Phenolic acids from Anisopus mannii modulates phosphofructokinase 1 to improve glycemic control in patients with type 2 diabetes: A double-blind, randomized, clinical trial by Peter U. Amadi, Justice O. Osuoha, Chidi N. Ekweogu, Suha J. Jarad, Esienanwan E. Efiong, Prince C. Odika, Chioma Ejiofor, Oluchi Aloy-Amadi, Govind S. Gill, Chiamaka W. Adumekwe, Ailun Gaowa, Dawei Zhang, Barbora de Courten, Emmanuel N. Agomuo

“…Among other glycolytic enzymes, in vitro, PhAM counteracted the binding of sodium orthovanadate to phosphofructokinase 1 (PFK-1), improving its activities. In a rat model of diet-induced diabetes, PhAM monotherapy reduced HbA1c by an average of 0.63 % and fasting plasma glucose by 25 mg/dl. …”
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Ichthyoarchaeological perspectives on roles of fish and red meat during Indus Civilization in Gujarat, India by G. S. Abhayan, Pramod P. Joglekar, Pramod P. Joglekar, P. Ajithprasad, S. V. Rajesh, Pankaj Goyal, Brad Chase, Jeevan Kharakwal, Prabodh Shirvalkar

“…Evidence of anthropogenic activities such as cut marks, charring, and chewing on the bones suggests various aspects of fish consumption. …”
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Incidence and pathological features of IgA nephropathy before and during the COVID-19 pandemic by Wen Liu, Ricong Xu, Di Wu, Zhihang Su, Yuan Cheng, Haofei Hu, Xinzhou Zhang, Qijun Wan

“…Specifically, the proportions of M1 and E1 lesions according to the Oxford classification significantly increased during the pandemic, with odds ratios of 11.764 (95% CI 5.583–24.789, P < 0.001) and 1.718 (95% CI 1.114–2.649, P = 0.014), respectively. …”
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Adjuvanted subunit intranasal vaccine reduces SARS-CoV-2 onward transmission in hamsters by Yongjun Sui, Swagata Kar, Bhavna Chawla, Tanya Hoang, YuanKai Yu, Shannon M. Wallace, Hanne Andersen, Jay A. Berzofsky

Subjects: “…SARS-CoV-2 vaccine…”
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Impact of resin tapping on the radial growth and climate sensitivity of naturally- regenerated Pinus roxburghii (Chir pine) in Western Nepal by Bipin Bhattarai, Narayan Prasad Gaire, Tek Maraseni, Bishnu Prasad Devkota, Badri Bhattarai, Shankar Tripathi, Kamal Raj Aryal, Hari Adhikari

“…It also emphasizes the importance of considering rainfall and temperature patterns when planning tapping activities to ensure sustained resin production and promote tree health.…”
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Development of real-time RT-PCR for N2 subtype avian influenza RNA-virus detection by P. B. Akshalova, A. V. Andriyasov, L. O. Scherbakova, S. N. Kolosov, N. G. Zinyakov, I. A. Chvala, D. B. Andreychuk

“…Currently, N2 subtype avian influenza (AI) virus actively circulates in domestic and wild bird populations and is regularly detected in China, other Asian countries and Russia, particularly in combination with H9 hemagglutinin. …”
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Grade IV oral mucositis treatment with Brazilian green propolis mucoadherent gel by Diogo Alvarenga Silva, Patrícia Carlos Caldeira, Silvia Ferreira de Sousa, Vagner Rodrigues Santos

“…It has several chemical compounds that confer anti-inflammatory, antimicrobial, healing, and antioxidant biological activities. To report a series of clinical cases in the treatment of oral mucositis (OM) in patients with cancer undergoing radiotherapy in the head and neck region. …”
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Knowledge, attitude, and practice toward vitiligo among vitiligo patients: a mediation analysis by Hua Feng, Xiulian Xu, Shuzhen Qi, Kun Chen, Mei Ju, Xiaofang Li, Shuxian Shang

“…Vitiligo patients exhibited significant gaps in knowledge and attitudes toward their condition despite active management practices. Given the chronic nature of vitiligo and its slow treatment response, tailored health education strategies focusing on improving knowledge and attitudes are essential for standardizing treatment and enhancing patient adherence.…”
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How mechanochemistry affects the composition and properties of disordered fluorite BaSnF4? by Mercadier, Briséïs, Legein, Christophe, Duttine, Mathieu, Body, Monique, Gutierrez, Ana Gabriela Porras, Leclerc, Sandrine, Lebedev, Oleg,  Masquelier, Christian, Dambournet, Damien

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Clinical characteristics and risk factors of Clostridioides difficile infection in children with diarrhoea by Ning Wang, Kun Jiang, Jinyue Huang, Mengzhu Hou, Lu Wang, Wei Wang, Yulian Fang

“…Multi-factor logistic regression analysis was used to show that a history of hospitalisation within the last three months, a history of antibiotic treatment for ≥7 days, non-breastfeeding, and a history of antibiotic combined with probiotic treatment were risk factors for CDI in children with diarrhoea (P &lt; 0.05).ConclusionsA history of hospitalisation within the last three months, previous antibiotic treatment for ≥7 days or combined with probiotic treatment, and non-breastfeeding are risk factors for CDI in children with diarrhoea, so children with diarrhoea who present as described above need to be alerted to CDI and are advised to have active investigations to facilitate rapid and effective control of the disease and improve prognosis.…”
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The guanine nucleotide exchange factor DOCK5 negatively regulates osteoblast differentiation and BMP2-induced bone regeneration via the MKK3/6 and p38 signaling pathways by Ju Ang Kim, Soomin Im, Jiwon Lim, Jung Min Hong, Hye Jung Ihn, Jong-Sup Bae, Jung-Eun Kim, Yong Chul Bae, Eui Kyun Park

