Editorial by Ann-Kristin Kölln, Antony Mason, Jörg Tremmel, Markus Rutsche, Maria Lenk

“…Daniel Stockemer and Aksel Sundström’s article titled “Youth’s underrepresentation in the European Parliament: Insights from interviews with young Members of the European Parliament (MEPs)” reports results from qualitative interviews with 23 MEPs on the factors contributing to the success and failure of young people to enter the European Parliament. …”
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Engineered CAF-cancer cell hybrid membrane biomimetic dual-targeted integrated platform for multi-dimensional treatment of ovarian cancer by Yuwei Yao, Jiarui Zhang, Kexin Huang, Yingying Peng, Shuangshuang Cheng, Shuangge Liu, Ting Zhou, Jinhua Chen, Haojia Li, Yingchao Zhao, Hongbo Wang

“…After CAF internalization, they inhibited pro-tumor factor release and activated immune effects, promoting immune system infiltration. …”
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Digestion, faeces microbiome, and selected blood parameters in dogs fed extruded food containing Black soldier fly (Hermetia illucens) meal by Kanber Kara, Oğuzhan Kahraman, Fatma İnal, Zekeriya Safa İnanç, Sena Yilmaz Öztaş, M. Selçuk Alataş, Ibrar Ahmed

“…As a result, HI larva meal can be used up to 100% instead of chicken meal in extruded dog food without any negative effects on body weight, digestibility, faecal score, consumption preference, kidney-liver enzyme activities and immunological parameters. Besides, HI larva meal at 7.5% and 15% in extruded dog food had different effects on the faecal microbiome.…”
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Comparative analysis of metabolic, reproductive, and sub-clinical mastitis in pure Holstein-Friesian and Sahiwal-crossbred cows by S. M. Khan, R. U. Khan, S. Naz, I. A. Alhidary, N. K. Momand, R. Tiwari

“…Progesterone levels were higher in F1 cows, supporting better luteal activity and ovarian resumption. The study concludes that crossbreeding HF with Sahiwal improves milk production and reproductive health while reducing the risk of mastitis, with F1 and F2 cows showing the most favorable outcomes.…”
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The negative aspects of injury on motivation of sports and physical exercise practitioners by Hugo Enrico Souza Machado, Hugo Enrico Souza Machado, Andreza do Socorro Dantas Oliveira, Andreza do Socorro Dantas Oliveira, Eldimberg Souza da Cunha Júnior, Adriano Lopes Lemos, Eduardo Macedo Penna, Eduardo Macedo Penna, Daniel Alvarez Pires, Daniel Alvarez Pires

“…Thus, it indicates the need for a rehabilitation approach also focused on motivational issues, to improve overall heath and prevent physical activity drop out.…”
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Levying evidence of the impact of Triphala in the mildly constipated human colon microbiota by Elizabeth Goya-Jorge, Pauline Bondue, Irma Gonza, Samiha Boutaleb, Caroline Douny, Marie-Louise Scippo, Joël Pincemail, Patrice Chiap, Jeoffrey Christyn de Ribaucourt, Fabienne Crahay, Véronique Delcenserie

“…Triphala is a wildly used nutritional and phytotherapeutic formulation combining three dry fruits (Terminalia bellirica, Terminalia chebula and Emblica officinalis). Despite its long-standing use to treat gastrointestinal discomfort, there is limited understanding of Triphala's effects on gut microbiota, especially among individuals with mild constipation. …”
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Filters Effect on Image Quality of 177Lu-DOTATATE SPECT Images for Neuro-Endocrine Tumors Scanning by Hussein Dakhil, Mohammad Reza Deevband, Mahasti Amoui, Ahmad Mostaar, Mahdi Ghorbani, Mohsen Khosroabadi, Mohammad Ali Ghodsirad

“…Seven parameters were considered, including the contrast/noise ratio, injection activity, uptake duration, acquisition time per injection, frame time, measuring time, and type of filters. …”
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Integrating MAPK pathway inhibition into standard-of-care therapy for pediatric low-grade glioma by Erin E. Crotty, Aimee A. Sato, Aimee A. Sato, Mohamed S. Abdelbaki

“…Pediatric low-grade gliomas (pLGG) are a group of tumors largely driven by alterations in a single genetic pathway, known as the RAS-RAF-mitogen-activated protein kinase (MAPK) pathway. Recent biologic insights and therapeutic targeting of MAPK-alterations have dramatically shifted the treatment approach in pLGG. …”
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The effects of tungsten content on the mechanical behavior, ignition and energy-release characteristics of short-tungsten-fibers/Zr-BMGCs under dynamic loading by Xin Yu, Jianbin Li, Xiqiang Gai, Chong Chen, Zhenxiong Wang, Xin Zhao, Hongwei Zhao, Kaichuang Zhang

“…This work could improve the understanding of energy-release behavior of ex-situ second-phase reinforced Zr-BMGs under impact and support their further application.…”
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High lipid diet can keep liver health but cause muscle oxidative stress of triploid rainbow trout treated with acute hypoxic challenge by Changye Li, Buying Han, Guoliang Sun, Haining Tian, Zezhong Wu, Changzhong Li, Yuqiong Meng, Rui Ma

“…Antioxidant gene expression in the liver were upregulated, but some genes expression in the muscle were downregulated in the HL group. 3) HL diet significantly increased inflammatory and immune genes expression in the liver and muscle (P < 0.05), and the increase is more pronounced in the muscle. 4) HL diet activated lipolysis, autophagy and gluconeogenesis related genes expression, but inhibited lipid synthesis and glycolysis related genes expression. …”
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Trace elements in children with pre-dialysis and end-stage renal disease by Alsalam Asmaa Abd, Ali Ruaa H., Hussain Haider K., Mahdi Montadher Ali

