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Studying the Oncolytic Activity of <i>Streptococcus pyogenes</i> Strains Against Hepatoma, Glioma, and Pancreatic Cancer <i>In Vitro</i> and <i>In Vivo</i>
Published 2025-01-01“…This strain exhibited moderate (38.0 ± 1.8%) and weak (16.3 ± 5.4%) oncolytic activities against glioma and hepatoma cells, respectively. …”
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11524
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Phytochemical Screening and In Vivo Antimalarial Activity of Two Traditionally Used Medicinal Plants of Afar Region, Ethiopia, against Plasmodium berghei in Swiss Albino Mice
Published 2019-01-01“…The results of this study provide support for the traditional therapeutic value and the reported antimalarial activity.…”
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11526
To be or not to be phosphorylated: understanding the role of Ebola virus nucleoprotein in the dynamic interplay with the transcriptional activator VP30 and the host phosphatase PP2A-B56
Published 2025-12-01“…Ebola virus (EBOV) transcription is essentially regulated via dynamic dephosphorylation of its viral transcription activator VP30 by the host phosphatase PP2A. …”
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11527
4,6-Disubstituted pyrimidine-based microtubule affinity-regulating kinase 4 (MARK4) inhibitors: synthesis, characterization, in-vitro activity and in-silico studies
Published 2025-01-01“…Despite the significant research efforts, the ability to completely prevent or effectively treat AD and its related dementias remains limited. Protein kinases are integral to AD pathology and represent promising targets for therapeutic intervention.MethodsA series of pyrimidine-based compounds 4-(4-(arylsulfonyl)piperazin-1-yl)-6-(thiophen-3-yl)pyrimidine derivatives (8-14) were synthesized and characterised. …”
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11528
Active Retrograde Extra Backup with a Mother-and-Child Catheter to Facilitate Retrograde Microcatheter Collateral Channel Tracking in Recanalization of Coronary Chronic Total Occlusion
Published 2020-01-01“…To explore the feasibility and safety of the active retrograde backup (ARB) for treatment of chronic total occlusion (CTO) during retrograde percutaneous coronary intervention (PCI). …”
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11529
FoxA1 knockdown promotes BMSC osteogenesis in part by activating the ERK1/2 signaling pathway and preventing ovariectomy-induced bone loss
Published 2025-02-01“…Downregulation of FOXA1 markedly augmented the expression of osteoblast-specific genes and proteins, activated the ERK1/2 signaling pathway, intensified ALP activity, and promoted mineral deposition. …”
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A Effect of Maltodextrin Concentration on Antioxidants Activity and Stability of Natural Coloring Powder of Secang Wood (Caesalpinia Sappan L) in Various Conditions of Ph and Temperature
Published 2023-09-01Subjects: “…sappan wood, maltodextrin, antioxidant activity, color stability…”
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11532
Elucidating the Prognostic Role of BRAFV600E and the Activation Status of the Downstream MAPK Pathway in PTC: A Study from a Tertiary Centre in India
Published 2024-12-01“…Although BRAFV600E mutation did not correlate with the MAPK activation status, it had an adverse impact on tumour sensitivity to radioiodine (P < 0.05). …”
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11533
Identifying Community-Built Environment’s Effect on Physical Activity and Depressive Symptoms Trajectories Among Middle-aged and Older Adults: Chinese National Longitudinal Study
Published 2025-01-01“… BackgroundThe effects of physical activity (PA) across different domains and intensities on depressive symptoms remain inconclusive. …”
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Screening of the Dichloromethane: Methanolic Extract of Centella asiatica for Antibacterial Activities against Salmonella typhi, Escherichia coli, Shigella sonnei, Bacillus subtilis, and Staphylococcus aureus
Published 2020-01-01“…The present study indicates that the tested plant can be an important source of antibacterial agents and recommends that the active phytoconstituents be isolated, identified, and screened individually for activities and also subjected further for in vivo and toxicological studies.…”
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The Effects of Artificial vs. Natural Rearing on Growth Performance, Thyroid Hormone Levels, Locomotor Activity, Carcass Traits and Meat Quality Characteristics in Chios Lambs
Published 2024-12-01“…The lambs’ behavior was continuously videotaped until weaning, and their standing percentage was recorded as an activity index. Blood samples were collected from the jugular vein of lambs on days 3, 10, 17 and 40 after birth to assess thyroid hormone levels. …”
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IL-13 Augments Histone Demethylase JMJD2B/KDM4B Expression Levels, Activity, and Nuclear Translocation in Airway Fibroblasts in Asthma
Published 2021-01-01“…There was also an increase in JMJD2B activity as evidenced by the demethylation of its downstream target, H3K36me3. …”
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Relationship Between Sedentary Lifestyle, Physical Activity and Stress in University Students and Their Life Habits: A Scoping Review with PRISMA Checklist (PRISMA-ScR)
Published 2025-01-01Subjects: “…physical activity…”
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A high-speed MPPT based horse herd optimization algorithm with dynamic linear active disturbance rejection control for PV battery charging system
Published 2025-01-01“…The HHOA is a bio-inspired technique that mimics the motion cycles of an entire herd of horses. Next, the linear active disturbance rejection control (LADRC) was applied to monitor the HHOA’s reference voltage output. …”
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