“…Abstract DOCK5 (dedicator of cytokinesis 5), a guanine nucleotide exchange factor for Rac1, has been implicated in BMP2-mediated osteoblast differentiation, but its specific role in osteogenesis and bone regeneration remained unclear. …”
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Anti-VEGF therapy improves EGFR-vIII-CAR-T cell delivery and efficacy in syngeneic glioblastoma models in mice by Dai Fukumura, Rakesh K Jain, Jun Ren, Xinyue Dong, Zohreh Amoozgar, Somin Lee, Meenal Datta, Sylvie Roberge, Mark Duquette

“…We engineered two syngeneic mouse GBM cell lines (CT2A and GSC005) to express EGFRvIII—one of the most common neoantigens in human GBM—and CAR T cells to recognize EGFRvIII. …”
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Membrane-bound model of the ternary complex between factor VIIa/tissue factor and factor X by Melanie P. Muller, Alex Mortenson, Josepha C. Sedzro, Po-Chao Wen, James H. Morrissey, Emad Tajkhorshid

“…Strikingly, in our model, FX makes contact with TF:FVIIa chiefly via its γ-carboxyglutamate–rich (GLA) domain and protease domain, with the majority of the FX light chain (ie, its 2 epidermal growth factor–like domains) out in the solvent, making no direct contact with TF:FVIIa. …”
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Synthesis and characterization of S-Scheme NiMn2O4/g-C3N4 nanocomposites heterojunction photocatalyst for effective degradation of organic pollutants under visible light by Masoumeh Yaqoubi, Mojgan Ghanbari, Rana Warid Maya, Hassan Abdulhadi Jasim, Masoud Salavati-Niasari

“…Many methods, including XRD, FTIR, EDS, SEM, TEM, BET, VSM, and DRS, were used to characterize NiMn2O4 and its nanocomposites. The photocatalytic activity of NiMn2O4, g-C3N4, and various NiMn2O4/g-C3N4 nanocomposites was studied for the degradation of eriochrome black T (EB). …”
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USING E-LEARNING TO PREVENT INFORMATIONAL STRESS OF EMPLOYEES WORKING REMOTELY by Oleksandra Pinchuk, Nataliia I. Pinchuk, Olena I. Bondarchuk, Valentyna V. Balakhtar, Kateryna S. Pavlenok

“…The following specific features of informational stress, by their information impact, are highlighted: 1) features associated with information overload, 2) features associated with human interaction with information technology, and 3) features associated with professional activities. The article presents the results of a comparative analysis of the psychological characteristics of employees with a conventional mode of remote work and the employees with a forced remote work mode due to crisis conditions (Covid-19, war, etc.). …”
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High and low dose radiotherapy combined with ICIs for MSS colorectal cancer patients with liver metastases: a phase I study (HaRyPOT) by Yuxuan Ding, Yong Feng, Yangfan Ye, Jiayi Shen, Chang Guo, Xia He, Liangjun Zhu, Lijun Wang

“…Plasma cytokines IL-10, IL-17, and INF-α increased after treatment with both drugs.DiscussionIn summary, this is the first clinical trial demonstrating the safety and immunogenic activity of combined high and low dose radiotherapy with ICIs in MSS colorectal cancer liver metastases (CRLMs). …”
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Effects of aminooxyacetic acid on learning and memory function and neurochemical changes in chronic alcoholism by Hongbo Jiang, Xunling Wang, Yingwei Liang, Yinghan Hou, Xinping Yue, Zhiyi Zhang, Dan Chen, Xinyi Fan, Ailin Du

“…Cognitive function was assessed using the Morris water maze, mitochondrial function was evaluated through ATPase activity, and H₂S levels were measured. CBS and 5-HT levels in the prefrontal cortex were analyzed by immunohistochemistry. …”
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Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models by Ling Xiong, Dustin Beyer, Na Liu, Tina Lehmann, Sophie Neugebauer, Sascha Schaeuble, Oliver Sommerfeld, Philipp Ernst, Carl-Magnus Svensson, Sandor Nietzsche, Sebastian Scholl, Tony Bruns, Nikolaus Gaßler, Markus H. Gräler, Marc Thilo Figge, Gianni Panagiotou, Michael Bauer, Adrian T. Press

“…Midostaurin is the clinically approved active pharmaceutical ingredient in Rydapt, approved for the adjuvant treatment of FTL3-mutated AML. …”
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Performance and gut microbiota of catfish (Clarias gariepinus) fed powdered Moringa oleifera leave as additive (Probiotics) by Jerimoth Kesena Ekelemu, Arnold Ebuka Irabor, Ruth Elohor Anderson

“…The antimicrobial activity of powdered Moringa oleifera leaves on the performance of Clarias gariepinus juveniles was investigated. …”
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Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis by Shumin Zhao, Shumin Zhao, Ranran Chen, Ranran Chen, Yi An, Yali Zhang, Yali Zhang, Cheng Ma, Ying Gao, Ying Gao, Yanchao Lu, Yanchao Lu, Fei Yang, Fei Yang, Xue Bai, Xue Bai, Jingjing Zhang, Jingjing Zhang, Jingjing Zhang

“…The phenotype onset date, life span, locomotor activity, and pathological changes in the spinal cord were determined and recorded subsequently. …”
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