“…Zn had the highest accuracy as a biomarker for CKD and ESRD, with an the area under the curve (AUC) of 0.999, sensitivity of 100 % and specificity of 98 %. …”
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Comprehensive Review of Wearable Antennas With Flexible Periodic Structures for Body-Effect Mitigation by Adel Ashyap, Raad Raad, Faisel Tubbal, Wajid Ali Khan, Suhila Abulgasem

“…Recent advancements in wireless technology have prompted the development of wearable antennas, particularly for Wireless Body Area Networks (WBANs) used in sports, military activities, healthcare, and identification systems. …”
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Reduction of chickens use to perform in vitro pre-screening of novel anticoccidials by miniaturisation and increased throughput of the current Eimeria tenella compound-screening mo... by Virginia Marugan-Hernandez, Javier Regidor-Cerrillo, Luis Ortega-Mora, Sara Arias-Maroto, Kelsilandia Aguiar-Martins

“…This disease is caused by protozoan parasites of the genus Eimeria (Apicomplexa), and it is mainly controlled by chemoprophylaxis with ionophores and chemical anticoccidials; however, there is an overall agreement about the limitation of these traditional drugs and the need to improve current methods of control. Anticoccidial activities of novel compounds is currently evaluated by expensive experiments that involve large numbers of chickens. …”
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Highly efficient assessment and selective determination of pancreatic cancer biomarker CA-19-9 using co-electrodeposited MXene-AgNPs nanocomposite by Mahsa Mirzayi, Balal Khalilzadeh, Sattar Akbari Nakhjavani, Rahim Mohammad-Rezaei

“…To examine the morphology of the developed immunosensor for the purpose of enhancing its optimal performance, the characterization methods employed include Field Emission Scanning Electron Microscopy (FE-SEM), Fourier-Transform Infrared Spectroscopy (FT-IR), and X-ray Diffraction (XRD). …”
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High-power ultrasound pretreatment for enhanced protein extraction from lupin flour: Impact on yield, anti-technological and anti-nutritional factors, and techno-functional propert... by Paola Navarro-Vozmediano, Esperanza Dalmau, Jose Benedito, Jose V. Garcia-Perez

“…In particular, HPU reduced fat (avg. 27 %), saponin (avg. 21 %) and phenolic content (avg. 17 %), as well as antioxidant activity (avg. 11 %). In addition, the highest protein yield was achieved by sonication using water at 30 °C. …”
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Overcoming hypoxia-induced breast cancer drug resistance: a novel strategy using hollow gold-platinum bimetallic nanoshells by Lian-Ying Zhang, Xiao-Tong Chen, Rong-Tian Li, Wei Meng, Guo-Qin Huang, Yong-Jian Chen, Feng-Jun Ge, Qun Zhang, Yu-Jun Quan, Cai-Tao Zhang, Yi-Fei Liu, Ming Chen, Jin-Xiang Chen

“…The photothermal effect, induced by the surface plasmon resonance (SPR) from the Au-Pt shell under near infrared-II (NIR-II) laser irradiation, not only directly causes tumor cell death through photothermal therapy (PTT), but also significantly enhances the catalase-like activity between Pt nanoparticles and endogenous H2O2. …”
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The Relationship Between Screen Time, Sleep and Obesity by Dominika Lewandowska, Dominika Rosińska-Lewandoska, Zofia Podraza, Dominika Strep, Julia Grabowska, Jakub Rosiński, Zofia Głowniak, Maciej Kwiatkowski, Izabela Kwiatkowska, Malwina Soja

“… Introduction Excessive screen time has emerged as a major public health concern, particularly due to its association with sleep disturbances and the rising prevalence of obesity. …”
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Scurvy as a Cause of Leg Pain and Limp in Pediatric and Adolescent Patients by Christopher J. DeFrancesco, MD, David Kell, BA, Sean Owens, BS, Matt Grady, MD, Naomi Brown, MD

“…Vitamin C deficiency (VCD) results in collagen dysfunction due to decreased lysyl and prolyl hydroxylase enzyme activity. The resulting disease, known as scurvy, can present with various findings, including gingival bleeding, bruising, other skin lesions, poor wound healing, and tooth and bone abnormalities. …”
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Multi-trace elements-enriched functional drink accelerates gastric ulcer repair via the HGF/c-Met/STAT3 pathway by Yongnan Piao, Nuoya Wang, Mingji Jin, Jianyu Piao, Mingfeng Han, Zifei Wang, Chunhua Quan, Jishan Yin, Zhonggao Gao, Wenxiang Cui, Shuangqing Wang, Xiuquan Quan

“…FD increased the activities of antioxidant factors (T-SOD, GSH, CAT, and IL-10), and decreased the inflammatory factors levels (TNF-α, IL-6, MDA, COX-2, and iNOS) by promoting the HGF/c-Met/STAT3 pathway. …”
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Meta-analysis on the entomological effects of differentially treated ITNs in a multi-site experimental hut study in sub-Saharan Africa by Natalie Lissenden, John Bradley, Benjamin Menze, Charles Wondji, Constant Edi, Benjamin Koudou, Raphael N’Guessan, Koama Bayili, Abdoulaye Diabaté, Njelembo Mbewe, Basiliana Emidi, Jacklin Mosha, Alphaxard Manjurano, Graham Small, Welbeck Oumbouke, Sarah Jane Moore, Derric Nimmo, Janneke Snetselaar

“…Abstract Background Restricting the placement of active ingredients (AIs) to specific panels on insecticide-treated nets (ITNs) has the potential to reduce the amount of AI required to treat a net. …”
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