Efficacy, safety, and tolerability of lifitegrast 5% eye drops: A randomized, double-blind, active-controlled trial in Indian patients with dry eye disease by Namrata Sharma, Sayan Basu, Rohit Shetty, Pramod Kumar, Anindita Mondal, P Seshu Babu, Richa Srivastava, Ranjana A Pande, Shubashree Karat, Hemaxi P Desai, S Manjula, M Krishna Kumar

“…Conclusion: To our knowledge, this is the first active-controlled trial informing on the efficacy, safety, and tolerability of lifitegrast 5%. …”
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Healthy Life Centres: a 3-month behaviour change programme’s impact on participants’ physical activity levels, aerobic fitness and obesity: an observational study by Ellen Eimhjellen Blom, Eivind Aadland, Ane Kristiansen Solbraa, Line Merethe Oldervoll

“…The participants had improved LPA (4.0, 95% CI 0.5 to 7.5), increased number of steps (362, 95% CI 172 to 552), reduced SED (−5.6, 95% CI −9.8 to –1.3), improved fitness (0.8, 95% CI 0.6 to 1.0), reduced BMI (−0.2, 95% CI −0.1 to –0.3) and reduced WC (−1.7, 95% CI −2.0 to –1.3). …”
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Synthesis and preliminary ex vivo evaluation of the spasmolytic activity of 1,3-thiazolium- and 1,3,4-thiadiazolium-5-methylthio- and 5-thioacetate derivatives by Luis José A. S., Aquino Thiago M. De, Lira Bruno F., Filho Petrônio F. A., Scotti Marcus T., Scotti Luciana, Moura Ricardo O. De, Junior Francisco J. B. Mendonça

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Long-term efficacy and safety of alemtuzumab in participants with highly active MS: TOPAZ clinical trial and interim analysis of TREAT-MS real-world study by Tjalf Ziemssen, Ann D. Bass, Bart Van Wijmeersch, Sara Eichau, Stephan Richter, Frank Hoffmann, Nicole M. Armstrong, Magdalena Chirieac, Janete Cunha-Santos, Barry A. Singer

“…Background: Alemtuzumab is a disease-modifying therapy for highly active relapsing-remitting multiple sclerosis (RRMS). …”
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Optimal Vase Solution for <i>Gerbera hybrida</i> Cut Flower Keeping Fresh by Activating SA and Cytokinin Signaling and Scavenging Reactive Oxygen Species by Chaoshui Xia, Yiyang Cao, Weixin Gan, Huifeng Lin, Huayang Li, Fazhuang Lin, Zhenhong Lu, Weiting Chen

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pDC Activation by TLR7/8 Ligand CL097 Compared to TLR7 Ligand IMQ or TLR9 Ligand CpG by Jing Wu, Shuang Li, Tete Li, Xinping Lv, Mingyou Zhang, Guoxia Zang, Chong Qi, Yong-Jun Liu, Liang Xu, Jingtao Chen

“…Our previous study demonstrated that pDCs activated by the TLR7 ligand imiquimod (IMQ) and the TLR9 ligand CpG A can kill breast cancer cells in vitro and inhibit tumor growth in vivo. …”
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CURRENT APPROACH TO DEVELOPMENT OF BIOSIMILAR PRODUCTS CONTAINING MONOCLONAL ANTIBODIES AS AN ACTIVE SUBSTANCE – NON-CLINICAL AND CLINICAL STUDIES OF THE FIRST RUSSIAN RITUXIMAB BIOSIMILAR, ACELLBIA® by S. M. Alekseev, K. D. Kaplanov, R. A. Ivanov, E. V. Chernyaeva

“…Evaluation of pharmacokinetics, pharmacodynamics, safety and efficacy of rituximab biosimilar (Acellbia,  BIOCAD, Russia) used as  monotherapy in patients with indolent B-cell non-Hodgkin’s lymphoma in comparison with the parameters of innovator rituximab – MabThera.Materials and methods. 92 patients (aged 18 years and older with diagnosed CD20-positive follicular non-Hodgkin’s lymphoma, stage II-IV by Ann Arbor, 1-2 histologic grade, or marginal zone lymphoma) were enrolled into the study. …”
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Increased susceptibility to diet-induced obesity in female mice impairs ovarian steroidogenesis: The role of elevated leptin signalling on nodal activity inhibition in theca cells by Karolina Wołodko, Tjaša Šentjurc, Edyta Walewska, Elżbieta Laniecka, Magdalena Jura, António Galvão

“…No changes were seen in the genes regulating steroidogenesis, Nodal signalling, or Socs3 and Smad7 activity in the ovaries of HFD-fed 129 mice. Importantly, the pharmacological treatment of lean mice with leptin, upregulated the ovarian transcription of Socs3 and Smad7, while downregulating Nodal and its receptors (p < 0.05). …”
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Commentary on “Association of accelerometer-measured sleep duration and different intensities of physical activity with incident type 2 diabetes in a population-based cohort study” by Barbara E. Ainsworth, Haili Tian

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Ultrasound-assisted extraction of phenolic compounds from ear mushrooms (Auricularia auricula-judae): Assessing composition and antioxidant activity during fruiting body development by Albert Nugraha, Asadin Briliantama, M Umar Harun, Li Sing-Chung, Chin Xuan Tan, Vuanghao Lim, Amir Husni, Widiastuti Setyaningsih

