C5a/C5aR regulates Th1/Th2 imbalance in sepsis-associated lung injury by promoting neutrophil activation to increase PAD4 expression by Zhenbing Lu, Ling Zhu, Changlin Yi, Bi Su, Renying Wang

“…T helper (Th) cell activation and phenotypic imbalance among them contribute significantly to sepsis-associated lung injury. …”
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Association of the Genetic Polymorphisms in Transcription Factor 7-Like 2 and Peroxisome Proliferator-Activated Receptors-γ2 with Type 2 Diabetes Mellitus and Its Interaction with Obesity Status in Emirati Population by Habiba Al-Safar, Ahmed Hassoun, Shaikha Almazrouei, Wala Kamal, Bachar Afandi, Naushad Rais

“…Transcription factor 7-like 2 gene (TCF7L2) and peroxisome proliferator-activated receptors-γ2 (PPAR-γ2) have a profound effect on the incidence of type 2 diabetes mellitus (T2DM) and had previously been found to be associated with T2DM risk in various ppopulations. …”
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Oral Cancer Stem Cell-Derived Small Extracellular Vesicles Promote M2 Macrophage Polarization and Suppress CD4+ T-Cell Activity by Transferring UCA1 and Targeting LAMC2 by Lan Wu, Sai Ye, Yilin Yao, Chenping Zhang, Wei Liu

“…We previously reported that miR-134 blocks the expression of its targeting protein LAMC2 via the PI3K/AKT pathway and inhibits cancer stem cell (CSC) migration and invasion in oral squamous cell carcinoma (OSCC). …”
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A new peptide inhibitor of C1QBP exhibits potent anti‐tumour activity against triple negative breast cancer by impairing mitochondrial function and suppressing homologous recombination repair by Xingxing Li, Yue Wu, Min Zhang, Fengliang Wang, Hong Yin, Yanrong Zhang, Shuli Zhao, Jiehua Ma, Mingming Lv, Cheng Lu

“…PDBAG1 has demonstrated substantial efficacy in suppressing triple‐negative breast cancer (TNBC) both in vitro and in vivo. Its mechanism of action involves mitochondrial impairment and the inhibition of oxidative phosphorylation (OXPHOS), achieved through direct binding to C1QBP, thereby promoting its ubiquitin‐dependent degradation. …”
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Physicochemical Properties of the CoO/AlO, AgO/AlO and AgO-CoO/AlO Systems and Their Catalytic Activities towards Acid-Base and Redox Reactions by E.A. El-Sharkawy, Shar S. Al-Shihry, A.M. Youssef

“…The surface acidity of the catalysts is an important factor in determining their catalytic activity towards the conversion of propan-2-ol whereas the redox-reactive ion-pairs formed between Ag and Co determine their activity towards H 2 O 2 decomposition.…”
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Pore Fluid Evolution Influenced by Volcanic Activities and Related Diagenetic Processes in a Rift Basin: Evidence from the Paleogene Medium-Deep Reservoirs of Huanghekou Sag, Bohai Bay Basin, China by Zhongheng Sun, Hongtao Zhu, Changgui Xu, Xianghua Yang, Xiaofeng Du, Qingbin Wang, Jinyang Qiao

“…Volcanic activities exert a significant influence on pore fluid property and related diagenetic processes that substantially controlled reservoirs quality. …”
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Effects of Probiotics Red Yeast Rhodotorula paludigena CM33 on enhancing color pigmentation, antioxidant activity, immune response, intestinal microbiota, and growth in a commercial ornamental fish: Flowerhorn fish by Jirawadee Kaewda, Papungkorn Sangsawad, Surintorn Boonanuntanasarn, Pimpisut Manassila, Apichat Boontawan, Mariena Ketudat‑Cairns, Cheeranan Sriphuttha, Chatsirin Nakharuthai

