Helping anti-cancer activity of cetuximab (Erbitux) by monoclonal antibody conjugated nanocurcumin - In vitro studies on human oral squamous carcinoma cell line (OECM) by Rethinam Senthil, S. Raghunandhakumar

Get full text

Synthesis and In Vitro Antibacterial Activity of New 2-(1-Methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles by Bahram Letafat, Negar Mohammadhosseini, Ali Asadipour, Alireza Foroumadi

“…In the present study we report the synthesis and antibacterial activity of a new series 2-(1-methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles (6a-c). …”
Get full text

Alcohol intake exacerbates experimental autoimmune prostatitis through activating PI3K/AKT/mTOR pathway-mediated Th1 differentiation by Shun Xu, Shun Xu, Shun Xu, Jing Chen, Jing Chen, Jing Chen, Shaoyu Yue, Shaoyu Yue, Shaoyu Yue, Yifan Zhang, Yifan Zhang, Yifan Zhang, Shengyu Zhao, Shengyu Zhao, Shengyu Zhao, Yongtao Hu, Yongtao Hu, Yongtao Hu, Cheng Zhang, Cheng Zhang, Cheng Zhang, Wenrui Guan, Wenrui Guan, Wenrui Guan, Li Zhang, Li Zhang, Li Zhang, Ligang Zhang, Ligang Zhang, Ligang Zhang, Chaozhao Liang, Chaozhao Liang, Chaozhao Liang

“…In contrast, PI3K inhibitor LY294002 and shRNA-PI3K plasmid inhibited PI3K/AKT/mTOR pathway activation, reduced Th1 cell differentiation, and alleviated EAP inflammation severity, respectively.ConclusionOur study is the first to demonstrate that alcohol intake promotes Th1 cell differentiation and exacerbates EAP by activating the PI3K/AKT/mTOR pathway. …”
Get full text

A Effect of Maltodextrin Concentration on Antioxidants Activity and Stability of Natural Coloring Powder of Secang Wood (Caesalpinia Sappan L) in Various Conditions of Ph and Temperature by Huswatun Hasanah, Daimon Syukri, Ismed Ismed

Subjects: “…sappan wood, maltodextrin, antioxidant activity, color stability…”
Get full text

Ursodeoxycholic acid protects against sepsis-induced acute kidney injury by activating Nrf2/HO-1 and inhibiting NF-κB pathway by Yunpeng Lou, Hongguang Shi, Ning Sha, Feifei Li, Xiaofeng Gu, Huiyan Lin

“…Abstract Background Ursodeoxycholic acid (UDCA), traditionally recognized for its hepatoprotective effects, has also shown potential in protecting kidney injury. …”
Get full text

PSCA-targeted BPX-601 CAR T cells with pharmacological activation by rimiducid in metastatic pancreatic and prostate cancer: a phase 1 dose escalation trial by Mark N. Stein, Ecaterina E. Dumbrava, Benjamin A. Teply, Usama S. Gergis, Martin E. Guiterrez, Ran Reshef, Sumit K. Subudhi, Céline F. Jacquemont, Joseph H. Senesac, J. Henri Bayle, Charity D. Scripture, Monica S. Chatwal, Mehmet A. Bilen, Walter M. Stadler, Carlos R. Becerra

“…Rimiducid increased circulating inflammatory cytokines/chemokines consistent with GoCAR-T® cell activation. These results suggest that pharmacological activation of GoCAR-T® cells is feasible and may offer a promising avenue to control chimeric antigen receptor-T cell activity with continued dose-optimization to improve tolerability.…”
Get full text

Preoperative Altered Spontaneous Brain Activity and Functional Connectivity Were Independent Risk Factors for Delayed Neurocognitive Recovery in Older Adults Undergoing Noncardiac Surgery by Zhaoshun Jiang, Xixue Zhang, Yating Lv, Xiaodong Zheng, Huibiao Zhang, Xuelin Zhang, Chongyi Jiang, Guangwu Lin, Weidong Gu

“…The multivariate logistic regression analysis showed that higher preoperative spontaneous activity in the bilateral MCC was independently associated with a higher risk of DNR (OR=3.11, 95% CI, 1.30-7.45; P=0.011). …”
Get full text

First Report on Bioaccessibility, Antioxidant Activity and Total Phenolic Compounds From Stachys thirkei C.Koch Using A Simulated In Vitro Digestion System by Gorkem Dulger, Emine Aydın, Pınar Göç Rasgele

Subjects: Get full text

The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis by Michael Yaroustovsky, Ekaterina Rogalskaya, Marina Plyushch, Ludmila Klimovich, Nataliya Samsonova, Marina Abramyan

“…To analyse the clinical informativity of the neutrophil oxidative response level (“Response”) during an Endotoxin Activity Assay (EAA) as a new biomarker defining the indications and effectiveness of intensive care in cardiac surgical patients with septic complications. …”
Get full text

Biogenic Synthesis of Silver Nanoparticles (AgNPs) Using Aqueous Leaf Extract of Buchanania lanzan Spreng and Evaluation of Their Antifungal Activity against Phytopathogenic Fungi by Ayushi Purohit, Radheshyam Sharma, R. Shiv Ramakrishnan, Stuti Sharma, Ashish Kumar, Devendra Jain, Himmat S. Kushwaha, Elina Maharjan