“…Auricularia auricula-judae (ear mushroom) exhibits significant biological and pharmacological properties, particularly as an antioxidant due to its phenolic compounds. This study introduces a novel ultrasound-assisted extraction technique to quantify phenolic compounds and assess antioxidant activity in ear mushrooms. …”
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TiO2 Photocatalyst Nanoparticle Separation: Flocculation in Different Matrices and Use of Powdered Activated Carbon as a Precoat in Low-Cost Fabric Filtration by Carlos F. Liriano-Jorge, Ugur Sohmen, Altan Özkan, Holger Gulyas, Ralf Otterpohl

“…As an alternative to photocatalyst separation by sedimentation, precoat vacuum filtration with powdered activated carbon (PAC) over low-cost spunbond polypropylene fabrics was tested in the presence of two PAC types in aqueous NaCl and NaHCO3 solutions as well as in biologically treated greywater and in secondary municipal effluent. …”
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Heart rate reserve effects on brain activation and cognitive-motor performance while doing an instrumented trail walking task in middle-aged to older adults by Alka Bishnoi, Manuel E. Hernandez

“…We hypothesized that there will be an increase in PFC activation and better cognitive-motor performance with increase in HRR during TWT. …”
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The Anti-Inflammatory Effects of Formononetin, an Active Constituent of <i>Pueraria montana</i> Var.... by Linyi Xu, Shuo Zhou, Jing Li, Wenbo Yu, Wenyi Gao, Haoming Luo, Xiaoxue Fang

“…The results of an in vitro anti-inflammatory activity screening assay showed that compounds <b>1</b>, <b>4</b>, <b>6</b>, <b>8</b>, and <b>15</b> were able to significantly reduce the levels of pro-inflammatory cytokines IL-6 and IL-1β in LPS-induced RAW264.7 macrophages, with the most obvious effect produced by compound <b>6</b> (formononetin), while formononetin was able to significantly reduce the number of macrophages at the site of inflammation in transgenic zebrafish. …”
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A novel conditional active biologic anti-EpCAM x anti-CD3 bispecific antibody with synergistic tumor selectivity for cancer immunotherapy by Gerhard Frey, Ana Paula G. Cugnetti, Haizhen Liu, Charles Xing, Christina Wheeler, Hwai Wen Chang, William J. Boyle, Jay M. Short

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“In the days of my life.” Elite activity and interactions in the Maya lowlands from Classic to Early Postclassic times (the long ninth century, AD 760-920) by Marie Charlotte Arnauld, Chloé Andrieu, Mélanie Forné

“…We aim to identify actions and strategies developed in those cities using well–dated archaeological sequences, and possibly envision how the calendric games stimulated an anticipation of political change.…”
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Anti-Inflammatory Activity of Ferula assafoetida Oleo-Gum-Resin (Asafoetida) against TNF-α-Stimulated Human Umbilical Vein Endothelial Cells (HUVECs) by Leila Mobasheri, Mohsen Khorashadizadeh, Hossein Safarpour, Maryam Mohammadi, Gholamreza Anani Sarab, Vahid Reza Askari

“…In addition, the LC-MS analysis was performed to determine the active substances. HUVECs were pretreated with EEA and then induced by TNF-α. …”
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RNA‐Binding Protein Hnrnpa1 Triggers Daughter Cardiomyocyte Formation by Promoting Cardiomyocyte Dedifferentiation and Cell Cycle Activity in a Post‐Transcriptional Manner by Chuling Li, Yijin Chen, Qiqi Chen, Haoxiang Huang, Michael Hesse, Yilin Zhou, Ming Jin, Yu Liu, Yifei Ruan, Xiang He, Guoquan Wei, Hao Zheng, Senlin Huang, Guojun Chen, Wangjun Liao, Yulin Liao, Yanmei Chen, Jianping Bin

Subjects: “…dedifferentiation and cell cycle activity…”
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Deficiency of ATF3 facilitates both angiotensin II‐induced and spontaneously formed aortic aneurysm and dissection development by activating cGAS–STING pathway by Yifan Du, Poyi Hu, Xiangchao Ding, Dashuai Wang, Jingjing Luo, Sheng Le, Lingyun Ren, Manhua Chen, Ping Ye, Jiahong Xia

“…Cytoplasmic micronuclei facilitating the activation of cGAS–STING pathway, thus inducing the phenotypic switch and apoptosis of VSMCs…”
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Methodical support of process of formation of professional communicative competence of cadets of universities of the federal penal service in the study course "communication in professional activity of the penal officers" by Tatyana V. Nikitina

“…On the basis of Perm Institute of the Federal Penal Service of Russia the author offers the program of the course «Communication in professional activity of the penal officers». The course content is considered in three aspects: the invariant, variable and specific. …”
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Understanding the potential impact of trimester-specific maternal immune activation due to SARS-CoV-2 on early human neurodevelopment and the role of cytokine balance by Alexandre Díaz-Pons, Sergio Castaño-Castaño, Víctor Ortiz-García de la Foz, Ángel Yorca-Ruiz, Carlos Martínez-Asensi, Eva Munarriz-Cuezva, Rosa Ayesa-Arriola

Subjects: “…Maternal immune activation (MIA)…”
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