“…It presented significant antioxidant activity, auto-aggregation, hydrophobicity, positive catalase activity, non-hemolytic properties, and resistance to 14 tested antibiotics. …”
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Facile and Promising Method for Michael Addition of Indole and Pyrrole to Electron-Deficient trans-β-Nitroolefins Catalyzed by a Hydrogen Bond Donor Catalyst Feist’s Acid and Preliminary Study of Antimicrobial Activity by Abdullah M. A. Al Majid, Mohammad Shahidul Islam, Assem Barakat, Mohamed H. M. Al-Agamy, Mu. Naushad

“…Some newly synthesized compounds were for examined in vitro antimicrobial activity and their preliminary results are reported.…”
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One-Pot Synthesis and Enhanced Vis-NIR Photocatalytic Activity of NiTiO₃/TiO₂ Templated by Waste Tobacco Stem-Silks by Weidong Yuan, Xiaohong Chen, Yi Zhao, Ying Fang, Han Zhang, Daomei Chen, Jiaqiang Wang

“…Interestingly, NiTiO₃(1.5)/TiO₂(TSS) even exhibited good activity under NIR light (λ = 840~850 nm) without upconversion materials or plasmon-assisted noble metals, which is 2.8 and 2.2 times than TiO₂ prepared without templates and TiO₂(TSS), respectively. …”
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Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activating the Nrf2/HO-1 pathway by Jiaochen Luan, Mengchi Yu, Qi Gu, Xuan Zhou, Yunqiang Shao, Tong Chen, Jiayi Zhang, Zheng Zhu, Ninghong Song, Jie Yang

“…In vivo, C75 treatment restored endothelial function and reversed erectile dysfunction, accompanied by decreased oxidative stress and pyroptosis in the penile corpus cavernosum.ConclusionThese findings suggest that Fasn inhibition may offer a promising therapeutic strategy for hypertension-induced ED by alleviating oxidative stress and suppressing NLRP3 inflammasome-dependent endothelial cell pyroptosis via activation of the Nrf2/HO-1 pathway.…”
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Anti-Inflammatory therapeutic potential of Bungur (Lagerstroemia speciosa L.) leaves ethanolic extract against LPS-activated macrophage through TLR4/MD2 signaling: A computational study by Rosyadah Nuraini, Dwijayanti Dinia Rizqi, Annisa Yuslinda, Kamila Fairuz Sarah, Widyananda Muhammad Hermawan, Ulfa Siti Mariyah, Widodo Nashi

“…The extract also showed excellent DPPH antioxidant activity, as evidenced by its low IC50 value. In silico studies identified luteolin, luteolin 7-sulfate, and quercetin as the three best compounds, which acted as potent competitive inhibitors of TLR4 activation. …”
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Entomological assessment of hessian fabric transfluthrin vapour emanators as a means to protect against outdoor-biting Aedes after providing them to households for routine use in Port-au-Prince, Haiti. by Chicoye Supreme, Obrillant Damus, Joseph Frederick, Jean-Frantz Lemoine, Christian Raccurt, Justin McBeath, Nosrat Mirzai, Sheila B Ogoma, Vincent Corbel, Daniel Impoinvil, Gerry F Killeen, Cyrille Czeher

“…Here these transfluthrin emanators were assessed in Port-au-Prince, Haiti against outdoor-biting Aedes.<h4>Methods</h4>Transfluthrin emanators were distributed to participating households in poor-to-middle class urban neighbourhoods and evaluated once every two months in terms of their effects on human landing rates of wild Aedes populations. …”
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Recombinant Human Brain Natriuretic Peptide Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting CD4+ T Cell Proliferation via PI3K/AKT/mTOR Pathway Activation by Kun-Peng Li, Hai-Yan Zhang, Xiao-Dong Xu, Ming-Yang, Tie-Jun Li, Shu-Tian Song

“…Recombinant human brain natriuretic peptide (rhBNP), a man-made version of a peptide that is elevated in heart failure, exhibits anti-inflammatory effects in various tissues. However, its role in myocardial IR injury remains unclear. …”
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Synthesis, Characterization and Antibacterial Activity of Mn(II), Co(II), Ni(II) and Cu(II) Complexes of 4-Carboxaldehyde Phenylhydrazone- 1-phenyl-3-methyl-2-pyrazolin-5-one by R. N. Pandya, A. K. Rana, H. R. Dabhi, R. B. Patel, D. K. Bhoi, M. B. Patel, K. S. Solanki, R. K. Rai, A. D. Raj

