The dual anti-inflammatory and anticoagulant effects of Jianpi Huashi Tongluo prescription on Rheumatoid Arthritis through inhibiting the activation of the PI3K/AKT signaling pathway by Fanfan Wang, Fanfan Wang, Jian Liu

“…In vitro co-culture model showed that XFC inhibited RA-related inflammatory responses and hypercoagulable states by suppressing the activation of the PI3K/AKT signaling pathway.ConclusionThis study demonstrates that XFC exerts its dual anti-inflammatory and anticoagulant effects, at least in part, by inhibiting the activation of the PI3K/AKT signaling pathway, providing potential insights into targeted therapy for RA.…”
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Effectiveness of physical activity counselling provided for people with type 2 diabetes mellitus in primary healthcare in North Karelia, Finland: a register-based evaluation study by Tiina Laatikainen, Tuula Marketta Martiskainen, Marja-Leena Lamidi, Mika Venojärvi, Heikki Tikkanen

“…Objectives Physical activity (PA) plays a significant role in the treatment of type two diabetes (T2D). …”
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Boosting curcumin bioavailability with egg white protein aerogels: A sustainable supercritical CO₂-based approach for enhanced bioaccessibility, antioxidant activity, and anti-inflammatory effects by Farhad Alavi, Ozan N. Ciftci

“…SC-CO2-assisted impregnation resulted in uniform curcumin distribution within the aerogel matrix, significantly enhancing its solubility, antioxidant activity, bioaccessibility, and bioactivity compared to free curcumin. …”
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Long non-coding RNA LBX2-AS1 activates IL4R to promote glioblastoma metastasis and angiogenesis by binding to the transcription factor NFKB1 by Qiang Li, Yong Cheng

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Inhibition of IGF-1R-Dependent PI3K Activation Sensitizes Colon Cancer Cells Specifically to DR5-Mediated Apoptosis But Not to rhTRAIL by Bodvael Pennarun, Jan H. Kleibeuker, Tjitske Oenema, Janet H. Stegehuis, Elisabeth G.E. de Vries, Steven de Jong

“…Background: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) initiates apoptosis in tumor cells upon binding to its cognate agonistic receptors, death receptors 4 and 5 (DR4 and DR5). …”
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Synergistic Activations of REG Iα and REG Iβ Promoters by IL-6 and Glucocorticoids through JAK/STAT Pathway in Human Pancreatic β Cells by Akiyo Yamauchi, Asako Itaya-Hironaka, Sumiyo Sakuramoto-Tsuchida, Maiko Takeda, Kiyomi Yoshimoto, Tomoko Miyaoka, Takanori Fujimura, Hiroki Tsujinaka, Chikatsugu Tsuchida, Hiroyo Ota, Shin Takasawa

“…Promoter assay revealed that a signal transducer and activator of transcription- (STAT-) binding site in each promoter of REG Iα (TGCCGGGAA) and REG Iβ (TGCCAGGAA) was essential for the IL-6+Dx-induced promoter activation. …”
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In Vitro Activity of Cefepime against Multidrug-Resistant Gram-Negative Bacilli, Viridans Group Streptococci and Streptococcus pneumoniae from a Cross-Canada Surveillance Study by Donald E Low, Joyce de Azavedo, Canadian Bacterial Surveillance Network, Ross Davidson

“…OBJECTIVE: To determine the in vitro activity of cefepime against multidrug-resistant Gram-negative bacilli and Gram-positive cocci obtained from an ongoing cross-Canada surveillance study.…”
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Synergistic antimicrobial activity of essential oils mixture of Moringa oleifera, Cinnamomum verum and Nigella sativa against Staphylococcus aureus using L-optimal mixture design by Samah H. Abu-Hussien, Antony R. Nasry, Ziad Samy, Salwa M. El-Sayed, Ashraf Bakry, Naglaa Ebeed, Hesham Elhariry, Thanaa ElNoby

“…The developed predictive models for IZD and MIC showed excellent fit, with R2 values of 0.9843 and 0.9958, respectively. …”
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P2Y2 Receptor Induces L. amazonensis Infection Control in a Mechanism Dependent on Caspase-1 Activation and IL-1β Secretion by Maria Luiza Thorstenberg, Monique Daiane Andrade Martins, Vanessa Figliuolo, Claudia Lucia Martins Silva, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva

“…NLRP3 inflammasome activation and IL-1β release resulting from P2X7 activation are important for outcomes of L. amazonensis infection. …”
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Effect of Triple Acupuncture Therapy Combined with Rehabilitation Training on CGRP Content in Peripheral Blood, Motor Function and Activity of Daily Living of Spinal Cord Injury Patients by Yinjie CUI, Qian WANG, Yue JIANG, Anren ZHANG

