Amebicidal and Antiadhesion Activities of Knema retusa Extract Against Acanthamoeba triangularis T4 Genotype on Contact Lenses and Modeling Simulation of Its Main Compound, E2N, Against Acanthamoeba Beta-Tubulin by Watcharapong Mitsuwan, Imran Sama-ae, Suthinee Sangkanu, Dhrubo Ahmed Khan, Partha Biswas, Md. Nazmul Hasan, Julalak Chuprom, Tajudeen O. Jimoh, Christophe Wiart, Masyitah Binti Zulkipli, Nor Hayati Abdullah, Maria de Lourdes Pereira, Sonia M. Rodrigues Oliveira, Shanmuga Sundar Saravanabhavan, Polrat Wilairatana, Tooba Mahboob, Veeranoot Nissapatorn

“…Then, amebicidal and antiadhesion activities of Kre against A. triangularis were investigated. …”
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Phase Ib open-label, multicenter study of pixatimod, an activator of TLR9, in combination with nivolumab in subjects with microsatellite-stable metastatic colorectal cancer, metastatic pancreatic ductal adenocarcinoma and other solid tumors by Matthew Burge, David Goldstein, Andrew Haydon, Nick Pavlakis, Charlotte Lemech, Edward Hammond, Darryn Bampton, Keith Dredge, Michael P Brown, Andrew Clouston, Nigel J Waterhouse, Amanda C Stanley, Lucie Leveque-El Mouttie, Grace M Chojnowski

“…Objectives included assessment of safety, antitumor activity, pharmacodynamics, and pharmacokinetic profile.Results Fifty-eight participants started treatment. …”
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Effects of Glycyrrhizin (GL) Supplementation on Survival, Growth Performance, Expression of Feeding-Related Genes, Activities of Digestive Enzymes, Antioxidant Capacity, and Expression of Inflammatory Factors in Large Yellow Croaker (Larimichthys crocea) Larvae by Yuntao Wang, Wenxuan Xu, Jianmin Zhang, Jiahui Liu, Zhen Wang, Yongtao Liu, Kangsen Mai, Qinghui Ai

“…The alkaline phosphatase (AKP) activity in larvae fed the diet with 0.01% GL was significantly higher than the control (P<0.05). …”
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Immunogenicity and safety of a live attenuated varicella vaccine in healthy subjects aged between 13 to 55 years: a double-blind, randomized, active-controlled phase iii clinical trial in China by Yang Zhang, Shiyuan Wang, Guifan Li, Jinhui Shi, Xianyun Chang, Hao Zhang, Fengcai Zhu, Jingxin Li, Hongxing Pan, Jinfang Sun

“…Vaccination with the varicella vaccine (VarV) effectively prevents chickenpox.Research design and methods In this phase III, single-center, randomized, double-blind, active-controlled trial, 1,200 healthy participants randomly assigned in a 1:1 ratio to receive two doses of either the test vaccine or the active control vaccine. …”
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Synthesis and Biological Activity of Some 3,4-Dihydro-4-(4-substituted aryl)-6-(naptho[2,1-b]furan-2-yl pyrimidine-2(1H)-one Derivatives by Sanjeevan S. Gaikwad, Venkat S. Suryawanshi, Kishan S. Lohar, Dhanaji V. Jadhav, Narayan D. Shinde

“…The synthesized oxopyrimidines derivatives were evaluated for antibacterial and antifungal activities, some of them were found to possess significant activity.…”
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KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition by Deniz Gökbuget, Liana Goehring, Ryan M. Boileau, Kayla Lenshoek, Tony T. Huang, Robert Blelloch

“…Summary: Mammalian genomes replicate in a cell-type-specific order during the S phase, correlated to transcriptional activity, histone modifications, and chromatin structure. …”
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Comparative analysis of Proximate and Anti-fungal Activities on Palm Oil Treated Ash Extracts of Musa sapientum and Musa paradisiaca Peels collected from Local Market in Akwa Ibom State, Southern Nigeria by I. D. Uffia, O. E. Udofia, M. E. Bassey, R. O. Esen, E. J. Egong, O. D. Akan

Subjects: “…Musa paradisiaca; Musa sapientum; anti-fungal activities; food adjuncts; fruit peels…”
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Resveratrol contributes to NK cell-mediated breast cancer cytotoxicity by upregulating ULBP2 through miR-17-5p downmodulation and activation of MINK1/JNK/c-Jun signaling by Bisha Ding, Jie Li, Jia-Lin Yan, Chun-Yan Jiang, Ling-Bo Qian, Jie Pan