“…All the compounds were tested for their antibacterial activity. The result indicates that the growth of the tested organisms was inhibited by most of the compounds.…”
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Elucidation of α-glucosidase inhibitory activity and UHPLC-ESI-QTOF-MS based metabolic profiling of endophytic fungi Alternaria alternata BRN05 isolated from seeds of Swietenia macrophylla king by Piyush Kumar, Sai Anand Kannakazhi Kantari, Ranendra Pratap Biswal, Prasanth Ghanta, Malleswara Dharanikota

“…Ethyl acetate extracts of Alternaria alternata BRN05 grown in full-strength (EFS) and quarter-strength (EQS) media, respectively were evaluated for their α-glucosidase inhibitory activities. Based on IC50 values, EQS exhibited significantly greater inhibitory activity (0.01482 ± 1.809 mg/mL) as compared to EFS (1.16 ± 0.173 mg/mL) as well as acarbose control (0.494 ± 0.009 mg/mL). …”
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Examining the impact of a community-based exercise intervention on cardiorespiratory fitness, cardiovascular health, strength, flexibility and physical activity among adults living with HIV: A three-phased intervention study. by Kelly K O'Brien, Aileen M Davis, Soo Chan Carusone, Lisa Avery, Ada Tang, Patricia Solomon, Rachel Aubry, Mehdi Zobeiry, Ivan Ilic, Zoran Pandovski, Ahmed M Bayoumi

“…<h4>Methods</h4>We conducted a longitudinal intervention study with community-dwelling adults living with HIV in Toronto, Canada. We measured cardiopulmonary fitness (V̇O2peak (primary outcome), heart rate, blood pressure), strength (grip strength, vertical jump, back extension, push-ups, curl ups), flexibility (sit and reach test), and self-reported physical activity bimonthly across three phases. …”
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Different Activity of the Biological Axis VEGF-Flt-1 (fms-Like Tyrosine Kinase 1) and CXC Chemokines between Pulmonary Sarcoidosis and Idiopathic Pulmonary Fibrosis: A Bronchoalveolar Lavage Study by Katerina M. Antoniou, Giannoula Soufla, Athanasia Proklou, George Margaritopoulos, Christiana Choulaki, Rena Lymbouridou, Katerina D. Samara, Demetrios A. Spandidos, Nikolaos M. Siafakas

“…We estimated the levels of vascular endothelial growth factor (VEGF) and its high-affinity receptor, Flt-1 (fms-like tyrosine kinase 1), in bronchoalveolar lavage fluid (BALF) of patients with IPF and pulmonary sarcoidosis. …”
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Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes by Kazuhiro Kakimi, Hirokazu Matsushita, Masaaki Komatsu, Eiryo Kawakami, Mikako Nishida, Nahoko Yamashita, Taisaku Ogawa, Keita Koseki, Eiji Warabi, Tomoyuki Ohue, Katsuyuki Shiroguchi, Heiichiro Udono

“…Nrf2 activates mTORC1, whereas mTORC1 activates Nrf2 in a p-p62(S351)-dependent manner, thus creating a feedback loop that ensures CD8TILs’ proliferation. …”
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Ethyl Acetate Extract of <i>Cichorium glandulosum</i> Activates the P21/Nrf2/HO-1 Pathway to Alleviate Oxidative Stress in a Mouse Model of Alcoholic Liver Disease by Shuwen Qi, Chunzi Zhang, Junlin Yan, Xiaoyan Ma, Yewei Zhong, Wenhui Hou, Juan Zhang, Tuxia Pang, Xiaoli Ma

“…The ethyl acetate extract of <i>Cichorium glandulosum</i> (CGE) exhibits antioxidant and hepatoprotective properties, but its detailed mechanism of action against ALD remains unclear. …”
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Predicting independent walking ability using the Simplified Stroke Rehabilitation Assessment of Movement, Berg Balance Scale, and Barthel Index for Activities of Daily Living in individuals post-stroke: an observational preliminary study by Mykola Romanyshyn

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