Secretion of One Adipokine Nampt/Visfatin Suppresses the Inflammatory Stress-Induced NF-κB Activity and Affects Nampt-Dependent Cell Viability in Huh-7 Cells by Yi-Ching Lin, Hui-Chung Wu, Chen-Chung Liao, Yi-Chih Chou, Shwu-Fen Pan, Chi-Ming Chiu

“…Nampt/visfatin acts in both intracellular and extracellular compartments to regulate multiple biological roles, including NAD metabolism, cancer, inflammation, and senescence. However, its function in chronic inflammation and carcinogenesis in hepatocellular carcinoma (HCC) has not been well-defined. …”
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A miR-activated hydrogel for the delivery of a pro-chondrogenic microRNA-221 inhibitor as a minimally invasive therapeutic approach for articular cartilage repair by Shan An, Claudio Intini, Donagh O'Shea, James E. Dixon, Yiran Zheng, Fergal J. O'Brien

“…Articular cartilage has limited capacity for repair (or for regeneration) under pathological conditions, given its non-vascularized connective tissue structure and low cellular density. …”
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Predicting the hub interactome of COVID-19 and oral squamous cell carcinoma: uncovering ALDH-mediated Wnt/β-catenin pathway activation via salivary inflammatory proteins by Pradeep Kumar Yadalam, Deepavalli Arumuganainar, Prabhu Manickam Natarajan, Carlos M. Ardila

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Impact of High Thermal Setting and Fluid Activities on Sandstone Compaction: A Case Study of the Baiyun Sag in the Pearl River Mouth Basin (Northern South China Sea) by Chi Li, Jinglan Luo, Caiwei Fan, Shanshan Li, Shijiu Wu, Chuan Lei, Kunpeng Song

“…The characteristics of compaction and the effect of thermal fluid activities on reservoir physical properties are carried out, based on the observation and identification of sandstone thin sections under a microscope, the measurement and simulation of the temperatures and trapping pressures of fluid inclusions, and the calculation of the compaction porosity loss as well. …”
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Transcriptional Regulation of Δ6-Desaturase by Peroxisome Proliferative-Activated Receptor δ Agonist in Human Pancreatic Cancer Cells: Role of MEK/ERK1/2 Pathway by Maryam Darabi, Shima Byagowi, Shabnam Fayezi, Masoud Darabi, Shahab Mirshahvaladi, Mehdi Sahmani

“…The aim of the present study was to investigate the effect of peroxisome proliferative-activated receptor δ (PPARδ) agonist and MEK/ERK1/2-dependent pathway on the expression of Δ6D in human pancreatic carcinoma cell line PANC-1. …”
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Researcher views on returning results from multi-omics data to research participants: insights from The Molecular Transducers of Physical Activity Consortium (MoTrPAC) Study by Kelly E. Ormond, Caroline Stanclift, Chloe M. Reuter, Jennefer N. Carter, Kathleen E. Murphy, Malene E. Lindholm, Matthew T. Wheeler

“…Results We interviewed a total of 16 individuals representative of 11 sites and 6 research roles across MoTrPAC. Many respondents expressed positive attitudes regarding hypothetical multi-omics results return, citing participant rights to their data and perception of minimal harm. …”
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Physical activity behaviour up to 1 year post-rehabilitation among adults with physical disabilities and/or chronic diseases: results of the prospective cohort study ReSpAct by Lucas H V van der Woude, Rienk Dekker, Trynke Hoekstra, Leonie A Krops, Femke Hoekstra, Florentina J Hettinga, Pim Brandenbarg, Bregje L Seves

“…Background Little is known of physical activity behaviour among adults with a disability and/or chronic disease during and up to 1 year post-rehabilitation. …”
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Biological and residual activity of candidate larvicide formulation, SumiLarv 2MR, against an exotic invasive mosquito Anopheles stephensi Liston, 1901 (Diptera: Culicidae) in Ethiopia by Delenasaw Yewhalaw, Ebisa Erena, Teshome Degefa, Yehenew G. Kifle, Endalew Zemene, Eba Alemayehu Simma

“…Abstract The study evaluated the efficacy and residual activity of SumiLarv 2MR, SumiLarv 0.5G, and Abate 1SG (used as a positive control) against Anopheles stephensi larvae in Awash Subath Kilo, Afar Regional State, Ethiopia, using a semi-field experimental setup. …”
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Assessing physical activity/behavior of adolescents living in the Pacific with accelerometer data: 231 GENEActiv records in New CaledoniaZenodoZenodoZenodoZenodoZenodoZenodoZenodo by Guillaume Wattelez, Stéphane Frayon, Olivier Galy

“…Participants were randomly recruited at school and trained staff fitted the devices on the nondominant wrist, at which time all were reminded of the expectations while wearing the device.The dataset contains restricted raw .bin accelerometer data provided by the GENEActiv software and open 1-second epoch .csv accelerometer data derived from the .bin files with an R script, provided in the repositories as well. …”
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Synthesis, Characterization, X-Ray Crystal Structure, and Antimicrobial Activity of 1,1′-(3,4-Diphenylthieno[2,3-b]thiophene-2,5-diyl)diethanone by Yahia Nasser Mabkhot, Fahad D. Aldawsari, S. S. Al-Showiman, Assem Barakat, M. Iqbal Choudhary, Sammer Yousuf

