. O. Ebesunun, K. Adigun, K. S. Akinlade, U. A. Fabian, O. O. Popoola, S. K. Rahamon, W. Okunbolade, M. A. Ogunlakin, O. G. Arinola, E. O Agbedana

“…Metabolic syndrome (MS) amplifies hypertension (HTN) associated with increased risk of cardiovascular disease (CVD). MS components and other CVD risk measures were investigated in different stages of hypertension. 534 apparently healthy Nigerian traders aged 18–105 years were participants of a cohort study. …”
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Syphilis among Female Sex Workers: Results of Point-of-Care Screening during a Cross-Sectional Behavioral Survey in Burkina Faso, West Africa by Henri Gautier Ouedraogo, Ivlabehire Bertrand Meda, Issaka Zongo, Odette Ky-Zerbo, Ashley Grosso, Benoit Cesaire Samadoulougou, Grissoum Tarnagda, Kadari Cisse, Apoline Sondo, Nongoba Sawadogo, Yves Traoré, Nicolas Barro, Stefan Baral, Seni Kouanda

“…Participants’ mean age was 27.2 ± 0.2 years. The syphilis serological markers were detected in 5.6% (95% CI: 4.4–7.2) of the participants whereas active syphilis was seen in 1.4% (95% CI: 0.9–2.4). …”
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The Correlation between Time in Range and Diabetic Microvascular Complications Utilizing Information Management Platform by Xia Sheng, Guo-Hui Xiong, Peng-Fei Yu, Jian-Ping Liu

“…TIR value less than 70% was a risk factor for DPN (OR = 1.030, 95% CI: 0.769–1.379). (4) There were 2,077 patients diagnosed with diabetic retinopathy (DR). …”
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