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Harmonizing measurement tools: examining the concurrent validity of the Daily Activity Behaviors Questionnaire compared to the ActiGraph to assess 24-hour movement behaviors among adults by Iris Willems, Vera Verbestel, Dorothea Dumuid, Patrick Calders, Bruno Lapauw, Marieke De Craemer

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An Enhanced Active Disturbance Rejection Control Scheme for DC Voltage Regulation in Photovoltaic Grid-Connected Four-Leg Inverter Using a Sliding Mode Observer by Chebabhi Ali, Defdaf Mabrouk, Syphax Ihammouchen, Nicu Bizon, Benbouhenni Habib, Kessal Abdelhalim, Rekioua Toufik, Benkhoris Mohamed Fouad

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Research on Small-Target Detection of Flax Pests and Diseases in Natural Environment by Integrating Similarity-Aware Activation Module and Bidirectional Feature Pyramid Network Module Features by Manxi Zhong, Yue Li, Yuhong Gao

“…Meanwhile, the integration of the SimAM attention mechanism enables the model to learn information from three-dimensional channels, enhancing its perception of pest and disease features. Additionally, this paper adopts the EIOU loss function to further optimize the model’s bounding box regression, reducing the distortion of bounding boxes caused by high sample variability. …”
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The PTP1B Inhibitor Trodusquemine (MSI-1436) Improves Glucose Uptake in Equine Metabolic Syndrome Affected Liver through Anti-Inflammatory and Antifibrotic Activity by Lynda Bourebaba, Anna Serwotka-Suszczak, Nabila Bourebaba, Magdalena Zyzak, Krzysztof Marycz

“…Moreover, MSI-1436 enhanced the anti-inflammatory profile of livers by elevating the expression of IL-10 and IL-4 and activating CD4+CD25+Foxp3+ regulatory T cells in treated PBMC. …”
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Analysis of Adsorption Data of Nitrogen and Carbon Dioxide on Chemically-Activated Carbons from Cherry and Wild Cherry Stones by considering Different Approaches Based on Different Models by M.N. Alaya, M.A. Hourieh, F. El-Sejariah, A.M. Youssef

“…Activated carbons were prepared by activation of cherry and wild cherry stones with phosphoric acid and zinc chloride. …”
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Retracted: Synthesis and Optimization of Cr (VI) Removal from Aqueous Solution by Activated Carbon with Magnetic Fe3O4Nanoparticles by Response Surface Methodology by Adsorption Science and Technology

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Structural study, optical properties, thermal stability, and biological activity of a non-centrosymmetric hybrid compound 3,4-Diaminopyridinium perchlorate (3,4-DAPP) by Soulayma Mtar, Sameh Sellami, Nassira Chniba-Boudjada, Mohamed Boujelbene

“…Finally, biological activity tests revealed that 3,4-DAPP exhibited moderate antibacterial activity, particularly against Bacillus cereus. …”
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Synthesis and Oral Hypoglycemic Activity of 3-[5'-Methyl-2'-aryl-3'-(thiazol-2ʺ-yl amino) thiazolidin-4'-one]coumarin Derivatives by Deepthi Kini, Manjunath Ghate

“…All the synthesized compounds were characterized and screened for hypoglycemic activity. Some of the compounds exhibited promising activity.…”
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Characterization and Antifungal Activity of Limonoid Constituents Isolated from Meliaceae Plants Melia dubia, Aphanamixis polystachya, and Swietenia macrophylla against Plant Pathogenic Fungi In Vitro by Thanh Nguyen Tan, Hieu Tran Trung, Quang Le Dang, Hien Vu Thi, Hoang Dinh Vu, Tuan Nguyen Ngoc, Hoai Thu Thi Do, Thanh Huong Nguyen, Dang Ngoc Quang, Thang Tran Dinh

“…Notably, chisocheton compound G (3) isolated from A. polystachya and khayanolide B (8) isolated from S. macrophylla were the most potent antifungal limonoids and exhibited a dose-dependent activity against Phytophthora species. Compounds 2 and 9 displayed moderate activity against M. oryzae. …”
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Self-reported sexually transmitted infections and associated factors among sexually active men in East Africa: a multilevel analysis of recent demographic and health surveys by Beminate Lemma Seifu, Yohannes Mekuria Negussie, Bezawit Melak Fente, Zufan Alamrie Asmare, Angwach Abrham Asnake, Meklit Melaku Bezie, Hiwot Atlaye Asebe

“…An adjusted OR with the corresponding 95% CI was used to estimate the strength of the association, and statistical significance was set at a p value <0.05.Results The pooled prevalence of self-reported STIs among sexually active men in East Africa was 5.22% (95% CI: 5.34, 5.69). …”
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