“…Compound 4 was found to be active against Gram-positive bacteria (Bacillus subtilis and Staphylococcus pneumoniae) and Gram-negative bacteria (Escherichia coli) and also was found to be active against fungi (Aspergillus fumigatus and Candida albicans).…”
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The relationship between vision status and its influencing factors among primary and secondary school students: The masking effect of physical activity level and the moderating effect of academic stress by Jiyan Xu, Yanjun Li, Siyuan Ma, Shimeng Dai, Weiwei Xu, Mengjiao Sang, Kaijie Feng

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Evidence in Lager Yeasts of β-Lyase Activity Breaking Down γ-GluCys-Conjugates More Efficiently Than Cys-Conjugates to Odorant Beer Polyfunctional Thiols by Romain Christiaens, Margaux Simon, Raphaël Robiette, Sonia Collin

“…This β-lyase activity on γ-GluCys-3SHol has never been described before. …”
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The Role of RaxST, a Prokaryotic Sulfotransferase, and RaxABC, a Putative Type I Secretion System, in Activation of the Rice XA21-Mediated Immune Response by Pamela C. Ronald

“…We have recently demonstrated that the plant pathogen Xanthomonas oryzae pv. oryzae (Xoo) carries a functional sulfotransferase (RaxST). raxST is required for activation of rice Xa21-mediated immunity indicating the critical, but unknown, function of raxST in mediating the Xoo/rice interaction. …”
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A universal gelation strategy of bivalent anions to construct nanofibrous lysozyme hydrogels for immunomemory anti‐recurrence of diabetic wound infection by activating the cGAS‐STING pathway by Aihui Wang, Liqun Li, Liqian Zheng, Bang‐Ping Jiang, Yihao Liu, Rimei Huang, Huimin Qiu, Shichen Ji, Hong Liang, Xing‐Can Shen

“…In addition, near‐infrared light‐mediated photothermal characteristics are endowed with LZF to enhance its inhibitory activity of multidrug‐resistant bacteria by the skeleton modification with genipin to produce genipin‐conjuagted LZF (GLZF). …”
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Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a Metabolic Syndrome Model by María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo del Valle-Mondragón, Elizabeth Soria-Castro, Juan Carlos Torres-Narváez, Elizabeth Carreón-Torres, Alicia Sánchez-Mendoza, María Esther Rubio-Ruíz

“…Ischemia activated the angiotensin-converting enzyme (ACE)/angiotensin II/angiotensin receptor 1 (AT1R) and angiotensin III/angiotensin IV/angiotensin receptor 4 (AT4R)-IRAP axes. …”
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Mebendazole Exerts Anticancer Activity in Ovarian Cancer Cell Lines via Novel Girdin-Mediated AKT/IKKα/β/NF-κB Signaling Axis by Rahul Gupta, Dipanjan Roy, Arijit Ghosh, Yasmin Begum, Dipanjan Ghosh, Snehasikta Swarnakar

“…Mebendazole (MBZ), a benzimidazole anthelmintic and cytoskeleton-disrupting compound, exhibits antitumor properties; however, its action on ovarian cancer (OC) is not clearly understood. …”
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N-Terminal Region of GbIspH1, Ginkgo biloba IspH Type 1, May Be Involved in the pH-Dependent Regulation of Enzyme Activity by Bok-Kyu Shin, Joong-Hoon Ahn, Jaehong Han

“…Interestingly, GbIspH1-full and GbIspH1-truncated showed significantly different pH-dependent activities, and the maximum enzyme activities were obtained at pH 8.0 and 7.5, respectively. …”
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Availability, accessibility and activation of mental health services among university students in Africa: a protocol of a mixed-methods systematic review with meta-analysis and meta-synthesis by Hesborn Wao, Melvin A Wao, Ian Muriithi, Paul Seraii, Jackline Syonguvi

“…OR, risk ratio or mean difference with 95% CI will be considered as the effect size. We will assess heterogeneity between studies by appropriate subgroup analyses. …”
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HВcorAg expression in HВeАg-negative hepatitis: correlation to clinical and histological activity and HВsAg-status by O. P. Dudanova, I. A. Pravdolyubova

“…Routine laboratory tests, Knodell histological activity index and modified index, Metavir fibrosis score were assessed.Results. …”
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Loss of Type 2 Bone Morphogenetic Protein Receptor Activates NOD‐Like Receptor Family Protein 3/Gasdermin E‐Mediated Pyroptosis in Pulmonary Arterial Hypertension by Xiao‐ting Tian, Zhou‐yang‐fan Peng, Yu‐si Wu, Yuan‐yuan Cao, Xue‐chun Li, Ying Li, Si‐Yuan Tang, Alex F. Chen, Xiao‐hui Li

“…Moreover, BMPR2 deficiency can induce GSDME‐mediated pyroptosis through NLRP3 activation in 2 animal models, whereas activation of BMPR2 signaling by FK506 or BMP9 can reverse these phenotypes. …”
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