“…In addition, the antifungal activities of the AgNPs were evaluated against two phytopathogenic fungi Rhizoctonia solani and Fusarium oxysporum f. sp. lycopersici in vitro using poison food techniques on PDA media. …”
Get full text

The activation of Chlamydomonas reinhardtii alpha amylase 2 by glutamine requires its N‐terminal aspartate kinase–chorismate mutase–tyrA (ACT) domain by Lisa Scholtysek, Ansgar Poetsch, Eckhard Hofmann, Anja Hemschemeier

“…This activating effect required the enzyme's N‐terminal aspartate kinase–chorismate mutase–tyrA domain. …”
Get full text

Exploring the Socio-personal Factors Associated with the Prevalence of Symptoms of Reproductive Tract Infections among Sexually Active Married Women in Ernakulam District of Kerala, India by Ann Merrin George, Leena Kunnath Chacko

“…Multivariate analysis showed that those women living in the urban areas (OR: 0.49, 95% CI: 0.334, 0.719), having no previous history of obstetric/gynecological risk factors (OR: 1.89, 95% CI: 1.119, 3.19) and using both clothes and sanitary pads interchangeably during menstruation (OR: 0.46, 95% CI: 0.282, 0.734) were found to be at less risk of contracting RTIs. …”
Get full text

EXAMINATIONS OF IMPACTS OF EMPOWERING LEADERSHIP ON INNOVATION ACTIVITIES IN SERVICE SECTOR AND EMPLOYEES - GÜÇLENDİRİCİ LİDERLİĞİN, HİZMET SEKTÖRÜNDEKİ YENİLİK FAALİYETLERİNE VE ÇALIŞANLARA ETKİLERİNİN İNCELENMESİ by Zafer Adıgüzel, Yeliz Cayan

“…When the findings are analyzed, it was found thatempowering leadership and proactive personality variables had positive effectson career satisfaction, innovation and creativity activities. Within the scopeof the study, survey were conducted with 483 white-collar workers (administrativepersonnel) who work in the service sector. …”
Get full text

Effectiveness of clove oil as a topical anesthetic during inferior alveolar nerve block: A randomized, single-blinded, active-controlled clinical study by Hiba Khalouf, Mawia Karkoutly, MHD Bashier Almonakel

Get full text

A novel activated carbon material from peanut shells for the removal of methyl orange and methylene blue dyes from wastewater: kinetics, isotherms and mechanism by Oluwagbemi Aladeokin, Ashleigh Fletcher

“…This study investigated the removal of methyl orange (MO) and methylene blue (MB) dyes from an aqueous phase using a novel activated carbon material derived from peanut shells. …”
Get full text

MMP-Activated Fluorescence Imaging Detects Early Joint Inflammation in Collagen-Antibody-Induced Arthritis in CC-Chemokine Receptor-2-Null Mice, In-Vivo by Jessica M. Ibarra, Fabio Jimenez, Hernan G. Martinez, Kassandra Clark, Seema S. Ahuja

“…The Standard measures of experimental arthritis fail to detect, visualize, and quantify early inflammation and disease activity. Here, we describe the use of an injectable MMP-activated fluorescence agent for in vivo quantification of acute inflammation produced by collagen-antibody-induced arthritis (CAIA) in CC chemokine receptor-2 (Ccr2−/−) null mice. …”
Get full text

Exosomal circPOLQ promotes macrophage M2 polarization via activating IL-10/STAT3 axis in a colorectal cancer model by Yang Liu, Chen Chen, Jinbo Liu, Zhenqiang Sun, Bo Shao, Yanxin Xu, Pengyuan Dang, Shengyun Hu, Haifeng Sun, Chaoguan Wang, Junhong Hu

“…In vitro and in vivo experiments showed that tumor-derived exosomal circPOLQ did not directly regulate CRC cell development but promoted CRC metastatic nodule formation by enhancing M2 macrophage polarization. circPOLQ activated the interleukin-10/signal transducer and activator of transcription 3 axis by targeting miR-379–3 p to promote M2 macrophage polarization.Conclusion circPOLQ can enter macrophages via CRC cell-derived exosomes and promote CRC metastatic nodule formation by enhancing M2 macrophage polarization. …”
Get full text

Comparing different montages of transcranial direct current stimulation on dual-task walking and cortical activity in chronic stroke: double-blinded randomized controlled trial by Pei-Ling Wong, Yea-Ru Yang, Shun-Chang Tang, Shih-Fong Huang, Ray-Yau Wang

Subjects: “…Contralesional cortical activity…”
Get full text

Effects of physical activity on depressive and anxiety symptoms of women in the menopausal transition and menopause: a comprehensive systematic review and meta-analysis of randomized controlled trials by Hongyu Yue, Yijiao Yang, Fangfang Xie, Jiahe Cui, Yang Li, Mengran Si, Shanshan Li, Fei Yao

Subjects: “…Physical activity…”
Get full text

Comparison of new secondgeneration H1 receptor blockers with some molecules; a study involving DFT, molecular docking, ADMET, biological target and activity by Velid Unsal, Erkan Oner, Reşit Yıldız, Başak Doğru Mert

“…Vitamin C and Quercetin were found to be safer in terms of cardiac toxicity and mutagenic risks, while Desloratadine and Levocetirizine carried high risks of neurotoxicity and hematotoxicity, while CAPE was noted for its high enzyme inhibitory activities and low toxicity profiles, while the hERG blockade, DILI, and cytotoxicity values of other compounds pointed to various safety concerns. …”
Get full text