“…Specifically, miR-17-5p directly targeted MINK1, leading to its suppression. MINK1 played a role in facilitating the activation of JNK and its downstream effector, c-Jun. …”
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Inhibiting ATP6V0D2 Aggravates Liver Ischemia-Reperfusion Injury by Promoting NLRP3 Activation via Impairing Autophagic Flux Independent of Notch1/Hes1 by Ziyi Wang, Hao Wang, Xuejiao Chen, Sheng Han, Yulin Zhu, Hanhua Wang, Feng Cheng, Liyong Pu

“…Further studies found that the exacerbated activation of NLRP3 was related to the autophagic flux regulated by ATP6V0D2. …”
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ÖĞRETMEN ADAYLARININ MÜZE EĞİTİMİ VE UYGULAMALARI DERSİ KAPSAMINDA YARATICI YAZMA ETKİNLİĞİNE YÖNELİK GÖRÜŞLERİ - TEACHER CANDIDATES OPINIONS ON CREATIVE WRITING ACTIVITY WITHIN THE SCOPE OF MUSEUM EDUCATION AND PRACTICE COURSE by Serdar Tuna

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Palm Tocotrienol Activates the Wnt3a/β-Catenin Signaling Pathway, Protecting MC3T3-E1 Osteoblasts from Cellular Damage Caused by Dexamethasone and Promoting Bone Formation by Norfarahin Abdullah Sani, Nur Aqilah Kamaruddin, Ima Nirwana Soelaiman, Kok-Lun Pang, Kok-Yong Chin, Elvy Suhana Mohd Ramli

“…Cellular alkaline phosphatase activity was measured to evaluate osteogenic activity. …”
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SCIENCE AS A COMPONENT OF THE HIGHER EDUCATION SYSTEM by Elena V. Sen’Ko

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EVOLUTION OF THE VALUES AND ECONOMIC STIMULUS IN RUSSIA (XIX-XXI cc.): TABLE OF CONTENTS, KEY STAGES. FACTORS OF DYNAMICS OF ENTREPRENEURSHIP AND BUSINESS IN RUSSIAN FEDERATION by S. Sazanova

Subjects: “…institutional incentives for entrepreneurial activity…”
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Searching for new genes associated with the familial hypercholesterolemia phenotype using whole-genome sequencing and machine learning by D. E. Ivanoshchuk, A. B. Kolker, O. V. Timoshchenko, S. E. Semaev, E. V. Shakhtshneider

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Lifestyle risk behaviours among adolescents: a two-year longitudinal study of the impact of the COVID-19 pandemic by Nicola Clare Newton, Maree Teesson, Jennifer Debenham, Cath Chapman, Bridie Osman, Lauren Anne Gardner, Fiona Elizabeth Wylie, Katrina Elizabeth Champion

“…Objective To examine changes in the prevalence of six key chronic disease risk factors (the “Big 6”), from before (2019) to during (2021) the COVID-19 pandemic, among a large and geographically diverse sample of adolescents, and whether differences over time are associated with lockdown status and gender.Design Prospective cohort study.Setting Three Australian states (New South Wales, Queensland and Western Australia) spanning over 3000 km.Participants 983 adolescents (baseline Mage=12.6, SD=0.5, 54.8% girl) drawn from the control group of the Health4Life Study.Primary outcomes The prevalence of physical inactivity, poor diet (insufficient fruit and vegetable intake, high sugar-sweetened beverage intake, high discretionary food intake), poor sleep, excessive recreational screen time, alcohol use and tobacco use.Results The prevalence of excessive recreational screen time (prevalence ratios (PR)=1.06, 95% CI=1.03 to 1.11), insufficient fruit intake (PR=1.50, 95% CI=1.26 to 1.79), and alcohol (PR=4.34, 95% CI=2.82 to 6.67) and tobacco use (PR=4.05 95% CI=1.86 to 8.84) increased over the 2-year period, with alcohol use increasing more among girls (PR=2.34, 95% CI=1.19 to 4.62). …”
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SOME “EXOTIC” INFORMATION SOURCES THAT HAVE BEEN DISCOVERED DURING THE SELECTION OF SERIAL PUBLICATIONS TO SUPPORT RESEARCH IN ENERGY SECURITY, ENERGY CONSERVATION AND ENERGY EFFIC... by V. S. Lazarev, I. V. Yurik

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Recrudescence de la pauvreté urbaine en Suisse : l’animation en tant qu’action communautaire auprès des familles sans-abri by Sylvia Garcia Delahaye, Caroline Dubath

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