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Inhibition of TFF3 synergizes with c-MET inhibitors to decrease the CSC-like phenotype and metastatic burden in ER+HER2+ mammary carcinoma
Published 2025-02-01“…Mechanistically, TFF3 was observed to activate c-MET signaling through a positive-feedback loop to enhance the CSC-like phenotype of ER+HER2+ MC. …”
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10063
Goats who stare at video screens – assessing behavioural responses of goats towards images of familiar and unfamiliar con- and heterospecifics
Published 2024-09-01“…Many cognitive paradigms rely on active decision-making, creating participation biases (e.g. subjects may lack motivation to participate in the training) and once-learned contingencies may bias the outcomes of subsequent similar tests. …”
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10064
Genome-wide identification, characterization, and expression analysis of BZR transcription factor family in Gerbera hybrida
Published 2025-02-01“…Phylogenetic analysis clustered these genes into two distinct subgroups. Analysis of cis-acting elements revealed their involvement in hormone response, stress response, and growth regulation. …”
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10065
Redesain Aplikasi Mobile Supervisi Observasi Kelas untuk Meningkatkan Tingkat Usability
Published 2024-10-01“…Abstract The LESON application, now renamed EDVISOR, is a mobile-based application devoted to recording the learning atmosphere and supporting classroom observation supervision activities. Although it has undergone updates, previous research revealed that there are still 24 problems in the application that need further improvement and development. …”
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10066
Integrative analysis of 5-methylcytosine associated signature in papillary thyroid cancer
Published 2025-02-01“…Additionally, we validate the downregulation of PPP1R12A-AS1 promotes proliferation and metastasis by activating the MAPK signaling pathway. Our research confirms that m5C-lncRNAs not only contribute to evaluating the prognosis of patients with PTC but also help predict immune cell infiltration and immunotherapy response.…”
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10067
Про методологію просторової фіксації в дослідженнях книгописання в Україні XI–XVIII ст.
Published 2024-12-01“…This makes it possible to reliably record the most active centers of the books copying on our territory. …”
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10068
The impact of anticoagulant-related bleeding on quality of life: Development of a novel measure based on perspectives from older adults.
Published 2025-01-01“…<h4>Conclusion</h4>Employing evidence-based methods for PROM development, we found that bleeding can have a marked impact on everyday activities, emotional wellbeing and interpersonal relations for older adults. …”
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10069
Protocol paper: randomized controlled trial of the smart online-to-offline model development for chronic diseases management through digital health in real world setting
Published 2025-02-01“…Innovative digital health services have the potential to revolutionize chronic disease management by providing patients with real-time, personalized care and empowering them to take an active role in their health. There is a critical need to evaluate the effectiveness of such services. …”
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10070
The Effects of Soft Tissue Flossing on Hamstring Range of Motion and Lower Extremity Power
Published 2021-06-01“… # Participants Twenty-one recreationally active individuals (8 male, 13 female; age = 22.62±2.99 years; height = 171.52±9.08 cm; mass = 73.57±11.37 kg)…”
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10071
Midwives’ knowledge and perspectives on neonatal resuscitation and survival before and after Helping Babies Breathe training: a qualitative study in Uganda
Published 2025-02-01“…A data-driven inductive content analysis approach was used for the analysis.Setting The high-risk labour ward and theatre at a National Referral Hospital, Uganda.Participants 45 clinically active midwives were enrolled; all had recently completed the HBB training programme.Intervention Semistructured individual interviews (n=2) and focus group discussions (n=43, distributed across seven groups) were held from 26 April to 4 May 2018. …”
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10072
Economic and Humanistic Burden of Moderate and Severe Hemophilia A and B in Spain: Real-World Evidence Insights from the CHESS II Study
Published 2024-05-01“…Severity is classified by the patient's baseline level of clotting factor activity as mild (>5%-40%), moderate (1%-5%), or severe (<1%). …”
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Enhancing Older Adults’ Lives Through Positive Aging Perception, Quality-of-Life Enhancement, and Social Support to Drive Acceptance and Readiness Toward Indoor Assistive Technolog...
Published 2025-02-01“…Indoor mobility is essential for daily activities and significantly impacts their lives. Limited indoor mobility can reduce quality of life and heighten the risk of falls. …”
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10074
Psilocybin-assisted therapy for reducing alcohol intake in patients with alcohol use disorder: protocol for a randomised, double-blinded, placebo-controlled 12-week clinical trial...
Published 2022-10-01“…The study results will be disseminated by peer-review publications and conference presentations.Trial registration number EudraCT 2020-000829-55 and NCT05416229.…”
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10075
Assessing molecular changes underlying isopropylated phenyl phosphate (IPP)-induced larval sensorimotor response deficits in zebrafish
Published 2025-01-01“…Isopropylated phenyl phosphates (IPP) are an additive organophosphate flame retardant (OPFR) that has been extensively used in furniture, electronics, automobiles, plastics, and children’s products to slow down the spread of fire but its continued leaching leads to toxicity concerns. …”
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10076
Non-inferiority study to compare the efficacy of relugolix with dienogest for endometriosis-associated pain and usefulness of administering relugolix prior to dienogest (READY stud...
Published 2025-02-01“…Methods A multicenter, open-label, active-controlled, non-inferiority randomized study will be conducted at 11 sites in Japan. …”
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10077
Effects of coal mine dust on lung function in rats
Published 2025-01-01“…Lung tissues were collected to measure reactive oxygen species (ROS) and adenosine triphosphate (ATP) levels using corresponding ELISA kits and ATP assay kits, respectively. The relative mRNA expressions of peroxisome proliferators-activated receptor gamma coactivator 1-alpha (PGC-1α) and mitochondrial transcription factor A (TFAM) were detected using real-time fluorescent quantitative polymerase chain reaction assay. …”
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“A one-stop shop”: Real-world use and app-users' experiences of a psychoeducational smartphone app for adults with ADHD
Published 2025-03-01“…Conclusion: The Adult ADHD App appears to meet its aims of providing psychoeducation on adult ADHD. …”
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10079
A comparison of the acute effects of high intensity interval training and moderate intensity continuous training on working memory and emotional state in adolescent women with subt...
Published 2025-02-01“…ObjectiveVarious guidelines emphasize the cognitive and emotional benefits of physical activity. However, it is not yet clear what kind of exercise intensity is suitable for individuals with subthreshold depression. …”
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10080
Laguna de fracasos
Published 2024-12-01“…What/where is its archive? How is collective knowledge built? …”
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